Publications by authors named "Hilda Yenuberi"

6 Publications

  • Page 1 of 1

Breast milk contains red cell isohaemagglutinins: An observational study of 176 mothers.

Vox Sang 2022 Jan 26:e13253. Epub 2022 Jan 26.

Department of Transfusion Medicine and Immunohaematology, Christian Medical College, Vellore, India.

Background And Objectives: Maternal antibodies are transferred to the child, predominantly IgG, via the transplacental route, and mostly IgA through breast milk. Cases reported by us and others have shown the transfer of red cell allo-antibodies through breast milk. This study was conducted to assess the presence of isohaemagglutinins in breast milk, the range of titres, and the correlation between breast milk and maternal plasma titres.

Materials And Methods: A total of 176 mothers were recruited in this study. Breast milk was collected after sufficient feeding was established and within 2-5 days of delivery in a sterile container without any anticoagulant. Antibody screen, identification and titres were performed on maternal plasma as well as breast milk.

Results: Anti-A and anti-B in breast milk corresponding to their respective maternal blood groups were found in all the samples. This study has shown titres in the breast milk of anti-A and anti-B ranging from 2 to 1024 in both saline and Coombs phases. There was no association between plasma and breast milk titres, thus making it impossible to predict which mother may potentially transfer a larger amount of these haemagglutinins. Isotypes of anti-A and anti-B were evaluated in both plasma and breast milk of 11 samples, which showed predominantly IgG in 7 (63.63%) and predominantly IgA in 4 (36.36%) samples.

Conclusion: Our study demonstrates the presence of a wide range of titres for IgG antibodies of the ABO blood group system in breast milk. The clinical impact of this finding needs to be studied further, as it assumes great relevance in developing countries where anaemia continues to challenge young infants.
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http://dx.doi.org/10.1111/vox.13253DOI Listing
January 2022

Audit of level II scans in a tertiary center of a middle-income country (MIC).

J Family Med Prim Care 2020 Jul 30;9(7):3242-3245. Epub 2020 Jul 30.

Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, South India.

Context: Significant anomalies are those that are lethal or those that require prolonged follow-up and unaffordable treatments. Detection of these anomalies allows early termination or the support systems necessary for pregnancies with these diagnoses. Anxiety associated with overdiagnosis makes the woman a victim of modern imaging technology. However, accurate detection of significant anomalies in a busy scan room of a developing country with the need to cater to large numbers is particularly challenging.

Aims: The aim was to audit the diagnostic accuracy in a busy scan room.

Settings And Design: Retrospective cohort in a tertiary center.

Methods And Materials: Audit of significant anomalies identified at the 20-week scan was performed after the expected date of confinement. Anomalies that were missed or overdiagnosed were noted.

Statistical Analysis Used: All the categorical variables in this research were summarized using counts and percentages.

Results: Twenty-eight thousand women underwent morphology ultrasound during the study period. 963 (3.4%) women were detected to have anomalies at birth. Multiple anomalies were seen in 285 (30%) cases and isolated ones in 678 (70%) cases. Anomalies of the genitourinary system were the commonest followed by the anomalies of central nervous system. Only 53 (0.2%) anomalies were missed. They were mainly syndromes and anomalies of the cardiovascular system. The most significant anomalies that were identified could be diagnosed with a basic ultrasound machine.

Conclusions: 910/963 (95%) of significant anomalies can be identified even in busy centers if a systematic assessment approach is ensured.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_88_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567275PMC
July 2020

Follow-up of offspring and mothers with gestational diabetes treated with metformin or glibenclamide: A randomized controlled trial.

Int J Gynaecol Obstet 2021 03 12;152(3):446-447. Epub 2020 Oct 12.

Department of Obstetrics and Gynecology, Christian Medical College, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1002/ijgo.13380DOI Listing
March 2021

Angiogenic factors and uterine artery Doppler in predicting preeclampsia and associated adverse outcomes in a tertiary hospital in south India.

Pregnancy Hypertens 2019 04 8;16:26-30. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.preghy.2019.01.012DOI Listing
April 2019

A randomised double-blind placebo-controlled trial comparing stepwise oral misoprostol with vaginal misoprostol for induction of labour.

Trop Doct 2016 Oct 19;46(4):198-205. Epub 2016 Jan 19.

Professor, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India

A comparison of induction of labour (IOL) using three doses of 25 µg vaginal misoprostol inserted at intervals of 4 h or more with a stepwise oral regime starting with 50 µg followed by two doses of 100 µg was studied in a double-blind placebo-controlled trial in a tertiary centre in South India. Primary outcome was vaginal delivery in 24 h. Significantly more women in the first group required oxytocin augmentation and a third dose of the drug than women in the second group. Uterine tachysystole and other maternal and neonatal complications were similar. Thus it is concluded that women induced with oral, as compared to vaginal misoprostol are more likely to labour without oxytocin.
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http://dx.doi.org/10.1177/0049475515624856DOI Listing
October 2016
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