Publications by authors named "Hidenori Ichijo"

100Publications

Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis.

J Biochem 2020 Dec 30. Epub 2020 Dec 30.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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December 2020

FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells.

Curr Biol 2020 Dec 16. Epub 2020 Dec 16.

The Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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December 2020

β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes.

PLoS One 2020 27;15(10):e0232645. Epub 2020 Oct 27.

The Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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November 2020

Apoptosis signal-regulating kinase 1 (ASK1) as a therapeutic target for neurological diseases.

Expert Opin Ther Targets 2020 Nov 30;24(11):1061-1064. Epub 2020 Sep 30.

The Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo , Tokyo, Japan.

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November 2020

The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.

J Biol Chem 2020 04 6;295(17):5588-5601. Epub 2020 Mar 6.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

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April 2020

Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu,Zn-superoxide dismutase.

J Biol Chem 2020 03 3;295(10):3148-3158. Epub 2020 Feb 3.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2020

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases.

Biochim Biophys Acta Gen Subj 2019 09 20;1863(9):1398-1409. Epub 2019 Jun 20.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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September 2019

Cell volume regulation in cancer cell migration driven by osmotic water flow.

Cancer Sci 2019 Aug 1;110(8):2337-2347. Epub 2019 Jul 1.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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August 2019

[Functional Analysis of Apoptosis Signal-regulating Kinase Family in a Murine Model of Tumor Metastasis].

Yakugaku Zasshi 2019 ;139(5):743-751

Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo.

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June 2019

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.

Biochim Biophys Acta Gen Subj 2018 10 18;1862(10):2271-2280. Epub 2018 Jul 18.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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October 2018

ASK family kinases mediate cellular stress and redox signaling to circadian clock.

Proc Natl Acad Sci U S A 2018 04 19;115(14):3646-3651. Epub 2018 Mar 19.

Department of Biological Sciences, School of Science, The University of Tokyo, Tokyo 113-0033, Japan

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April 2018

A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.

Cell Rep 2018 03;22(11):2809-2817

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

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March 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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March 2018

Apoptosis signal-regulating kinase 1 in regulated necrosis.

Cell Cycle 2018 2;17(1):5-6. Epub 2018 Jan 2.

a The Laboratory of Cell Signaling , Graduate School of Pharmaceutical Sciences , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan.

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September 2019

mASKing cancer cells in a tumor microenvironment.

Cell Cycle 2018 4;17(2):139-140. Epub 2018 Jan 4.

a Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences , The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan.

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June 2019

Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging.

J Alzheimers Dis 2018 ;61(1):259-263

Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Chuo-ku, Kumamoto, Japan.

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July 2018

Foreword.

Authors:
Hidenori Ichijo

Adv Biol Regul 2017 12 11;66. Epub 2017 Nov 11.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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December 2017

Cold stress-induced ferroptosis involves the ASK1-p38 pathway.

EMBO Rep 2017 11 8;18(11):2067-2078. Epub 2017 Sep 8.

The Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

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November 2017

ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y in platelets.

Cell Death Differ 2017 12 28;24(12):2066-2076. Epub 2017 Jul 28.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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December 2017

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Structure 2017 07 22;25(7):1089-1099.e3. Epub 2017 Jun 22.

Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University and Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main, Germany; Nuffield Department of Clinical Medicine, Structural Genomics Consortium and Target Discovery Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

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July 2017

Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice.

Allergol Int 2017 Sep 16;66S:S50-S52. Epub 2017 Jun 16.

Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

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September 2017

Ask1 regulates murine platelet granule secretion, thromboxane A generation, and thrombus formation.

Blood 2017 03 27;129(9):1197-1209. Epub 2016 Dec 27.

Cardeza Center for Vascular Biology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA.

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March 2017

Pleiotropic properties of ASK1.

Biochim Biophys Acta Gen Subj 2017 Jan 30;1861(1 Pt A):3030-3038. Epub 2016 Sep 30.

The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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January 2017

KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.

PLoS One 2016 15;11(9):e0163118. Epub 2016 Sep 15.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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August 2017

The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.

Elife 2016 08 16;5. Epub 2016 Aug 16.

Laboratory of Protein Metabolism, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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August 2016

Mitogen-activated protein kinases as key players in osmotic stress signaling.

Biochim Biophys Acta 2016 09 31;1860(9):2037-52. Epub 2016 May 31.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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September 2016

The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.

EBioMedicine 2016 Mar 29;5:82-92. Epub 2016 Jan 29.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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March 2016

ASK1 signalling regulates brown and beige adipocyte function.

Nat Commun 2016 Apr 5;7:11158. Epub 2016 Apr 5.

The laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2016

Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.

Sci Rep 2016 Jan 6;6:18710. Epub 2016 Jan 6.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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January 2016

The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

Hum Mol Genet 2016 Jan 24;25(2):245-53. Epub 2015 Nov 24.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan,

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January 2016

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.

Cell Rep 2015 Nov 22;13(5):944-56. Epub 2015 Oct 22.

Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address:

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November 2015

SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS.

Adv Biol Regul 2016 Jan 31;60:95-104. Epub 2015 Oct 31.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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January 2016

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

Neurobiol Dis 2015 Oct 18;82:478-486. Epub 2015 Aug 18.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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October 2015

Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.

J Neurosci 2015 Jun;35(24):9088-105

Division of Pediatric Neurology and Department of Neurology and Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,

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June 2015

In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression.

Cancer Sci 2015 Jul 25;106(7):785-96. Epub 2015 May 25.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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July 2015

Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis.

J Biol Chem 2015 Apr 9;290(17):10791-803. Epub 2015 Mar 9.

From the Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan,

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April 2015

Mitochondrial proteolysis: its emerging roles in stress responses.

Biochim Biophys Acta 2015 Feb 23;1850(2):274-80. Epub 2014 Oct 23.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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February 2015

The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.

J Biol Chem 2014 Nov 6;289(47):32926-36. Epub 2014 Oct 6.

From the Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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November 2014

Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice.

Neurobiol Aging 2015 Jan 31;36(1):519-26. Epub 2014 Jul 31.

Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, Rutgers - Robert Wood Johnson Medical School, Piscataway, NJ, USA. Electronic address:

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January 2015

The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.

Sci Signal 2014 Apr 29;7(323):ra40. Epub 2014 Apr 29.

1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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April 2014

ASK1 promotes the contact hypersensitivity response through IL-17 production.

Sci Rep 2014 Apr 16;4:4714. Epub 2014 Apr 16.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan, 113-0033.

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April 2014

Apoptosis signal-regulating kinase 1 as a therapeutic target.

Expert Opin Ther Targets 2014 Jun 24;18(6):651-64. Epub 2014 Mar 24.

The University of Tokyo, Graduate School of Pharmaceutical Sciences, Cell Signaling , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 , Japan +81 3 5841 4858 ; +81 3 5841 4798 ;

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June 2014

Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.

Sci Signal 2014 Jan 21;7(309):ra8. Epub 2014 Jan 21.

1Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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January 2014

Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion.

Arterioscler Thromb Vasc Biol 2014 Mar 26;34(3):616-25. Epub 2013 Dec 26.

From the Department of Pharmacology and Molecular Therapeutics (K.T., N.K., K.U., Y.H., K.K., T.K., D.S., M.J.M., T.N., S.K.-M.) and Department of Cardiovascular Medicine, Faculty of Life Science (K.T., H.O.), Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan; Research Fellowship of the Japan Society for the Promotion of Science, Tokyo, Japan (K.T.); Department of Cardiovascular Clinical and Translational Research, Kumamoto University Hospital, Kumamoto, Japan (O.Y.); Department of Neurology, Graduate School of Medicine, Mie University, Tsu, Japan (H.T.); and Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, and Global Center of Excellence (GCOE) Program, The University of Tokyo, Tokyo, Japan (H.I.).

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March 2014

SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

Mol Cell 2013 Oct 26;52(1):75-86. Epub 2013 Sep 26.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Education and Research for Chemical Biology of the Diseases, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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October 2013

Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.

Int Arch Allergy Immunol 2013 31;162(2):104-14. Epub 2013 Jul 31.

Department of Immunology, Tokyo Medical University, Tokyo, Japan.

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December 2013

[Stress signaling and diseases via the ASK family kinases].

Seikagaku 2013 Mar;85(3):167-73

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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March 2013

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Ann Neurol 2012 Nov;72(5):739-49

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Global Center of Education and Research for Chemical Biology of the Diseases, University of Tokyo, Hongo, Tokyo, Japan.

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November 2012

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

Mol Cell 2012 Dec 25;48(5):692-704. Epub 2012 Oct 25.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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December 2012

Therapeutic targets in the ASK1-dependent stress signaling pathways.

Proc Jpn Acad Ser B Phys Biol Sci 2012 ;88(8):434-53

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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June 2013

Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.

Adv Biol Regul 2013 Jan 13;53(1):135-44. Epub 2012 Sep 13.

Laboratory of Cell signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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January 2013

Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

J Biol Chem 2012 Oct 22;287(41):34635-45. Epub 2012 Aug 22.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

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October 2012

The phosphorylation-dependent regulation of mitochondrial proteins in stress responses.

J Signal Transduct 2012 15;2012:931215. Epub 2012 Jul 15.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2012

Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway.

Int J Cell Biol 2012 13;2012:439587. Epub 2012 May 13.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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August 2012

Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.

PLoS One 2012 7;7(2):e30265. Epub 2012 Feb 7.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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July 2012

Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation.

PLoS One 2012 10;7(1):e29935. Epub 2012 Jan 10.

Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America.

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May 2012

Novel mechanism of angiotensin II-induced cardiac injury in hypertensive rats: the critical role of ASK1 and VEGF.

Hypertens Res 2012 Feb 17;35(2):194-200. Epub 2011 Nov 17.

Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

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February 2012

Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis.

Arterioscler Thromb Vasc Biol 2011 Jul 28;31(7):1555-64. Epub 2011 Apr 28.

Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.

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July 2011

Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.

Genetics 2011 Mar 6;187(3):785-92. Epub 2011 Jan 6.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

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March 2011

Identification of novel ASK1 inhibitors using virtual screening.

Bioorg Med Chem 2011 Jan 12;19(1):486-9. Epub 2010 Nov 12.

Drug Discovery Department, Research & Development Division, PharmaDesign, Inc., 2-19-8 Hatchobori, Chuo-ku, Tokyo 104-0032, Japan.

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January 2011

Mitogen-activated protein kinases in mammalian oxidative stress responses.

Antioxid Redox Signal 2011 Jul 8;15(1):205-18. Epub 2011 Apr 8.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.

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July 2011

Apoptosis signaling kinases: from stress response to health outcomes.

Antioxid Redox Signal 2011 Aug 20;15(3):719-61. Epub 2011 Apr 20.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, The University of Tokyo, Tokyo, Japan.

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August 2011

Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet.

J Hypertens 2011 Jan;29(1):76-84

Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

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January 2011

Regulation of apoptosis signal-regulating kinase 1 in redox signaling.

Methods Enzymol 2010 20;474:277-88. Epub 2010 Jun 20.

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

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October 2010

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

Int Immunopharmacol 2010 Oct 6;10(10):1170-6. Epub 2010 Jul 6.

Discovery Biology, Global Research and Development, St. Louis Laboratories Pfizer Inc., 700 Chesterfield Parkway West, mail zone AA3C, Chesterfield, MO 63017, USA.

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October 2010

CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.

EMBO J 2010 Aug 29;29(15):2501-14. Epub 2010 Jun 29.

Department of Medical Pharmaceutics, Laboratory of Cell Signaling, Japan Science and Technology Corporation, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

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August 2010

Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts.

Cardiovasc Res 2010 Sep 28;87(4):647-55. Epub 2010 Apr 28.

Department of Surgery, The Ohio State University Medical Center, 513 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA.

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September 2010

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

Mol Cell 2009 Dec;36(5):805-18

Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, Strategic Approach to Drug Discovery and Development in Pharmaceutical Sciences, Global Center of Excellence Program and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

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December 2009