Hildegund C J Ertl

Hildegund C J Ertl

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Hildegund C J Ertl

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Publications by authors named "Hildegund C J Ertl"

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100Publications

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New human rabies vaccines in the pipeline.

Vaccine 2018 Aug 25. Epub 2018 Aug 25.

Wistar Institute, Philadelphia, PA, USA. Electronic address:

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August 2018

Safety and immunogenicity of a potential checkpoint blockade vaccine for canine melanoma.

Cancer Immunol Immunother 2018 Jul 26. Epub 2018 Jul 26.

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA.

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July 2018

Preclinical models to assess the immunogenicity of AAV vectors.

Cell Immunol 2017 Nov 23. Epub 2017 Nov 23.

The Wistar Institute, Philadelphia, PA, United States. Electronic address:

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November 2017

Vaccine Design: Replication-Defective Adenovirus Vectors.

Methods Mol Biol 2016 ;1404:329-49

The Wistar Institute, Philadelphia, PA, 19104, USA.

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December 2016

Antibody responses to prime-boost vaccination with an HIV-1 gp145 envelope protein and chimpanzee adenovirus vectors expressing HIV-1 gp140.

AIDS 2016 10;30(16):2405-2414

aUniversity of Pennsylvania, Philadelphia bThe Wistar Institute, Philadelphia, Pennsylvania cThe Henry M. Jackson Foundation, Rockville dMilitary HIV Research Program eWalter Reed Army Institute of Research, Silver Spring, Maryland, USA.

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October 2016

Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors.

Oncotarget 2016 Apr;7(17):23282-99

The Wistar Institute, Philadelphia, Pennsylvania, USA.

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April 2016

Age-related changes in the transcriptome of antibody-secreting cells.

Oncotarget 2016 Mar;7(12):13340-53

The Wistar Institute Vaccine Center, Philadelphia, Pennsylvania, USA.

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March 2016

Starved and Asphyxiated: How Can CD8(+) T Cells within a Tumor Microenvironment Prevent Tumor Progression.

Front Immunol 2016 10;7:32. Epub 2016 Feb 10.

The Wistar Institute Vaccine Center , Philadelphia, PA , USA.

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February 2016

Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer.

J Innate Immun 2015 20;7(3):302-14. Epub 2015 Jan 20.

Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, Fla., USA.

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January 2016

Repeated Low-Dose Influenza Virus Infection Causes Severe Disease in Mice: a Model for Vaccine Evaluation.

J Virol 2015 Aug 20;89(15):7841-51. Epub 2015 May 20.

Vaccine Research Center, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Science, Shanghai, China

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August 2015

Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques.

Proc Natl Acad Sci U S A 2015 Jan 30;112(2):518-23. Epub 2014 Dec 30.

Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329;

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January 2015

The effect of adenovirus-specific antibodies on adenoviral vector-induced, transgene product-specific T cell responses.

J Leukoc Biol 2014 Nov 31;96(5):821-31. Epub 2014 Jul 31.

The Wistar Institute, Philadelphia, Pennsylvania, USA; and

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November 2014

Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models.

Mol Ther Nucleic Acids 2014 Nov 4;3:e208. Epub 2014 Nov 4.

Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.

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November 2014

The effect of adjuvanting cancer vaccines with herpes simplex virus glycoprotein D on melanoma-driven CD8+ T cell exhaustion.

J Immunol 2014 Aug 14;193(4):1836-46. Epub 2014 Jul 14.

Gene Therapy and Vaccines Program, University of Pennsylvania School of Medicine, Philadelphia, PA 19104; and Wistar Institute Vaccine Center, University of Pennsylvania, Philadelphia, PA 19104

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August 2014

Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans.

PLoS One 2013 14;8(10):e77164. Epub 2013 Oct 14.

Institute for Immunology, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.

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June 2014

Enhancement of recombinant adenovirus vaccine-induced primary but not secondary systemic and mucosal immune responses by all-trans retinoic acid.

Vaccine 2014 Jun 26;32(27):3386-92. Epub 2014 Apr 26.

Wistar Institute, Philadelphia, PA, United States. Electronic address:

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June 2014

Construction and characterization of E1- and E3-deleted adenovirus vectors expressing two antigens from two separate expression cassettes.

Hum Gene Ther 2014 Apr 25;25(4):328-38. Epub 2014 Mar 25.

1 Cellular and Molecular Biology, University of Pennsylvania , Philadelphia, PA 19104.

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April 2014

Immunogenicity of a prime-boost vaccine containing the circumsporozoite proteins of Plasmodium vivax in rodents.

Infect Immun 2014 Feb 9;82(2):793-807. Epub 2013 Dec 9.

Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, SP, Brazil.

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February 2014

Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B.

J Transl Med 2014 Jan 25;12:25. Epub 2014 Jan 25.

Department of Pediatrics, Division of Cellular and Molecular Therapy, University of Florida, Gainesville, Florida, USA.

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January 2014

Gene therapy research at the frontiers of viral immunology.

Front Microbiol 2012 24;3:182. Epub 2012 May 24.

Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine Gainesville, FL, USA.

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October 2012

Preventative childhood vaccination to rabies.

Expert Opin Biol Ther 2012 Aug 24;12(8):1067-75. Epub 2012 Jun 24.

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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August 2012

Progress in the development of hepatitis C virus vaccines.

Mol Ther 2012 Apr;20(4):697-8

The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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April 2012

Defective CD8 T cell responses in aged mice are due to quantitative and qualitative changes in virus-specific precursors.

J Immunol 2012 Feb 13;188(4):1933-41. Epub 2012 Jan 13.

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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February 2012

Capsid-specific T-cell responses to natural infections with adeno-associated viruses in humans differ from those of nonhuman primates.

Mol Ther 2011 Nov 17;19(11):2021-30. Epub 2011 May 17.

Immunology Program, Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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November 2011

Can Viruses be Modified to Achieve Sustained Gene Transfer.

Front Microbiol 2011 12;2:152. Epub 2011 Jul 12.

Immunology Program, Wistar Institute Philadelphia, PA, USA.

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November 2011

Viruses - from pathogens to vaccine carriers.

Curr Opin Virol 2011 Oct;1(4):241-5

University of Pennsylvania Graduate Program, Philadelphia, PA, USA.

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October 2011

The ideal vaccine: until death do us part.

Mol Ther 2011 May;19(5):820-2

The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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May 2011

Adeno-associated virus vectors serotype 2 induce prolonged proliferation of capsid-specific CD8+ T cells in mice.

Mol Ther 2011 Mar 14;19(3):536-46. Epub 2010 Dec 14.

Immunology Program, Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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March 2011

Vaccination with Ad5 vectors expands Ad5-specific CD8 T cells without altering memory phenotype or functionality.

PLoS One 2010 Dec 22;5(12):e14385. Epub 2010 Dec 22.

Department of Microbiology and Center for AIDS Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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December 2010

Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys.

Virology 2010 Nov 24;407(1):1-6. Epub 2010 Aug 24.

Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil.

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November 2010

An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector.

Nat Protoc 2010 Nov 14;5(11):1775-1785. Epub 2010 Oct 14.

The Wistar Institute, Philadelphia, Pennsylvania, USA.

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November 2010

Simian recombinant adenovirus delivered by the mucosal route modulates gammadelta T cells from murine genital tract.

Vaccine 2010 Jun 9;28(29):4600-8. Epub 2010 May 9.

Departamento de Microbiologia, Imunologia e Parasitologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil.

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June 2010

Targeting inhibitory pathways in cancer immunotherapy.

Curr Opin Immunol 2010 Jun 12;22(3):385-90. Epub 2010 May 12.

The Wistar Institute, Philadelphia, PA 19104, USA.

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June 2010

Current Opinion in Immunology. Vaccines. Introduction.

Curr Opin Immunol 2010 Jun 24;22(3):355-7. Epub 2010 May 24.

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June 2010

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive.

Vaccine 2010 Feb;28(8):1932-41

Microbiology Department, University of Pennsylvania, Philadelphia, PA 19104, United States.

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February 2010

Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine.

J Leukoc Biol 2009 Oct 13;86(4):779-93. Epub 2009 Jul 13.

Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil.

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October 2009

Pandemic influenza vaccines.

Curr Top Microbiol Immunol 2009 ;333:291-321

The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA.

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October 2009

Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors.

Vaccine 2009 Sep 4;27(42):5837-45. Epub 2009 Aug 4.

Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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September 2009

Novel vaccines to human rabies.

PLoS Negl Trop Dis 2009 Sep 29;3(9):e515. Epub 2009 Sep 29.

The Wistar Institute, Philadelphia, Pennsylvania, United States of America.

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September 2009

New insights on adenovirus as vaccine vectors.

Mol Ther 2009 Aug 9;17(8):1333-9. Epub 2009 Jun 9.

The Wistar Institute Vaccine Center, Philadelphia, Pennsylvania 19104, USA.

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August 2009

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.

Nat Med 2009 Aug 20;15(8):876-8. Epub 2009 Jul 20.

Department of Microbiology and Center for AIDS Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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August 2009

Effect of preexisting immunity on an adenovirus vaccine vector: in vitro neutralization assays fail to predict inhibition by antiviral antibody in vivo.

J Virol 2009 Jun 11;83(11):5567-73. Epub 2009 Mar 11.

Division of Infectious Diseases, the Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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June 2009

Potentiating vaccine immunogenicity by manipulating the HVEM/BTLA pathway and other co-stimulatory and co-inhibitory signals of the immune system.

Hum Vaccin 2009 Jan-Feb;5(1):6-14. Epub 2009 Jan 8.

The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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April 2009

Immune barriers to successful gene therapy.

Trends Mol Med 2009 Jan 26;15(1):32-9. Epub 2008 Dec 26.

University of Pennsylvania School of Medicine, The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA.

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January 2009

Recombinant adeno-associated virus vectors induce functionally impaired transgene product-specific CD8+ T cells in mice.

J Clin Invest 2007 Dec;117(12):3958-70

University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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December 2007

CD8(+) T-cell responses to adeno-associated virus capsid in humans.

Nat Med 2007 Apr 18;13(4):419-22. Epub 2007 Mar 18.

The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA.

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April 2007

Structure-based identification of a major neutralizing site in an adenovirus hexon.

J Virol 2007 Feb 15;81(4):1680-9. Epub 2006 Nov 15.

Abramson Research Center, Room 1205G, Immunologic and Infectious Disease, The Children's Hospital of Philadelphia, 3601 Civic Center Blvd., Pennsylvania, PA 19104, USA.

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February 2007

Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.

Mol Ther 2007 Feb;15(2):393-403

Cell and Molecular Biology Group, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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February 2007

Genital CD8+ T cell response to HIV-1 gag in mice immunized by mucosal routes with a recombinant simian adenovirus.

Vaccine 2007 Jan 24;25(1):109-16. Epub 2006 Jul 24.

Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.

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January 2007

A chimpanzee-origin adenovirus vector expressing the rabies virus glycoprotein as an oral vaccine against inhalation infection with rabies virus.

Mol Ther 2006 Nov 22;14(5):662-72. Epub 2006 Jun 22.

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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November 2006

Chimpanzee adenovirus antibodies in humans, sub-Saharan Africa.

Emerg Infect Dis 2006 Oct;12(10):1596-9

The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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October 2006

Therapeutic potential of adenovirus as a vaccine vector for chronic virus infections.

Expert Opin Biol Ther 2006 Jan;6(1):63-72

The Wistar Institute, Philadelphia, PA 19104, USA.

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January 2006

Identification of mouse AAV capsid-specific CD8+ T cell epitopes.

Mol Ther 2005 Dec 2;12(6):1023-33. Epub 2005 Nov 2.

The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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December 2005

Dendritic cell maturation, but not CD8+ T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors.

J Immunol 2005 Nov;175(9):6032-41

Cell and Molecular Biology Group, Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA.

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November 2005

Challenges of immune responses in gene replacement therapy.

IDrugs 2005 Sep;8(9):736-8

Wistar Institute, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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September 2005

Immunological insights from genetic vaccines.

Virus Res 2005 Jul 7;111(1):89-92. Epub 2005 Apr 7.

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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July 2005

Adenoviruses as vaccine vectors.

Mol Ther 2004 Oct;10(4):616-29

The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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October 2004

DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins.

Cancer Gene Ther 2004 Jun;11(6):457-64

The Wistar Institute, 3601 Spruce St., Philadelphia, Pennsylvania 19104, USA.

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June 2004

Vaccine-induced CD8+ T cells eliminate tumors by a two-staged attack.

Cancer Gene Ther 2003 Dec;10(12):870-8

Department of Cancer Immunology, Greatpoland Cancer Center, Garbary 15, 61-866 Poznan, Poland.

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December 2003

A DNA vaccine expressing tyrosinase-related protein-2 induces T-cell-mediated protection against mouse glioblastoma.

Cancer Gene Ther 2003 Sep;10(9):678-88

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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September 2003

Rabies DNA vaccines for protection and therapeutic treatment.

Expert Opin Biol Ther 2003 Jul;3(4):639-44

Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

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July 2003

Technology evaluation: ALVAC-CEA/B7.1, Aventis Pasteur/Therion.

Curr Opin Mol Ther 2002 Dec;4(6):601-5

Wistar Institute, 3600 Spruce Street, Philadelphia, PA 19104, USA.

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December 2002