Hidehito Tochio

Hidehito Tochio

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Hidehito Tochio

Publications by authors named "Hidehito Tochio"

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Tracking the 3D Rotational Dynamics in Nanoscopic Biological Systems.

J Am Chem Soc 2020 Apr 14;142(16):7542-7554. Epub 2020 Apr 14.

Institute for Quantum Life Science, National Institute for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan.

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http://dx.doi.org/10.1021/jacs.0c01191DOI Listing
April 2020

Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and F Magnetic Resonance Imaging.

Chembiochem 2017 05 24;18(10):951-959. Epub 2017 Mar 24.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan.

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http://dx.doi.org/10.1002/cbic.201700071DOI Listing
May 2017

[Non-invasive analysis of proteins in living cells using NMR spectroscopy].

Yakugaku Zasshi 2015 ;135(3):391-8

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University.

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https://www.jstage.jst.go.jp/article/yakushi/135/3/135_14-00
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http://dx.doi.org/10.1248/yakushi.14-00240-3DOI Listing
July 2016

Selective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes.

Nanomaterials (Basel) 2016 Mar 25;6(4). Epub 2016 Mar 25.

Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa-oiwake, Sakyo-ku, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.3390/nano6040056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302567PMC
March 2016

Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin.

Arch Biochem Biophys 2016 Mar 10;594:1-7. Epub 2016 Feb 10.

Departments of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, 770-8503, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2016.02.014DOI Listing
March 2016

UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion.

Biochem Biophys Res Commun 2016 Mar 23;472(1):108-13. Epub 2016 Feb 23.

Department of Nutritional Physiology, Institute of Health Biosciences, University of Tokushima, Tokushima, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2016.02.075DOI Listing
March 2016

Magnetic resonance imaging of tumor with a self-traceable phosphorylcholine polymer.

J Am Chem Soc 2015 Jan 6;137(2):799-806. Epub 2015 Jan 6.

Advanced Biomedical Engineering Research Unit, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University , Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1021/ja510479vDOI Listing
January 2015

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates.

Nat Commun 2015 Jan 20;6:6116. Epub 2015 Jan 20.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku Katsura, Nishikyo-Ku, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1038/ncomms7116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309437PMC
January 2015

The structural basis for receptor recognition of human interleukin-18.

Nat Commun 2014 Dec 15;5:5340. Epub 2014 Dec 15.

1] Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu 501-1194, Japan [2] Biomedical Informatics, Medical Information Sciences Division, The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1194, Japan.

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http://dx.doi.org/10.1038/ncomms6340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275594PMC
December 2014

Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes.

Acta Crystallogr F Struct Biol Commun 2014 Oct 25;70(Pt 10):1351-6. Epub 2014 Sep 25.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188078PMC
http://dx.doi.org/10.1107/S2053230X14016926DOI Listing
October 2014

Solution structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin.

J Biol Chem 2014 May 1;289(20):13890-902. Epub 2014 Apr 1.

From the Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.555441
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http://dx.doi.org/10.1074/jbc.M114.555441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022861PMC
May 2014

[Application of nitrogen-vacancy centers of diamonds to biological imaging].

Seikagaku 2014 Apr;86(2):145-53

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April 2014

Functional assessment of the mutational effects of human IRAK4 and MyD88 genes.

Mol Immunol 2014 Mar 5;58(1):66-76. Epub 2013 Dec 5.

Department of Pediatrics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan; Heisei College of Health Sciences, 180 Kurono, Gifu 501-1131, Japan.

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http://dx.doi.org/10.1016/j.molimm.2013.11.008DOI Listing
March 2014

Pruning the ALS-associated protein SOD1 for in-cell NMR.

J Am Chem Soc 2013 Jul 8;135(28):10266-9. Epub 2013 Jul 8.

Department of Biochemistry and Biophysics, Arrhenius Laboratories of Natural Sciences, Stockholm University, S-106 91 Stockholm, Sweden.

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http://dx.doi.org/10.1021/ja404425rDOI Listing
July 2013

Quantitative comparison of protein dynamics in live cells and in vitro by in-cell (19)F-NMR.

Chem Commun (Camb) 2013 Apr;49(27):2801-3

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, Japan.

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http://dx.doi.org/10.1039/c3cc39205hDOI Listing
April 2013

A structured monodisperse PEG for the effective suppression of protein aggregation.

Angew Chem Int Ed Engl 2013 Feb 30;52(9):2430-4. Epub 2013 Jan 30.

Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1, Katahira, Sendai, Japan.

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http://dx.doi.org/10.1002/anie.201206563DOI Listing
February 2013

Watching protein structure at work in living cells using NMR spectroscopy.

Authors:
Hidehito Tochio

Curr Opin Chem Biol 2012 Dec 21;16(5-6):609-13. Epub 2012 Nov 21.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1016/j.cbpa.2012.10.022DOI Listing
December 2012

Real-time background-free selective imaging of fluorescent nanodiamonds in vivo.

Nano Lett 2012 Nov 22;12(11):5726-32. Epub 2012 Oct 22.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1021/nl302979dDOI Listing
November 2012

Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling.

Mol Immunol 2012 Oct 4;52(3-4):108-16. Epub 2012 Jun 4.

Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu 501-1194, Japan.

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http://dx.doi.org/10.1016/j.molimm.2012.05.003DOI Listing
October 2012

Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.

Proc Natl Acad Sci U S A 2012 Aug 25;109(32):12950-5. Epub 2012 Jul 25.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1073/pnas.1203701109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420164PMC
August 2012

[Structural analysis of proteins in living eukaryotic cells using magnetic resonance spectroscopy].

Yakugaku Zasshi 2012 ;132(2):185-93

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1248/yakushi.132.185DOI Listing
July 2012

NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80.

J Biomol NMR 2012 Apr 18;52(4):339-50. Epub 2012 Feb 18.

Graduate School of Engineering, Kyoto University, Kyoto daigaku-Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

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http://link.springer.com/content/pdf/10.1007/s10858-012-9614
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http://link.springer.com/10.1007/s10858-012-9614-9
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http://dx.doi.org/10.1007/s10858-012-9614-9DOI Listing
April 2012

Substrate/Product-targeted NMR monitoring of pyrimidine catabolism and its inhibition by a clinical drug.

ACS Chem Biol 2012 Mar 19;7(3):535-42. Epub 2012 Jan 19.

Advanced Biomedical Engineering Research Unit, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

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http://pubs.acs.org/doi/10.1021/cb2003972
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http://dx.doi.org/10.1021/cb2003972DOI Listing
March 2012

Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.

J Biol Chem 2011 Sep 29;286(36):31864-74. Epub 2011 Jun 29.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku Katsura, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1074/jbc.M111.259630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173063PMC
September 2011

Application of NMR spectroscopy in medicinal chemistry and drug discovery.

Curr Top Med Chem 2011 ;11(1):68-73

Division of Nutritional physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Japan.

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http://dx.doi.org/10.2174/156802611793611878DOI Listing
April 2011

1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88.

Biomol NMR Assign 2010 Oct 31;4(2):123-5. Epub 2010 Mar 31.

Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu, 501-1194, Japan.

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http://dx.doi.org/10.1007/s12104-010-9222-0DOI Listing
October 2010

Purification, crystallization and preliminary crystallographic studies of Lys48-linked polyubiquitin chains.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Jul 24;66(Pt 7):834-7. Epub 2010 Jun 24.

Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8015, Japan.

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http://dx.doi.org/10.1107/S1744309110018804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898474PMC
July 2010

Distance determination in proteins inside Xenopus laevis oocytes by double electron-electron resonance experiments.

J Am Chem Soc 2010 Jun;132(24):8228-9

Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1021/ja906104eDOI Listing
June 2010

A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization.

J Biol Chem 2010 May 25;285(22):16822-9. Epub 2010 Mar 25.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku Katsura, Nishikyo-ku, Kyoto 615-8530, Japan.

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http://dx.doi.org/10.1074/jbc.M110.108365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878028PMC
May 2010

Solution structure of a zinc-finger domain that binds to poly-ADP-ribose.

Genes Cells 2010 Feb 19;15(2):101-10. Epub 2010 Jan 19.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto-Daigaku Katsura, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2009.01369.xDOI Listing
February 2010

Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging.

Nat Chem 2009 Oct 23;1(7):557-61. Epub 2009 Sep 23.

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Japan.

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http://www.nature.com/articles/nchem.365
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http://dx.doi.org/10.1038/nchem.365DOI Listing
October 2009

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.

Proc Natl Acad Sci U S A 2009 Jun 8;106(25):10260-5. Epub 2009 Jun 8.

Department of Pediatrics, Graduate School of Medicine, Center for Emerging Infectious Diseases, and Center for Advanced Drug Research, Gifu University, Gifu, Japan.

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http://dx.doi.org/10.1073/pnas.0812956106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693180PMC
June 2009

High-resolution multi-dimensional NMR spectroscopy of proteins in human cells.

Nature 2009 Mar;458(7234):106-9

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-Ku, Kyoto 615-8510, Japan.

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http://www.nature.com/articles/nature07839
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http://dx.doi.org/10.1038/nature07839DOI Listing
March 2009

Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2.

J Biol Chem 2009 Jan 18;284(4):2435-47. Epub 2008 Nov 18.

Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1074/jbc.M806392200DOI Listing
January 2009

Expression, purification and structural analysis of human IL-18 binding protein: a potent therapeutic molecule for allergy.

Allergol Int 2008 Dec 1;57(4):367-76. Epub 2008 Dec 1.

Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan.

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http://dx.doi.org/10.2332/allergolint.O-08-546DOI Listing
December 2008

The solution structure of the C-terminal domain of NfeD reveals a novel membrane-anchored OB-fold.

Protein Sci 2008 Nov 7;17(11):1915-24. Epub 2008 Aug 7.

Field of Supramolecular Biology, International Graduate School of Arts and Sciences, Yokohama City University, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.

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http://doi.wiley.com/10.1110/ps.034736.108
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http://dx.doi.org/10.1110/ps.034736.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578811PMC
November 2008

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism.

Nature 2008 Oct 3;455(7214):818-21. Epub 2008 Sep 3.

Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1038/nature07249DOI Listing
October 2008

Kinetic and thermodynamic evidence for flipping of a methyl-CpG binding domain on methylated DNA.

Biochemistry 2008 Mar 12;47(10):3266-71. Epub 2008 Feb 12.

Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.

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http://dx.doi.org/10.1021/bi7019029DOI Listing
March 2008

Paramagnetic relaxation-based 19f MRI probe to detect protease activity.

J Am Chem Soc 2008 Jan 23;130(3):794-5. Epub 2007 Dec 23.

Division of Advanced Science and Biotechnology, Graduate School of Engineering, Osaka University, Osaka 565-0871, Japan.

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http://pubs.acs.org/doi/abs/10.1021/ja077058z
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http://dx.doi.org/10.1021/ja077058zDOI Listing
January 2008

Fluoroscopic assessment of protein leakage during Xenopus oocytes in-cell NMR experiment by co-injected EGFP.

Anal Biochem 2007 Dec 10;371(2):247-9. Epub 2007 Aug 10.

Division of Biophysics, Graduate School of Integrated Sciences, Yokohama City University, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1016/j.ab.2007.08.006DOI Listing
December 2007

Structure of RNA aptamer complexed with an RNA-binding peptide of Tat with aid of residue-specific 13C, 15N labeling.

Nucleic Acids Symp Ser (Oxf) 2005 (49):69-70

Supramolecular Biology, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1093/nass/49.1.69DOI Listing
June 2007

Fine-tuning of protein domain boundary by minimizing potential coiled coil regions.

J Biomol NMR 2007 Jan 16;37(1):53-63. Epub 2006 Dec 16.

Field of Supramolecular Biology, International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Tsurumi, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1007/s10858-006-9103-0DOI Listing
January 2007

In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes.

J Biomol NMR 2006 Nov 20;36(3):179-88. Epub 2006 Sep 20.

International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, 230-0045, Japan.

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http://dx.doi.org/10.1007/s10858-006-9079-9DOI Listing
November 2006

Crystal structure of SUMO-3-modified thymine-DNA glycosylase.

J Mol Biol 2006 May 31;359(1):137-47. Epub 2006 Mar 31.

Graduate School of Integrated Science, Yokohama City University, Japan.

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http://dx.doi.org/10.1016/j.jmb.2006.03.036DOI Listing
May 2006

Structural characterization of the MIT domain from human Vps4b.

Biochem Biophys Res Commun 2005 Aug;334(2):460-5

International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa 230 0045, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.06.110DOI Listing
August 2005

Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae.

J Biol Chem 2005 Jul 2;280(26):25127-33. Epub 2005 May 2.

Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414579200
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http://dx.doi.org/10.1074/jbc.M414579200DOI Listing
July 2005

Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.

Nature 2005 Jun;435(7044):979-82

Graduate School of Integrated Science, Yokohama City University, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1038/nature03634DOI Listing
June 2005

Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition.

Structure 2005 Apr;13(4):521-32

Graduate School of Integrated Science, Yokohama City University, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1016/j.str.2005.01.011DOI Listing
April 2005

[Structural biology of ubiquitin and ubiquitin binding domain/motif].

Tanpakushitsu Kakusan Koso 2004 May;49(7 Suppl):1042-3

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May 2004

Intracellular phosphate serves as a signal for the regulation of the PHO pathway in Saccharomyces cerevisiae.

J Biol Chem 2004 Apr 13;279(17):17289-94. Epub 2004 Feb 13.

Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M312202200
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http://dx.doi.org/10.1074/jbc.M312202200DOI Listing
April 2004

High-throughput construction method for expression vector of peptides for NMR study suited for isotopic labeling.

Protein Eng Des Sel 2004 Apr 27;17(4):305-14. Epub 2004 May 27.

Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehirocho, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1093/protein/gzh044DOI Listing
April 2004

Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B.

J Biol Chem 2004 Feb 29;279(6):4760-7. Epub 2003 Oct 29.

Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro, Tsurumi, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1074/jbc.M309448200DOI Listing
February 2004

Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95.

J Mol Biol 2003 Mar;327(1):203-14

Department of Biochemistry, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People's Republic of China.

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http://dx.doi.org/10.1016/s0022-2836(03)00113-xDOI Listing
March 2003

Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity.

J Biomol NMR 2002 Jun;23(2):103-14

Department of Biochemistry, The Hong Kong University of Science and Technology, Kowloon, PR China.

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http://dx.doi.org/10.1023/a:1016332918178DOI Listing
June 2002