Publications by authors named "Hiroaki Satoh"

443 Publications

A Pilot Study of Intervention With a Mobile Application Visualizing the Macronutrient Content for Type 2 Diabetes at a Japanese Center.

J Clin Med Res 2021 Aug 30;13(8):425-433. Epub 2021 Aug 30.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Background: Estimating the nutritional content of food is essential for self-management in people with type 2 diabetes mellitus, but it is a difficult skill to learn. The aim of this study was to investigate how diabetes management was impacted by the ability of patients to search for items they ate from a database of 26,300 different foods, and to visualize nutritional intake using the Japanese mobile application (app) "Calomeal."

Methods: This was a single-arm, single-center, pilot study. Eighteen outpatients with type 2 diabetes mellitus used the "Calomeal" app for 3 months. The primary endpoint was change in hemoglobin A1c (HbA1c). Secondary endpoints were changes in body weight (BW), lipid parameters, and quality of life scores.

Results: The baseline characteristics of the study subjects were as follows: age: 53.4 ± 7.8 years; male/female ratio: 11/7; HbA1c: 7.9 (7.58 - 8.23)%; and body mass index (BMI): 25.17 (21.63 - 28.59) kg/m. Significant reductions in HbA1c and BMI were observed over 3 months (HbA1c: 7.9 (7.58 - 8.23)% to 7.6 (7.3 - 8.23)%, P = 0.0410; BMI: 25.17 (21.63 - 28.59) to 24.54 (21.57 - 27.81) kg/m, P = 0.0057). Reductions in HbA1c and BMI both correlated with decreased carbohydrate intake estimated by the mobile app.

Conclusions: Japanese patients who used their smartphones to visualize their nutritional intake using the "Calomeal" app demonstrated improved short-term glycemic control and BMI. Although the validity of the results should be tested in future randomized controlled trials, this approach may be a clinical option for improving self-management in Japanese patients with type 2 diabetes mellitus.
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http://dx.doi.org/10.14740/jocmr4558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425790PMC
August 2021

Fluoro-deoxyglucose-positron emission tomography/CT scan in superior vena cava syndrome due to radiation-induced fibrosis.

Rep Pract Oncol Radiother 2021 9;26(3):451-453. Epub 2021 Jun 9.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito-city, Japan.

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http://dx.doi.org/10.5603/RPOR.a2021.0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281899PMC
June 2021

Complete disappearance of intra-bullous component in a patient with infectious bullae.

Tuberk Toraks 2021 06;69(2):291-292

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.

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http://dx.doi.org/10.5578/tt.20219822DOI Listing
June 2021

A tracheobronchial adenoid cystic carcinoma incidentally detected by chest radiography and pulmonary function test.

Adv Respir Med 2021 ;89(3):320-323

Department of Thoracic Surgery, Tokyo Medical University Ibaraki Medical Center, Ami-machi, Ibaraki, Japan.

Tracheobronchial adenoid cystic carcinomas are rare tumors that progress slowly. Diagnosis by chest plain radiography is difficult, and suspecting the existence of a disease that causes stenosis in the airways is an important key for diagnosis. A 51-year-old woman referred to our hospital because of dyspnea on exertion. Chest plain radiograph showed a slight widening of the mediastinum. The flow-volume curve of respiratory function test revealed flat portions of the curve suggesting the central airway obstruction pattern. Chest CT confirmed the existence of tracheobronchial tumor, which was pathologically diagnosed as adenoid cystic carcinoma. Chest physicians and thoracic surgeons should be careful not to miss these trivial findings in the first inspections.
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http://dx.doi.org/10.5603/ARM.a2021.0003DOI Listing
January 2021

Pseudoprogression during successful rechallenge of immune checkpoint inhibitor in a NSCLC patient.

Adv Respir Med 2021 ;89(3):316-319

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito-city, Japan.

Rechallenge of immune checkpoint inhibitors (ICPIs) is one of the attractive but unestablished treatment for recurrent non-small cell lung cancer (NSCLC) patients who have been treated with several-lines of systemic chemotherapy. In some NSCLC patients, effects of ICPI rechallenge therapy have become apparent. In ICPI treatment, although very rare, a phenomenon called pseudoprogression is known. We report the first case of a patient who had pseudoprogression during successful rechallenge of ICPI in a NSCLC patient. Although not fully clarified, factors related to the onset of pseudoprogression and good response to ICPI rechallenge are being investigated. Our case showed that pseudoprogression could be developed even in patients with ICPI rechallenge therapy.
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http://dx.doi.org/10.5603/ARM.a2021.0016DOI Listing
January 2021

Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes.

BMJ Open Diabetes Res Care 2021 06;9(1)

Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan

Introduction: Changes in albuminuria or estimated glomerular filtration rate (eGFR) can be used as a surrogate endpoint of end-stage kidney disease (ESKD) in people with type 2 diabetes. We investigated whether the combined changes in albuminuria and eGFR are more strongly associated with future risk of ESKD.

Research Design And Methods: Using data from a multicenter observational cohort study of people with type 2 diabetes, we evaluated the association of percentage change in urine albumin to creatinine ratio (UACR) and/or annual change in eGFR over 2 years with subsequent ESKD risk.

Results: Among 1417 patients with repeated albuminuria and eGFR over 2 years, 129 (9.1%) developed ESKD. Patients with >30% UACR decline had lower ESKD risk (HR 0.47; 95% CI 0.29 to 0.77), whereas those with >30% UACR increase had higher ESKD risk (HR 2.31; 95% CI 1.52 to 3.51), compared with those with minor UACR change. Patients with greater eGFR decline had an increased ESKD risk than those with minor eGFR change (a decline of <2.5 mL/min/1.73 m/year): HR 4.19 (95% CI 1.87 to 9.38) and 2.89 (95% CI 1.32 to 6.33) for those with a decline of >5 and 2.5-5 mL/min/1.73 m/year, respectively. When the combined changes in UACR and eGFR were used, the highest ESKD risk (HR 5.60; 95% CI 2.08 to 15.09) was observed among patients with >30% UACR increase and an eGFR decline of >5 mL/min/1.73 m/year compared with those with a minor change in UACR and eGFR.

Conclusions: Combined changes in albuminuria and eGFR over 2 years were strongly associated with future risk of kidney failure in patients with type 2 diabetes.
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http://dx.doi.org/10.1136/bmjdrc-2021-002311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8246293PMC
June 2021

Time-to-treatment failure and peripheral eosinophils in non-small cell lung cancer patients treated with immune checkpoint inhibitors.

Pol Arch Intern Med 2021 Jun 28. Epub 2021 Jun 28.

Introduction: There is an unmet clinical need to identify biomarkers to predict which non-small cell lung cancer (NSCLC) patients will benefit from immune checkpoint inhibitor (ICPI) treatment.

Objectives: The purpose of this study was to draw a detailed time-to-treatment failure (TTF) curve with information on peripheral eosinophils during ICPI treatment for NSCLC, and to clarify whether eosinophil information can predict prolonged TTF.

Patients And Methods: In 259 patients with NSCLC treated with ICPI therapy, peripheral eosinophil counts and percentages at the time of each ICPI administration were evaluated in each patient from the beginning of ICPI treatment up to TTF. Univariable and multivariable analyses were performed to identify clinical factors that were associated with TTF.

Results: When 180 patients receiving ICPI monotherapy were divided into three groups - "TTF≤6 weeks", "6 weeks
Conclusions: In NSCLC patients treated with ICPI therapy, especially ICPI monotherapy, eosinophil measurements during treatment might provide information useful in predicting prolonged TTF.
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http://dx.doi.org/10.20452/pamw.16049DOI Listing
June 2021

Radiotherapy for Breast Cancer and Pulmonary Toxicity Outside the Radiation Field.

Authors:
Hiroaki Satoh

Respir Care 2021 06;66(6):1046-1048

Division of Respiratory MedicineMito Medical CenterUniversity of Tsukuba-Mito Kyodo General HospitalIbaraki, Japan

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http://dx.doi.org/10.4187/respcare.08972DOI Listing
June 2021

Adverse effect of muscle damage due to osimertinib.

Cancer Treat Res Commun 2021 8;28:100389. Epub 2021 May 8.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Miya-machi 3-2-7, Mito, Ibaraki, 310-0015, Japan.

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http://dx.doi.org/10.1016/j.ctarc.2021.100389DOI Listing
May 2021

Imaging characteristics of nontuberculous mycobacterial pulmonary nodules.

Rom J Intern Med 2021 Apr 30. Epub 2021 Apr 30.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Miya-macho 3-2-7, Mito-city, Ibaraki, 310-0015, Japan.

: Nontuberculous mycobacteriosis (NTM) of the lungs can develop nodules. In order to clarify some of the characteristics of lung NTM nodules, we examined volume doubling time (VDT) and maximum standardized uptake value (SUVmax) in positron emission tomography (PET) of pathologically diagnosed NTM nodules.: From November 2012 to August 2018, clinical and radiological information were retrospectively investigated in 8 patients who were surgically resected and diagnosed as NTM. These eight patients were followed up until November 2020 and were confirmed to have no appearance of lung cancer or reappearance of lung NTM nodules. The VDT was calculated using the Schwartz formula.: The median maximum diameter of the nodule at the time of the first CT scan was 16.0 (range: 9.9-20.0) mm. The median maximum diameter of the nodule on CT performed before the surgical biopsy was 18.8 (range: 10.4-32.8) mm. The median doubling time calculated from these results was 203 (range: 20-568) days. Caseous granulomas and acid-fast bacilli were histologically confirmed in all 8 patients. Culture of excised nodules revealed in 5 patients and in 3 patients. Six patients received PET, and median SUVmax was: 7.0 (range: 3.3-21.0). Median VDT was around 200 days. Some patients had irregular-shaped nodules.: CT/PET-CT characteristics of lung nodules are not reliable in differentiating lung NTM nodules from malignant ones. To avoid unnecessary resection, it may be better to collect various information on imaging findings in the nodule itself and in opacities other than the nodule.
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http://dx.doi.org/10.2478/rjim-2021-0016DOI Listing
April 2021

Diaphragm thinning due to phrenic nerve palsy.

Tuberk Toraks 2021 03;69(1):111-113

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.

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http://dx.doi.org/10.5578/tt.20219915DOI Listing
March 2021

Changes in Body Weight and Serum Albumin Levels in Patients Requiring Home Long-term Oxygen Therapy.

Asian Pac Isl Nurs J 2021 ;5(4):199-206

University of Tsukuba, Mito Medical Center, Ibaraki, Japan.

To investigate the long-term changes in body weight and serum albumin levels in patients with respiratory failure, and those with chronic heart failure, who were treated with home long-term oxygen therapy (LTOT) to understand the current status and contribute to future measures. Patients with chronic obstructive pulmonary disease (COPD), those with interstitial pneumonia (IP), and those with chronic heart failure (CHF) undergoing home LTOT for 6 months or more between January 2011 and January 2019 were included in the study. Body weight and serum albumin levels were assessed at the start of home LTOT and at the end of the observation period, a minimum of 6 months after commencing home LTOT. Sixty-two patients (29 COPDs, 23 IPs, and 10 CHFs) were included. In COPD patients and IP patients, body weight decreased ( = 0.0017,  = 0.0018, respectively, Wilcoxon signed-rank test). Serum albumin levels decreased in IP patients ( = 0.0185) but not in COPD patients. There was neither significant decrease in body weight nor serum albumin levels in patients with CHF. Chronic respiratory failure patients who have home LTOT were likely to have a decreased nutritional status. In order to provide prolonged home LTOT, medical staff need to pay close attention to the nutritional status of patients receiving home LTOT.
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http://dx.doi.org/10.31372/20200504.1113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993891PMC
January 2021

Letter to the Editor Regarding "Cutaneous Toxicities in Lung Cancer Patients on Immune Checkpoint Inhibitor Therapy".

Clin Lung Cancer 2021 Feb 27. Epub 2021 Feb 27.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.

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http://dx.doi.org/10.1016/j.cllc.2021.02.016DOI Listing
February 2021

Long-term control in a patient with metastatic lung adenocarcinoma after discontinuation of nivolumab.

J Oncol Pharm Pract 2021 Jun 27;27(4):1052-1053. Epub 2021 Mar 27.

Mito Medical Center, University of Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1177/10781552211004694DOI Listing
June 2021

Successful dacomitinib treatment after osimertinib resistance in a patient with lung adenocarcinoma.

Clin Respir J 2021 07 25;15(7):851-852. Epub 2021 Mar 25.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito City, Japan.

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http://dx.doi.org/10.1111/crj.13360DOI Listing
July 2021

Outcome of SARS-CoV-2 infection in patients with severe asthma on biologics.

Respir Med 2021 Mar 6:106358. Epub 2021 Mar 6.

Mito Medical Center, University of Tsukuba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2021.106358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936774PMC
March 2021

Effect of Shakuyakukanzoto on Chemotherapy-Induced Hiccups in Patients with Lung Cancer.

Eurasian J Med 2021 Feb 19;53(1):2-4. Epub 2021 Jan 19.

Department of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki, Japan.

Objective: Shakuyakukanzoto, one of the traditional herbal medicines commonly used in North-East Asian countries, is known to be effective for muscle cramps. This retrospective study aimed to evaluate the effect of shakuyakukanzoto on chemotherapy-induced metoclopramide-uncontrolled hiccups.

Materials And Methods: We retrospectively investigated the medical records of all the consecutive patients with lung cancer who were prescribed with shakuyakukanzoto (Tsumura Co. Tokyo, Japan) for chemotherapy-induced hiccups in our hospital from September 2013 to November 2017. In the medical record from the initiation of shakuyakukanzoto until the start of the next chemotherapy, when there was description of "complete or partial disappearance of hiccups" after the prescription of shakuyakukanzoto, it was judged as a complete or partial response. A statement of "unchanged," no description of improvement, or exacerbation was judged as no change.

Results: Of the 49 chemotherapy courses in 15 patients with lung cancer, 93.9% had a "partial or complete" response within a few hours after the administration of shakuyakukanzoto. The effect of shakuyakukanzoto was observed irrespective of the pathological type of lung cancer, platinum-containing or non-platinum chemotherapy, and with or without other anti-hiccup drugs. No adverse event was observed.

Conclusion: Shakuyakukanzoto may offer an effective pharmacological approach to treat chemotherapy-induced metoclopramide-uncontrolled hiccups. Well-planned prospective studies will confirm our results.
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http://dx.doi.org/10.5152/eurasianjmed.2020.18184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929594PMC
February 2021

Prevalence and Features of Impaired Glucose Tolerance in Young Underweight Japanese Women.

J Clin Endocrinol Metab 2021 04;106(5):e2053-e2062

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Objective: In Japan, while it is known that underweight women over the age of 40 years have a high risk for type 2 diabetes, there is a lack of clarity on the association between glucose tolerance and underweight in younger women. Accordingly, we investigate the prevalence and features of impaired glucose tolerance (IGT) in young underweight Japanese women.

Designs And Methods: In this cross-sectional study, we recruited 56 normal weight and 98 underweight young Japanese women and evaluated their glucose tolerance levels using an oral glucose tolerance test. Then, we compared the clinical characteristics associated with normal glucose tolerance (NGT) and IGT in the underweight women. Insulin secretion, whole-body insulin sensitivity, and adipose tissue insulin resistance values were measured using the insulinogenic index, whole-body insulin sensitivity index (Matsuda index), and adipose insulin resistance index (Adipo-IR), respectively. Fitness level (peak VO2) was measured using an ergometer.

Results: The prevalence of IGT was higher in the underweight women than the normal weight women (13.3% vs 1.8%). The underweight women with IGT showed a lower insulinogenic index, lower peak VO2, and Matsuda index and a higher fasting free fatty acid level and Adipo-IR than those with NGT. The whole-body composition was comparable between the NGT and IGT groups.

Conclusions: The prevalence of IGT was higher in young Japanese women with underweight than those with a normal weight. The underweight women with IGT showed impaired early-phase insulin secretion, low fitness levels, and reduced whole-body and adipose tissue insulin sensitivity levels.
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http://dx.doi.org/10.1210/clinem/dgab052DOI Listing
April 2021

Association between peripheral eosinophils and clinical outcomes in patients with non-small cell lung cancer treated with immune checkpoint inhibitors.

Pol Arch Intern Med 2021 02 25;131(2):152-160. Epub 2021 Jan 25.

Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Introduction: Programmed cell death ligand 1 is considered a predictor of the therapeutic effect of immune checkpoint inhibitors (ICPIs), but a more simple and useful predictor is needed.

Objectives: The aim of this study was to identify the relationship between eosinophil counts and percentages and response to ICPI therapy.

Patients And Methods: In 190 patients with non-small cell lung cancer (NSCLC) treated with ICPI therapy, peripheral eosinophil counts and percentages at the time of ICPI therapy initiation, the maximum counts and percentages of eosinophils during ICPI therapy, response to therapy, and time to treatment failure (TTF) were investigated.

Results: Both an increase in the peripheral eosinophil count and an elevation of eosinophil percentage following the initiation of ICPI therapy were observed, regardless of whether the patients had controlled or progressive disease. The median time to the maximum eosinophil percentage was 5 weeks in patients with controlled disease and 2 weeks in those with progressive disease. The cutoff value for the maximum eosinophil counts and percentage during ICPI therapy was set at 300/μl and 5%, respectively, to identify the presence or absence of a therapeutic effect. Time to treatment failure was longer in patients with maximum eosinophil counts exceeding 300/μl and a maximum eosinophil percentage above 5%. In a multivariable analysis, a maximum eosinophil percentage of 5% during ICPI therapy was a significant predictive factor for therapeutic efficacy.

Conclusions: The measurement of peripheral eosinophils up to around 5 weeks following the initiation of treatment, especially the maximum eosinophils count and percentage, might provide useful information about the efficacy of ICPIs.
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http://dx.doi.org/10.20452/pamw.15776DOI Listing
February 2021

Adipose Insulin Resistance and Decreased Adiponectin Are Correlated With Metabolic Abnormalities in Nonobese Men.

J Clin Endocrinol Metab 2021 04;106(5):e2228-e2238

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Context: Adipose tissue dysfunction is characterized by decreased adiponectin (AN) levels and impaired adipose tissue insulin sensitivity (ATIS) and is associated with metabolic disorders. While Asians readily develop metabolic disease without obesity, it remains unclear how decreased AN level and impaired ATIS affect metabolic abnormalities in nonobese Asians.

Design And Setting: To investigate the relationships between decreased AN level, impaired ATIS, and metabolic abnormalities, we studied 94 Japanese men whose body mass index was less than 25 kg/m2. We divided the subjects into 4 groups based on their median AN level and ATIS, the latter calculated as the degree of insulin-mediated suppression of free fatty acids during hyperinsulinemic euglycemic clamp, and compared the metabolic parameters in the 4 groups.

Results: The High-ATIS/High-AN group (n = 29) showed similar anthropometric data to the High-ATIS/Low-AN group (n = 18). In contrast, both the Low-ATIS/High-AN (n = 18) and Low-ATIS/Low-AN (n = 29) groups showed significantly lower muscle insulin sensitivity than the High-ATIS groups. The intrahepatic lipid level in the Low-ATIS/Low-AN group was significantly higher than that in the High-ATIS groups. In addition, the Low-ATIS/Low-AN group had a significantly higher fasting serum triglyceride level and significantly lower high-density lipoprotein cholesterol level than the other 3 groups.

Conclusions: In nonobese Japanese men with high ATIS, the AN level was not associated with metabolic characteristics. On the other hand, subjects with low ATIS showed reduced muscle insulin sensitivity, and those with a decreased AN level demonstrated multiple metabolic abnormalities, represented by fatty liver and dyslipidemia.
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http://dx.doi.org/10.1210/clinem/dgab037DOI Listing
April 2021

Thymic cancer superimposed opacity of the mediastinal anatomical structures.

Adv Respir Med 2021;89(1):77-78. Epub 2021 Jan 20.

Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Tsukuba, Japan.

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http://dx.doi.org/10.5603/ARM.a2020.0184DOI Listing
January 2021

Fatal contralateral pneumothorax in a patient with pneumonectomy.

Tuberk Toraks 2020 12;68(4):461-462

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.

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http://dx.doi.org/10.5578/tt.69969DOI Listing
December 2020

Relationship between risk of hyper- low-density lipoprotein cholesterolemia and evacuation after the Great East Japan Earthquake.

J Epidemiol 2021 Jan 13. Epub 2021 Jan 13.

Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University.

BackgroundThe Great East Japan Earthquake and the Fukushima Daiichi nuclear disaster forced the evacuation of residents and led to many changes in lifestyle for the evacuees. The Comprehensive Health Check was implemented to support the prevention of lifestyle-related disease and we analyzed the effect of prolonged evacuation (average of 3.0 years) on the new onset of hyper-LDL cholesterolemia.MethodsThe study participants were Japanese adults living near the Fukushima Daiichi nuclear power plant in Fukushima Prefecture. Annual health checkups focusing on metabolic syndromes were conducted for persons ≥ 40 years by the Specific Health Checkup. Based on data from annual checkups from 2011 or 2012, we followed 18,670 non-hyper-LDL cholesterolemia who underwent at least one other annual checkup during 2013-2015.ResultsWe found that the new onset of hyper-LDL cholesterolemia was significantly by 31% higher in evacuees than in non-evacuees. Evacuees had a significantly higher prevalence of obesity, hypertension, and diabetes, and higher frequency of weight change. Furthermore, logistic regression model analysis showed that the evacuation was significantly associated with the new onset of hyper-LDL cholesterolemia after adjusting age, gender, body mass index (BMI), smoking habit, alcohol consumption, diabetes, weight change, sleep deprivation, and exercise.ConclusionsThe findings of the present study suggest that prolonged evacuation after a disaster is a risk factor for the new onset of hyper-LDL cholesterolemia, and lead to an increase in cardiovascular disease. It is therefore important to follow-up evacuees and recommend lifestyle changes where necessary.
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http://dx.doi.org/10.2188/jea.JE20200267DOI Listing
January 2021

Fast walking is a preventive factor against new-onset diabetes mellitus in a large cohort from a Japanese general population.

Sci Rep 2021 01 12;11(1):716. Epub 2021 Jan 12.

Department of Diabetes, Endocrinology and Metabolism, School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.

Based on questionnaires from 197,825 non-diabetic participants in a large Japanese cohort, we determined impact of (1) habit of exercise, (2) habit of active physical activity (PA) and (3) walking pace on new-onset of type 2 diabetes mellitus. Unadjusted and multivariable-adjusted logistic regression models were used to determine the odds ratio of new-onset diabetes mellitus incidence in a 3-year follow-up. There were two major findings. First, habits of exercise and active PA were positively associated with incidence of diabetes mellitus. Second, fast walking, even after adjusting for multiple covariates, was associated with low incidence of diabetes mellitus. In the subgroup analysis, the association was also observed in participants aged ≥ 65 years, in men, and in those with a body mass index ≥ 25. Results suggest that fast walking is a simple and independent preventive factor for new-onset of diabetes mellitus in the health check-up and guidance system in Japan. Future studies may be warranted to verify whether interventions involving walking pace can reduce the onset of diabetes in a nation-wide scale.
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http://dx.doi.org/10.1038/s41598-020-80572-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804125PMC
January 2021

Successfully managed combined pulmonary fibrosis and emphysema in a lung large cell neuroendocrine carcinoma patient treated with pembrolizumab.

Clin Respir J 2021 05 9;15(5):574-575. Epub 2021 Feb 9.

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito-city, Japan.

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http://dx.doi.org/10.1111/crj.13327DOI Listing
May 2021

A decrease in plasma glucose levels is required for increased endogenous glucose production with a single administration of a sodium-glucose co-transporter-2 inhibitor tofogliflozin.

Diabetes Obes Metab 2021 05 19;23(5):1092-1100. Epub 2021 Jan 19.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: To investigate whether changes in endogenous glucose production (EGP) and insulin and glucagon levels are elicited by the decrease in plasma glucose (PG) levels induced by the sodium-glucose co-transporter-2 (SGLT2) inhibitor tofogliflozin.

Materials And Methods: We evaluated EGP in 12 Japanese patients with type 2 diabetes under the conditions of no drugs administered (CON), single administration of the SGLT2 inhibitor tofogliflozin (TOF), and single administration of TOF with adjustment of PG levels with exogenous glucose infusion to mimic changes in PG levels observed with CON (TOF + G). We evaluated changes in EGP and levels of C-peptide and glucagon from baseline to 180 minutes after drug administration.

Results: Endogenous glucose production decreased in the CON (-0.22 ± 0.11 mg/kg·min) and TOF + G experiments (-0.31 ± 0.24 mg/kg·min), but not in the TOF experiment (+0.08 ± 0.19 mg/kg·min). The decrease in C-peptide was significantly greater in the TOF experiment (-0.11 ± 0.06 nmol/L) than in the CON (-0.03 ± 0.06 nmol/L) and the TOF + G experiments (-0.01 ± 0.11 nmol/L), while the increase in glucagon was significantly greater in the TOF experiment (+11.1 ± 6.3 pmol/L), but not in the TOF + G experiment (+8.6 ± 7.6 pmol/L) compared to the CON experiment (+5.1 ± 4.3 pmol/L).

Conclusions: These results indicate that the decrease in PG levels induced by SGLT2 inhibitor administration is required for the increase in EGP and decrease in insulin secretion.
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http://dx.doi.org/10.1111/dom.14312DOI Listing
May 2021

Change in Body Weight and Serum Albumin Levels in Febrile Neutropenic Lung Cancer Patients.

Asian Pac Isl Nurs J 2020 ;5(3):120-127

University of Tsukuba, Mito Medical Center, Japan.

Although advances have been made in the treatment and prevention of febrile neutropenia (FN) in cancer patients treated with chemotherapy, it is still a complication that requires clinical attention. Impaired nutritional status in patients who develop FN can affect the continuation of cancer treatment, but it has not been investigated. We conducted a retrospective longitudinal study in order to clarify (1) if body weight and serum albumin levels change in lung cancer patients who do and do not develop FN, and (2) if these indicators are more likely to worsen in patients with FN than in patients without FN. Patients undergoing cytotoxic chemotherapy between January 2011 and June 2020 were consecutively included in the study. Changes in body weight and serum albumin levels were investigated in a case-control study of patients with FN, and control patients without FN who were matched by age, gender, histopathology, and stage of lung cancer, at a ratio of 1:2. During the study period, 226 patients received cytotoxic chemotherapy. Among those, 33 (14.6%) patients developed FN during the first course of cytotoxic chemotherapy. We found a more pronounced decrease in both body weight and serum albumin level at four weeks after the initiation of chemotherapy in FN patients. In order to safely administer effective chemotherapy, medical staff need to pay close attention to the nutritional status of patients receiving chemotherapy.
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http://dx.doi.org/10.31372/20200503.1106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733627PMC
January 2020

Completely disappearance of opacity of pulmonary cryptococcosis with salazosulfapyridine for rheumatoid arthritis.

Authors:
Hiroaki Satoh

Tuberk Toraks 2020 09;68(3):351-352

Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Japan.

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http://dx.doi.org/10.5578/tt.70011DOI Listing
September 2020

A population-based study of outcomes in patients with surgically resected non-small cell lung cancer with anaplastic lymphoma kinase-rearranged mutations: A matched-pair study.

Mol Clin Oncol 2021 Jan 19;14(1):11. Epub 2020 Nov 19.

Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 3058575, Japan.

The present study aimed to evaluate clinical outcomes in patients with surgically resected non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearranged mutations. A matched-pair analysis in completely resected ALK-rearranged NSLC patients and those with neither ALK nor epidermal growth factor receptor (EGFR) mutations diagnosed at 11 institutes was performed between April 2008 and March 2019. A total of 51 patients with surgically resected ALK-rearranged NSCLC were included. Women constituted 68.6%, and smokers 29.4%. The median age was 65 years. In matched-pair analysis, disease-free survival and overall survival did not differ between patients with ALK-rearranged mutations and those without mutations. Post-recurrence survival in patients with ALK mutations was longer than that of patients with neither ALK nor epidermal growth factor receptor mutations. ALK genetic testing should be performed, even in elderly patients with NSCLC. Favorable prognosis might be expected after appropriate treatment for patients with recurrent ALK-mutated disease.
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http://dx.doi.org/10.3892/mco.2020.2173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709561PMC
January 2021
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