Publications

Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles.
Int J Nanomedicine 2017 24;12:3967-3975. Epub 2017 May 24.
Center for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki.

Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells.
Nucleic Acids Res 2016 Jul 20;44(12):5515-28. Epub 2016 May 20.
Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan Computational Biology Research Center, Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan

PM2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways.
Environ Toxicol Pharmacol 2016 Jul 22;45:362-9. Epub 2016 Jun 22.
Department of Health Sciences, Oita University of Nursing and Health Sciences, 2944-9 Megusuno, Oita City, Oita Prefecture, 870-1201, Japan.


Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.
Carcinogenesis 2015 Jun;36 Suppl 1:S254-96
Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.


Peroxisome proliferator-activated receptor α mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice.
Toxicol Lett 2014 Aug 5;228(3):235-40. Epub 2014 May 5.
Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. Electronic address:

Primary fibroblast cultures and karyotype analysis for the olive ridley sea turtle (Lepidochelys olivacea).
In Vitro Cell Dev Biol Anim 2014 6;50(5):381-3. Epub 2013 Dec 6.
Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi Aoba-ku, Sendai, 981-8555, Japan,


Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase.
J Biotechnol 2014 Apr 28;176:50-7. Epub 2014 Feb 28.
Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-amamiyamachi, Aoba-ku, Sendai 981-8555, Japan. Electronic address:

Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring.
Environ Toxicol 2013 Nov 24;28(11):617-29. Epub 2011 Aug 24.
Health Risk Research Section, Center for Environmental Risk Research, National Institute for Environmental Studies 16-2, Onogawa, Tsukuba, Ibaraki 305-8506, Japan.

Efficient establishment of primary fibroblast cultures from the hawksbill sea turtle (Eretmochelys imbricata).
In Vitro Cell Dev Biol Anim 2012 Dec 13;48(10):660-5. Epub 2012 Nov 13.
Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi Aobaku, Sendai, 981-8555, Japan.

Effect of low-dose thalidomide on dopaminergic neuronal differentiation of human neural progenitor cells: a combined study of metabolomics and morphological analysis.
Neurotoxicology 2012 Oct 7;33(5):1375-80. Epub 2012 Sep 7.
Health Risk Research Section, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8606, Japan.

Identification of Stage-Specific Gene Expression Signatures in Response to Retinoic Acid during the Neural Differentiation of Mouse Embryonic Stem Cells.
Front Genet 2012 7;3:141. Epub 2012 Aug 7.
Health Risk Research Section, Center for Environmental Risk Research, National Institute for Environmental Studies Tsukuba, Ibaraki, Japan.

Effects of methylmercury exposure on neuronal differentiation of mouse and human embryonic stem cells.
Toxicol Lett 2012 Jul 23;212(1):1-10. Epub 2012 Apr 23.
Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.



Multi-parametric profiling network based on gene expression and phenotype data: a novel approach to developmental neurotoxicity testing.
Int J Mol Sci 2012 23;13(1):187-207. Epub 2011 Dec 23.
Health Risk Research Section, Research Center for Environmental Risk, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan; E-Mails: (R.N.); (H.A.); (X.-Y.Q.); (H.T.).


siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells.
FEBS Lett 2011 Oct 19;585(20):3310-5. Epub 2011 Sep 19.
Health Risk Research Section, Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.

Comparative contribution of the aryl hydrocarbon receptor gene to perinatal stage development and dioxin-induced toxicity between the urogenital complex and testis in the mouse.
Biol Reprod 2010 Mar 9;82(3):636-43. Epub 2009 Dec 9.
Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Induction of spermatogenic cell apoptosis in prepubertal rat testes irrespective of testicular steroidogenesis: a possible estrogenic effect of di(n-butyl) phthalate.
Reproduction 2010 Feb 10;139(2):427-37. Epub 2009 Nov 10.
Department of Veterinary Anatomy, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta.
Environ Health Perspect 2004 Aug;112(12):1217-24
Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.


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