Hidewaki Nakagawa

Hidewaki Nakagawa

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Hidewaki Nakagawa

Publications by authors named "Hidewaki Nakagawa"

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Quantifying immune-based counterselection of somatic mutations.

PLoS Genet 2019 Jul 25;15(7):e1008227. Epub 2019 Jul 25.

Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1008227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657826PMC
July 2019

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Cancer Cell 2019 Jun 23;35(6):932-947.e8. Epub 2019 May 23.

Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China; Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.04.007DOI Listing
June 2019

Germline pathogenic variants in 7,636 Japanese patients with prostate cancer and 12,366 controls.

J Natl Cancer Inst 2019 Jun 19. Epub 2019 Jun 19.

RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1093/jnci/djz124DOI Listing
June 2019

Genome sequencing analysis of liver cancer for precision medicine.

Semin Cancer Biol 2019 04 29;55:120-127. Epub 2018 Mar 29.

Laboratory for Cancer Genomics, RIKEN Center of Integrative Medical Sciences, Tokyo 108-8639, Japan; Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

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http://dx.doi.org/10.1016/j.semcancer.2018.03.004DOI Listing
April 2019

ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data.

BMC Genomics 2018 Nov 1;19(1):790. Epub 2018 Nov 1.

Health Intelligence Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

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https://bmcgenomics.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12864-018-5169-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211482PMC
November 2018

Loss-of-function mutations in Zn-finger DNA-binding domain of cause aberrant transcriptional regulation in liver cancer.

Oncotarget 2018 May 25;9(40):26144-26156. Epub 2018 May 25.

Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.18632/oncotarget.25456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995239PMC
May 2018

Whole genome sequencing analysis for cancer genomics and precision medicine.

Cancer Sci 2018 Mar 26;109(3):513-522. Epub 2018 Feb 26.

Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.

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http://doi.wiley.com/10.1111/cas.13505
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http://dx.doi.org/10.1111/cas.13505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834793PMC
March 2018

Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells.

Sci Rep 2017 09 6;7(1):10739. Epub 2017 Sep 6.

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/s41598-017-11208-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587585PMC
September 2017

Identification of a p53-repressed gene module in breast cancer cells.

Oncotarget 2017 Aug 26;8(34):55821-55836. Epub 2017 Jul 26.

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.18632/oncotarget.19608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593526PMC
August 2017

The Transcriptional Landscape of p53 Signalling Pathway.

EBioMedicine 2017 Jun 18;20:109-119. Epub 2017 May 18.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequence, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478243PMC
June 2017

Systematic analysis of mutation distribution in three dimensional protein structures identifies cancer driver genes.

Sci Rep 2016 05 26;6:26483. Epub 2016 May 26.

Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Japan.

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http://dx.doi.org/10.1038/srep26483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880911PMC
May 2016

Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes.

PLoS One 2015 1;10(7):e0130329. Epub 2015 Jul 1.

Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Human Genetics and Disease Diversity, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130329PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488844PMC
April 2016

[Genome-wide association study(GWAS) and genetic risk of prostate cancer].

Nihon Rinsho 2016 Jan;74(1):34-9

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January 2016

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

Nat Commun 2015 Dec 9;6:10001. Epub 2015 Dec 9.

CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/ncomms10001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682041PMC
December 2015

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.

Hum Mol Genet 2015 Oct 10;24(19):5603-18. Epub 2015 Jul 10.

Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center,

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http://dx.doi.org/10.1093/hmg/ddv269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572069PMC
October 2015

Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy.

Cell Mol Gastroenterol Hepatol 2015 Sep 17;1(5):516-534. Epub 2015 Jun 17.

Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan; Liver Research Project Center, Hiroshima University, Hiroshima, Japan; Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan.

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http://dx.doi.org/10.1016/j.jcmgh.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301414PMC
September 2015

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Sonja I Berndt David V Conti Fredrick Schumacher Ying Han Sara Benlloch Dennis J Hazelett Zhaoming Wang Ed Saunders Daniel Leongamornlert Sara Lindstrom Sara Jugurnauth-Little Tokhir Dadaev Malgorzata Tymrakiewicz Daniel O Stram Kristin Rand Peggy Wan Alex Stram Xin Sheng Loreall C Pooler Karen Park Lucy Xia Jonathan Tyrer Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Merideth Yeager Laurie Burdette Charles C Chung Amy Hutchinson Kai Yu Chee Goh Mahbubl Ahmed Koveela Govindasami Michelle Guy Teuvo L J Tammela Anssi Auvinen Tiina Wahlfors Johanna Schleutker Tapio Visakorpi Katri A Leinonen Jianfeng Xu Markus Aly Jenny Donovan Ruth C Travis Tim J Key Afshan Siddiq Federico Canzian Kay-Tee Khaw Atsushi Takahashi Michiaki Kubo Paul Pharoah Nora Pashayan Maren Weischer Borge G Nordestgaard Sune F Nielsen Peter Klarskov Martin Andreas Røder Peter Iversen Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Janet L Stanford Suzanne Kolb Sarah Holt Beatrice Knudsen Antonio Hurtado Coll Susan M Gapstur W Ryan Diver Victoria L Stevens Christiane Maier Manuel Luedeke Kathleen Herkommer Antje E Rinckleb Sara S Strom Curtis Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Lisa Cannon-Albright Cezary Cybulski Dominika Wokołorczyk Wojciech Kluźniak Jong Park Thomas Sellers Hui-Yi Lin William B Isaacs Alan W Partin Hermann Brenner Aida Karina Dieffenbach Christa Stegmaier Constance Chen Edward L Giovannucci Jing Ma Meir Stampfer Kathryn L Penney Lorelei Mucci Esther M John Sue A Ingles Rick A Kittles Adam B Murphy Hardev Pandha Agnieszka Michael Andrzej M Kierzek William Blot Lisa B Signorello Wei Zheng Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Barbara Nemesure John Carpten Cristina Leske Suh-Yuh Wu Anselm Hennis Adam S Kibel Benjamin A Rybicki Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein S Lilly Zheng Jyotsna Batra Judith Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Chavdar Slavov Radka Kaneva Vanio Mitev John S Witte Graham Casey Elizabeth M Gillanders Daniella Seminara Elio Riboli Freddie C Hamdy Gerhard A Coetzee Qiyuan Li Matthew L Freedman David J Hunter Kenneth Muir Henrik Gronberg David E Neal Melissa Southey Graham G Giles Gianluca Severi Michael B Cook Hidewaki Nakagawa Fredrik Wiklund Peter Kraft Stephen J Chanock Brian E Henderson Douglas F Easton Rosalind A Eeles Christopher A Haiman

Nat Genet 2014 Oct 14;46(10):1103-9. Epub 2014 Sep 14.

1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].

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http://dx.doi.org/10.1038/ng.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383163PMC
October 2014

Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes.

Sci Rep 2014 Aug 29;4:6232. Epub 2014 Aug 29.

Laboratory for Genome Sequencing Analysis, Center for Integrated Medical Sciences, RIKEN, Tokyo, Japan.

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http://dx.doi.org/10.1038/srep06232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148700PMC
August 2014

High cortisol and cortisone levels are associated with breast milk dioxin concentrations in Vietnamese women.

Eur J Endocrinol 2014 Jan 29;170(1):131-9. Epub 2013 Nov 29.

School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1530/EJE-13-0410DOI Listing
January 2014

Comprehensive genome sequencing of the liver cancer genome.

Cancer Lett 2013 Nov 8;340(2):234-40. Epub 2012 Nov 8.

Center for Genomic Medicine, RIKEN, Yokohama, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835120064
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http://dx.doi.org/10.1016/j.canlet.2012.10.035DOI Listing
November 2013

Plasma low-molecular-weight proteome profiling identified neuropeptide-Y as a prostate cancer biomarker polypeptide.

J Proteome Res 2013 Oct 11;12(10):4497-506. Epub 2013 Sep 11.

Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN , General Research Building 6F, Institute of Medical Science, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1021/pr400547sDOI Listing
October 2013

Prostate cancer genomics by high-throughput technologies: genome-wide association study and sequencing analysis.

Endocr Relat Cancer 2013 Aug 24;20(4):R171-81. Epub 2013 Jun 24.

Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

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http://dx.doi.org/10.1530/ERC-13-0113DOI Listing
August 2013

Quantitative structural characterization of local N-glycan microheterogeneity in therapeutic antibodies by energy-resolved oxonium ion monitoring.

Anal Chem 2012 Nov 2;84(22):9655-62. Epub 2012 Oct 2.

Life Science Research Center, Shimadzu Corporation, Kanda-Nishikicho 1, Chiyoda-ku, Tokyo, Japan.

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http://pubs.acs.org/doi/10.1021/ac3023372
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http://dx.doi.org/10.1021/ac3023372DOI Listing
November 2012

[Biomarker research and molecular targeting therapy].

Nihon Rinsho 2012 Nov;70 Suppl 8:294-7

Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN.

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November 2012

In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy.

Cancer Immunol Immunother 2012 Aug 6;61(8):1211-20. Epub 2012 Jan 6.

Department of Diagnosis of Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan.

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http://dx.doi.org/10.1007/s00262-011-1186-0DOI Listing
August 2012

[Research and development for cancer biomarker].

Nihon Rinsho 2012 May;70(5):743-7

Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN.

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May 2012

Prostate cancer genomics, biology, and risk assessment through genome-wide association studies.

Cancer Sci 2012 Apr 29;103(4):607-13. Epub 2012 Jan 29.

Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Yokohama, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2011.02193.x
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http://dx.doi.org/10.1111/j.1349-7006.2011.02193.xDOI Listing
April 2012

CLCA2 as a p53-inducible senescence mediator.

Neoplasia 2012 Feb;14(2):141-9

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306259PMC
http://dx.doi.org/10.1593/neo.111700DOI Listing
February 2012

Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility.

J Hum Genet 2011 Jun 7;56(6):436-9. Epub 2011 Apr 7.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2011.35DOI Listing
June 2011

[Prostate cancer biomarker search by genome analysis].

Nihon Rinsho 2011 Jun;69 Suppl 5:145-9

Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN.

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June 2011

Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.

Nat Genet 2011 May 17;43(5):455-8. Epub 2011 Apr 17.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/ng.809DOI Listing
May 2011

Serum tumor antigen REG4 as a useful diagnostic biomarker in gastric cancer.

Hepatogastroenterology 2010 Nov-Dec;57(104):1631-4

Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan.

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April 2011

Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer.

Proteome Sci 2011 Apr 8;9:18. Epub 2011 Apr 8.

Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tsurumiku-Suehirocho1-7-22, Yokohama, Japan.

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http://dx.doi.org/10.1186/1477-5956-9-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090313PMC
April 2011

Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility.

Cancer Sci 2011 Jan 28;102(1):245-52. Epub 2010 Sep 28.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01737.xDOI Listing
January 2011

C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage.

Genes Chromosomes Cancer 2011 Jan;50(1):13-24

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1002/gcc.20828
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http://dx.doi.org/10.1002/gcc.20828DOI Listing
January 2011

A functional variant in NKX3.1 associated with prostate cancer susceptibility down-regulates NKX3.1 expression.

Hum Mol Genet 2010 Nov 17;19(21):4265-72. Epub 2010 Aug 17.

Laboratory for Biomarker Development, Center of Genome Medicine, RIKEN, Yokohama, Japan.

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http://dx.doi.org/10.1093/hmg/ddq350DOI Listing
November 2010

5alphaDH-DOC (5alpha-dihydro-deoxycorticosterone) activates androgen receptor in castration-resistant prostate cancer.

Cancer Sci 2010 Aug 17;101(8):1897-904. Epub 2010 May 17.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01620.xDOI Listing
August 2010

Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma.

J Gastroenterol 2010 30;45(1):52-9. Epub 2009 Sep 30.

Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-0021, Japan.

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http://dx.doi.org/10.1007/s00535-009-0114-yDOI Listing
April 2010

International network of cancer genome projects.

Authors:
Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

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http://dx.doi.org/10.1038/nature08987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902243PMC
April 2010

Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.

Cancer Sci 2009 Nov 7;100(11):2109-14. Epub 2009 Jul 7.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2009.01277.x
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http://dx.doi.org/10.1111/j.1349-7006.2009.01277.xDOI Listing
November 2009

Regulation of protein Citrullination through p53/PADI4 network in DNA damage response.

Cancer Res 2009 Nov 20;69(22):8761-9. Epub 2009 Oct 20.

Laboratory of Molecular Medicine, Human Genome Center, Division of Gene Expression and Regulation, Institute of Medical Science, the University of Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2280DOI Listing
November 2009

Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells.

Int J Oncol 2009 Oct;35(4):673-81

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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October 2009

Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism.

Cancer Res 2009 Oct 13;69(20):8133-40. Epub 2009 Oct 13.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0775DOI Listing
October 2009

Stanniocalcin 2 overexpression in castration-resistant prostate cancer and aggressive prostate cancer.

Cancer Sci 2009 May 26;100(5):914-9. Epub 2009 Feb 26.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2009.01117.x
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http://dx.doi.org/10.1111/j.1349-7006.2009.01117.xDOI Listing
May 2009

Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis.

Cancer Sci 2009 Mar 16;100(3):457-64. Epub 2008 Dec 16.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.01058.xDOI Listing
March 2009

Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth.

Cancer Sci 2008 Aug;99(8):1626-32

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00869.xDOI Listing
August 2008

Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer.

Cancer Sci 2008 Jan 6;99(1):81-6. Epub 2007 Nov 6.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1 Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00656.xDOI Listing
January 2008

Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit.

Cancer Res 2007 Oct;67(20):9704-12

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-07-2099DOI Listing
October 2007

Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer.

Cancer Res 2007 Mar;67(6):2568-76

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4356DOI Listing
March 2007

Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4.

Cancer Sci 2006 Nov 17;97(11):1191-7. Epub 2006 Aug 17.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2006.00297.xDOI Listing
November 2006

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth.

Cancer Sci 2006 Nov 5;97(11):1211-6. Epub 2006 Sep 5.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2006.00313.x
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http://dx.doi.org/10.1111/j.1349-7006.2006.00313.xDOI Listing
November 2006

Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.

Clin Cancer Res 2006 May;12(9):2767-73

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1995DOI Listing
May 2006

Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinoma.

Diagn Mol Pathol 2006 Mar;15(1):17-23

Department of Pathology, Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, OH 43210, USA.

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March 2006