Prof. Hikmet Geckil, PhD - Inonu University - Professor

Prof. Hikmet Geckil

PhD

Inonu University

Professor

Malatya, - | Turkey

Main Specialties: Biochemical Genetics, Biology, Biotechnology

Additional Specialties: Molecular Biology, Genetic Engineering

ORCID logohttps://orcid.org/0000-0003-0070-0691


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Prof. Hikmet Geckil, PhD - Inonu University - Professor

Prof. Hikmet Geckil

PhD

Introduction

Hikmet Geckil is a Turkish academic who received PhD degree in Molecular Biology (with Benjamin C. Stark) at Illinois Institute of Technology (IIT.) A postdoctoral study (1999-2000) at Ben Gurion University and the Fulbright Fellowship (2009-2010) at the HST of Harvard University and Massachusetts Institute of Technology (MIT) are among his science endeavors. His research is in the area of genetic engineering. His current affiliation is with the Department of Molecular Biology and Genetics at Inonu University

Research in Geckil’s GE Laboratory is primarily based on the function of Vitreoscilla hemoglobin (VHb), the first prokaryotic hemoglobin. Using VHb, Geckil’s group engineered various bacteria for the purpose of producing industrially important products ranging from microbial fuels butanediol, acetoin to drugs used in Alzheimer’s and Parkinson disease (e.g., dopa, dopamine) and to asparaginase, an enzyme used in cancer chemotherapy. One of the recent endeavors of his laboratory is to understand the role of mTOR signal complex on the “aerobic glycolysis of cancer cells” also known as Warburg effect, one of the 10 hallmarks of all cancers.

Geckil has published in the areas of biochemistry, biomedicine, and biotechnology, and has over 30 peer-reviewed publications. He is the lead editor of the Moleküler Hücre Biyolojisi, the Turkish version of the highly acclaimed textbook "Molecular Cell Biology" by Harvey Lodish et al. He is also the editor of Biyokimya, the Turkish translated version of "Instant Notes in Biochemistry" by David Hames and Nigel Hooper. He has served on the editorial board of several international scientific journals, including the Biotechnology Journal (Wiley) and the Turkish Journal of Biology (TUBITAK).

He is the founding director (2010-2012) of the Center for Gifted and Talented at Inonu University and the founding director of Inonu Children’s University (2010-2012), the founding member of European Children Universities. Dr. Geckil is also the founding chairman (2010-2013) of the Department of Molecular Biology and Genetics, the only department with fully English curricula at Inonu University. Nominated by TUBITAK (The Scientific and Technical Research Council of Turkey), in 2012 he represented Turkey in COMSTECH (OIC's Committee on Scientific and Technological Cooperation) as Chief Scientific Officer.

URLs
http://hikmet-geckil.weebly.com
https://bilimblogum.wordpress.com/
https://cms.inonu.edu.tr/hikmet.geckil
http://bilim-blogu.blogspot.com.tr/
https://bilimweb.wordpress.com/

Primary Affiliation: Inonu University - Malatya, - , Turkey

Specialties:

Additional Specialties:

Research Interests:


View Prof. Hikmet Geckil’s Resume / CV

Education

Mar 2010
Harvard University-MIT Health Sciences and Technology
Fulbright Fellow
Jan 2009 - Jan 2010
Massachusetts Institute of Technology
Fulbright Research Associate
Health Sciences
Jan 2009 - Jan 2010
Harvard University
Fulbright Research Associate
Medical School
Jan 1999 - Jan 2000
Ben-Gurion University of the Negev
CHA Postdoctoral Fellow
Biochemistry
Sep 1999
Ben Gurion University
CHI Post-doc
Sep 1990
Illinois Institute of Technology
PhD

Experience

Jan 2009 - Jan 2010
Harvard-MIT Division of Health Sciences and Technology
Senior Research Associate
Jan 2005 - Jan 2010
Inönü Üniversitesi
Associate Professor
Biology
Jan 1991 - Jan 1995
Illinois Institute of Technology
Teaching Assistant
Life Sciences
Jan 2012
Inönü Üniversitesi
Professor
Molecular Biology and Genetics

Publications

23Publications

468Reads

2Profile Views

Triumph or tragedy: progress in cancer

Turk J Biol (2014) 38: 701-707

Turkish Journal of Biology

Abstract: Cancer is probably the number one research area among all human endeavors, receiving the largest portion of science funding in most countries. This is because cancer remains one of the oldest conundrums among all human maladies. Although we now have a greater understanding of the biological and molecular basis of cancer, its diagnosis and therapy still pose great challenges. In this review, our aim is not to establish a comprehensive understanding of cancer, which is essentially impossible, but to outline, in a more provocative way, why cancer research in the pursuit of a cure did not live up to its promise, as the death rate from cancer has not changed much after almost half a century. In addition, we discuss some future perspectives to give some insight into cancer research and debunk the old view that pouring money into cancer research is the only way to overcome this dreadful disease. Key words: Cancer, cancer research, cancer statistics, progress in cancer, cancer publications

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November 2014

Impact Factor 1.000

2 Reads

Effect of vitreoscilla hemoglobin and culture conditions on production of bacterial L-asparaginase, an oncolytic enzyme.

Appl Biochem Biotechnol 2014 Aug 27;173(8):2140-51. Epub 2014 Jun 27.

Department of Biology, Inonu University, Malatya, 44280, Turkey,

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http://dx.doi.org/10.1007/s12010-014-1016-xDOI Listing
August 2014
35 Reads
1.735 Impact Factor

Editorial: Micro and nanofluidics - applications in biotechnology.

Biotechnol J 2011 Feb;6(2):131

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http://dx.doi.org/10.1002/biot.201100009DOI Listing
February 2011
13 Reads
3.708 Impact Factor

Miniaturized lensless imaging systems for cell and microorganism visualization in point-of-care testing.

Biotechnol J 2011 Feb;6(2):138-49

Demirci Bio-Acoustic MEMS in Medicine (BAMM) Labs at the HST-BWH Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1002/biot.201000427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066565PMC
February 2011
13 Reads
3.708 Impact Factor

Engineering hydrogels as extracellular matrix mimics.

Nanomedicine (Lond) 2010 Apr;5(3):469-84

Health Sciences and Technology, Harvard-MIT Health Sciences and Technology, Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, 65 Landsdowne St., #267, 02139 Cambridge, MA, USA.

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http://dx.doi.org/10.2217/nnm.10.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892416PMC
April 2010
55 Reads
5.413 Impact Factor

Production of L-DOPA and dopamine in recombinant bacteria bearing the Vitreoscilla hemoglobin gene.

Biotechnol J 2009 Jul;4(7):1077-88

Department of Biology, Inonu University, Malatya, Turkey.

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http://dx.doi.org/10.1002/biot.200900130DOI Listing
July 2009
22 Reads
3.708 Impact Factor

Editorial: Biotech in Turkey.

Biotechnol J 2009 Jul;4(7):951

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http://dx.doi.org/10.1002/biot.200900155DOI Listing
July 2009
128 Reads
3.708 Impact Factor

Simultaneous quantification of acylated and desacylated ghrelin in biological fluids.

Biomed Chromatogr 2008 Dec;22(12):1354-9

Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.

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http://dx.doi.org/10.1002/bmc.1065DOI Listing
December 2008
46 Reads
1.723 Impact Factor

Milk and blood ghrelin level in diabetics.

Nutrition 2007 Nov-Dec;23(11-12):807-11

Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, Elazig, Turkey.

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http://dx.doi.org/10.1016/j.nut.2007.08.015DOI Listing
February 2008
8 Reads
2.926 Impact Factor

Ghrelin: a novel peptide with therapeutic effect in certain cancers?

Med Hypotheses 2007 18;69(5):1157-8. Epub 2007 Apr 18.

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http://dx.doi.org/10.1016/j.mehy.2007.02.027DOI Listing
December 2007
6 Reads
1.152 Impact Factor

Ghrelin is present in teeth.

J Biochem Mol Biol 2007 May;40(3):368-72

Department of Biochemistry and Clinical Biochemistry, Firat University, Medical School (Firat Medical Center), 23119 Elazig, Turkey.

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May 2007
13 Reads

Ghrelin in plants: what is the function of an appetite hormone in plants?

Peptides 2006 Jul 17;27(7):1597-602. Epub 2006 Feb 17.

Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.

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http://dx.doi.org/10.1016/j.peptides.2006.01.005DOI Listing
July 2006
9 Reads
2.618 Impact Factor

Effect of Vitreoscilla hemoglobin on production of a chemotherapeutic enzyme, L-asparaginase, by Pseudomonas aeruginosa.

Biotechnol J 2006 Feb;1(2):203-8

Department of Biology, Inonu University, Malatya 44280, Turkey.

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http://dx.doi.org/10.1002/biot.200500048DOI Listing
February 2006
13 Reads
3.708 Impact Factor

Vitreoscilla hemoglobin renders Enterobacter aerogenes highly susceptible to heavy metals.

Biometals 2004 Dec;17(6):715-23

Department of Biology, Inonu University, Malatya 44069, Turkey.

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December 2004
9 Reads
2.503 Impact Factor

Enhanced production of acetoin and butanediol in recombinant Enterobacter aerogenes carrying Vitreoscilla hemoglobin gene.

Bioprocess Biosyst Eng 2004 Oct;26(5):325-30

Department of Biology, Inonu University, Malatya 44069, Turkey.

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http://dx.doi.org/10.1007/s00449-004-0373-1DOI Listing
October 2004
27 Reads
1.997 Impact Factor

Protective role of melatonin given either before ischemia or prior to reperfusion on intestinal ischemia-reperfusion damage.

J Pineal Res 2004 Oct;37(3):149-52

Department of Chemistry, Inonu University, Malatya 44069, Turkey.

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http://dx.doi.org/10.1111/j.1600-079X.2004.00148.xDOI Listing
October 2004
25 Reads
9.600 Impact Factor

Production of L-asparaginase in Enterobacter aerogenes expressing Vitreoscilla hemoglobin for efficient oxygen uptake.

Authors:
H Geckil S Gencer

Appl Microbiol Biotechnol 2004 Feb 31;63(6):691-7. Epub 2003 Oct 31.

Department of Biology, Inonu University, 44069, Malatya, Turkey.

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http://dx.doi.org/10.1007/s00253-003-1482-5DOI Listing
February 2004
5 Reads
3.337 Impact Factor

Effects of simulated acid rain on the pollen germination and pollen tube growth of apple (Malus sylvestris Miller cv. Golden).

Acta Biol Hung 2003 ;54(1):95-103

Department of Biology, Faculty of Science, Firat University, Elazig 23119, Turkey.

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http://dx.doi.org/10.1556/ABiol.54.2003.1.10DOI Listing
December 2003
18 Reads
0.589 Impact Factor

Genetic engineering of Enterobacter aerogenes with the Vitreoscilla hemoglobin gene: cell growth, survival, and antioxidant enzyme status under oxidative stress.

Res Microbiol 2003 Jul-Aug;154(6):425-31

Department of Biology, Inonu University, Malatya 44069, Turkey.

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http://dx.doi.org/10.1016/S0923-2508(03)00083-4DOI Listing
October 2003
10 Reads
2.705 Impact Factor

The synthesis of indole-3-acetic acid by the industrially important white-rot fungus Lentinus sajor-caju under different culture conditions.

Mycol Res 2003 Mar;107(Pt 3):305-9

Department of Biology, Faculty of Arts and Sciences, Inonu University, Malatya 44069, Turkey.

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March 2003
6 Reads

Effects of metals on seed germination, root elongation, and coleoptile and hypocotyl growth in Triticum aestivum and Cucumis sativus.

Arch Environ Contam Toxicol 2002 Aug;43(2):203-13

Department of Biology, School of Arts and Sciences, Firat University, Elazig 23169, Turkey.

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http://link.springer.com/content/pdf/10.1007/s00244-002-1116
Web Search
http://link.springer.com/10.1007/s00244-002-1116-4
Publisher Site
http://dx.doi.org/10.1007/s00244-002-1116-4DOI Listing
August 2002
3 Reads
1.895 Impact Factor

Cell growth and oxygen uptake of Escherichia coli and Pseudomonas aeruginosa are differently effected by the genetically engineered Vitreoscilla hemoglobin gene.

J Biotechnol 2001 Jan;85(1):57-66

Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, IIT Center, Chicago, IL 60616, USA.

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January 2001
4 Reads
2.871 Impact Factor