Publications by authors named "Hilaire C Lam"

21Publications

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

J Exp Med 2019 11 10;216(11):2635-2652. Epub 2019 Sep 10.

Cancer Genetics Laboratory, Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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November 2019

Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ).

Oncogene 2019 12 16;38(49):7367-7383. Epub 2019 Aug 16.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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December 2019

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis.

Sci Rep 2018 09 21;8(1):14161. Epub 2018 Sep 21.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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September 2018

Renal disease in tuberous sclerosis complex: pathogenesis and therapy.

Nat Rev Nephrol 2018 11;14(11):704-716

Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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November 2018

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

JCI Insight 2018 04 19;3(8). Epub 2018 Apr 19.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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April 2018

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.

Hum Mol Genet 2018 05;27(9):1654-1663

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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May 2018

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization.

Am J Pathol 2016 12 18;186(12):3261-3272. Epub 2016 Oct 18.

Developmental Biology and Regenerative Medicine Program, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California; Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

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December 2016

New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex.

J Pathol 2017 Jan 29;241(2):219-225. Epub 2016 Nov 29.

Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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January 2017

Cecal ligation and puncture-induced sepsis as a model to study autophagy in mice.

J Vis Exp 2014 Feb 9(84):e51066. Epub 2014 Feb 9.

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital;

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February 2014

"Ciliophagy": The consumption of cilia components by autophagy.

Autophagy 2014 Mar 7;10(3):532-4. Epub 2014 Jan 7.

Division of Pulmonary and Critical Care Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston, MA USA; Pulmonary and Critical Care Medicine; Weill Cornell Medical College; New York, NY USA.

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March 2014

TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema.

Am J Physiol Lung Cell Mol Physiol 2012 Nov 14;303(9):L748-57. Epub 2012 Sep 14.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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November 2012

Isolation of mouse respiratory epithelial cells and exposure to experimental cigarette smoke at air liquid interface.

J Vis Exp 2011 Feb 21(48). Epub 2011 Feb 21.

Department of Medicine, Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, USA.

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February 2011

Deadly triplex: smoke, autophagy and apoptosis.

Autophagy 2011 Apr 1;7(4):436-7. Epub 2011 Apr 1.

Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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April 2011

Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema.

Proc Natl Acad Sci U S A 2010 Nov 18;107(44):18880-5. Epub 2010 Oct 18.

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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November 2010