Publications by authors named "Hicham Souhi"

18 Publications

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[IManagement of patients with relapsed primary naso-sinusal tuberculosis].

Pan Afr Med J 2020 12;36:84. Epub 2020 Jun 12.

Service de Pneumologie, Hôpital Militaire d'Instruction Mohamed V, Rabat, Maroc.

Primary naso-sinusal tuberculosis (TB) is a relatively rare or exceptional disorder characterized by polymorphic or non-specific clinical manifestation. Diagnosis is based on anatomo-pathological examination and mycobacteriology test of biopsy specimen. Predictor of good outcome is early conventional anti-tuberculous antibiotic therapy. However, our study reports recurrence at this rare site in an immunocompetent patient despite early suitable TB treatment and good adherence with therapy. Relapse was correlated with underdosing of rifampicin. This study highlights the diagnostic, etiological and therapeutic management of this relapse. Our experience could help clinicians to better manage this uncommon condition.
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http://dx.doi.org/10.11604/pamj.2020.36.84.13067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392870PMC
December 2020

Typical presentation of pulmonary lepidic adenocarcinoma: a rare case report.

Pan Afr Med J 2020 11;36:11. Epub 2020 May 11.

Department of Pathology, Military Hospital Mohamed V, Rabat, Morocco.

Bronchioloalveolar carcinoma (BAC) is a rare subtype of adenocarcinoma of lung with distinct features and distinctive characteristics. It accounts approximately for 4% of lung cancers. In the following study we report a rare observation of a 50 years old female with a clinical, radiological and histological presentation, which is typical of an invasive mucinous lepidic adenocarcinoma formerly named BAC.
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http://dx.doi.org/10.11604/pamj.2020.36.11.22660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282614PMC
December 2020

Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Morocco.

PLoS One 2019 15;14(8):e0221081. Epub 2019 Aug 15.

Genetics Unit, Military Hospital Mohamed V, Rabat, Morocco.

Increased prevalence of latent tuberculosis infection (LTBI) has been observed among high-risk populations such as healthcare workers (HCWs). The results may depend on the method of LTBI assessment, interferon-gamma release assay (IGRA) and/or tuberculin skin test (TST). Here, we investigated the prevalence and risk factors for LTBI assessed by both IGRAs and TST in HCWs living in Morocco, a country with intermediate tuberculosis (TB) endemicity and high BCG vaccination coverage. HCWs were recruited in two Moroccan hospitals, Rabat and Meknes. All the participants underwent testing for LTBI by both IGRA (QuantiFERON-TB Gold In-Tube, QFT-GIT) and TST. Different combinations of IGRA and TST results defined the LTBI status. Risk factors associated with LTBI were investigated using a mixed-effect logistic regression model. The prevalence of LTBI among 631 HCWs (age range 18-60 years) varied from 40.7% (95%CI 36.9-44.5%) with QFT-GIT to 52% (95%CI 48.2-56.0%) with TST using a 10 mm cut-off. The highest agreement between QFT-GIT and TST (κ = 0.50; 95%CI 0.43-0.56) was observed with the 10 mm cut-off for a positive TST. For a definition of LTBI status using a double positive result for both QFT-GIT and TST, significant associations were found with the following risk factors: being male (OR = 2.21; 95%CI 1.40-3.49; p = 0.0007), belonging to age groups 35-44 years (OR = 2.43; 95%CI 1.45-4.06; p = 0.0007) and even more 45-60 years (OR = 4.81; 95%CI 2.72-8.52; p = 7.10-8), having a family history of TB (OR = 6.62; 95%CI 2.59-16.94; p = 8.10-5), and working at a pulmonology unit (OR = 3.64; 95%CI 1.44-9.23; p = 0.006). Smoking was associated with LTBI status when defined by a positive QFT-GIT result (OR = 1.89; 95%CI 1.12-3.21; p = 0.02). A high prevalence of LTBI was observed among HCWs in two Moroccan hospitals. Male gender, increased age, family history of TB, and working at a pulmonology unit were consistent risk factors associated with LTBI.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221081PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695119PMC
March 2020

Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common missense variant.

Sci Immunol 2018 12;3(30)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.

Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12- and IL-23-dependent IFN-γ immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 individuals. We show that homozygosity for the common P1104A allele, which is found in about 1/600 Europeans and between 1/1000 and 1/10,000 individuals in regions other than East Asia, is more frequent in a cohort of patients with tuberculosis from endemic areas than in ethnicity-adjusted controls ( = 8.37 × 10; odds ratio, 89.31; 95% CI, 14.7 to 1725). Moreover, the frequency of P1104A in Europeans has decreased, from about 9% to 4.2%, over the past 4000 years, consistent with purging of this variant by endemic tuberculosis. Surprisingly, we also show that TYK2 P1104A impairs cellular responses to IL-23, but not to IFN-α, IL-10, or even IL-12, which, like IL-23, induces IFN-γ via activation of TYK2 and JAK2. Moreover, TYK2 P1104A is properly docked on cytokine receptors and can be phosphorylated by the proximal JAK, but lacks catalytic activity. Last, we show that the catalytic activity of TYK2 is essential for IL-23, but not IL-12, responses in cells expressing wild-type JAK2. In contrast, the catalytic activity of JAK2 is redundant for both IL-12 and IL-23 responses, because the catalytically inactive P1057A JAK2, which is also docked and phosphorylated, rescues signaling in cells expressing wild-type TYK2. In conclusion, homozygosity for the catalytically inactive P1104A missense variant of selectively disrupts the induction of IFN-γ by IL-23 and is a common monogenic etiology of tuberculosis.
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http://dx.doi.org/10.1126/sciimmunol.aau8714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341984PMC
December 2018

Tuberculosis of the scalp: the tubercle bacilli has not ceased to surprise us.

Pan Afr Med J 2017;28:28. Epub 2017 Sep 13.

Service de Pneumologie, Hôpital Militaire d'Instruction Mohamed V, Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2017.28.28.13131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681012PMC
September 2017

[Swelling of the pectoralis muscle revealing isolated muscular tuberculosis].

Pan Afr Med J 2017 18;27:44. Epub 2017 May 18.

Service de Pneumologie, Hôpital Militaire et d'Instruction Mohammed V, Rabat, Maroc.

Soft tissue tuberculosis is one of the rare forms of extrapulmonary tuberculosis. Furthermore, isolated muscular tuberculosis is exceptional. We here report the original case of a young immunocompetent patient with isolated muscular tuberculosis involving major pectoralis muscle. The diagnosis was mainly based on histology. The patient was successfully treated with anti bacterial therapy only. This rare case study has been combined with a literature review.
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http://dx.doi.org/10.11604/pamj.2017.27.44.12419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516675PMC
August 2017

[A rare cause of posterior mediastinal tumors: mediastinal hydatid cyst].

Pan Afr Med J 2016 27;25:122. Epub 2016 Oct 27.

Service de Pneumologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Mediastinal hydatid cyst is extremely rare even in endemic areas, representing 0-4% of all hydatid cyst locations. We report the case of a 50-year old patient admitted to our Department with a mass in the left dorsal paraspinal region; chest X-ray showed posterior left basal opacity. Chest CT scan showed posterior mediastinal mass located in the left costovertebral gutter extending from D9 to D11. MRI confirmed the existence of a posterior mediastinal mass with endocanalar extension and spinal cord compression, first evoking cystic schwannoma. These radioclinical data were consistent with a neoplastic origin; a transparietal biopsy was performed which showed a paucicellular specimen composed of translucent eosinophilic material with appearance just barely compatible with hydatid cyst. Hydatic serology was positive. The diagnosis of hydatid cyst was retained and the patient underwent thoracotomy which revealed mediastinal hydatid cyst, confirmed by histologic examination. The postoperative course was uneventful. Mediastinal location of hydatid cyst is very rare and poses a problem in differential diagnosis with other mediastinal tumors.
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http://dx.doi.org/10.11604/pamj.2016.25.122.9949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325506PMC
April 2017

[Severe pulmonary involvement in hypocomplementemic urticarial vasculitis (HUV)].

Pan Afr Med J 2016 28;24:285. Epub 2016 Jul 28.

Service de Pneumologie, Hôpital Militaire Mohamed V, Rabat, Maroc.

Pulmonary involvement in hypocomplementemic urticarial vasculitis (HUV) or Mac Duffie syndrome is extremely rare with a poor prognosis. We report the case of a 55-year-old female patient treated for HUV over a period of 20 years. The diagnosis was confirmed on the basis of urticarial lesions, ocular inflammation, positive C1q-p test by immunodiffusion, with low rate of C1q. The patient was treated with cycles of cyclophosphamide, corticoids and rituximab as she developed class III dyspnea (NYHA classification ). The clinico-radiological and functional assessment showed thoracic distension and severe obstructive pulmonary disease which found no significant improvement with systemic treatment Aerosol therapy was started and the patient had a marked clinical improvement. Pulmonary involvement in Mac Duffie hypocomplementemic urticarial vasculitis worsens the patient short-term vital prognosis. The knowledge of the different types of pulmonary involvement opens new therapeutic prospects.
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http://dx.doi.org/10.11604/pamj.2016.24.285.8168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267844PMC
March 2017

[Simultaneous bilateral spontaneous pneumothorax].

Pan Afr Med J 2016 13;24:57. Epub 2016 May 13.

Service de Pneumologie de l'Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2016.24.57.8729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012779PMC
February 2017

[Tuberculous pyopneumothorax: about 18 cases].

Pan Afr Med J 2016 9;24:26. Epub 2016 May 9.

Service de Pneumologie de l'Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Tuberculous pyopneumothorax is a rare but serious complication of evolutive pulmonary tuberculosis. We report a series of 18 cases with tuberculous pyopneumothorax admitted to the Pneumo-Phthisiology Department of the Mohammed V Military Teaching Hospital in Rabat between January 2005 and December 2009. Our study included 15 men and 3 women, the average age was 35 ± 7 years. 4 patients were diabetic. Smoking was found in 9 cases. Right-sided pneumothorax was found in 13 cases. Chest radiograph showed cavitary lesions in 15 patients and extensive bilateral lesions in 8 cases. The search for Mycobacterium tuberculosis in the fluid from the gastric tube was positive in 16 cases. Chest drainage associated with antituberculosis treatment according to the 2SRHZ/7RH regimen and respiratory kinesitherapy were performed in all cases. The average duration of pleural drainage was 4 weeks. In 3 cases we noted persistent pleural suppuration requiring pleural toilet using thoracoscopy with pleurectomy and limited pulmonary resection to eliminate tuberculous parenchymal lesions and the persistence of a large pleural pocket with restrictive ventilatory defect that required surgery for pleural decortication in two cases. The outcome was favorable with minimal pachypleuritis as sequelae in the remaining cases. Tuberculous pyopneumothorax is a severe form, which is often associated with active cavitary tuberculosis. Evolution is generally progressive despite antituberculosis treatment and thoracic drainage, hence the need for early diagnosis and treatment of all forms of tuberculosis.
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http://dx.doi.org/10.11604/pamj.2016.24.26.8675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992394PMC
March 2017

[Intramedullary metastasis of lung adenocarcinoma: about a case].

Pan Afr Med J 2015 14;20:37. Epub 2015 Jan 14.

Service de Pneumo-Phtisiologie, Hôpital Militaire d'Instruction Mohammed V, CHU Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2015.20.37.5500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441140PMC
March 2016

[Massive hydatid pulmonary embolism].

Pan Afr Med J 2014 9;19:20. Epub 2014 Sep 9.

Service de Pneumologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2014.19.20.5243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286219PMC
September 2015

Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.

J Infect Dis 2014 Aug 8;210(4):611-8. Epub 2014 Mar 8.

Genetics Unit, Military Hospital Mohamed V, Hay Riad, Rabat, Morocco.

Background: Only a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M. tuberculosis, underlined the importance of the interleukin 12 (IL-12)/interferon γ (IFN-γ) circuit in antimycobacterial immunity.

Methods: We conducted an association study in Morocco between pulmonary tuberculosis and a panel of single-nucleotide polymorphisms (SNPs) covering 14 core IL-12/IFN-γ circuit genes. The analyses were performed in a discovery family-based sample followed by replication in a case-control population.

Results: Out of 228 SNPs tested in the family-based sample, 6 STAT4 SNPs were associated with pulmonary tuberculosis (P = .0013-.01). We replicated the same direction of association for 1 cluster of 3 SNPs encompassing the promoter region of STAT4. In the combined sample, the association was stronger among younger subjects (pulmonary tuberculosis onset <25 years) with an odds ratio of developing pulmonary tuberculosis at rs897200 for GG vs AG/AA subjects of 1.47 (1.06-2.04). Previous functional experiments showed that the G allele of rs897200 was associated with lower STAT4 expression.

Conclusions: Our present findings in a Moroccan population support an association of pulmonary tuberculosis with STAT4 promoter-region polymorphisms that may impact STAT4 expression.
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http://dx.doi.org/10.1093/infdis/jiu140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111910PMC
August 2014

[Pulmonary tuberculosis mortality risk factors].

Pan Afr Med J 2014 3;19:347. Epub 2014 Dec 3.

Service de Phtisiologie de l'Hôpital Moulay Youssef, CHU Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2014.19.347.5321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406387PMC
February 2016

[Do smokers know the harmful effects of tobacco?].

Pan Afr Med J 2014 3;19:127. Epub 2014 Oct 3.

Service de Pneumologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

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http://dx.doi.org/10.11604/pamj.2014.19.127.5163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341264PMC
October 2015