Publications by authors named "Hideki Itoh"

100Publications

Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls.

Authors:
Roddy Walsh Najim Lahrouchi Rafik Tadros Florence Kyndt Charlotte Glinge Pieter G Postema Ahmad S Amin Eline A Nannenberg James S Ware Nicola Whiffin Francesco Mazzarotto Doris Škorić-Milosavljević Christian Krijger Elena Arbelo Dominique Babuty Hector Barajas-Martinez Britt M Beckmann Stéphane Bézieau J Martijn Bos Jeroen Breckpot Oscar Campuzano Silvia Castelletti Candan Celen Sebastian Clauss Anniek Corveleyn Lia Crotti Federica Dagradi Carlo de Asmundis Isabelle Denjoy Sven Dittmann Patrick T Ellinor Cristina Gil Ortuño Carla Giustetto Jean-Baptiste Gourraud Daisuke Hazeki Minoru Horie Taisuke Ishikawa Hideki Itoh Yoshiaki Kaneko Jørgen K Kanters Hiroki Kimoto Maria-Christina Kotta Ingrid P C Krapels Masahiko Kurabayashi Julieta Lazarte Antoine Leenhardt Bart L Loeys Catarina Lundin Takeru Makiyama Jacques Mansourati Raphaël P Martins Andrea Mazzanti Stellan Mörner Carlo Napolitano Kimie Ohkubo Michael Papadakis Boris Rudic Maria Sabater Molina Frédéric Sacher Hatice Sahin Georgia Sarquella-Brugada Regina Sebastiano Sanjay Sharma Mary N Sheppard Keiko Shimamoto M Benjamin Shoemaker Birgit Stallmeyer Johannes Steinfurt Yuji Tanaka David J Tester Keisuke Usuda Paul A van der Zwaag Sonia Van Dooren Lut Van Laer Annika Winbo Bo G Winkel Kenichiro Yamagata Sven Zumhagen Paul G A Volders Steven A Lubitz Charles Antzelevitch Pyotr G Platonov Katja E Odening Dan M Roden Jason D Roberts Jonathan R Skinner Jacob Tfelt-Hansen Maarten P van den Berg Morten S Olesen Pier D Lambiase Martin Borggrefe Kenshi Hayashi Annika Rydberg Tadashi Nakajima Masao Yoshinaga Johan B Saenen Stefan Kääb Pedro Brugada Tomas Robyns Daniela F Giachino Michael J Ackerman Ramon Brugada Josep Brugada Juan R Gimeno Can Hasdemir Pascale Guicheney Silvia G Priori Eric Schulze-Bahr Naomasa Makita Peter J Schwartz Wataru Shimizu Takeshi Aiba Jean-Jacques Schott Richard Redon Seiko Ohno Vincent Probst Elijah R Behr Julien Barc Connie R Bezzina

Genet Med 2020 Sep 7. Epub 2020 Sep 7.

Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/s41436-020-00946-5DOI Listing
September 2020

Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1.

J Am Heart Assoc 2020 Sep 19;9(17):e015709. Epub 2020 Aug 19.

Department of Neurology National Hospital Organization Osaka Toneyama Medical Center 5-1-1 Toyonaka Japan.

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http://dx.doi.org/10.1161/JAHA.119.015709DOI Listing
September 2020

A computational analysis of the effect of sevoflurane in a human ventricular cell model of long QT syndrome: Importance of repolarization reserve in the QT-prolonging effect of sevoflurane.

Eur J Pharmacol 2020 Sep 22;883:173378. Epub 2020 Jul 22.

Department of Physiology, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2020.173378DOI Listing
September 2020

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome.

Authors:
Najim Lahrouchi Rafik Tadros Lia Crotti Yuka Mizusawa Pieter G Postema Leander Beekman Roddy Walsh Kanae Hasegawa Julien Barc Marko Ernsting Kari L Turkowski Andrea Mazzanti Britt M Beckmann Keiko Shimamoto Ulla-Britt Diamant Yanushi D Wijeyeratne Yu Kucho Tomas Robyns Taisuke Ishikawa Elena Arbelo Michael Christiansen Annika Winbo Reza Jabbari Steven A Lubitz Johannes Steinfurt Boris Rudic Bart Loeys M Ben Shoemaker Peter E Weeke Ryan Pfeiffer Brianna Davies Antoine Andorin Nynke Hofman Federica Dagradi Matteo Pedrazzini David J Tester J Martijn Bos Georgia Sarquella-Brugada Óscar Campuzano Pyotr G Platonov Birgit Stallmeyer Sven Zumhagen Eline A Nannenberg Jan H Veldink Leonard H van den Berg Ammar Al-Chalabi Christopher E Shaw Pamela J Shaw Karen E Morrison Peter M Andersen Martina Müller-Nurasyid Daniele Cusi Cristina Barlassina Pilar Galan Mark Lathrop Markus Munter Thomas Werge Marta Ribasés Tin Aung Chiea C Khor Mineo Ozaki Peter Lichtner Thomas Meitinger J Peter van Tintelen Yvonne Hoedemaekers Isabelle Denjoy Antoine Leenhardt Carlo Napolitano Wataru Shimizu Jean-Jacques Schott Jean-Baptiste Gourraud Takeru Makiyama Seiko Ohno Hideki Itoh Andrew D Krahn Charles Antzelevitch Dan M Roden Johan Saenen Martin Borggrefe Katja E Odening Patrick T Ellinor Jacob Tfelt-Hansen Jonathan R Skinner Maarten P van den Berg Morten Salling Olesen Josep Brugada Ramón Brugada Naomasa Makita Jeroen Breckpot Masao Yoshinaga Elijah R Behr Annika Rydberg Takeshi Aiba Stefan Kääb Silvia G Priori Pascale Guicheney Hanno L Tan Christopher Newton-Cheh Michael J Ackerman Peter J Schwartz Eric Schulze-Bahr Vincent Probst Minoru Horie Arthur A Wilde Michael W T Tanck Connie R Bezzina

Circulation 2020 Jul 20;142(4):324-338. Epub 2020 May 20.

Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, The Netherlands (N.L., R.T., Y.M., P.G.P., L.B., R.W., N.H., H.L.T., A.A.W., C.R.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.045956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382531PMC
July 2020

Microscopic heat pulses activate cardiac thin filaments.

J Gen Physiol 2019 06 22;151(6):860-869. Epub 2019 Apr 22.

Department of Physics, Faculty of Science and Engineering, Waseda University, Tokyo, Japan

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http://dx.doi.org/10.1085/jgp.201812243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572001PMC
June 2019

Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation.

Br J Clin Pharmacol 2018 06 16;84(6):1301-1312. Epub 2018 Apr 16.

Laboratory of Clinical Pharmaceutics and Therapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga, 525-8577, Japan.

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http://dx.doi.org/10.1111/bcp.13561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980466PMC
June 2018

A challenge for mutation specific risk stratification in long QT syndrome type 1.

J Cardiol 2018 07 10;72(1):56-65. Epub 2018 Feb 10.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jjcc.2017.12.011DOI Listing
July 2018

Bradycardia Is a Specific Phenotype of Catecholaminergic Polymorphic Ventricular Tachycardia Induced by RYR2 Mutations.

Intern Med 2018 Jul 9;57(13):1813-1817. Epub 2018 Feb 9.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan.

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http://dx.doi.org/10.2169/internalmedicine.9843-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064684PMC
July 2018

Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome.

J Cardiol 2018 04 14;71(4):401-408. Epub 2017 Nov 14.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jjcc.2017.10.004DOI Listing
April 2018

Drug-induced Brugada-type Electrocardiogram: A Cause of Sudden Death in Patients with Schizophrenia?

Authors:
Hideki Itoh

Intern Med 2017 11 16;56(22):2969-2970. Epub 2017 Oct 16.

Department of Cardiovascular Medicine, Shiga University of Medical Science, Japan.

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http://dx.doi.org/10.2169/internalmedicine.9087-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725848PMC
November 2017

Impact of ABCB1, ABCG2, and CYP3A5 polymorphisms on plasma trough concentrations of apixaban in Japanese patients with atrial fibrillation.

Pharmacogenet Genomics 2017 Sep;27(9):329-336

aLaboratory of Clinical Pharmaceutics and Therapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu bDepartment of Pharmacy cDepartment of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1097/FPC.0000000000000294DOI Listing
September 2017

Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes.

Pharmacol Ther 2017 Aug 18;176:48-59. Epub 2017 May 18.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2017.05.001DOI Listing
August 2017

A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.

PLoS One 2016 25;11(8):e0161872. Epub 2016 Aug 25.

Cardiovascular and Respiratory Medicine, Shiga Univ. School of Medicine, Otsu, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999187PMC
August 2017

Early repolarization and risk of arrhythmia events in long QT syndrome.

Int J Cardiol 2016 Nov 11;223:540-542. Epub 2016 Aug 11.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.08.215DOI Listing
November 2016

Direct organelle thermometry with fluorescence lifetime imaging microscopy in single myotubes.

Chem Commun (Camb) 2016 Mar;52(24):4458-61

Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.

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http://dx.doi.org/10.1039/c5cc09943aDOI Listing
March 2016

Multigenerational Inheritance of Long QT Syndrome Type 2 in a Japanese Family.

Intern Med 2016 1;55(3):259-62. Epub 2016 Feb 1.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan.

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http://dx.doi.org/10.2169/internalmedicine.55.6014DOI Listing
August 2016

Pediatric Cohort With Long QT Syndrome - KCNH2 Mutation Carriers Present Late Onset But Severe Symptoms.

Circ J 2016 26;80(3):696-702. Epub 2016 Jan 26.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science.

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http://dx.doi.org/10.1253/circj.CJ-15-0933DOI Listing
November 2016

Löffler Endocarditis and Lacking Heart.

Intern Med 2015 1;54(23):3093. Epub 2015 Dec 1.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan.

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http://dx.doi.org/10.2169/internalmedicine.54.5622DOI Listing
March 2016

Triggering of high-speed neurite outgrowth using an optical microheater.

Sci Rep 2015 Nov 16;5:16611. Epub 2015 Nov 16.

Department of Physics, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.

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http://dx.doi.org/10.1038/srep16611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645119PMC
November 2015

Directional bleb formation in spherical cells under temperature gradient.

Biophys J 2015 Jul;109(2):355-64

Department of Physics, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan; WASEDA Bioscience Research Institute in Singapore (WABIOS), Singapore, Singapore; Organization for University Research Initiatives, Waseda University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621819PMC
July 2015

A Common Mutation of Long QT Syndrome Type 1 in Japan.

Circ J 2015 29;79(9):2026-30. Epub 2015 Jun 29.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science.

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http://dx.doi.org/10.1253/circj.CJ-15-0342DOI Listing
May 2016

Long-term pharmacological therapy of Brugada syndrome: is J-wave attenuation a marker of drug efficacy?

Intern Med 2014 15;53(14):1523-6. Epub 2014 Jul 15.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Japan.

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http://dx.doi.org/10.2169/internalmedicine.53.1829DOI Listing
June 2015

Long QT syndrome type 8: novel CACNA1C mutations causing QT prolongation and variant phenotypes.

Europace 2014 Dec 12;16(12):1828-37. Epub 2014 Apr 12.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga 520-2192, Japan

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http://europace.oxfordjournals.org/content/europace/16/12/18
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http://europace.oxfordjournals.org/cgi/doi/10.1093/europace/
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http://dx.doi.org/10.1093/europace/euu063DOI Listing
December 2014

A Kir3.4 mutation causes Andersen-Tawil syndrome by an inhibitory effect on Kir2.1.

Neurology 2014 Mar 26;82(12):1058-64. Epub 2014 Feb 26.

From the Department of Neurology (Y.K., M.F., M.N., T.K., H.M., M.P.T.), and Laboratory of Integrative Physiology, Department of Physiology (S.S., Y. Okamura), Osaka University Graduate School of Medicine, Suita, Osaka; Division of Neurogenetics (T.N., K.O.), Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Aichi; Department of Cardiovascular and Respiratory Medicine (H.K., H.I., M.H.), Shiga University of Medical Science, Otsu, Shiga; Division of Arrhythmia and Electrophysiology (T.A., W.S.), Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka; Department of Pediatrics (M.Y.), National Hospital Organization Kagoshima Medical Center, Kagoshima; Department of Neurology (Y. Osaki, K.S.), Kurashiki Central Hospital, Kurashiki, Okayama; Department of Legal Medicine (T.S.), Osaka Medical College, Takatsuki, Osaka; Department of Cardiology (K.K.), Kurashiki Central Hospital, Kurashiki, Okayama; and Department of Cardiovascular Medicine (W.S.), Nippon Medical School, Bunkyo, Tokyo, Japan. Y.K. is currently affiliated with the Department of Neurology, Osaka General Medical Center, Sumiyoshi, Osaka, Japan; and T.K. is currently affiliated with the Department of Biochemistry and Molecular Biology, Division of Biological Sciences, The University of Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000000239DOI Listing
March 2014

Gain-of-function KCNH2 mutations in patients with Brugada syndrome.

J Cardiovasc Electrophysiol 2014 May 30;25(5):522-530. Epub 2014 Jan 30.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1111/jce.12361DOI Listing
May 2014

Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction.

Europace 2014 Nov 6;16(11):1646-54. Epub 2014 Jan 6.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta-Tsukinowa-cho, Otsu, Shiga 520-2192, Japan

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http://dx.doi.org/10.1093/europace/eut382DOI Listing
November 2014

Microscopic heat pulse-induced calcium dynamics in single WI-38 fibroblasts.

Biophysics (Nagoya-shi) 2014 17;10:109-19. Epub 2014 Dec 17.

Department of Pure and Applied Physics, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan; Department of Physics, Faculty of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan; Waseda Bioscience Research Institute in Singapore (WABIOS), 11 Biopolis Way, #05-02 Helios, Singapore 138667, Singapore; Organization for University Research Initiatives, Waseda University, 513 Waseda Tsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan.

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http://dx.doi.org/10.2142/biophysics.10.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629654PMC
August 2016

Nonsense-mediated mRNA decay due to a CACNA1C splicing mutation in a patient with Brugada syndrome.

Heart Rhythm 2014 Apr 7;11(4):629-34. Epub 2013 Dec 7.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2013.12.011DOI Listing
April 2014

Cardiac channelopathies associated with infantile fatal ventricular arrhythmias: from the cradle to the bench.

J Cardiovasc Electrophysiol 2014 Jan 24;25(1):66-73. Epub 2013 Sep 24.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan.

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http://doi.wiley.com/10.1111/jce.12270
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http://dx.doi.org/10.1111/jce.12270DOI Listing
January 2014

A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.

Heart Rhythm 2014 Jan 1;11(1):67-75. Epub 2013 Oct 1.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2013.09.073DOI Listing
January 2014

Trans-resectoscope stimulation predicts the need to block adductor response during bladder tumor resection.

Anesth Analg 2013 Sep 18;117(3):740-4. Epub 2013 Jul 18.

Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1213/ANE.0b013e3182a07063DOI Listing
September 2013

L-type calcium channel mutations in Japanese patients with inherited arrhythmias.

Circ J 2013 11;77(7):1799-806. Epub 2013 Apr 11.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1253/circj.cj-12-1457DOI Listing
February 2014

Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia.

Circ J 2013 20;77(6):1534-42. Epub 2013 Mar 20.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu 520-2192, Japan.

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http://dx.doi.org/10.1253/circj.cj-12-1446DOI Listing
December 2013

Seasonal and circadian distributions of cardiac events in genotyped patients with congenital long QT syndrome.

Circ J 2012 23;76(9):2112-8. Epub 2012 Jun 23.

Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

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http://dx.doi.org/10.1253/circj.cj-12-0213DOI Listing
February 2013

Phenotype variability in patients carrying KCNJ2 mutations.

Circ Cardiovasc Genet 2012 Jun 15;5(3):344-53. Epub 2012 May 15.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1161/CIRCGENETICS.111.962316DOI Listing
June 2012

Microscopic heat pulses induce contraction of cardiomyocytes without calcium transients.

Biochem Biophys Res Commun 2012 Jan 11;417(1):607-12. Epub 2011 Dec 11.

Department of Physics, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.12.015DOI Listing
January 2012

Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population.

Heart Rhythm 2012 Jan 17;9(1):66-74. Epub 2011 Aug 17.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

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http://dx.doi.org/10.1016/j.hrthm.2011.08.016DOI Listing
January 2012

KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.

Circ Arrhythm Electrophysiol 2011 Jun 14;4(3):352-61. Epub 2011 Apr 14.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan.

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http://dx.doi.org/10.1161/CIRCEP.110.959619DOI Listing
June 2011

Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome.

Circ J 2010 Nov 21;74(12):2562-71. Epub 2010 Oct 21.

Department of Respiratory and Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1253/circj.cj-10-0498DOI Listing
November 2010

Intrathecally administered Sema3A protein attenuates neuropathic pain behavior in rats with chronic constriction injury of the sciatic nerve.

Neurosci Res 2011 Jan 1;69(1):17-24. Epub 2010 Oct 1.

Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.neures.2010.09.006DOI Listing
January 2011

Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome.

Europace 2010 Nov 29;12(11):1623-9. Epub 2010 Sep 29.

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.

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http://dx.doi.org/10.1093/europace/euq342DOI Listing
November 2010

High prevalence of early repolarization in short QT syndrome.

Heart Rhythm 2010 May 15;7(5):647-52. Epub 2010 Jan 15.

Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1016/j.hrthm.2010.01.012DOI Listing
May 2010

Aortopulmonary artery dissection.

J Am Coll Cardiol 2009 Nov;54(21):1990

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan.

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http://dx.doi.org/10.1016/j.jacc.2009.02.092DOI Listing
November 2009

Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long QT syndrome.

J Cardiovasc Electrophysiol 2008 Aug 26;19(8):794-9. Epub 2008 Mar 26.

Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1111/j.1540-8167.2008.01138.xDOI Listing
August 2008

Disorders of cardiac repolarization: long QT and short QT syndromes.

Circ J 2007 ;71 Suppl A:A50-3

Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Japan.

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http://dx.doi.org/10.1253/circj.71.a50DOI Listing
June 2011

Differential effects of isoflurane on A-type and delayed rectifier K channels in rat substantia nigra.

Eur J Pharmacol 2008 Feb 30;580(1-2):122-9. Epub 2007 Oct 30.

Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1016/j.ejphar.2007.10.062DOI Listing
February 2008

A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome.

Int J Cardiol 2007 Oct 18;121(3):239-48. Epub 2007 Apr 18.

Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8787, Japan.

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http://dx.doi.org/10.1016/j.ijcard.2007.02.007DOI Listing
October 2007

N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome.

Heart Rhythm 2007 Mar 10;4(3):332-40. Epub 2006 Nov 10.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.hrthm.2006.11.004DOI Listing
March 2007

Arrhythmogenesis in the short-QT syndrome associated with combined HERG channel gating defects: a simulation study.

Circ J 2006 Apr;70(4):502-8

Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.

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http://dx.doi.org/10.1253/circj.70.502DOI Listing
April 2006

A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs.

J Cardiovasc Electrophysiol 2005 May;16(5):486-93

Department of Information Physiology, National Institute for Physiological Sciences, Okazaki 444-8787, Japan.

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http://dx.doi.org/10.1111/j.1540-8167.2005.40711.xDOI Listing
May 2005

Clinical and electrophysiological characteristics of Brugada syndrome caused by a missense mutation in the S5-pore site of SCN5A.

J Cardiovasc Electrophysiol 2005 Apr;16(4):378-83

Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan.

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http://dx.doi.org/10.1046/j.1540-8167.2005.40606.xDOI Listing
April 2005

Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats.

Neuroreport 2004 Jul;15(10):1617-21

Division of Physiology and Pathophysiology, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan.

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http://dx.doi.org/10.1097/01.wnr.0000134991.97051.6bDOI Listing
July 2004

PKC-independent inhibition of neuronal nicotinic acetylcholine receptors by diacylglycerol.

Brain Res 2004 Jul;1013(1):125-33

Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1016/j.brainres.2004.04.012DOI Listing
July 2004

Effects of isoflurane and ketamine on ATP-sensitive K channels in rat substantia nigra.

Neuropharmacology 2004 Jun 2;46(8):1201-1212. Epub 2004 Mar 2.

Department of Anaesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2004.01.012DOI Listing
June 2004

Effects of isoflurane and ketamine on ATP-sensitive K channels in rat substantia nigra.

Neuropharmacology 2004 Jun;46(8):1201-12

Department of Anaesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1016/j.neuropharm.2004.01.012DOI Listing
June 2004

Spectral analyses of electroencephalography and heart rate variability during sleep in normal subjects.

Auton Neurosci 2003 Jan;103(1-2):114-20

Department of Anesthesiology, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1016/s1566-0702(02)00259-xDOI Listing
January 2003

Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia.

Circ J 2003 Jan;67(1):93-5

Department of Cardiology, Saiseikai Kanazawa Hospital, Japan.

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http://dx.doi.org/10.1253/circj.67.93DOI Listing
January 2003

Inhibitory effects of isoflurane and nonimmobilizing halogenated compounds on neuronal nicotinic acetylcholine receptors.

Anesthesiology 2002 Dec;97(6):1541-9

Department of Anaesthesiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

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http://dx.doi.org/10.1097/00000542-200212000-00029DOI Listing
December 2002

Role of N-methyl-D-aspartate receptors and the nitric oxide pathway in nociception/hyperalgesia elicited by protease-activated receptor-2 activation in mice and rats.

Neurosci Lett 2002 Sep;329(3):349-53

Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi-Osaka 577-8502, Japan.

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http://dx.doi.org/10.1016/s0304-3940(02)00702-4DOI Listing
September 2002

Capsazepine inhibits thermal hyperalgesia but not nociception triggered by protease-activated receptor-2 in rats.

Jpn J Pharmacol 2002 Jun;89(2):184-7

Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, Higashi-Osaka, Japan.

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http://dx.doi.org/10.1254/jjp.89.184DOI Listing
June 2002

Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats.

Neuroreport 2002 Mar;13(4):511-4

Department of Pathophysiology and Therapeutics, School of Pharmaceutical Sciences, Kinki University, 3-4-1 Kowakae, Higashi-Osaka 577-8502, Japan.

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http://dx.doi.org/10.1097/00001756-200203250-00031DOI Listing
March 2002