Hideo Negishi

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Hideo Negishi

Publications by authors named "Hideo Negishi"

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30Publications

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Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.

Proc Natl Acad Sci U S A 2018 May 30;115(20):5253-5258. Epub 2018 Apr 30.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, 153-8505 Tokyo, Japan;

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May 2018

Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.

Proc Natl Acad Sci U S A 2017 09 6;114(38):10178-10183. Epub 2017 Sep 6.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan;

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September 2017

The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor (IRF) Transcription Factor Family.

Cold Spring Harb Perspect Biol 2017 Sep 29. Epub 2017 Sep 29.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan.

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September 2017

The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.

Proc Natl Acad Sci U S A 2016 12 21;113(49):14097-14102. Epub 2016 Nov 21.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan;

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December 2016

PGE2 induced in and released by dying cells functions as an inhibitory DAMP.

Proc Natl Acad Sci U S A 2016 Apr 21;113(14):3844-9. Epub 2016 Mar 21.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan;

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April 2016

S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.

Proc Natl Acad Sci U S A 2016 Feb 19;113(5):1351-6. Epub 2016 Jan 19.

Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037;

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February 2016

Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.

Proc Natl Acad Sci U S A 2015 Oct 29;112(41):12770-5. Epub 2015 Sep 29.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan; Department of Immunology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-033, Japan; Max Planck-The University of Tokyo Center for Integrative Inflammology, Meguro-ku, Tokyo 153-8505, Japan;

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October 2015

The IRF family transcription factors at the interface of innate and adaptive immune responses.

Cold Spring Harb Symp Quant Biol 2013 3;78:105-16. Epub 2013 Oct 3.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo 153-8505, Japan.

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March 2015

Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.

Elife 2014 Aug 22;3:e04177. Epub 2014 Aug 22.

Department of Molecular Immunology, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.

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August 2014

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.

Proc Natl Acad Sci U S A 2013 Dec 3;110(51):20699-704. Epub 2013 Dec 3.

Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan.

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December 2013

Regulation of cooperative function of the Il12b enhancer and promoter by the interferon regulatory factors 3 and 5.

Biochem Biophys Res Commun 2013 Jan 12;430(1):95-100. Epub 2012 Nov 12.

Department of Molecular Immunology, The University of Tokyo, Komaba 4-6-1, Meguro-Ku, Tokyo 153-8505, Japan.

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January 2013

Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction.

Proc Natl Acad Sci U S A 2012 Dec 3;109(51):21016-21. Epub 2012 Dec 3.

Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro-ku, Tokyo 153-8505, Japan.

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December 2012

The IRF family of transcription factors: Inception, impact and implications in oncogenesis.

Oncoimmunology 2012 Nov;1(8):1376-1386

Department of Molecular Immunology; Institute of Industrial Science; The University of Tokyo; Tokyo, Japan ; Core Research for Evolution Science and Technology; Japan Science and Technology Agency; Chiyoda-ku, Tokyo, Japan.

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November 2012

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA.

Proc Natl Acad Sci U S A 2009 Oct 1;106(42):17870-5. Epub 2009 Oct 1.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2009

Critical role for constitutive type I interferon signaling in the prevention of cellular transformation.

Cancer Sci 2009 Mar 14;100(3):449-56. Epub 2008 Dec 14.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.

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March 2009

A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.

Proc Natl Acad Sci U S A 2008 Dec 11;105(51):20446-51. Epub 2008 Dec 11.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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December 2008

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.

Proc Natl Acad Sci U S A 2008 Apr 28;105(14):5477-82. Epub 2008 Mar 28.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan.

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April 2008

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.

Nature 2007 Jul 8;448(7152):501-5. Epub 2007 Jul 8.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2007

Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation.

Biochem Biophys Res Commun 2007 Mar 25;354(4):1045-51. Epub 2007 Jan 25.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Tokyo, Japan.

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March 2007

Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.

Proc Natl Acad Sci U S A 2006 Oct 3;103(41):15136-41. Epub 2006 Oct 3.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2006

Negative regulation of Toll-like-receptor signaling by IRF-4.

Proc Natl Acad Sci U S A 2005 Nov 19;102(44):15989-94. Epub 2005 Oct 19.

Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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November 2005

IRF-7 is the master regulator of type-I interferon-dependent immune responses.

Nature 2005 Apr 30;434(7034):772-7. Epub 2005 Mar 30.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2005

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction.

Nature 2005 Apr 6;434(7036):1035-40. Epub 2005 Apr 6.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2005

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.

Nature 2005 Mar 23;434(7030):243-9. Epub 2005 Jan 23.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2005

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.

Proc Natl Acad Sci U S A 2004 Oct 18;101(43):15416-21. Epub 2004 Oct 18.

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2004

Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock.

Biochem Biophys Res Commun 2003 Jul;306(4):860-6

Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2003

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.

Nature 2003 Jul;424(6948):516-23

Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

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July 2003