Publications by authors named "Hideyuki Okano"

96Publications

New trends in cellular therapy.

Development 2020 Sep 17;147(18). Epub 2020 Sep 17.

Keio University School of Medicine, Department of Physiology, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1242/dev.192567DOI Listing
September 2020

Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disorders.

Inflamm Regen 2020 11;40:32. Epub 2020 Sep 11.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 Japan.

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http://dx.doi.org/10.1186/s41232-020-00143-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485212PMC
September 2020

Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells.

Mol Brain 2020 Sep 3;13(1):120. Epub 2020 Sep 3.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1186/s13041-020-00662-wDOI Listing
September 2020

Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms.

Mol Autism 2020 Sep 1;11(1):68. Epub 2020 Sep 1.

Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1186/s13229-020-00373-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465329PMC
September 2020

Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research.

Proc Natl Acad Sci U S A 2020 Aug 19. Epub 2020 Aug 19.

California National Primate Research Center, University of California, Davis, CA 95616;

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http://dx.doi.org/10.1073/pnas.2006515117DOI Listing
August 2020

Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ.

iScience 2020 Jul 30;23(7):101329. Epub 2020 Jun 30.

Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan; Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan; Section of Pediatric Dentistry, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.isci.2020.101329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363706PMC
July 2020

Generation of an ALS human iPSC line KEIOi001-A from peripheral blood of a Charcot disease-affected patient carrying TARDBP p.N345K heterozygous SNP mutation.

Stem Cell Res 2020 Jun 28;47:101896. Epub 2020 Jun 28.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2020.101896DOI Listing
June 2020

Low-dose rapamycin-induced autophagy in cochlear outer sulcus cells.

Laryngoscope Investig Otolaryngol 2020 Jun 29;5(3):520-528. Epub 2020 May 29.

Department of Otorhinolaryngology, Head and Neck Surgery Keio University School of Medicine Tokyo Japan.

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http://dx.doi.org/10.1002/lio2.392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314457PMC
June 2020

Steps towards COVID-19 suppression.

Inflamm Regen 2020 22;40:13. Epub 2020 Jun 22.

Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1186/s41232-020-00120-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306400PMC
June 2020

Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?

Inflamm Regen 2020 18;40:10. Epub 2020 Jun 18.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 Japan.

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http://dx.doi.org/10.1186/s41232-020-00122-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302355PMC
June 2020

Human-specific increases size and folding of primate neocortex in the fetal marmoset.

Science 2020 07 18;369(6503):546-550. Epub 2020 Jun 18.

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

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http://dx.doi.org/10.1126/science.abb2401DOI Listing
July 2020

Quantitative analysis of intervertebral disc degeneration using Q-space imaging in a rat model.

J Orthop Res 2020 Oct 5;38(10):2220-2229. Epub 2020 Jun 5.

Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan.

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http://dx.doi.org/10.1002/jor.24757DOI Listing
October 2020

The NanoZoomer artificial intelligence connectomics pipeline for tracer injection studies of the marmoset brain.

Brain Struct Funct 2020 May 4;225(4):1225-1243. Epub 2020 May 4.

Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan.

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http://dx.doi.org/10.1007/s00429-020-02073-yDOI Listing
May 2020

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling.

iScience 2020 May 11;23(5):101048. Epub 2020 Apr 11.

Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan; Department of Neurology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.101048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183160PMC
May 2020

The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.

FEBS J 2020 Apr 23. Epub 2020 Apr 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/febs.15341DOI Listing
April 2020

Primed to Naive-Like Conversion of the Common Marmoset Embryonic Stem Cells.

Stem Cells Dev 2020 06 27;29(12):761-773. Epub 2020 Apr 27.

Department of Physiology, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1089/scd.2019.0259DOI Listing
June 2020

Generation of a male common marmoset embryonic stem cell line DSY127-BV8VT1 carrying double reporters specific for the germ cell linage using the CRISPR-Cas9 and PiggyBac transposase systems.

Stem Cell Res 2020 04 21;44:101740. Epub 2020 Feb 21.

Department of Physiology, School of Medicine, Keio University, Tokyo, Japan; Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Saitama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2020.101740DOI Listing
April 2020

Reprogramming of chimpanzee fibroblasts into a multipotent cancerous but not fully pluripotent state by transducing iPSC factors in 2i/LIF culture.

Differentiation 2020 Mar - Apr;112:67-76. Epub 2020 Feb 4.

Molecular Biology Section, Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, 484-8506, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2020.01.002DOI Listing
February 2020

Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.

Trends Pharmacol Sci 2020 Feb 8;41(2):99-109. Epub 2020 Jan 8.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan; Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan; Department of Neurology and Stroke, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka-shi, Saitama, Japan.

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http://dx.doi.org/10.1016/j.tips.2019.12.002DOI Listing
February 2020

Dr. Seiji Ogawa and the Past, Present, and Future of Functional MRI Research.

Authors:
Hideyuki Okano

Keio J Med 2019 ;68(4):71-72

Department of Physiology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.2302/kjm.68-4_EditorialDOI Listing
January 2019

Polarization of Reactive Astrocytes in Response to Spinal Cord Injury is Enhanced by M2 Macrophage-Mediated Activation of Wnt/β-Catenin Pathway.

Mol Neurobiol 2020 Apr 17;57(4):1847-1862. Epub 2019 Dec 17.

Department of Physiology, Keio University Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s12035-019-01851-yDOI Listing
April 2020

Distribution of tight junctions in the primate cochlear lateral wall.

Neurosci Lett 2020 01 12;717:134686. Epub 2019 Dec 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.neulet.2019.134686DOI Listing
January 2020

Distribution of tight junctions in the primate cochlear lateral wall.

Neurosci Lett 2020 01 12;717:134686. Epub 2019 Dec 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.neulet.2019.134686DOI Listing
January 2020

[Ropinirole Hydrochloride for ALS].

Brain Nerve 2019 Nov;71(11):1279-1288

Department of Neurology and Stroke, Saitama medical university International medical center.

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http://dx.doi.org/10.11477/mf.1416201438DOI Listing
November 2019

Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.

Cell Rep 2019 10;29(3):645-658.e5

Imagine Institute of Genetic Diseases, Université de Paris, Paris 75015, France; Institute of Psychiatry and Neuroscience of Paris, INSERM U1266, Université de Paris, Paris 75014, France; Institut Jacques Monod, CNRS UMR 7592, Université de Paris, 75205 Paris Cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.007DOI Listing
October 2019

A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition.

Neurosci Res 2020 Sep 10;158:47-55. Epub 2019 Oct 10.

Department of Physiology, Keio University, School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2019.10.006DOI Listing
September 2020

Sex-specific effects of apolipoprotein ε4 allele on mortality in very old and centenarian Japanese men.

J Gerontol A Biol Sci Med Sci 2019 Oct 11. Epub 2019 Oct 11.

Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1093/gerona/glz242DOI Listing
October 2019

Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers.

Development 2019 11 4;146(21). Epub 2019 Nov 4.

Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan

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http://dx.doi.org/10.1242/dev.174938DOI Listing
November 2019

Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs.

Neurosci Res 2020 Jun 3;155:1-11. Epub 2019 Oct 3.

Department of Physiology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Wako City, Saitama, 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2019.09.005DOI Listing
June 2020

[Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment].

Brain Nerve 2019 Sep;71(9):943-952

Department of Neurology and Stroke, Saitama Medical University International Medical Center.

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http://dx.doi.org/10.11477/mf.1416201386DOI Listing
September 2019

atlasBREX: Automated template-derived brain extraction in animal MRI.

Sci Rep 2019 08 21;9(1):12219. Epub 2019 Aug 21.

Center for Brain Science Institute, RIKEN, Marmoset Neural Architecture, Wako-shi, Saitama, Japan.

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http://dx.doi.org/10.1038/s41598-019-48489-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704255PMC
August 2019

[Modeling Familial Parkinson's Disease Using Patient-specific Induced Pluripotent Stem Cells].

Brain Nerve 2019 Aug;71(8):875-883

Department of Physiology, Keio University School of Medicine.

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http://dx.doi.org/10.11477/mf.1416201368DOI Listing
August 2019

Comparison of inner ear drug availability of combined treatment with systemic or local drug injections alone.

Neurosci Res 2020 Jun 3;155:27-33. Epub 2019 Jul 3.

Department of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.neures.2019.07.001DOI Listing
June 2020

Cell therapy for spinal cord injury using induced pluripotent stem cells.

Regen Ther 2019 Dec 13;11:75-80. Epub 2019 Jun 13.

Department of Physiology, Keio University School of Medicine, Japan.

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http://dx.doi.org/10.1016/j.reth.2019.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581851PMC
December 2019

Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila.

iScience 2019 Jun 27;16:218-229. Epub 2019 May 27.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.isci.2019.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562144PMC
June 2019

Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming.

Biochem Biophys Res Commun 2019 08 6;515(4):593-599. Epub 2019 Jun 6.

Department of Physiology, School of Medicine, Keio University, Tokyo, Japan; Laboratory for Marmoset Neural Architecture, RIKEN Center for Brain Science, Saitama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.175DOI Listing
August 2019

Tau isoform expression and phosphorylation in marmoset brains.

J Biol Chem 2019 07 5;294(30):11433-11444. Epub 2019 Jun 5.

Laboratory of Molecular Neuroscience, Faculty of Sciences, Tokyo Metropolitan University, Minami-osawa, Hachioji, Tokyo 192-0397, Japan

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http://dx.doi.org/10.1074/jbc.RA119.008415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663862PMC
July 2019

Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling.

Stem Cell Reports 2019 06 9;12(6):1313-1328. Epub 2019 May 9.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565990PMC
June 2019

Semi-supervised deep learning of brain tissue segmentation.

Neural Netw 2019 Aug 1;116:25-34. Epub 2019 Apr 1.

Graduate School of Informatics, Kyoto University, Yoshida-honmachi, Kyoto, 606-8501, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08936080193009
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http://dx.doi.org/10.1016/j.neunet.2019.03.014DOI Listing
August 2019

Analysis of skeletal-muscle condition after excessive loading of the lower legs by sequential magnetic resonance imaging.

J Orthop Sci 2019 Sep 13;24(5):873-880. Epub 2019 Mar 13.

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1016/j.jos.2019.01.016DOI Listing
September 2019

Application of Hepatocyte Growth Factor for Acute Spinal Cord Injury: The Road from Basic Studies to Human Treatment.

Int J Mol Sci 2019 Feb 28;20(5). Epub 2019 Feb 28.

Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.3390/ijms20051054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429374PMC
February 2019

Comparative Principles for Next-Generation Neuroscience.

Front Behav Neurosci 2019 5;13:12. Epub 2019 Feb 5.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States.

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http://dx.doi.org/10.3389/fnbeh.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373779PMC
February 2019

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset.

J Vis Exp 2019 02 1(144). Epub 2019 Feb 1.

Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science; Department of Ultrastructural Research, National Center of Neurology and Psychiatry.

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http://dx.doi.org/10.3791/58980DOI Listing
February 2019

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset.

J Vis Exp 2019 02 1(144). Epub 2019 Feb 1.

Laboratory for Molecular Analysis of Higher Brain Function, RIKEN Center for Brain Science; Department of Ultrastructural Research, National Center of Neurology and Psychiatry.

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http://dx.doi.org/10.3791/58980DOI Listing
February 2019

Neuroethical Issues of the Brain/MINDS Project of Japan.

Neuron 2019 02;101(3):385-389

Department of Cellular Neurobiology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1016/j.neuron.2019.01.006DOI Listing
February 2019

MR Imaging Properties of ex vivo Common Marmoset Brain after Formaldehyde Fixation.

Magn Reson Med Sci 2019 Oct 7;18(4):253-259. Epub 2019 Feb 7.

Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University Graduate School.

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http://dx.doi.org/10.2463/mrms.mp.2018-0086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883083PMC
October 2019

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression.

Stem Cell Reports 2019 02 31;12(2):305-318. Epub 2019 Jan 31.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Center for Genomic and Regenerative Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373546PMC
February 2019

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations.

Mol Brain 2019 01 18;12(1). Epub 2019 Jan 18.

Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Ebara, Shinagawa-ku, Tokyo, 142-8501, Japan.

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https://molecularbrain.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13041-019-0426-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339354PMC
January 2019

Estimating the concentration of therapeutic range using disease-specific iPS cells: Low-dose rapamycin therapy for Pendred syndrome.

Regen Ther 2019 Jun 17;10:54-63. Epub 2018 Dec 17.

Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.reth.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299162PMC
June 2019

Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury.

Stem Cell Reports 2018 12 29;11(6):1416-1432. Epub 2018 Nov 29.

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Electron Microscope Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294244PMC
December 2018