Publications


The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.
Proc Natl Acad Sci U S A 2016 Dec 21;113(49):14097-14102. Epub 2016 Nov 21.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan;


PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Proc Natl Acad Sci U S A 2016 Apr 21;113(14):3844-9. Epub 2016 Mar 21.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan;

Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.
Proc Natl Acad Sci U S A 2015 Oct 29;112(41):12770-5. Epub 2015 Sep 29.
Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan; Department of Immunology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-033, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Meguro-ku, Tokyo 153-8505, Japan;



Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.
Proc Natl Acad Sci U S A 2013 Dec 3;110(51):20699-704. Epub 2013 Dec 3.
Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan.

Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction.
Proc Natl Acad Sci U S A 2012 Dec 3;109(51):21016-21. Epub 2012 Dec 3.
Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan.

Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses.
Nat Immunol 2012 May 20;13(7):659-66. Epub 2012 May 20.
Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan.

Chelating fibers prepared with a wet spinning technique using a mixture of a viscose solution and a polymer ligand for the separation of metal ions in an aqueous solution.
J Hazard Mater 2012 Feb 19;203-204:370-3. Epub 2011 Dec 19.
Graduate School of Science and Engineering for Research, University of Toyama, Gofuku 3190, Toyama 930-8555, Japan.

Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth.
Biochem Biophys Res Commun 2011 Jul 12;411(1):7-13. Epub 2011 Jun 12.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.



A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.
Proc Natl Acad Sci U S A 2009 Oct 1;106(42):17870-5. Epub 2009 Oct 1.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

A solid phase extraction using a chelate resin immobilizing carboxymethylated pentaethylenehexamine for separation and preconcentration of trace elements in water samples.
Talanta 2009 Jul 20;79(2):146-52. Epub 2009 Mar 20.
Graduate School of Science and Engineering for Research, University of Toyama, Gofuku 3190, Toyama 930-8555, Japan.

Critical role for constitutive type I interferon signaling in the prevention of cellular transformation.
Cancer Sci 2009 Mar 14;100(3):449-56. Epub 2008 Dec 14.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.
Proc Natl Acad Sci U S A 2008 Dec 11;105(51):20446-51. Epub 2008 Dec 11.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Nature 2007 Jul 8;448(7152):501-5. Epub 2007 Jul 8.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Characterization of a Borna disease virus field isolate which shows efficient viral propagation and transmissibility.
Microbes Infect 2007 Apr 12;9(4):417-27. Epub 2007 Jan 12.
Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Suita, Osaka 565-0871, Japan.

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
Proc Natl Acad Sci U S A 2006 Oct 3;103(41):15136-41. Epub 2006 Oct 3.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Proc Natl Acad Sci U S A 2004 Oct 18;101(43):15416-21. Epub 2004 Oct 18.
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Proc Natl Acad Sci U S A 2003 Sep 5;100(19):10872-7. Epub 2003 Sep 5.
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan.

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.
Nature 2003 Jul;424(6948):516-23
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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