Hideo Tsukada

Hideo Tsukada

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Hideo Tsukada

Publications by authors named "Hideo Tsukada"

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BCPP compounds, PET probes for early therapeutic evaluations, specifically bind to mitochondrial complex I.

Mitochondrion 2019 05 18;46:97-102. Epub 2018 Mar 18.

PET Research Group, Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita, Hamamatsu, Shizuoka 434-8601, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2018.03.001DOI Listing
May 2019

Sensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with F-BCPP-BF.

EJNMMI Res 2018 Jul 16;8(1):61. Epub 2018 Jul 16.

Central Research Laboratory, Hamamatsu Photonics KK, 5000 Hirakuchi, Hamakita-ku, Hamamatsu, Sizuoka, 434-8601, Japan.

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http://dx.doi.org/10.1186/s13550-018-0420-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047947PMC
July 2018

Potential Therapeutic Applications of Adenosine A Receptor Ligands and Opportunities for A Receptor Imaging.

Med Res Rev 2018 01 27;38(1):5-56. Epub 2017 Jan 27.

University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, 1, 9713 GZ, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/med.21432DOI Listing
January 2018

Effect of MPTP on Serotonergic Neuronal Systems and Mitochondrial Complex I Activity in the Living Brain: A PET Study on Conscious Rhesus Monkeys.

J Nucl Med 2017 07 9;58(7):1111-1116. Epub 2017 Mar 9.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan

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http://dx.doi.org/10.2967/jnumed.116.189159DOI Listing
July 2017

In Vivo Evaluation of C-Preladenant for PET Imaging of Adenosine A Receptors in the Conscious Monkey.

J Nucl Med 2017 May 6;58(5):762-767. Epub 2017 Jan 6.

University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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http://dx.doi.org/10.2967/jnumed.116.182410DOI Listing
May 2017

Reduction of dopamine D receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.

Eur Arch Psychiatry Clin Neurosci 2017 Mar 18;267(2):173-176. Epub 2016 Apr 18.

Central Research Laboratory, Hamamatsu Photonics KK, Hamamatsu, Shizuoka, 434-0041, Japan.

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http://dx.doi.org/10.1007/s00406-016-0692-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323469PMC
March 2017

Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography.

J Pharmacol Exp Ther 2017 03 16;360(3):457-465. Epub 2016 Dec 16.

Discovery Research Laboratories I (K.M., N.M., T.N., S.K.), and Pharmaceutical Technology Laboratories (Y.Y.), ONO Pharmaceutical Co., Ltd., Osaka, and Central Research Laboratory, Hamamatsu Photonics K.K., Shizuoka (H.O., H.T.), Japan

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http://dx.doi.org/10.1124/jpet.116.238568DOI Listing
March 2017

In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study.

J Neuroinflammation 2017 03 29;14(1):69. Epub 2017 Mar 29.

Department of Biofunctional Imaging, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

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http://dx.doi.org/10.1186/s12974-017-0851-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372312PMC
March 2017

Effects of acetaminophen on mitochondrial complex I activity in the rat liver and kidney: a PET study with F-BCPP-BF.

EJNMMI Res 2016 Dec 21;6(1):82. Epub 2016 Nov 21.

Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamamatsu, Shizuoka, 434-8601, Japan.

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http://dx.doi.org/10.1186/s13550-016-0241-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118230PMC
December 2016

Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[F]fluoro- and 10-O-p-[C]methylbenzyl ginkgolide B in monkey and rat brains.

Bioorg Med Chem 2016 11 23;24(21):5148-5157. Epub 2016 Aug 23.

Department of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.08.032DOI Listing
November 2016

Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity.

Sci Rep 2016 07 21;6:30127. Epub 2016 Jul 21.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1038/srep30127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954989PMC
July 2016

PET Imaging of Mitochondrial Complex I with 18F-BCPP-EF in the Brains of MPTP-Treated Monkeys.

J Nucl Med 2016 06 11;57(6):950-3. Epub 2016 Feb 11.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan.

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http://dx.doi.org/10.2967/jnumed.115.169615DOI Listing
June 2016

The effect of mucoadhesive excipient on the nasal retention time of and the antibody responses induced by an intranasal influenza vaccine.

Vaccine 2016 Feb 20;34(9):1201-7. Epub 2016 Jan 20.

Department of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2016.01.020DOI Listing
February 2016

Comparing α7 nicotinic acetylcholine receptor binding, amyloid-β deposition, and mitochondria complex-I function in living brain: A PET study in aged monkeys.

Synapse 2015 Oct 12;69(10):475-83. Epub 2015 Aug 12.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, 434-8601, Japan.

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http://dx.doi.org/10.1002/syn.21842DOI Listing
October 2015

The use of ¹⁸F-BCPP-EF as a PET probe for complex I activity in the brain.

Authors:
Hideo Tsukada

Methods Enzymol 2014 ;547:417-31

Central Research Laboratory, Hamamatsu Photonics K.K., Hamakita, Shizuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801415-8.00020-5DOI Listing
August 2015

Synthesis of 6-[(11)C]methyl-m-tyrosine ([(11)C]6MemTyr) for dopamine synthesis imaging in living brain using PET.

Bioorg Med Chem 2015 Feb 3;23(4):729-34. Epub 2015 Jan 3.

Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita, Hamamatsu, Shizuoka 434-8601, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.12.061DOI Listing
February 2015

Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys.

J Neurosci 2015 Jan;35(1):84-95

Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Saitama, 3320012, Japan, Division of Bio-Function Dynamics Imaging, Center for Life Science Technologies, RIKEN, Kobe, Hyogo, 6500047, Japan.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1737-14.2
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http://dx.doi.org/10.1523/JNEUROSCI.1737-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287160PMC
January 2015

Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin.

PLoS One 2014 3;9(2):e85520. Epub 2014 Feb 3.

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Shizuoka, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911897PMC
December 2014

Comparing amyloid-β deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys.

Eur J Nucl Med Mol Imaging 2014 Nov 12;41(11):2127-36. Epub 2014 Jun 12.

Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita, Shizuoka, 434-8601, Japan,

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http://dx.doi.org/10.1007/s00259-014-2821-8DOI Listing
November 2014

[In vivo imaging of liposomal small interfering RNA (siRNA) trafficking by positron emission tomography].

Yakugaku Zasshi 2012 ;132(12):1373-81

Department of Medical Biochemistry, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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http://dx.doi.org/10.1248/yakushi.12-00235-1DOI Listing
April 2014

Evaluation of 18F-BCPP-EF for mitochondrial complex 1 imaging in the brain of conscious monkeys using PET.

Eur J Nucl Med Mol Imaging 2014 Apr 21;41(4):755-63. Epub 2013 Nov 21.

Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita, Hamamatsu, Shizuoka, 434-8601, Japan,

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http://link.springer.com/content/pdf/10.1007%2Fs00259-013-26
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http://link.springer.com/10.1007/s00259-013-2628-z
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http://dx.doi.org/10.1007/s00259-013-2628-zDOI Listing
April 2014

PET imaging of ischemia-induced impairment of mitochondrial complex I function in monkey brain.

J Cereb Blood Flow Metab 2014 Apr 22;34(4):708-14. Epub 2014 Jan 22.

Central Research Laboratory, Hamamatsu Photonics K.K., Shizuoka, Japan.

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http://dx.doi.org/10.1038/jcbfm.2014.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982099PMC
April 2014

Novel PET probes 18F-BCPP-EF and 18F-BCPP-BF for mitochondrial complex I: a PET study in comparison with 18F-BMS-747158-02 in rat brain.

J Nucl Med 2014 Mar 27;55(3):473-80. Epub 2014 Jan 27.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan.

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http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.113.125328
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http://dx.doi.org/10.2967/jnumed.113.125328DOI Listing
March 2014

Liposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: longitudinal observation.

Artif Organs 2013 Oct 6;37(10):904-12. Epub 2013 May 6.

Tokai University School of Medicine, Isehara.

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http://dx.doi.org/10.1111/aor.12091DOI Listing
October 2013

Development of novel PET probes, [18F]BCPP-EF, [18F]BCPP-BF, and [11C]BCPP-EM for mitochondrial complex 1 imaging in the living brain.

J Labelled Comp Radiopharm 2013 Sep 30;56(11):553-61. Epub 2013 Jul 30.

Central Research Laboratory, Hamamatsu Photonics K. K., Hamamatsu, Shizuoka, 434-8601, Japan.

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http://dx.doi.org/10.1002/jlcr.3056DOI Listing
September 2013

Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.

Biol Pharm Bull 2013 ;36(2):287-91

Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52–1 Yada, Suruga-ku, Shizuoka 422–8526, Japan.

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http://dx.doi.org/10.1248/bpb.b12-00817DOI Listing
August 2013

Radiosynthesis and initial evaluation of (18)F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide.

Nucl Med Biol 2013 Apr 22;40(3):387-94. Epub 2013 Jan 22.

Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2012.12.008DOI Listing
April 2013

A new in vivo model to analyze hepatic metastasis of the human colon cancer cell line HCT116 in NOD/Shi-scid/IL-2Rγ(null) (NOG) mice by (18)F-FDG PET/CT.

Oncol Rep 2013 Feb 15;29(2):464-8. Epub 2012 Nov 15.

Pathology Research Department, Central Institute for Experimental Animals, Kawasaki, Kanagawa 210-0821, Japan.

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http://dx.doi.org/10.3892/or.2012.2141DOI Listing
February 2013

Application of feedback-controlled bolus plus infusion (FC-B/I) method for quantitative PET imaging of dopamine transporters with [(18)F]β-CFT-FE in conscious monkey brain.

Synapse 2013 Jan 31;67(1):42-50. Epub 2012 Oct 31.

Central Research Laboratory, Hamamatsu Photonics KK, 5000 Hirakuchi, Hamakita, Hamamatsu, Shizuoka 434-8601, Japan.

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http://dx.doi.org/10.1002/syn.21614DOI Listing
January 2013

Detection of ischemic neuronal damage with [¹⁸F]BMS-747158-02, a mitochondrial complex-1 positron emission tomography ligand: small animal PET study in rat brain.

Synapse 2012 Oct 27;66(10):909-17. Epub 2012 Jul 27.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka, Japan.

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http://dx.doi.org/10.1002/syn.21584DOI Listing
October 2012

The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey.

Neurosci Res 2012 Oct 28;74(2):122-8. Epub 2012 Jul 28.

Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

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http://dx.doi.org/10.1016/j.neures.2012.07.006DOI Listing
October 2012

Neural substrates for the motivational regulation of motor recovery after spinal-cord injury.

PLoS One 2011 28;6(9):e24854. Epub 2011 Sep 28.

Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024854PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182173PMC
April 2012

[Application of pre-clinical PET imaging for drug development].

Authors:
Hideo Tsukada

Nihon Shinkei Seishin Yakurigaku Zasshi 2011 Nov;31(5-6):231-7

Central Research Laboratory, Hamamatsu Photonics K. K., Hamamatsu, Japan.

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November 2011

Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: a monkey PET study with [(11)C](+)3-MPB.

Neuroimage 2011 Sep 25;58(1):1-9. Epub 2011 Jun 25.

Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neuroimage.2011.06.031DOI Listing
September 2011

α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics.

Br J Clin Pharmacol 2011 Aug;72(2):205-17

Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1111/j.1365-2125.2011.03922.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162650PMC
August 2011

Medial orbitofrontal cortex is associated with fatigue sensation.

Neurol Res Int 2010 10;2010:671421. Epub 2010 Jun 10.

Hyogo Children's Sleep and Development Medical Research Center, Hyogo Rehabilitation Centre Central Hospital, 1070 Akebono-cho, Nishi-ku, Kobe 651-2181, Japan.

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http://dx.doi.org/10.1155/2010/671421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003967PMC
July 2011

Validation of reference tissue model of PET ligand [¹¹C]+3-MPB for the muscarinic cholinergic receptor in the living brain of conscious monkey.

Synapse 2011 Jun 10;65(6):548-51. Epub 2011 Mar 10.

Osaka-Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.

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http://dx.doi.org/10.1002/syn.20881DOI Listing
June 2011

Muscarinic receptor occupancy and cognitive impairment: a PET study with [11C](+)3-MPB and scopolamine in conscious monkeys.

Neuropsychopharmacology 2011 Jun 23;36(7):1455-65. Epub 2011 Mar 23.

Osaka-Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

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http://dx.doi.org/10.1038/npp.2011.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096814PMC
June 2011

In vivo evaluation of carbon-11-labelled non-sarcosine-based glycine transporter 1 inhibitors in mice and conscious monkeys.

Nucl Med Biol 2011 May 4;38(4):517-27. Epub 2011 Feb 4.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan 260-8670.

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http://dx.doi.org/10.1016/j.nucmedbio.2010.11.009DOI Listing
May 2011

PET imaging of nobiletin based on a practical total synthesis.

Chem Commun (Camb) 2011 Mar 18;47(10):2868-70. Epub 2011 Jan 18.

School of Pharmaceutical Sciences, University of Shizuoka and Global COE Program, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1039/c0cc04936kDOI Listing
March 2011

Synthesis of long-chain [¹⁸F]Deoxyfluoropoly(ethylene glycol) methyl ethers and their noninvasive pharmacokinetic analysis by positron emission tomography.

Mol Pharm 2011 Feb 15;8(1):302-8. Epub 2010 Dec 15.

Department of Synthetic Organic Chemistry, Department of Medical Biochemistry, and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1021/mp100271gDOI Listing
February 2011

Differential effects of stress on [¹¹C]raclopride and [¹¹C]MNPA binding to striatal D₂/D₃ dopamine receptors: a PET study in conscious monkeys.

Synapse 2011 Jan;65(1):84-9

Central Research Laboratory, Hamamatsu Photonics K.K., Hamakita, Hamamatsu, Shizuoka, Japan.

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http://dx.doi.org/10.1002/syn.20845DOI Listing
January 2011

PET imaging of brain cancer with positron emitter-labeled liposomes.

Int J Pharm 2011 Jan 8;403(1-2):170-7. Epub 2010 Oct 8.

Department of Medical Biochemistry, University of Shizuoka, Yada, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2010.10.001DOI Listing
January 2011

Cortical activation during color discrimination task in macaques as revealed by positron emission tomography.

Neurosci Lett 2010 Nov 19;484(3):168-73. Epub 2010 Aug 19.

Department of Neuroscience, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S03043940100108
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http://dx.doi.org/10.1016/j.neulet.2010.08.040DOI Listing
November 2010

In vivo molecular imaging analysis of a nasal vaccine that induces protective immunity against botulism in nonhuman primates.

J Immunol 2010 Nov 29;185(9):5436-43. Epub 2010 Sep 29.

Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1001789
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http://dx.doi.org/10.4049/jimmunol.1001789DOI Listing
November 2010

D-18F-fluoromethyl tyrosine imaging of bone metastases in a mouse model.

J Nucl Med 2010 Oct 16;51(10):1632-6. Epub 2010 Sep 16.

Global Drug Discovery, Bayer Schering Pharma AG, Berlin, Germany.

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http://dx.doi.org/10.2967/jnumed.110.078899DOI Listing
October 2010

Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines.

Nat Mater 2010 Jul 20;9(7):572-8. Epub 2010 Jun 20.

Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/nmat2784DOI Listing
July 2010

Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography.

Life Sci 2010 Jul 18;87(5-6):175-80. Epub 2010 Jun 18.

Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.lfs.2010.06.008DOI Listing
July 2010

T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

Int J Pharm 2010 Jun 21;392(1-2):218-23. Epub 2010 Mar 21.

Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.

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http://dx.doi.org/10.1016/j.ijpharm.2010.03.022DOI Listing
June 2010

Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography.

Bioconjug Chem 2010 Apr;21(4):756-63

Department of Medical Biochemistry and Global COE Program, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka-city, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1021/bc9005267DOI Listing
April 2010

Synthesis and evaluation of new imaging agent for central nicotinic acetylcholine receptor α7 subtype.

Nucl Med Biol 2010 Apr 15;37(3):347-55. Epub 2010 Jan 15.

Photon Medical Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2009.11.007DOI Listing
April 2010

Positron emission tomography analysis of the analgesic effects of acupuncture in rhesus monkeys.

Am J Chin Med 2006 ;34(5):787-801

Graduate School of Health Science, Suzuka University of Medical Science, Mie, Japan.

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http://dx.doi.org/10.1142/S0192415X06004296DOI Listing
March 2010

Liposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: an acute study.

J Pharmacol Exp Ther 2010 Feb 12;332(2):429-36. Epub 2009 Nov 12.

Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.

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http://dx.doi.org/10.1124/jpet.109.160051DOI Listing
February 2010

[Applications of PET imaging in the preclinical stage of drug development].

Authors:
Hideo Tsukada

Nihon Yakurigaku Zasshi 2010 Feb;135(2):80-3

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http://dx.doi.org/10.1254/fpj.135.80DOI Listing
February 2010

Ketamine/xylazine anesthesia alters [11C]MNPA binding to dopamine D2 receptors and response to methamphetamine challenge in monkey brain.

Synapse 2009 Jun;63(6):534-7

Central Research Laboratory, Hamamatsu Photonics K. K., 5000 Hirakuchi, Hamakita, Hamamatsu, Shizuoka 434-8601, Japan.

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http://dx.doi.org/10.1002/syn.20632DOI Listing
June 2009

Positron emission tomographic measure of brain dopamine dependence to nicotine as a model of drugs of abuse.

Psychopharmacology (Berl) 2009 May 10;204(1):149-53. Epub 2009 Jan 10.

Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA.

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http://dx.doi.org/10.1007/s00213-008-1445-8DOI Listing
May 2009

Nicotine sensitization of monkey striatal dopamine release.

Eur J Pharmacol 2009 Apr 14;607(1-3):91-5. Epub 2009 Feb 14.

Central Research Laboratory, Hamamatsu Photonics K.K., Hamamatsu, Shizuoka 484-6601, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2009.02.011DOI Listing
April 2009

Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.

Nucl Med Biol 2009 Apr;36(3):295-303

Department of Medical Biochemistry and Global COE, University of Shizuoka Graduate School of Pharmaceutical Sciences, Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2008.12.012DOI Listing
April 2009

The potential of (-)-o-[11C]methylvesamicol for diagnosing cholinergic deficit dementia.

Synapse 2009 Feb;63(2):167-71

Advanced Science Research Center, Kanazawa University, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1002/syn.20590DOI Listing
February 2009

In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.

Artif Organs 2009 Feb;33(2):164-8

Department of Medical Biochemistry and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.

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http://dx.doi.org/10.1111/j.1525-1594.2008.00702.xDOI Listing
February 2009

S-nitrosylated pegylated hemoglobin reduces the size of cerebral infarction in rats.

Artif Organs 2009 Feb;33(2):183-8

Tokai University School of Medicine, Isehara, Kanagawa, Japan.

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http://dx.doi.org/10.1111/j.1525-1594.2008.00705.xDOI Listing
February 2009

In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment.

J Pharmacol Exp Ther 2008 Jun 7;325(3):774-81. Epub 2008 Mar 7.

Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1124/jpet.108.136390DOI Listing
June 2008

Amyloid imaging in aged and young macaques with [11C]PIB and [18F]FDDNP.

Synapse 2008 Jun;62(6):472-5

Basic Research Division, The Medical and Pharmacological Research Center Foundation, Hakui, Japan.

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http://dx.doi.org/10.1002/syn.20508DOI Listing
June 2008

Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.

Biol Pharm Bull 2008 May;31(5):847-51

Department of Medical Biochemistry and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.

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http://dx.doi.org/10.1248/bpb.31.847DOI Listing
May 2008

Incorporation and translocation of 2-deoxy-2-[(18)F]fluoro-D-glucose in Sorghum bicolor (L.) Moench monitored using a planar positron imaging system.

Planta 2008 Apr 14;227(5):1181-6. Epub 2008 Feb 14.

Bio Research Laboratory, Future Project Division, Toyota Motor Corporation, Toyota, Aichi, Japan.

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http://dx.doi.org/10.1007/s00425-008-0701-9DOI Listing
April 2008

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711.

Biol Psychiatry 2008 Jan 28;63(1):92-7. Epub 2007 Jun 28.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

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http://dx.doi.org/10.1016/j.biopsych.2007.04.034DOI Listing
January 2008

Feasibility study of quantitative radioactivity monitoring of tumor tissues inoculated into mice with a planar positron imaging system (PPIS).

Ann Nucl Med 2008 Jan;22(1):57-63

PET Center, Central Research Laboratory, Hamamatsu Photonics K.K., 5000 Hirakuchi, Hamakita-ku, Hamamatsu, 434-8601, Japan.

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http://dx.doi.org/10.1007/s12149-007-0082-3DOI Listing
January 2008

Novel amphiphilic probes for [18F]-radiolabeling preformed liposomes and determination of liposomal trafficking by positron emission tomography.

J Med Chem 2007 Dec 1;50(26):6454-7. Epub 2007 Dec 1.

Department of Medical Biochemistry and Global COE, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Japan.

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http://dx.doi.org/10.1021/jm7010518DOI Listing
December 2007

[Analysis of censored data in multi-factorial analgesic test].

Yakugaku Zasshi 2007 Dec;127(12):2079-84

Research Planning and Coordination, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Inc, 5-2 Taketoyo-cho, Chita-gun. Aichi 470-2393, Japan.

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http://dx.doi.org/10.1248/yakushi.127.2079DOI Listing
December 2007

Activation of parieto-frontal stream during reaching and grasping studied by positron emission tomography in monkeys.

Neurosci Res 2007 Nov 17;59(3):243-50. Epub 2007 Jul 17.

Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S016801020701687
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http://dx.doi.org/10.1016/j.neures.2007.07.003DOI Listing
November 2007

Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection.

J Gene Med 2007 Nov;9(11):976-85

Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.

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http://doi.wiley.com/10.1002/jgm.1104
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http://dx.doi.org/10.1002/jgm.1104DOI Listing
November 2007

Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.

Science 2007 Nov;318(5853):1150-5

Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan.

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http://dx.doi.org/10.1126/science.1147243DOI Listing
November 2007

Effects of increased endogenous serotonin on the in vivo binding of [11C]DASB to serotonin transporters in conscious monkey brain.

Synapse 2007 Sep;61(9):724-31

Department of Physiology, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.

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http://dx.doi.org/10.1002/syn.20422DOI Listing
September 2007

Synthesis and evaluation of fluorine-18-labeled SA4503 as a selective sigma1 receptor ligand for positron emission tomography.

Nucl Med Biol 2007 Jul 11;34(5):571-7. Epub 2007 May 11.

Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0022, Japan.

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http://dx.doi.org/10.1016/j.nucmedbio.2007.03.009DOI Listing
July 2007

Enhancement of anticancer activity in antineovascular therapy is based on the intratumoral distribution of the active targeting carrier for anticancer drugs.

Biol Pharm Bull 2006 Sep;29(9):1936-40

Department of Medical Biochemistry and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka, Japan.

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http://dx.doi.org/10.1248/bpb.29.1936DOI Listing
September 2006