Hideyuki Saya

Hideyuki Saya

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Hideyuki Saya

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The vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy.

Cancer Sci 2019 Nov 6. Epub 2019 Nov 6.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.14224DOI Listing
November 2019

Neuroprotective effects of memantine via enhancement of autophagy.

Biochem Biophys Res Commun 2019 Oct 17;518(1):161-170. Epub 2019 Aug 17.

Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, 113-8421, Japan; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Bunkyo, Tokyo, 113-8421, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.08.025DOI Listing
October 2019

ROCK Inhibition Induces Terminal Adipocyte Differentiation and Suppresses Tumorigenesis in Chemoresistant Osteosarcoma Cells.

Cancer Res 2019 Jun 16;79(12):3088-3099. Epub 2019 Apr 16.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2693DOI Listing
June 2019

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors.

J Control Release 2019 May 4;301:28-41. Epub 2019 Mar 4.

Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan; Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.02.021DOI Listing
May 2019

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori-Infected CAPZA1-Overexpressing Cells.

Cell Mol Gastroenterol Hepatol 2019 27;8(3):319-334. Epub 2019 May 27.

Department of Gastroenterology and Hepatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713896PMC
May 2019

Inhibiting xCT Improves 5-Fluorouracil Resistance of Gastric Cancer Induced by CD44 Variant 9 Expression.

Anticancer Res 2018 Nov;38(11):6163-6170

Fellowship Training Center and Medical Education Center, Keio University School of Medicine, Tokyo, Japan

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12969DOI Listing
November 2018

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.

Nat Med 2018 10 20;24(10):1579-1589. Epub 2018 Aug 20.

Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

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http://www.nature.com/articles/s41591-018-0140-5
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http://dx.doi.org/10.1038/s41591-018-0140-5DOI Listing
October 2018

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.

Oncotarget 2018 Sep 18;9(73):33832-33843. Epub 2018 Sep 18.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://www.oncotarget.com/fulltext/26112
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http://dx.doi.org/10.18632/oncotarget.26112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173468PMC
September 2018

HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer.

Int J Mol Sci 2018 Jul 24;19(8). Epub 2018 Jul 24.

Department of Breast Surgery and Oncology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

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http://dx.doi.org/10.3390/ijms19082158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121890PMC
July 2018

Prospects for new lung cancer treatments that target EMT signaling.

Dev Dyn 2018 03 25;247(3):462-472. Epub 2017 Oct 25.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/dvdy.24596DOI Listing
March 2018

Development of a functional thyroid model based on an organoid culture system.

Biochem Biophys Res Commun 2018 03 19;497(2):783-789. Epub 2018 Feb 19.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.02.154DOI Listing
March 2018

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model.

Neuro Oncol 2018 02;20(3):343-354

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1093/neuonc/nox170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817950PMC
February 2018

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake.

Sci Rep 2018 02 12;8(1):2785. Epub 2018 Feb 12.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1038/s41598-018-20973-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809395PMC
February 2018

Modeling phenotypes of malignant gliomas.

Cancer Sci 2018 Jan 15;109(1):6-14. Epub 2017 Nov 15.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.13351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765309PMC
January 2018

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model.

J Neurooncol 2018 Jan 19;136(1):23-31. Epub 2017 Sep 19.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

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http://dx.doi.org/10.1007/s11060-017-2621-7DOI Listing
January 2018

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407).

Gastric Cancer 2017 Nov 2;20(6):1004-1009. Epub 2017 May 2.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

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http://dx.doi.org/10.1007/s10120-017-0720-yDOI Listing
November 2017

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.

Cancer Med 2017 Nov 4;6(11):2635-2645. Epub 2017 Oct 4.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/cam4.1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673912PMC
November 2017

Establishment of pten knockout medaka with transcription activator-like effector nucleases (TALENs) as a model of PTEN deficiency disease.

PLoS One 2017 20;12(10):e0186878. Epub 2017 Oct 20.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186878PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650176PMC
November 2017

CD44 variant-dependent regulation of redox balance in EGFR mutation-positive non-small cell lung cancer: A target for treatment.

Lung Cancer 2017 11 14;113:72-78. Epub 2017 Sep 14.

Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.09.008DOI Listing
November 2017

ZEB1 expression is a potential indicator of invasive endometriosis.

Acta Obstet Gynecol Scand 2017 Sep 7;96(9):1128-1135. Epub 2017 Jul 7.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://doi.wiley.com/10.1111/aogs.13179
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http://dx.doi.org/10.1111/aogs.13179DOI Listing
September 2017

Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.

Cancer Sci 2017 Sep 16;108(9):1793-1802. Epub 2017 Jul 16.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.13304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581526PMC
September 2017

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.

J Control Release 2017 09 27;261:275-286. Epub 2017 Jun 27.

Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1016/j.jconrel.2017.06.021DOI Listing
September 2017

Endothelium-induced three-dimensional invasion of heterogeneous glioma initiating cells in a microfluidic coculture platform.

Integr Biol (Camb) 2017 09;9(9):762-773

Department of System Design Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

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http://dx.doi.org/10.1039/c7ib00091jDOI Listing
September 2017

Stat3 as a potential therapeutic target for rheumatoid arthritis.

Sci Rep 2017 09 8;7(1):10965. Epub 2017 Sep 8.

Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1038/s41598-017-11233-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591217PMC
September 2017

Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents.

PLoS One 2016 9;11(8):e0160952. Epub 2016 Aug 9.

Department of Dermatology, Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, 830-0011, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160952PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978388PMC
August 2017

CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

PLoS One 2016 2;11(6):e0156595. Epub 2016 Jun 2.

Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Department of Surgery, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890777PMC
July 2017

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells.

J Neurooncol 2017 Jun 29;133(2):297-307. Epub 2017 May 29.

Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1007/s11060-017-2457-1DOI Listing
June 2017

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma.

Free Radic Biol Med 2017 05 6;106:91-99. Epub 2017 Feb 6.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan; Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2017.02.011DOI Listing
May 2017

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma.

J Neurooncol 2017 04 10;132(2):231-238. Epub 2017 Mar 10.

Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima, 770-8503, Japan.

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http://dx.doi.org/10.1007/s11060-017-2380-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763415PMC
April 2017

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

Bioconjug Chem 2017 02 15;28(2):302-306. Epub 2016 Dec 15.

CREST, Japan Science and Technology Agency , 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00618DOI Listing
February 2017

RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis.

Biomed Res Int 2017 22;2017:8032910. Epub 2017 Jan 22.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1155/2017/8032910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292181PMC
February 2017

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis.

United European Gastroenterol J 2017 Feb 23;5(1):37-44. Epub 2016 Jun 23.

Department of Surgery, Vanderbilt University School of Medicine, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, USA; Nashville VA Medical Center, Vanderbilt University School of Medicine, USA.

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http://dx.doi.org/10.1177/2050640616644142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384548PMC
February 2017

Simvastatin-Induced Apoptosis in Osteosarcoma Cells: A Key Role of RhoA-AMPK/p38 MAPK Signaling in Antitumor Activity.

Mol Cancer Ther 2017 01 31;16(1):182-192. Epub 2016 Oct 31.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0499DOI Listing
January 2017

Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras.

Genes Cells 2016 Nov 23;21(11):1244-1252. Epub 2016 Sep 23.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1111/gtc.12435DOI Listing
November 2016

Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors.

J Bone Miner Metab 2016 Sep 23;34(5):526-31. Epub 2015 Jul 23.

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1007/s00774-015-0702-2DOI Listing
September 2016

Sulfasalazine, a therapeutic agent for ulcerative colitis, inhibits the growth of CD44v9(+) cancer stem cells in ulcerative colitis-related cancer.

Clin Res Hepatol Gastroenterol 2016 Sep 5;40(4):487-93. Epub 2016 Jan 5.

Department of surgery, Keio university school of medicine, 35, Shinano-machi, 1608582 Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.clinre.2015.11.007DOI Listing
September 2016

[p53 mutations in brain tumors].

Nihon Rinsho 2016 09;74 Suppl 7:112-116

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September 2016

Variant isoforms of CD44 expression in upper tract urothelial cancer as a predictive marker for recurrence and mortality.

Urol Oncol 2016 08 26;34(8):337.e19-26. Epub 2016 Apr 26.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.urolonc.2016.03.015DOI Listing
August 2016

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets.

Stem Cells 2016 08 20;34(8):1997-2007. Epub 2016 Jun 20.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1002/stem.2406DOI Listing
August 2016

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

Nat Commun 2016 06 30;7:11961. Epub 2016 Jun 30.

National Creative Research Initiatives Center for Cell Division and Differentiation, Department of Biological Science, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.1038/ncomms11961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931324PMC
June 2016

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.

J Control Release 2016 05 31;230:26-33. Epub 2016 Mar 31.

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan; Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Innovation Center of Nanomedicine, Kawasaki Institute of Industry Promotion, 66-20 Horikawa-cho, Saiwai-ku, Kawasaki 212-0013, Japan; Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Center for Disease Biology and Integrative Medicine, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.03.038DOI Listing
May 2016

Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer.

Med Oncol 2016 May 4;33(5):45. Epub 2016 Apr 4.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-Ku, 160-8582, Japan.

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http://dx.doi.org/10.1007/s12032-016-0760-xDOI Listing
May 2016

Periostin Is a Key Niche Component for Wound Metastasis of Melanoma.

PLoS One 2015 17;10(6):e0129704. Epub 2015 Jun 17.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129704PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471156PMC
March 2016

Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.

Cancer Prev Res (Phila) 2016 Mar 17;9(3):253-63. Epub 2016 Feb 17.

Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. AMED-CREST, AMED, Japan Agency for Medical Research and Development, Tokyo, Japan.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0315DOI Listing
March 2016

Therapeutic strategies targeting cancer stem cells.

Cancer Sci 2016 Jan 21;107(1):5-11. Epub 2015 Oct 21.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1111/cas.12817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724810PMC
January 2016

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells.

Biochem Biophys Res Commun 2016 Jan 11;470(1):239-244. Epub 2016 Jan 11.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.01.045DOI Listing
January 2016

Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.

Mol Cancer Ther 2015 Dec 6;14(12):2687-99. Epub 2015 Oct 6.

Section of Translational Breast Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674309PMC
December 2015

Application of clotrimazole via a novel controlled release device provides potent retinal protection.

J Mater Sci Mater Med 2015 Sep 3;26(9):230. Epub 2015 Sep 3.

Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan.

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http://dx.doi.org/10.1007/s10856-015-5561-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559097PMC
September 2015

Ink4a/Arf-Dependent Loss of Parietal Cells Induced by Oxidative Stress Promotes CD44-Dependent Gastric Tumorigenesis.

Cancer Prev Res (Phila) 2015 Jun 26;8(6):492-501. Epub 2015 Mar 26.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0025-TDOI Listing
June 2015

[Redox regulation in cancer stem cells].

Authors:
Hideyuki Saya

Nihon Rinsho 2015 May;73(5):790-4

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May 2015

Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.

Int J Cancer 2015 Apr 17;136(7):1504-14. Epub 2014 Sep 17.

Division of Diagnostic Pathology, Keio University Hospital, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1002/ijc.29137DOI Listing
April 2015

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry.

Nitric Oxide 2015 Apr 11;46:102-13. Epub 2014 Nov 11.

Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan; Japan Science and Technology Agency, Exploratory Research for Advanced Technology, Suematsu Gas Biology Project, Tokyo 160-8582, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10898603140049
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http://dx.doi.org/10.1016/j.niox.2014.11.005DOI Listing
April 2015

Functional analysis of a novel glioma antigen, EFTUD1.

Neuro Oncol 2014 Dec 11;16(12):1618-29. Epub 2014 Jul 11.

Department of Neurosurgery, Keio University School of Medicine, Tokyo, Japan (K.S., S.T., K.Y., M.T.); Neuro-immunology Research Group, Keio University School of Medicine, Tokyo, Japan (Y.I., S.O., M.T.); Department of Physiology, Keio University School of Medicine, Tokyo, Japan (S.O.); Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan (K.N., Y.K.); Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan (H.S.).

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http://dx.doi.org/10.1093/neuonc/nou132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232085PMC
December 2014

IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.

Cancer Res 2014 Nov 1;74(22):6531-41. Epub 2014 Oct 1.

Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. CREST, Japan Science and Technology Agency, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0914DOI Listing
November 2014

Loss of E-cadherin promotes migration and invasion of cholangiocarcinoma cells and serves as a potential marker of metastasis.

Tumour Biol 2014 Sep 28;35(9):8645-52. Epub 2014 May 28.

Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.

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http://link.springer.com/content/pdf/10.1007/s13277-014-2087
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http://link.springer.com/10.1007/s13277-014-2087-6
Publisher Site
http://dx.doi.org/10.1007/s13277-014-2087-6DOI Listing
September 2014

Tumor necrosis factor-α modulates epithelial mesenchymal transition mediators ZEB2 and S100A4 to promote cholangiocarcinoma progression.

J Hepatobiliary Pancreat Sci 2014 Sep 27;21(9):703-11. Epub 2014 May 27.

Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand; Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, Thailand.

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http://dx.doi.org/10.1002/jhbp.125DOI Listing
September 2014