Hildur Helgadottir

Hildur Helgadottir

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Hildur Helgadottir

Hildur Helgadottir

Publications by authors named "Hildur Helgadottir"

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26Publications

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Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label study.

Authors:
Henrik Jespersen Roger Olofsson Bagge Gustav Ullenhag Ana Carneiro Hildur Helgadottir Ingrid Ljuslinder Max Levin Charlotta All-Eriksson Bengt Andersson Ulrika Stierner Lisa M Nilsson Jonas A Nilsson Lars Ny

BMC Cancer 2019 05 2;19(1):415. Epub 2019 May 2.

Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Blå stråket 2, 413 45, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s12885-019-5623-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498539PMC
May 2019

Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.

Authors:
Sebastian Walpole Antonia L Pritchard Colleen M Cebulla Robert Pilarski Meredith Stautberg Frederick H Davidorf Arnaud de la Fouchardière Odile Cabaret Lisa Golmard Dominique Stoppa-Lyonnet Erin Garfield Ching-Ni Njauw Mitchell Cheung Joni A Turunen Pauliina Repo Reetta-Stiina Järvinen Remco van Doorn Martine J Jager Gregorius P M Luyten Marina Marinkovic Cindy Chau Miriam Potrony Veronica Höiom Hildur Helgadottir Lorenza Pastorino William Bruno Virginia Andreotti Bruna Dalmasso Giulia Ciccarese Paola Queirolo Luca Mastracci Karin Wadt Jens Folke Kiilgaard Michael R Speicher Natasha van Poppelen Emine Kilic Rana'a T Al-Jamal Irma Dianzani Marta Betti Carsten Bergmann Sandro Santagata Sonika Dahiya Saleem Taibjee Jo Burke Nicola Poplawski Sally J O'Shea Julia Newton-Bishop Julian Adlard David J Adams Anne-Marie Lane Ivana Kim Sonja Klebe Hilary Racher J William Harbour Michael L Nickerson Rajmohan Murali Jane M Palmer Madeleine Howlie Judith Symmons Hayley Hamilton Sunil Warrier William Glasson Peter Johansson Carla Daniela Robles-Espinoza Raul Ossio Annelies de Klein Susana Puig Paola Ghiorzo Maartje Nielsen Tero T Kivelä Hensin Tsao Joseph R Testa Pedram Gerami Marc-Henri Stern Brigitte Bressac-de Paillerets Mohamed H Abdel-Rahman Nicholas K Hayward

J Natl Cancer Inst 2018 12;110(12):1328-1341

QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1093/jnci/djy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292796PMC
December 2018

CM-Score: a validated scoring system to predict germline mutations in melanoma families from Northern Europe.

Authors:
Thomas P Potjer Hildur Helgadottir Mirjam Leenheer Nienke van der Stoep Nelleke A Gruis Veronica Höiom Håkan Olsson Remco van Doorn Hans F A Vasen Christi J van Asperen Olaf M Dekkers Frederik J Hes

J Med Genet 2018 10 16;55(10):661-668. Epub 2018 Apr 16.

Department of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/jmedgenet-2017-105205DOI Listing
October 2018

Efficacy of novel immunotherapy regimens in patients with metastatic melanoma with germline mutations.

Authors:
Hildur Helgadottir Paola Ghiorzo Remco van Doorn Susana Puig Max Levin Richard Kefford Martin Lauss Paola Queirolo Lorenza Pastorino Ellen Kapiteijn Miriam Potrony Cristina Carrera Håkan Olsson Veronica Höiom Göran Jönsson

J Med Genet 2018 Oct 5. Epub 2018 Oct 5.

Department of Oncology, Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2018-105610
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http://dx.doi.org/10.1136/jmedgenet-2018-105610DOI Listing
October 2018

Phenocopies in melanoma-prone families with germ-line CDKN2A mutations.

Authors:
Hildur Helgadottir Håkan Olsson Margaret A Tucker Xiaohong R Yang Veronica Höiom Alisa M Goldstein

Genet Med 2018 09 7;20(9):1087-1090. Epub 2017 Dec 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/gim.2017.216DOI Listing
September 2018

Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment.

Authors:
Hildur Helgadottir Iara Rocha Trocoli Drakensjö Ada Girnita

Front Oncol 2018 12;8:202. Epub 2018 Jun 12.

Skin Tumor Center, Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fonc.2018.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006716PMC
June 2018

Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status.

Authors:
Hildur Helgadottir Rainer Tuominen Håkan Olsson Johan Hansson Veronica Höiom

J Am Acad Dermatol 2017 Nov 14;77(5):893-901. Epub 2017 Aug 14.

Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jaad.2017.05.050DOI Listing
November 2017

[Increased knowledge on familial melanoma and the underlying genetics].

Authors:
Hildur Helgadottir Kari Nielsen Veronica Höiom

Lakartidningen 2017 05 9;114. Epub 2017 May 9.

Karolinska Institutet - Stockholm, Sweden Karolinska Institutet - Stockholm, Sweden.

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May 2017

[The melanoma incidence continues to rise].

Authors:
Hildur Helgadottir Ulrika Stierner

Lakartidningen 2017 05 9;114. Epub 2017 May 9.

Sahlgrenska universitetssjukhuset - Goteborg, Sweden Sahlgrenska universitetssjukhuset - Goteborg, Sweden.

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May 2017

Germline CDKN2A Mutation Status and Survival in Familial Melanoma Cases.

Authors:
Hildur Helgadottir Veronica Höiom Rainer Tuominen Kari Nielsen Göran Jönsson Håkan Olsson Johan Hansson

J Natl Cancer Inst 2016 11 10;108(11). Epub 2016 Jun 10.

Affiliations of authors: Department of Oncology-Pathology, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden (HH, VH, RT, JH); Department of Oncology, Clinical Sciences Lund, Lund University and Skåne University Hospital (GJ, HO); Department of Dermatology, Clinical Sciences Lund, Lund University and Helsingborg Hospital (KN).

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http://dx.doi.org/10.1093/jnci/djw135DOI Listing
November 2016

Multiple rare variants in high-risk pancreatic cancer-related genes may increase risk for pancreatic cancer in a subset of patients with and without germline CDKN2A mutations.

Authors:
Xiaohong R Yang Melissa Rotunno Yanzi Xiao Christian Ingvar Hildur Helgadottir Lorenza Pastorino Remco van Doorn Hunter Bennett Cole Graham Joshua N Sampson Michael Malasky Aurelie Vogt Bin Zhu Giovanna Bianchi-Scarra William Bruno Paola Queirolo Giuseppe Fornarini Johan Hansson Rainer Tuominen Laurie Burdett Belynda Hicks Amy Hutchinson Kristine Jones Meredith Yeager Stephen J Chanock Maria Teresa Landi Veronica Höiom Håkan Olsson Nelleke Gruis Paola Ghiorzo Margaret A Tucker Alisa M Goldstein

Hum Genet 2016 Nov 23;135(11):1241-1249. Epub 2016 Jul 23.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

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http://link.springer.com/10.1007/s00439-016-1715-1
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http://dx.doi.org/10.1007/s00439-016-1715-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152573PMC
November 2016

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.

Authors:
Elizabeth M Kass Pei Xin Lim Hildur R Helgadottir Mary Ellen Moynahan Maria Jasin

Nat Commun 2016 10 25;7:13241. Epub 2016 Oct 25.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms13241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093336PMC
October 2016

The genetics of uveal melanoma: current insights.

Authors:
Hildur Helgadottir Veronica Höiom

Appl Clin Genet 2016 6;9:147-55. Epub 2016 Sep 6.

Department of Oncology and Pathology, Karolinska institutet.

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http://dx.doi.org/10.2147/TACG.S69210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019476PMC
September 2016

The role of germline alterations in the DNA damage response genes BRIP1 and BRCA2 in melanoma susceptibility.

Authors:
Rainer Tuominen Pär G Engström Hildur Helgadottir Hanna Eriksson Per Unneberg Sanela Kjellqvist Muyi Yang Diana Lindén Daniel Edsgärd Johan Hansson Veronica Höiom

Genes Chromosomes Cancer 2016 07 2;55(7):601-11. Epub 2016 May 2.

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/gcc.22363DOI Listing
July 2016

CDKN2a mutation-negative melanoma families have increased risk exclusively for skin cancers but not for other malignancies.

Authors:
Hildur Helgadottir Veronica Höiom Rainer Tuominen Göran Jönsson Eva Månsson-Brahme Håkan Olsson Johan Hansson

Int J Cancer 2015 Nov 21;137(9):2220-6. Epub 2015 May 21.

Department of Oncology Pathology, Karolinska Institutet and Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.29595DOI Listing
November 2015

High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families.

Authors:
Hildur Helgadottir Veronica Höiom Göran Jönsson Rainer Tuominen Christian Ingvar Ake Borg Håkan Olsson Johan Hansson

J Med Genet 2014 Aug 16;51(8):545-52. Epub 2014 Jun 16.

Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/jmedgenet-2014-102320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112445PMC
August 2014

Hereditary uveal melanoma: a report of a germline mutation in BAP1.

Authors:
Veronica Höiom Daniel Edsgärd Hildur Helgadottir Hanna Eriksson Charlotta All-Ericsson Rainer Tuominen Ivayla Ivanova Joakim Lundeberg Olof Emanuelsson Johan Hansson

Genes Chromosomes Cancer 2013 Apr 23;52(4):378-84. Epub 2013 Jan 23.

Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1002/gcc.22035DOI Listing
April 2013

Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase.

Authors:
Elizabeth M Kass Hildur R Helgadottir Chun-Chin Chen Maria Barbera Raymond Wang Ulrica K Westermark Thomas Ludwig Mary Ellen Moynahan Maria Jasin

Proc Natl Acad Sci U S A 2013 Apr 18;110(14):5564-9. Epub 2013 Mar 18.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1216824110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619303PMC
April 2013

Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 proteoglycan.

Authors:
Krissa Gibby Weon-Kyoo You Kuniko Kadoya Hildur Helgadottir Lawrence Jt Young Lesley G Ellies Yunchao Chang Robert D Cardiff William B Stallcup

Breast Cancer Res 2012 Apr 24;14(2):R67. Epub 2012 Apr 24.

Cancer Center, Tumor Microenvironment Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 USA.

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http://www.breast-cancer-research.com/content/pdf/bcr3174.pd
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http://breast-cancer-research.com/content/14/2/R67
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http://dx.doi.org/10.1186/bcr3174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446402PMC
April 2012

RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.

Authors:
Ulrica K Westermark Nanna Lindberg Pernilla Roswall Daniel Bråsäter Hildur R Helgadottir Sanna-Maria Hede Anders Zetterberg Maria Jasin Monica Nistér Lene Uhrbom

Neuro Oncol 2011 Dec 16;13(12):1277-87. Epub 2011 Sep 16.

Karolinska Institutet, Department of Oncology-Pathology, Stockholm, Sweden.

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http://dx.doi.org/10.1093/neuonc/nor131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223091PMC
December 2011

The common Scandinavian human leucocyte antigen ancestral haplotype 62.1 as prognostic factor in patients with advanced malignant melanoma.

Authors:
Hildur Helgadottir Emilia Andersson Lisa Villabona Lena Kanter Henk van der Zanden Geert W Haasnoot Barbara Seliger Kjell Bergfeldt Johan Hansson Boel Ragnarsson-Olding Rolf Kiessling Giuseppe Valentino Masucci

Cancer Immunol Immunother 2009 Oct 13;58(10):1599-608. Epub 2009 Feb 13.

Department of Oncology-Pathology, Karolinska Institute, Radiumhemmet, Karolinska University Hospital, 171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-009-0669-8DOI Listing
October 2009

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.

Authors:
Christos Gekas Katrin E Rhodes Laurraine M Gereige Hildur Helgadottir Roberto Ferrari Siavash K Kurdistani Encarnación Montecino-Rodriguez Rhonda Bassel-Duby Eric Olson Andrei V Krivtsov Scott Armstrong Stuart H Orkin Matteo Pellegrini Hanna K A Mikkola

Blood 2009 Apr 11;113(15):3461-71. Epub 2009 Feb 11.

Department of Molecular, Cell and Developmental Biology, University of California-Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1182/blood-2008-07-167577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945827PMC
April 2009

Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase.

Authors:
David M Weinstock Koji Nakanishi Hildur R Helgadottir Maria Jasin

Methods Enzymol 2006 ;409:524-40

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)09031-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036680PMC
August 2006

Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients.

Authors:
Hakon Hakonarson Unnur S Bjornsdottir Eva Halapi Jonathan Bradfield Florian Zink Magali Mouy Hildur Helgadottir Asta S Gudmundsdottir Hjalti Andrason Asdis E Adalsteinsdottir Kristleifur Kristjansson Illugi Birkisson Thor Arnason Margret Andresdottir David Gislason Thorarinn Gislason Jeffrey R Gulcher Kari Stefansson

Proc Natl Acad Sci U S A 2005 Oct 3;102(41):14789-94. Epub 2005 Oct 3.

deCODE genetics, Inc., Sturlugata 8, IS-101 Reykjavik, Iceland.

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http://dx.doi.org/10.1073/pnas.0409904102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253826PMC
October 2005

Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window during hematopoietic stem-cell development.

Authors:
Thorsten M Schlaeger Hanna K A Mikkola Christos Gekas Hildur B Helgadottir Stuart H Orkin

Blood 2005 May 27;105(10):3871-4. Epub 2005 Jan 27.

Division of Hematology-Oncology, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2004-11-4467DOI Listing
May 2005

TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro.

Authors:
Jonas Larsson Ulrika Blank Hildur Helgadottir Jon Mar Björnsson Mats Ehinger Marie-José Goumans Xiaolong Fan Per Levéen Stefan Karlsson

Blood 2003 Nov 3;102(9):3129-35. Epub 2003 Jul 3.

Department of Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund University Hospital, BMC A12, 221 84 Lund, Sweden.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-04-13
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http://dx.doi.org/10.1182/blood-2003-04-1300DOI Listing
November 2003