Heyu Ni

Heyu Ni

UNVERIFIED PROFILE

Are you Heyu Ni?   Register this Author

Register author
Heyu Ni

Heyu Ni

Publications by authors named "Heyu Ni"

Are you Heyu Ni?   Register this Author

91Publications

4708Reads

46Profile Views

The effect of tantalum incorporation on the physical and chemical properties of ternary silicon-calcium-phosphorous mesoporous bioactive glasses.

J Biomed Mater Res B Appl Biomater 2019 Oct 24;107(7):2229-2237. Epub 2019 Jan 24.

Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, M5B 1W8, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.b.34310DOI Listing
October 2019

Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth.

Mol Nutr Food Res 2019 Sep 12:e1900662. Epub 2019 Sep 12.

Guangdong Provincial Key Laboratory for Food, Nutrition and Health, Guangzhou, Guangdong Province, 510080, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mnfr.201900662DOI Listing
September 2019

Low platelet count as risk factor for infections in patients with primary immune thrombocytopenia: a retrospective evaluation.

Ann Hematol 2018 Sep 18;97(9):1701-1706. Epub 2018 May 18.

Department of Hematology, Erasmus Medical Center Rotterdam, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075, EA, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00277-018-3367-9
Publisher Site
http://dx.doi.org/10.1007/s00277-018-3367-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097778PMC
September 2018

Pathophysiology of immune thrombocytopenia.

Curr Opin Hematol 2018 09;25(5):373-381

Department of Laboratory Medicine and Pathobiology.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00062752-900000000-9930
Publisher Site
http://dx.doi.org/10.1097/MOH.0000000000000447DOI Listing
September 2018

MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling.

Mol Ther 2018 09 12;26(9):2189-2205. Epub 2018 Jul 12.

Department of Biology, York University, Toronto, ON M3J 1P3, Canada; Centre for Research in Biomolecular Interactions, York University, Toronto, ON M3J 1P3, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymthe.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127878PMC
September 2018

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents.

Blood 2018 04 8;131(16):1777-1789. Epub 2018 Mar 8.

Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-05-743187DOI Listing
April 2018

Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets.

Blood 2018 02 4;131(7):787-796. Epub 2017 Dec 4.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-05-784975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814932PMC
February 2018

Elucidating mechanisms of sunitinib resistance in renal cancer: an integrated pathological-molecular analysis.

Oncotarget 2018 Jan 8;9(4):4661-4674. Epub 2017 Dec 8.

Department of Laboratory Medicine, and The Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/23163
Publisher Site
http://dx.doi.org/10.18632/oncotarget.23163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797004PMC
January 2018

Plant-based Food Cyanidin-3-Glucoside Modulates Human Platelet Glycoprotein VI Signaling and Inhibits Platelet Activation and Thrombus Formation.

J Nutr 2017 10 30;147(10):1917-1925. Epub 2017 Aug 30.

Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, People's Republic of China;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3945/jn.116.245944DOI Listing
October 2017

Endothelial-specific deletion of autophagy-related 7 (ATG7) attenuates arterial thrombosis in mice.

J Thorac Cardiovasc Surg 2017 09 16;154(3):978-988.e1. Epub 2017 Mar 16.

Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Surgery, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00225223173042
Publisher Site
http://dx.doi.org/10.1016/j.jtcvs.2017.02.058DOI Listing
September 2017

Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia.

Platelets 2017 Jul 25;28(5):521-524. Epub 2016 Nov 25.

a The Toronto Platelet Immunobiology Group , Keenan Research Centre for Biomedical Science of St. Michael's Hospital , Toronto , ON , Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09537104.2016.1246718DOI Listing
July 2017

Platelet Immunology in China: Research and Clinical Applications.

Transfus Med Rev 2017 04 6;31(2):118-125. Epub 2016 Dec 6.

Canadian Blood Services and Department of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tmrv.2016.12.001DOI Listing
April 2017

Mitochondrial Inner Membrane Depolarization as a Marker of Platelet Apoptosis : Disclosure of Nonapoptotic Membrane Depolarization

Clin Appl Thromb Hemost 2017 03 24;23(2):139-147. Epub 2016 Sep 24.

1 Toronto Platelet Immunobiology Group, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1076029616665924DOI Listing
March 2017

The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.

Blood 2017 03 25;129(13):1840-1854. Epub 2017 Jan 25.

Toronto Platelet Immunobiology Group and Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-07-729400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374287PMC
March 2017

Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia.

J Hematol Oncol 2017 02 8;10(1):46. Epub 2017 Feb 8.

Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13045-017-0413-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304552PMC
February 2017

Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.

Crit Rev Clin Lab Sci 2016 12 22;53(6):409-30. Epub 2016 Jul 22.

a Department of Laboratory Medicine and Pathobiology , University of Toronto , Toronto , ON , Canada .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10408363.2016.1200008DOI Listing
December 2016

The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia.

Exp Hematol 2016 10 12;44(10):924-930.e1. Epub 2016 Jul 12.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Departments of Medicine and Pharmacology, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2016.07.004DOI Listing
October 2016

Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies.

Thromb J 2016 4;14(Suppl 1):29. Epub 2016 Oct 4.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON Canada ; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON Canada ; Canadian Blood Services, Toronto, ON Canada ; CCOA Therapeutics Inc, Toronto, ON Canada ; Department of Medicine and Department of Physiology, University of Toronto, Toronto, ON Canada.

View Article

Download full-text PDF

Source
http://thrombosisjournal.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12959-016-0100-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056500PMC
October 2016

Fibronectin maintains the balance between hemostasis and thrombosis.

Authors:
Yiming Wang Heyu Ni

Cell Mol Life Sci 2016 09 21;73(17):3265-77. Epub 2016 Apr 21.

Room 420, LKSKI-Keenan Research Centre for Biomedical Science, Department of Laboratory Medicine, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00018-016-2225-y
Publisher Site
http://dx.doi.org/10.1007/s00018-016-2225-yDOI Listing
September 2016

Glucagon-Like Peptide 1 Receptor Activation Attenuates Platelet Aggregation and Thrombosis.

Diabetes 2016 06 2;65(6):1714-23. Epub 2016 Mar 2.

Department of Physiology, University of Toronto, Toronto, Ontario, Canada Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada Ted Rogers Centre for Heart Research, University Health Network, Toronto, Ontario, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-1141DOI Listing
June 2016

Extracellular matrix proteins in the regulation of thrombus formation.

Curr Opin Hematol 2016 May;23(3):280-7

aDepartment of Laboratory Medicine and Pathobiology, University of Toronto bDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital cToronto Platelet Immunobiology Group dCanadian Blood Services eDepartment of Physiology fDepartment of Medicine, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0000000000000237DOI Listing
May 2016

Platelets, immune-mediated thrombocytopenias, and fetal hemorrhage.

Thromb Res 2016 May;141 Suppl 2:S76-9

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Medicine and Department of Physiology, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0049-3848(16)30372-3DOI Listing
May 2016

Successful treatment with oseltamivir phosphate in a patient with chronic immune thrombocytopenia positive for anti-GPIb/IX autoantibody.

Platelets 2015 28;26(5):495-7. Epub 2014 Aug 28.

Department of Hematology, Qilu Hospital, Shandong University , Jinan , China .

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/09537104.2014.94
Publisher Site
http://dx.doi.org/10.3109/09537104.2014.948838DOI Listing
March 2016

CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia.

Blood 2016 Feb 10;127(6):735-8. Epub 2015 Nov 10.

The Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; and Department of Medicine, Department of Laboratory Medicine and Pathobiology, and Department of Pharmacology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/content/bloodjournal/127/6/735.f
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-06-65
Publisher Site
http://dx.doi.org/10.1182/blood-2015-06-655126DOI Listing
February 2016

Fetal and neonatal alloimmune thrombocytopenia.

Semin Fetal Neonatal Med 2016 Feb 20;21(1):19-27. Epub 2016 Jan 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Clinical Immunology and Transfusion Medicine, University and Regional Laboratories Region Skåne, Lund, Sweden; Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.siny.2015.12.004DOI Listing
February 2016

Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of hemostasis.

J Biomed Res 2015 Oct 30;29. Epub 2015 Oct 30.

Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital and Toronto Platelet Immunobiology Group, Toronto, M5B 1W8, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7555/JBR.29.20150121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662204PMC
October 2015

Fibronectin orchestrates thrombosis and hemostasis.

Oncotarget 2015 Aug;6(23):19350-1

Toronto Platelet Immunobiology Group, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637283PMC
http://dx.doi.org/10.18632/oncotarget.5097DOI Listing
August 2015

CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia.

Blood 2015 Jul 2;126(2):247-56. Epub 2015 Jun 2.

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Medicine and Department of Physiology, University of Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-03-63
Publisher Site
http://dx.doi.org/10.1182/blood-2015-03-635417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505012PMC
July 2015

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia.

Nat Commun 2015 Jul 17;6:7737. Epub 2015 Jul 17.

1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8 [2] Toronto Platelet Immunobiology Group, Toronto, Ontario, Canada M5B 1W8 [3] Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, Ontario, Canada M5B 1W8 [4] Canadian Blood Services, Ottawa, Ontario, Canada K1G 4J5 [5] Department of Medicine, University of Toronto, Ontario, Canada M5S 1A8 [6] Department of Physiology, University of Toronto, Ontario, Canada M5S 1A8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms8737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518313PMC
July 2015

Platelets and platelet alloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia.

Genes Dis 2015 Jun;2(2):173-185

Toronto Platelet Immunobiology Group, Toronto, ON, Canada; Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Canadian Blood Services, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gendis.2015.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362271PMC
June 2015

Angiogenesis and bleeding disorders in FNAIT.

Oncotarget 2015 Jun;6(18):15724-5

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599221PMC
http://dx.doi.org/10.18632/oncotarget.4757DOI Listing
June 2015

The fibrinogen but not the Factor VIII content of transfused plasma determines its effectiveness at reducing bleeding in coagulopathic mice.

Transfusion 2015 May 18;55(5):1040-50. Epub 2014 Nov 18.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/trf.12931DOI Listing
May 2015

Low-dose decitabine promotes megakaryocyte maturation and platelet production in healthy controls and immune thrombocytopenia.

Thromb Haemost 2015 May 8;113(5):1021-34. Epub 2015 Jan 8.

Ming Hou, Department of Hematology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, Shandong, 250012, China, Tel.: +86 531 82169879, Fax: +86 531 86927544, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1160/TH14-04-0342DOI Listing
May 2015

Sialidase inhibition to increase platelet counts: A new treatment option for thrombocytopenia.

Am J Hematol 2015 May 17;90(5):E94-5. Epub 2015 Feb 17.

Department of Hematology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajh.23953DOI Listing
May 2015

Fibronectin: extra domain brings extra risk?

Authors:
Yiming Wang Heyu Ni

Blood 2015 May;125(20):3043-4

ST. MICHAEL'S HOSPITAL; CANADIAN BLOOD SERVICES.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-03-630855DOI Listing
May 2015

[Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura].

Zhonghua Xue Ye Xue Za Zhi 2015 Mar;36(3):202-5

Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2015.03.006DOI Listing
March 2015

Plant food anthocyanins inhibit platelet granule secretion in hypercholesterolaemia: Involving the signalling pathway of PI3K-Akt.

Thromb Haemost 2014 Nov 31;112(5):981-91. Epub 2014 Jul 31.

Prof. Yan Yang, MD, PhD, Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), No. 74, Zhongshan 2 Road, 510080 Guangzhou, PR China, Tel.: +86 20 87330687, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1160/TH13-12-1002DOI Listing
November 2014

Prevention of thrombogenesis from whole human blood on plastic polymer by ultrathin monoethylene glycol silane adlayer.

Langmuir 2014 Mar 13;30(11):3217-22. Epub 2014 Mar 13.

Institute of Biomaterials & Biomedical Engineering, University of Toronto , Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/la500745pDOI Listing
March 2014

Targeting activated platelets and fibrinolysis: hitting two birds with one stone.

Circ Res 2014 Mar;114(7):1070-3

From the Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science of St. Michael's Hospital (A.R., X.X., E.C.R., H.N.), Department of Laboratory Medicine and Pathobiology (X.X., H.N.), and Departments of Medicine and Physiology (H.N.) University of Toronto, Toronto, ON, Canada; and Toronto Platelet Immunobiology Group (A.R., X.X., E.C.R., H.N.) and Canadian Blood Services (H.N.), Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.114.303600DOI Listing
March 2014

Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis.

Thromb Haemost 2014 Feb 31;111(2):279-89. Epub 2013 Oct 31.

Dr. Heyu Ni, MD, PhD, Canadian Blood Services and, Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Room 420, LKSKI - Keenan Research Center, 209 Victoria Street, Toronto, Ontario, M5B 1W8, Canada, Tel.: +1 416 847 1738, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1160/TH13-06-0490DOI Listing
February 2014

Co-stimulation with LPS or Poly I:C markedly enhances the anti-platelet immune response and severity of fetal and neonatal alloimmune thrombocytopenia.

Thromb Haemost 2013 Dec 26;110(6):1250-8. Epub 2013 Sep 26.

Heyu Ni, MD, PhD, Canadian Blood Services and Department of Laboratory Medicine and Pathobiology, University of Toronto, St. Michael's Hospital, Room 420, LKSKI - Keenan Research Centre, 209 Victoria Street, Toronto, Ontario M5B 1W8, Canada, Tel.: +1 416 847 1738, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1160/TH13-04-0354DOI Listing
December 2013

Fc-independent phagocytosis: implications for IVIG and other therapies in immune-mediated thrombocytopenia.

Cardiovasc Hematol Disord Drug Targets 2013 Mar;13(1):50-8

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
March 2013

Platelets in thrombosis and hemostasis: old topic with new mechanisms.

Cardiovasc Hematol Disord Drug Targets 2012 Dec;12(2):126-32

Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
December 2012

Towards a prophylactic treatment of HPA-related foetal and neonatal alloimmune thrombocytopenia.

Curr Opin Hematol 2012 Nov;19(6):469-74

Department of Clinical Immunology and Transfusion Medicine, University and Regional Laboratories Region Skåne, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0b013e328358f86cDOI Listing
November 2012

Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia.

Ann Hematol 2012 Oct 13;91(10):1623-31. Epub 2012 Apr 13.

Hematology Oncology Centre, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, Shandong 250012, China.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00277-012-1451-0
Publisher Site
http://dx.doi.org/10.1007/s00277-012-1451-0DOI Listing
October 2012

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia.

Blood 2012 Sep 3;120(10):2127-32. Epub 2012 Jul 3.

Toronto Platelet Immunobiology Group, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, ON.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-02-413526DOI Listing
September 2012

The cell motility modulator Slit2 is a potent inhibitor of platelet function.

Circulation 2012 Sep 3;126(11):1385-95. Epub 2012 Aug 3.

The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.112.105452DOI Listing
September 2012

Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries.

Adv Hematol 2012 12;2012:384685. Epub 2012 Sep 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A8 ; Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, and Toronto Platelet Immunobiology Group, University of Toronto, Toronto, ON, Canada M5S 1A8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/384685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447344PMC
September 2012

Cadherin 6 has a functional role in platelet aggregation and thrombus formation.

Arterioscler Thromb Vasc Biol 2012 Jul 26;32(7):1724-31. Epub 2012 Apr 26.

Royal College of Surgeons in Ireland, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.112.250464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155514PMC
July 2012

The platelet "sugar high" in diabetes.

Authors:
Heyu Ni

Blood 2012 Jun;119(25):5949-51

Canadian Blood Services.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-04-420794DOI Listing
June 2012

Platelet antibodies and fetal growth: maternal antibodies against fetal platelet antigen 1a are strongly associated with reduced birthweight in boys.

Acta Obstet Gynecol Scand 2012 Jan 13;91(1):79-86. Epub 2011 Oct 13.

Laboratory Medicine, Department of Obstetrics and Gynecology, University Hospital of North Norway, Tromsø, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1600-0412.2011.01269.xDOI Listing
January 2012

Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb.

J Gene Med 2011 Sep;13(9):470-7

Division of Endocrinology and Metabolism, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jgm.1598DOI Listing
September 2011

Anthocyanin extract from black rice significantly ameliorates platelet hyperactivity and hypertriglyceridemia in dyslipidemic rats induced by high fat diets.

J Agric Food Chem 2011 Jun 1;59(12):6759-64. Epub 2011 Jun 1.

Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou 510080, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jf201079hDOI Listing
June 2011

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice.

J Clin Invest 2011 Feb 25;121(2):593-603. Epub 2011 Jan 25.

Puget Sound Blood Center, 921 Terry Ave., Seattle, Washington 98104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI41062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026714PMC
February 2011

Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy.

Blood 2010 Nov 20;116(18):3660-8. Epub 2010 Jul 20.

Canadian Blood Services, and Toronto Platelet Immunobiology Group/Department of Laboratory Medicine, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-05-284919DOI Listing
November 2010

Mice with deleted multimerin 1 and alpha-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1.

Thromb Res 2010 May;125(5):e177-83

Department of Laboratory Medicine and Pathobiology, Keenan Research Centre, Li Ka-Shing Knowledge Institute, St Michael's Hospital, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2010.01.009DOI Listing
May 2010

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

Blood 2009 Jul 30;114(2):425-36. Epub 2009 Mar 30.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-03-145821DOI Listing
July 2009

CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo.

Blood 2009 Feb 13;113(8):1818-28. Epub 2008 Nov 13.

Burnet Institute incorporating the Austin Research Institute, Heidelberg, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-06-165043DOI Listing
February 2009

Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor.

Blood 2009 Feb 25;113(8):1809-17. Epub 2008 Nov 25.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-04-148361DOI Listing
February 2009

Fc-independent phagocytosis: implications for intravenous IgG therapy in immune thrombocytopenia.

Cardiovasc Hematol Disord Drug Targets 2008 Dec;8(4):278-82

Canadian Blood Services and Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Room 2-006, Bond Wing, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
December 2008

In vivo response to vascular injury in the absence of factor IX: examination in factor IX knockout mice.

Thromb Res 2007 9;121(2):225-34. Epub 2007 May 9.

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.thromres.2007.03.026DOI Listing
March 2008

A novel fibrinogen Bbeta chain frameshift mutation in a patient with severe congenital hypofibrinogenaemia.

Thromb Haemost 2006 Jun;95(6):931-5

The Center Laboratory of Anhui Provincial Hospital, the Second Affiliated Hospital of Anhui Medical University, Hefei, China.

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1160/TH06-01-0020
Publisher Site
http://dx.doi.org/10.1160/TH06-01-0020DOI Listing
June 2006

A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy.

Blood 2006 Apr 29;107(7):2976-83. Epub 2005 Nov 29.

Canadian Blood Services and Dept of Laboratory Medicine and Pathobiology, St Michael's Hospital, University of Toronto, 30 Bond St Rm 2-006, Bond Wing, Toronto, ON, Canada M5B 1W8.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2005-06-25
Publisher Site
http://dx.doi.org/10.1182/blood-2005-06-2562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895387PMC
April 2006

Intravenous immunoglobulin inhibits anti-glycoprotein IIb-induced platelet apoptosis in a murine model of immune thrombocytopenia.

Br J Haematol 2006 Apr;133(1):78-82

Division of Transfusion Medicine, Department of Laboratory Medicine, St Michael's Hospital, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2141.2006.05981.xDOI Listing
April 2006

Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function.

J Exp Med 2005 Dec;202(11):1587-97

Division of Respirology, Department of Medicine, and the McLaughlin Center for Molecular Medicine, University of Toronto and Toronto General Hospital Research Institute of the University Health Network, Toronto, Ontario M5S 1A8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20051108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213338PMC
December 2005

Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain.

Blood 2003 Nov 10;102(10):3609-14. Epub 2003 Jul 10.

Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2003-03-0850DOI Listing
November 2003

Platelets in hemostasis and thrombosis: role of integrins and their ligands.

Transfus Apher Sci 2003 Jun;28(3):257-64

Transfusion Medicine Research, Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto and the Canadian Blood Services, Toronto, Ont.,Canada M5B1W8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-0502(03)00044-2DOI Listing
June 2003

Plasma fibronectin promotes thrombus growth and stability in injured arterioles.

Proc Natl Acad Sci U S A 2003 Mar 26;100(5):2415-9. Epub 2003 Feb 26.

Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.2628067100
Publisher Site
http://dx.doi.org/10.1073/pnas.2628067100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151355PMC
March 2003

Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha.

Blood 2002 Aug;100(4):1340-6

Vascular Research Division, Department of Pathology, Brigham and Women's Hospital and Center for Blood Research, Harvard Medical School, Boston, MA 02130, USA.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/content/100/4/1340.full.pdf
Web Search
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2002-01-03
Publisher Site
http://dx.doi.org/10.1182/blood-2002-01-0316DOI Listing
August 2002

[Detection of platelet fibronectin from congenital fibrinogenopenic patients and its clinical significance].

Zhonghua Xue Ye Xue Za Zhi 2002 Mar;23(3):143-6

Department of Hematology, Anhui provincial Hospital, Hefei 230001, China.

View Article

Download full-text PDF

Source
March 2002