Heyo K Kroemer

Heyo K Kroemer

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Heyo K Kroemer

Publications by authors named "Heyo K Kroemer"

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Expression of Slc35f1 in the murine brain.

Cell Tissue Res 2019 Aug 13;377(2):167-176. Epub 2019 Mar 13.

Institute of Anatomy and Cell Biology, Universitätsmedizin Greifswald, Friedrich Loeffler Str. 23c, 17487, Greifswald, Germany.

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http://dx.doi.org/10.1007/s00441-019-03008-8DOI Listing
August 2019

Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins.

Thromb Haemost 2018 01 5;118(1):132-142. Epub 2018 Jan 5.

Department of Pharmacology, Center of Drug Absorption and Transport, University Medicine Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1160/TH17-04-0291DOI Listing
January 2018

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.

Biochem Pharmacol 2017 11 12;144:108-119. Epub 2017 Aug 12.

Dept. of Pharmacology at the Center of Drug Absorption and Transport (C_DAT), University Medicine, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.008DOI Listing
November 2017

Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

Thromb Haemost 2017 01 20;117(1):105-115. Epub 2016 Oct 20.

Gabriele Jedlitschky PhD, Department of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, Felix-Hausdorff-Str. 3, 17487 Greifswald, Germany, Tel.: +49 3834 8622146, Fax: +49 3834 865631, E-mail:

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http://dx.doi.org/10.1160/TH16-01-0045DOI Listing
January 2017

Open letter on access to the BIA 10-2474 clinical trial data.

Lancet 2017 01 10;389(10065):156. Epub 2016 Dec 10.

Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany.

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http://dx.doi.org/10.1016/S0140-6736(16)32515-6DOI Listing
January 2017

Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy.

Drug Metab Dispos 2016 10 8;44(10):1562-8. Epub 2016 Aug 8.

Department of Pharmacology (A.H., G.J., H.K.K., M.G.) and Department of Clinical Pharmacology (M.K., S.O., W.S.) at the Center of Drug Absorption and Transport (C_DAT), University Medicine, Greifswald, Germany

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http://dx.doi.org/10.1124/dmd.116.069807DOI Listing
October 2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Authors:
Cristian Pattaro Alexander Teumer Mathias Gorski Audrey Y Chu Man Li Vladan Mijatovic Maija Garnaas Adrienne Tin Rossella Sorice Yong Li Daniel Taliun Matthias Olden Meredith Foster Qiong Yang Ming-Huei Chen Tune H Pers Andrew D Johnson Yi-An Ko Christian Fuchsberger Bamidele Tayo Michael Nalls Mary F Feitosa Aaron Isaacs Abbas Dehghan Pio d'Adamo Adebowale Adeyemo Aida Karina Dieffenbach Alan B Zonderman Ilja M Nolte Peter J van der Most Alan F Wright Alan R Shuldiner Alanna C Morrison Albert Hofman Albert V Smith Albert W Dreisbach Andre Franke Andre G Uitterlinden Andres Metspalu Anke Tonjes Antonio Lupo Antonietta Robino Åsa Johansson Ayse Demirkan Barbara Kollerits Barry I Freedman Belen Ponte Ben A Oostra Bernhard Paulweber Bernhard K Krämer Braxton D Mitchell Brendan M Buckley Carmen A Peralta Caroline Hayward Catherine Helmer Charles N Rotimi Christian M Shaffer Christian Müller Cinzia Sala Cornelia M van Duijn Aude Saint-Pierre Daniel Ackermann Daniel Shriner Daniela Ruggiero Daniela Toniolo Yingchang Lu Daniele Cusi Darina Czamara David Ellinghaus David S Siscovick Douglas Ruderfer Christian Gieger Harald Grallert Elena Rochtchina Elizabeth J Atkinson Elizabeth G Holliday Eric Boerwinkle Erika Salvi Erwin P Bottinger Federico Murgia Fernando Rivadeneira Florian Ernst Florian Kronenberg Frank B Hu Gerjan J Navis Gary C Curhan George B Ehret Georg Homuth Stefan Coassin Gian-Andri Thun Giorgio Pistis Giovanni Gambaro Giovanni Malerba Grant W Montgomery Gudny Eiriksdottir Gunnar Jacobs Guo Li H-Erich Wichmann Harry Campbell Helena Schmidt Henri Wallaschofski Henry Völzke Hermann Brenner Heyo K Kroemer Holly Kramer Honghuang Lin I Mateo Leach Ian Ford Idris Guessous Igor Rudan Inga Prokopenko Ingrid Borecki Iris M Heid Ivana Kolcic Ivana Persico J Wouter Jukema James F Wilson Janine F Felix Jasmin Divers Jean-Charles Lambert Jeanette M Stafford Jean-Michel Gaspoz Jennifer A Smith Jessica D Faul Jie Jin Wang Jingzhong Ding Joel N Hirschhorn John Attia John B Whitfield John Chalmers Jorma Viikari Josef Coresh Joshua C Denny Juha Karjalainen Jyotika K Fernandes Karlhans Endlich Katja Butterbach Keith L Keene Kurt Lohman Laura Portas Lenore J Launer Leo-Pekka Lyytikäinen Loic Yengo Lude Franke Luigi Ferrucci Lynda M Rose Lyudmyla Kedenko Madhumathi Rao Maksim Struchalin Marcus E Kleber Margherita Cavalieri Margot Haun Marilyn C Cornelis Marina Ciullo Mario Pirastu Mariza de Andrade Mark A McEvoy Mark Woodward Martin Adam Massimiliano Cocca Matthias Nauck Medea Imboden Melanie Waldenberger Menno Pruijm Marie Metzger Michael Stumvoll Michele K Evans Michele M Sale Mika Kähönen Mladen Boban Murielle Bochud Myriam Rheinberger Niek Verweij Nabila Bouatia-Naji Nicholas G Martin Nick Hastie Nicole Probst-Hensch Nicole Soranzo Olivier Devuyst Olli Raitakari Omri Gottesman Oscar H Franco Ozren Polasek Paolo Gasparini Patricia B Munroe Paul M Ridker Paul Mitchell Paul Muntner Christa Meisinger Johannes H Smit Peter Kovacs Philipp S Wild Philippe Froguel Rainer Rettig Reedik Mägi Reiner Biffar Reinhold Schmidt Rita P S Middelberg Robert J Carroll Brenda W Penninx Rodney J Scott Ronit Katz Sanaz Sedaghat Sarah H Wild Sharon L R Kardia Sheila Ulivi Shih-Jen Hwang Stefan Enroth Stefan Kloiber Stella Trompet Benedicte Stengel Stephen J Hancock Stephen T Turner Sylvia E Rosas Sylvia Stracke Tamara B Harris Tanja Zeller Tatijana Zemunik Terho Lehtimäki Thomas Illig Thor Aspelund Tiit Nikopensius Tonu Esko Toshiko Tanaka Ulf Gyllensten Uwe Völker Valur Emilsson Veronique Vitart Ville Aalto Vilmundur Gudnason Vincent Chouraki Wei-Min Chen Wilmar Igl Winfried März Wolfgang Koenig Wolfgang Lieb Ruth J F Loos Yongmei Liu Harold Snieder Peter P Pramstaller Afshin Parsa Jeffrey R O'Connell Katalin Susztak Pavel Hamet Johanne Tremblay Ian H de Boer Carsten A Böger Wolfram Goessling Daniel I Chasman Anna Köttgen W H Linda Kao Caroline S Fox

Nat Commun 2016 Jan 21;7:10023. Epub 2016 Jan 21.

NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms10023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735748PMC
January 2016

Protective effects of endothelin receptor A and B inhibitors against doxorubicin-induced cardiomyopathy.

Biochem Pharmacol 2015 Mar 7;94(2):109-29. Epub 2015 Feb 7.

Center of Drug Absorption and Transport (C_DAT), Institute of Pharmacology, University Medicine, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.01.014DOI Listing
March 2015

Incidence of all-cause and cardiovascular mortality predicted by symmetric dimethylarginine in the population-based study of health in pomerania.

PLoS One 2014 12;9(5):e96875. Epub 2014 May 12.

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096875PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018357PMC
January 2015

Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort.

Pharmacogenet Genomics 2015 Jan;25(1):8-18

aBiopharmacy Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland bInstitute of Pharmacology cInstitute of Community Medicine dInstitute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1097/FPC.0000000000000098DOI Listing
January 2015

Targeting CNS transporters for treatment of neurodegenerative diseases.

Curr Pharm Des 2014 ;20(10):1523-33

Department of Pharmacology, Center of Drug Absorption and Transport (C_DAT), Ernst-Moritz-Arndt University, Felix-Hausdorff-Str. 3, D-17487 Greifswald, Germany.

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http://dx.doi.org/10.2174/13816128113199990460DOI Listing
November 2014

Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α.

Am J Physiol Renal Physiol 2014 Nov 10;307(9):F1041-51. Epub 2014 Sep 10.

University of Basel, Department of Pharmaceutical Sciences, Biopharmacy, Basel, Switzerland;

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http://www.physiology.org/doi/10.1152/ajprenal.00640.2013
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http://dx.doi.org/10.1152/ajprenal.00640.2013DOI Listing
November 2014

cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway.

Pharmacogenet Genomics 2014 Oct;24(10):522-6

Department of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine, Greifswald, Germany.

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http://dx.doi.org/10.1097/FPC.0000000000000084DOI Listing
October 2014

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report.

BMC Res Notes 2014 Oct 3;7:688. Epub 2014 Oct 3.

Institute for Neurorehabilitational Research (InFo), BDH-Clinic, Hessisch Old- endorf, Germany, Teaching Hospital of Hannover Medical School (MHH), Germany.

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http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0
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http://dx.doi.org/10.1186/1756-0500-7-688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192324PMC
October 2014

Tooth loss, periodontitis, and statins in a population-based follow-up study.

J Periodontol 2014 Jun 5;85(6):e160-8. Epub 2013 Dec 5.

Dental Clinics, Unit of Periodontology, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.

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http://doi.wiley.com/10.1902/jop.2013.130456
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http://dx.doi.org/10.1902/jop.2013.130456DOI Listing
June 2014

Cell-specific expression of uptake transporters--a potential approach for cardiovascular drug delivery devices.

Mol Pharm 2014 Mar 19;11(3):665-72. Epub 2014 Feb 19.

Biopharmacy, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1021/mp400245gDOI Listing
March 2014

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide.

Diabetes 2014 Feb 22;63(2):775-84. Epub 2013 Oct 22.

Biopharmacy, Department of Pharmaceutical Sciences, University Basel, Basel, Switzerland.

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http://dx.doi.org/10.2337/db13-1005DOI Listing
February 2014

Common variants in Mendelian kidney disease genes and their association with renal function.

Authors:
Afshin Parsa Christian Fuchsberger Anna Köttgen Conall M O'Seaghdha Cristian Pattaro Mariza de Andrade Daniel I Chasman Alexander Teumer Karlhans Endlich Matthias Olden Ming-Huei Chen Adrienne Tin Young J Kim Daniel Taliun Man Li Mary Feitosa Mathias Gorski Qiong Yang Claudia Hundertmark Meredith C Foster Nicole Glazer Aaron Isaacs Madhumathi Rao Albert V Smith Jeffrey R O'Connell Maksim Struchalin Toshiko Tanaka Guo Li Shih-Jen Hwang Elizabeth J Atkinson Kurt Lohman Marilyn C Cornelis Asa Johansson Anke Tönjes Abbas Dehghan Vincent Couraki Elizabeth G Holliday Rossella Sorice Zoltan Kutalik Terho Lehtimäki Tõnu Esko Harshal Deshmukh Sheila Ulivi Audrey Y Chu Federico Murgia Stella Trompet Medea Imboden Barbara Kollerits Giorgio Pistis Tamara B Harris Lenore J Launer Thor Aspelund Gudny Eiriksdottir Braxton D Mitchell Eric Boerwinkle Helena Schmidt Edith Hofer Frank Hu Ayse Demirkan Ben A Oostra Stephen T Turner Jingzhong Ding Jeanette S Andrews Barry I Freedman Franco Giulianini Wolfgang Koenig Thomas Illig Angela Döring H-Erich Wichmann Lina Zgaga Tatijana Zemunik Mladen Boban Cosetta Minelli Heather E Wheeler Wilmar Igl Ghazal Zaboli Sarah H Wild Alan F Wright Harry Campbell David Ellinghaus Ute Nöthlings Gunnar Jacobs Reiner Biffar Florian Ernst Georg Homuth Heyo K Kroemer Matthias Nauck Sylvia Stracke Uwe Völker Henry Völzke Peter Kovacs Michael Stumvoll Reedik Mägi Albert Hofman Andre G Uitterlinden Fernando Rivadeneira Yurii S Aulchenko Ozren Polasek Nick Hastie Veronique Vitart Catherine Helmer Jie Jin Wang Bénédicte Stengel Daniela Ruggiero Sven Bergmann Mika Kähönen Jorma Viikari Tiit Nikopensius Michael Province Helen Colhoun Alex Doney Antonietta Robino Bernhard K Krämer Laura Portas Ian Ford Brendan M Buckley Martin Adam Gian-Andri Thun Bernhard Paulweber Margot Haun Cinzia Sala Paul Mitchell Marina Ciullo Peter Vollenweider Olli Raitakari Andres Metspalu Colin Palmer Paolo Gasparini Mario Pirastu J Wouter Jukema Nicole M Probst-Hensch Florian Kronenberg Daniela Toniolo Vilmundur Gudnason Alan R Shuldiner Josef Coresh Reinhold Schmidt Luigi Ferrucci Cornelia M van Duijn Ingrid Borecki Sharon L R Kardia Yongmei Liu Gary C Curhan Igor Rudan Ulf Gyllensten James F Wilson Andre Franke Peter P Pramstaller Rainer Rettig Inga Prokopenko Jacqueline Witteman Caroline Hayward Paul M Ridker Murielle Bochud Iris M Heid David S Siscovick Caroline S Fox W Linda Kao Carsten A Böger

J Am Soc Nephrol 2013 Dec 12;24(12):2105-17. Epub 2013 Sep 12.

Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland;

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http://dx.doi.org/10.1681/ASN.2012100983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839542PMC
December 2013

Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction.

Int J Cardiol 2013 Dec 16;170(2):e23-4. Epub 2013 Oct 16.

Universitätsklinikum Düsseldorf, Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsstraße 1, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2013.10.050DOI Listing
December 2013

Protease-activated receptor-2 regulates the innate immune response to viral infection in a coxsackievirus B3-induced myocarditis.

J Am Coll Cardiol 2013 Nov 17;62(19):1737-45. Epub 2013 Jul 17.

Department of Cardiology and Pneumology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute for Chemistry-Biochemistry, Freie Universität Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.jacc.2013.05.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077621PMC
November 2013

Genome-wide association study of chronic periodontitis in a general German population.

J Clin Periodontol 2013 Nov 11;40(11):977-85. Epub 2013 Sep 11.

Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1111/jcpe.12154DOI Listing
November 2013

A new, accurate predictive model for incident hypertension.

J Hypertens 2013 Nov;31(11):2142-50; discussion 2150

aInstitute for Community Medicine, Ernst Moritz Arndt University, Greifswald, Germany bSiemens Healthcare, Malvern, Pennsylvania, USA cClinic of Internal Medicine B, Ernst Moritz Arndt University, Greifswald dInstitute of Epidemiology, Christian Albrechts University, Kiel eInterfaculty Institute of Functional Genomics, Ernst Moritz Arndt University, Greifswald, Germany fResearch Centre for Prevention and Health, Glostrup University Hospital, Glostrup gFaculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark hInstitute of Physiology, University Medicine, Ernst Moritz Arndt University, Greifswald iUniversity Medical Center, Göttingen, Germany *Henry Völzke and Glenn Fung contributed equally to the writing of this article.

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http://pdfs.journals.lww.com/jhypertension/2013/11000/A_new,
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HJH.0b013e328364a16dDOI Listing
November 2013

In vitro dissolution testing of drug-eluting stents.

Curr Pharm Biotechnol 2013 ;14(1):67-75

Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17487 Greifswald, Germany.

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August 2013

Advances in coronary stent technology--active drug-loaded stent surfaces for prevention of restenosis and improvement of biocompatibility.

Curr Pharm Biotechnol 2013 ;14(1):76-90

University of Rostock, Faculty of Medicine, Institute for Biomedical Engineering, Friedrich-Barnewitz-Str. 4, D-18119 Rostock, Germany.

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August 2013

Personalized cardiovascular medicine: concepts and methodological considerations.

Nat Rev Cardiol 2013 Jun 26;10(6):308-16. Epub 2013 Mar 26.

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. voelzke@ uni-greifswald.de

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http://dx.doi.org/10.1038/nrcardio.2013.35DOI Listing
June 2013

Potentially relevant incidental findings on research whole-body MRI in the general adult population: frequencies and management.

Eur Radiol 2013 Mar 22;23(3):816-26. Epub 2012 Aug 22.

Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. 1, 17475 Greifswald, Germany.

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http://dx.doi.org/10.1007/s00330-012-2636-6DOI Listing
March 2013

Molecular changes in the early phase of renin-dependent cardiac hypertrophy in hypertensive cyp1a1ren-2 transgenic rats.

J Renin Angiotensin Aldosterone Syst 2013 Mar 11;14(1):41-50. Epub 2012 Oct 11.

Institute of Pathophysiology, University Medicine Greifswald, Germany.

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http://dx.doi.org/10.1177/1470320312460070DOI Listing
March 2013

Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.

Authors:
Daniel I Chasman Christian Fuchsberger Cristian Pattaro Alexander Teumer Carsten A Böger Karlhans Endlich Matthias Olden Ming-Huei Chen Adrienne Tin Daniel Taliun Man Li Xiaoyi Gao Mathias Gorski Qiong Yang Claudia Hundertmark Meredith C Foster Conall M O'Seaghdha Nicole Glazer Aaron Isaacs Ching-Ti Liu Albert V Smith Jeffrey R O'Connell Maksim Struchalin Toshiko Tanaka Guo Li Andrew D Johnson Hinco J Gierman Mary F Feitosa Shih-Jen Hwang Elizabeth J Atkinson Kurt Lohman Marilyn C Cornelis Asa Johansson Anke Tönjes Abbas Dehghan Jean-Charles Lambert Elizabeth G Holliday Rossella Sorice Zoltan Kutalik Terho Lehtimäki Tõnu Esko Harshal Deshmukh Sheila Ulivi Audrey Y Chu Federico Murgia Stella Trompet Medea Imboden Stefan Coassin Giorgio Pistis Tamara B Harris Lenore J Launer Thor Aspelund Gudny Eiriksdottir Braxton D Mitchell Eric Boerwinkle Helena Schmidt Margherita Cavalieri Madhumathi Rao Frank Hu Ayse Demirkan Ben A Oostra Mariza de Andrade Stephen T Turner Jingzhong Ding Jeanette S Andrews Barry I Freedman Franco Giulianini Wolfgang Koenig Thomas Illig Christa Meisinger Christian Gieger Lina Zgaga Tatijana Zemunik Mladen Boban Cosetta Minelli Heather E Wheeler Wilmar Igl Ghazal Zaboli Sarah H Wild Alan F Wright Harry Campbell David Ellinghaus Ute Nöthlings Gunnar Jacobs Reiner Biffar Florian Ernst Georg Homuth Heyo K Kroemer Matthias Nauck Sylvia Stracke Uwe Völker Henry Völzke Peter Kovacs Michael Stumvoll Reedik Mägi Albert Hofman Andre G Uitterlinden Fernando Rivadeneira Yurii S Aulchenko Ozren Polasek Nick Hastie Veronique Vitart Catherine Helmer Jie Jin Wang Bénédicte Stengel Daniela Ruggiero Sven Bergmann Mika Kähönen Jorma Viikari Tiit Nikopensius Michael Province Shamika Ketkar Helen Colhoun Alex Doney Antonietta Robino Bernhard K Krämer Laura Portas Ian Ford Brendan M Buckley Martin Adam Gian-Andri Thun Bernhard Paulweber Margot Haun Cinzia Sala Paul Mitchell Marina Ciullo Stuart K Kim Peter Vollenweider Olli Raitakari Andres Metspalu Colin Palmer Paolo Gasparini Mario Pirastu J Wouter Jukema Nicole M Probst-Hensch Florian Kronenberg Daniela Toniolo Vilmundur Gudnason Alan R Shuldiner Josef Coresh Reinhold Schmidt Luigi Ferrucci David S Siscovick Cornelia M van Duijn Ingrid B Borecki Sharon L R Kardia Yongmei Liu Gary C Curhan Igor Rudan Ulf Gyllensten James F Wilson Andre Franke Peter P Pramstaller Rainer Rettig Inga Prokopenko Jacqueline Witteman Caroline Hayward Paul M Ridker Afshin Parsa Murielle Bochud Iris M Heid W H Linda Kao Caroline S Fox Anna Köttgen

Hum Mol Genet 2012 Dec 8;21(24):5329-43. Epub 2012 Sep 8.

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1093/hmg/dds369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607468PMC
December 2012

Steroid hormones specifically modify the activity of organic anion transporting polypeptides.

Eur J Pharm Sci 2012 Nov 8;47(4):774-80. Epub 2012 Sep 8.

Department of Pharmacology, Ernst Moritz Arndt University, Felix-Haussdorf-Str.3, 17487 Greifswald, Germany.

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http://dx.doi.org/10.1016/j.ejps.2012.08.017DOI Listing
November 2012

Heart rate reduction by ivabradine improves aortic compliance in apolipoprotein E-deficient mice.

J Vasc Res 2012 3;49(5):432-40. Epub 2012 Jul 3.

Kliniken für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1159/000339547DOI Listing
October 2012

Genome-wide association and functional follow-up reveals new loci for kidney function.

Authors:
Cristian Pattaro Anna Köttgen Alexander Teumer Maija Garnaas Carsten A Böger Christian Fuchsberger Matthias Olden Ming-Huei Chen Adrienne Tin Daniel Taliun Man Li Xiaoyi Gao Mathias Gorski Qiong Yang Claudia Hundertmark Meredith C Foster Conall M O'Seaghdha Nicole Glazer Aaron Isaacs Ching-Ti Liu Albert V Smith Jeffrey R O'Connell Maksim Struchalin Toshiko Tanaka Guo Li Andrew D Johnson Hinco J Gierman Mary Feitosa Shih-Jen Hwang Elizabeth J Atkinson Kurt Lohman Marilyn C Cornelis Åsa Johansson Anke Tönjes Abbas Dehghan Vincent Chouraki Elizabeth G Holliday Rossella Sorice Zoltan Kutalik Terho Lehtimäki Tõnu Esko Harshal Deshmukh Sheila Ulivi Audrey Y Chu Federico Murgia Stella Trompet Medea Imboden Barbara Kollerits Giorgio Pistis Tamara B Harris Lenore J Launer Thor Aspelund Gudny Eiriksdottir Braxton D Mitchell Eric Boerwinkle Helena Schmidt Margherita Cavalieri Madhumathi Rao Frank B Hu Ayse Demirkan Ben A Oostra Mariza de Andrade Stephen T Turner Jingzhong Ding Jeanette S Andrews Barry I Freedman Wolfgang Koenig Thomas Illig Angela Döring H-Erich Wichmann Ivana Kolcic Tatijana Zemunik Mladen Boban Cosetta Minelli Heather E Wheeler Wilmar Igl Ghazal Zaboli Sarah H Wild Alan F Wright Harry Campbell David Ellinghaus Ute Nöthlings Gunnar Jacobs Reiner Biffar Karlhans Endlich Florian Ernst Georg Homuth Heyo K Kroemer Matthias Nauck Sylvia Stracke Uwe Völker Henry Völzke Peter Kovacs Michael Stumvoll Reedik Mägi Albert Hofman Andre G Uitterlinden Fernando Rivadeneira Yurii S Aulchenko Ozren Polasek Nick Hastie Veronique Vitart Catherine Helmer Jie Jin Wang Daniela Ruggiero Sven Bergmann Mika Kähönen Jorma Viikari Tiit Nikopensius Michael Province Shamika Ketkar Helen Colhoun Alex Doney Antonietta Robino Franco Giulianini Bernhard K Krämer Laura Portas Ian Ford Brendan M Buckley Martin Adam Gian-Andri Thun Bernhard Paulweber Margot Haun Cinzia Sala Marie Metzger Paul Mitchell Marina Ciullo Stuart K Kim Peter Vollenweider Olli Raitakari Andres Metspalu Colin Palmer Paolo Gasparini Mario Pirastu J Wouter Jukema Nicole M Probst-Hensch Florian Kronenberg Daniela Toniolo Vilmundur Gudnason Alan R Shuldiner Josef Coresh Reinhold Schmidt Luigi Ferrucci David S Siscovick Cornelia M van Duijn Ingrid Borecki Sharon L R Kardia Yongmei Liu Gary C Curhan Igor Rudan Ulf Gyllensten James F Wilson Andre Franke Peter P Pramstaller Rainer Rettig Inga Prokopenko Jacqueline C M Witteman Caroline Hayward Paul Ridker Afshin Parsa Murielle Bochud Iris M Heid Wolfram Goessling Daniel I Chasman W H Linda Kao Caroline S Fox

PLoS Genet 2012 29;8(3):e1002584. Epub 2012 Mar 29.

Institute of Genetic Medicine, European Academy of Bozen/Bolzano (EURAC) and Affiliated Institute of the University of Lübeck, Bolzano, Italy.

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http://dx.doi.org/10.1371/journal.pgen.1002584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455PMC
September 2012

Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.

Eur J Clin Pharmacol 2012 Jun;68(6):923-35

Research Center of Pharmacology and Experimental Therapeutics,Department of Pharmacology, Ernst-Moritz-Arndt-Universityof Greifswald,Greifswald, Germany.

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http://dx.doi.org/10.1007/s00228-011-1209-yDOI Listing
June 2012

Transporters in human platelets: physiologic function and impact for pharmacotherapy.

Blood 2012 Apr 14;119(15):3394-402. Epub 2012 Feb 14.

Department of Pharmacology, Center of Drug Absorption and Transport, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-09-33
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April 2012

Virus-induced dilated cardiomyopathy is characterized by increased levels of fibrotic extracellular matrix proteins and reduced amounts of energy-producing enzymes.

Proteomics 2011 Nov 22;11(22):4310-20. Epub 2011 Sep 22.

Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1002/pmic.201100229DOI Listing
November 2011

Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.

Expert Rev Clin Pharmacol 2011 Nov;4(6):729-42

Institute of Pharmacology, Ernst Moritz Arndt University, Friedrich-Loeffler-Straße 23, 17487 Greifswald, Germany.

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http://dx.doi.org/10.1586/ecp.11.58DOI Listing
November 2011

Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression.

J Pharm Sci 2011 Sep 17;100(9):3951-8. Epub 2011 May 17.

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt University, Greifswald, Germany.

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http://dx.doi.org/10.1002/jps.22622DOI Listing
September 2011

Oral absorption of clarithromycin is nearly abolished by chronic comedication of rifampicin in foals.

Drug Metab Dispos 2011 Sep 20;39(9):1643-9. Epub 2011 Jun 20.

Department of Clinical Pharmacology, Ernst Moritz Arndt University, Friedrich-Loeffler-Str. 23d, D-17487 Greifswald, Germany.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.111.039206
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September 2011

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Authors:
Louise V Wain Germaine C Verwoert Paul F O'Reilly Gang Shi Toby Johnson Andrew D Johnson Murielle Bochud Kenneth M Rice Peter Henneman Albert V Smith Georg B Ehret Najaf Amin Martin G Larson Vincent Mooser David Hadley Marcus Dörr Joshua C Bis Thor Aspelund Tõnu Esko A Cecile J W Janssens Jing Hua Zhao Simon Heath Maris Laan Jingyuan Fu Giorgio Pistis Jian'an Luan Pankaj Arora Gavin Lucas Nicola Pirastu Irene Pichler Anne U Jackson Rebecca J Webster Feng Zhang John F Peden Helena Schmidt Toshiko Tanaka Harry Campbell Wilmar Igl Yuri Milaneschi Jouke-Jan Hottenga Veronique Vitart Daniel I Chasman Stella Trompet Jennifer L Bragg-Gresham Behrooz Z Alizadeh John C Chambers Xiuqing Guo Terho Lehtimäki Brigitte Kühnel Lorna M Lopez Ozren Polašek Mladen Boban Christopher P Nelson Alanna C Morrison Vasyl Pihur Santhi K Ganesh Albert Hofman Suman Kundu Francesco U S Mattace-Raso Fernando Rivadeneira Eric J G Sijbrands Andre G Uitterlinden Shih-Jen Hwang Ramachandran S Vasan Thomas J Wang Sven Bergmann Peter Vollenweider Gérard Waeber Jaana Laitinen Anneli Pouta Paavo Zitting Wendy L McArdle Heyo K Kroemer Uwe Völker Henry Völzke Nicole L Glazer Kent D Taylor Tamara B Harris Helene Alavere Toomas Haller Aime Keis Mari-Liis Tammesoo Yurii Aulchenko Inês Barroso Kay-Tee Khaw Pilar Galan Serge Hercberg Mark Lathrop Susana Eyheramendy Elin Org Siim Sõber Xiaowen Lu Ilja M Nolte Brenda W Penninx Tanguy Corre Corrado Masciullo Cinzia Sala Leif Groop Benjamin F Voight Olle Melander Christopher J O'Donnell Veikko Salomaa Adamo Pio d'Adamo Antonella Fabretto Flavio Faletra Sheila Ulivi Fabiola M Del Greco Maurizio Facheris Francis S Collins Richard N Bergman John P Beilby Joseph Hung A William Musk Massimo Mangino So-Youn Shin Nicole Soranzo Hugh Watkins Anuj Goel Anders Hamsten Pierre Gider Marisa Loitfelder Marion Zeginigg Dena Hernandez Samer S Najjar Pau Navarro Sarah H Wild Anna Maria Corsi Andrew Singleton Eco J C de Geus Gonneke Willemsen Alex N Parker Lynda M Rose Brendan Buckley David Stott Marco Orru Manuela Uda Melanie M van der Klauw Weihua Zhang Xinzhong Li James Scott Yii-Der Ida Chen Gregory L Burke Mika Kähönen Jorma Viikari Angela Döring Thomas Meitinger Gail Davies John M Starr Valur Emilsson Andrew Plump Jan H Lindeman Peter A C 't Hoen Inke R König Janine F Felix Robert Clarke Jemma C Hopewell Halit Ongen Monique Breteler Stéphanie Debette Anita L Destefano Myriam Fornage Gary F Mitchell Nicholas L Smith Hilma Holm Kari Stefansson Gudmar Thorleifsson Unnur Thorsteinsdottir Nilesh J Samani Michael Preuss Igor Rudan Caroline Hayward Ian J Deary H-Erich Wichmann Olli T Raitakari Walter Palmas Jaspal S Kooner Ronald P Stolk J Wouter Jukema Alan F Wright Dorret I Boomsma Stefania Bandinelli Ulf B Gyllensten James F Wilson Luigi Ferrucci Reinhold Schmidt Martin Farrall Tim D Spector Lyle J Palmer Jaakko Tuomilehto Arne Pfeufer Paolo Gasparini David Siscovick David Altshuler Ruth J F Loos Daniela Toniolo Harold Snieder Christian Gieger Pierre Meneton Nicholas J Wareham Ben A Oostra Andres Metspalu Lenore Launer Rainer Rettig David P Strachan Jacques S Beckmann Jacqueline C M Witteman Jeanette Erdmann Ko Willems van Dijk Eric Boerwinkle Michael Boehnke Paul M Ridker Marjo-Riitta Jarvelin Aravinda Chakravarti Goncalo R Abecasis Vilmundur Gudnason Christopher Newton-Cheh Daniel Levy Patricia B Munroe Bruce M Psaty Mark J Caulfield Dabeeru C Rao Martin D Tobin Paul Elliott Cornelia M van Duijn

Nat Genet 2011 Sep 11;43(10):1005-11. Epub 2011 Sep 11.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445021PMC
September 2011

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Authors:
Georg B Ehret Patricia B Munroe Kenneth M Rice Murielle Bochud Andrew D Johnson Daniel I Chasman Albert V Smith Martin D Tobin Germaine C Verwoert Shih-Jen Hwang Vasyl Pihur Peter Vollenweider Paul F O'Reilly Najaf Amin Jennifer L Bragg-Gresham Alexander Teumer Nicole L Glazer Lenore Launer Jing Hua Zhao Yurii Aulchenko Simon Heath Siim Sõber Afshin Parsa Jian'an Luan Pankaj Arora Abbas Dehghan Feng Zhang Gavin Lucas Andrew A Hicks Anne U Jackson John F Peden Toshiko Tanaka Sarah H Wild Igor Rudan Wilmar Igl Yuri Milaneschi Alex N Parker Cristiano Fava John C Chambers Ervin R Fox Meena Kumari Min Jin Go Pim van der Harst Wen Hong Linda Kao Marketa Sjögren D G Vinay Myriam Alexander Yasuharu Tabara Sue Shaw-Hawkins Peter H Whincup Yongmei Liu Gang Shi Johanna Kuusisto Bamidele Tayo Mark Seielstad Xueling Sim Khanh-Dung Hoang Nguyen Terho Lehtimäki Giuseppe Matullo Ying Wu Tom R Gaunt N Charlotte Onland-Moret Matthew N Cooper Carl G P Platou Elin Org Rebecca Hardy Santosh Dahgam Jutta Palmen Veronique Vitart Peter S Braund Tatiana Kuznetsova Cuno S P M Uiterwaal Adebowale Adeyemo Walter Palmas Harry Campbell Barbara Ludwig Maciej Tomaszewski Ioanna Tzoulaki Nicholette D Palmer Thor Aspelund Melissa Garcia Yen-Pei C Chang Jeffrey R O'Connell Nanette I Steinle Diederick E Grobbee Dan E Arking Sharon L Kardia Alanna C Morrison Dena Hernandez Samer Najjar Wendy L McArdle David Hadley Morris J Brown John M Connell Aroon D Hingorani Ian N M Day Debbie A Lawlor John P Beilby Robert W Lawrence Robert Clarke Jemma C Hopewell Halit Ongen Albert W Dreisbach Yali Li J Hunter Young Joshua C Bis Mika Kähönen Jorma Viikari Linda S Adair Nanette R Lee Ming-Huei Chen Matthias Olden Cristian Pattaro Judith A Hoffman Bolton Anna Köttgen Sven Bergmann Vincent Mooser Nish Chaturvedi Timothy M Frayling Muhammad Islam Tazeen H Jafar Jeanette Erdmann Smita R Kulkarni Stefan R Bornstein Jürgen Grässler Leif Groop Benjamin F Voight Johannes Kettunen Philip Howard Andrew Taylor Simonetta Guarrera Fulvio Ricceri Valur Emilsson Andrew Plump Inês Barroso Kay-Tee Khaw Alan B Weder Steven C Hunt Yan V Sun Richard N Bergman Francis S Collins Lori L Bonnycastle Laura J Scott Heather M Stringham Leena Peltonen Markus Perola Erkki Vartiainen Stefan-Martin Brand Jan A Staessen Thomas J Wang Paul R Burton Maria Soler Artigas Yanbin Dong Harold Snieder Xiaoling Wang Haidong Zhu Kurt K Lohman Megan E Rudock Susan R Heckbert Nicholas L Smith Kerri L Wiggins Ayo Doumatey Daniel Shriner Gudrun Veldre Margus Viigimaa Sanjay Kinra Dorairaj Prabhakaran Vikal Tripathy Carl D Langefeld Annika Rosengren Dag S Thelle Anna Maria Corsi Andrew Singleton Terrence Forrester Gina Hilton Colin A McKenzie Tunde Salako Naoharu Iwai Yoshikuni Kita Toshio Ogihara Takayoshi Ohkubo Tomonori Okamura Hirotsugu Ueshima Satoshi Umemura Susana Eyheramendy Thomas Meitinger H-Erich Wichmann Yoon Shin Cho Hyung-Lae Kim Jong-Young Lee James Scott Joban S Sehmi Weihua Zhang Bo Hedblad Peter Nilsson George Davey Smith Andrew Wong Narisu Narisu Alena Stančáková Leslie J Raffel Jie Yao Sekar Kathiresan Christopher J O'Donnell Stephen M Schwartz M Arfan Ikram W T Longstreth Thomas H Mosley Sudha Seshadri Nick R G Shrine Louise V Wain Mario A Morken Amy J Swift Jaana Laitinen Inga Prokopenko Paavo Zitting Jackie A Cooper Steve E Humphries John Danesh Asif Rasheed Anuj Goel Anders Hamsten Hugh Watkins Stephan J L Bakker Wiek H van Gilst Charles S Janipalli K Radha Mani Chittaranjan S Yajnik Albert Hofman Francesco U S Mattace-Raso Ben A Oostra Ayse Demirkan Aaron Isaacs Fernando Rivadeneira Edward G Lakatta Marco Orru Angelo Scuteri Mika Ala-Korpela Antti J Kangas Leo-Pekka Lyytikäinen Pasi Soininen Taru Tukiainen Peter Würtz Rick Twee-Hee Ong Marcus Dörr Heyo K Kroemer Uwe Völker Henry Völzke Pilar Galan Serge Hercberg Mark Lathrop Diana Zelenika Panos Deloukas Massimo Mangino Tim D Spector Guangju Zhai James F Meschia Michael A Nalls Pankaj Sharma Janos Terzic M V Kranthi Kumar Matthew Denniff Ewa Zukowska-Szczechowska Lynne E Wagenknecht F Gerald R Fowkes Fadi J Charchar Peter E H Schwarz Caroline Hayward Xiuqing Guo Charles Rotimi Michiel L Bots Eva Brand Nilesh J Samani Ozren Polasek Philippa J Talmud Fredrik Nyberg Diana Kuh Maris Laan Kristian Hveem Lyle J Palmer Yvonne T van der Schouw Juan P Casas Karen L Mohlke Paolo Vineis Olli Raitakari Santhi K Ganesh Tien Y Wong E Shyong Tai Richard S Cooper Markku Laakso Dabeeru C Rao Tamara B Harris Richard W Morris Anna F Dominiczak Mika Kivimaki Michael G Marmot Tetsuro Miki Danish Saleheen Giriraj R Chandak Josef Coresh Gerjan Navis Veikko Salomaa Bok-Ghee Han Xiaofeng Zhu Jaspal S Kooner Olle Melander Paul M Ridker Stefania Bandinelli Ulf B Gyllensten Alan F Wright James F Wilson Luigi Ferrucci Martin Farrall Jaakko Tuomilehto Peter P Pramstaller Roberto Elosua Nicole Soranzo Eric J G Sijbrands David Altshuler Ruth J F Loos Alan R Shuldiner Christian Gieger Pierre Meneton Andre G Uitterlinden Nicholas J Wareham Vilmundur Gudnason Jerome I Rotter Rainer Rettig Manuela Uda David P Strachan Jacqueline C M Witteman Anna-Liisa Hartikainen Jacques S Beckmann Eric Boerwinkle Ramachandran S Vasan Michael Boehnke Martin G Larson Marjo-Riitta Järvelin Bruce M Psaty Gonçalo R Abecasis Aravinda Chakravarti Paul Elliott Cornelia M van Duijn Christopher Newton-Cheh Daniel Levy Mark J Caulfield Toby Johnson

Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy.

Am J Nephrol 2011 18;33(3):209-17. Epub 2011 Feb 18.

Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany.

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July 2011

Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice.

Int J Alzheimers Dis 2011 29;2011:690121. Epub 2011 May 29.

Department of Neuropathology, Institute of Pathology, University of Greifswald, 17487 Greifswald, Germany.

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http://dx.doi.org/10.4061/2011/690121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109772PMC
July 2011

Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell.

Eur J Pharm Biopharm 2011 May 21;78(1):36-48. Epub 2010 Dec 21.

Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, EMA University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2010.12.021DOI Listing
May 2011

Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation.

J Mol Cell Cardiol 2011 Apr 6;50(4):678-85. Epub 2011 Jan 6.

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.yjmcc.2010.12.019DOI Listing
April 2011

Pharmacogenomics: the genetics of variable drug responses.

Circulation 2011 Apr;123(15):1661-70

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-0575, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.914820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093198PMC
April 2011

Towards a unified concept of individualized medicine.

Per Med 2011 Mar;8(2):111-113

Institute of Pharmacology, Ernst-Moritz-Arndt University of Greifswald, Germany.

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http://dx.doi.org/10.2217/pme.11.6DOI Listing
March 2011

CUBN is a gene locus for albuminuria.

Authors:
Carsten A Böger Ming-Huei Chen Adrienne Tin Matthias Olden Anna Köttgen Ian H de Boer Christian Fuchsberger Conall M O'Seaghdha Cristian Pattaro Alexander Teumer Ching-Ti Liu Nicole L Glazer Man Li Jeffrey R O'Connell Toshiko Tanaka Carmen A Peralta Zoltán Kutalik Jian'an Luan Jing Hua Zhao Shih-Jen Hwang Ermeg Akylbekova Holly Kramer Pim van der Harst Albert V Smith Kurt Lohman Mariza de Andrade Caroline Hayward Barbara Kollerits Anke Tönjes Thor Aspelund Erik Ingelsson Gudny Eiriksdottir Lenore J Launer Tamara B Harris Alan R Shuldiner Braxton D Mitchell Dan E Arking Nora Franceschini Eric Boerwinkle Josephine Egan Dena Hernandez Muredach Reilly Raymond R Townsend Thomas Lumley David S Siscovick Bruce M Psaty Bryan Kestenbaum Talin Haritunians Sven Bergmann Peter Vollenweider Gerard Waeber Vincent Mooser Dawn Waterworth Andrew D Johnson Jose C Florez James B Meigs Xiaoning Lu Stephen T Turner Elizabeth J Atkinson Tennille S Leak Knut Aasarød Frank Skorpen Ann-Christine Syvänen Thomas Illig Jens Baumert Wolfgang Koenig Bernhard K Krämer Olivier Devuyst Josyf C Mychaleckyj Cosetta Minelli Stephan J L Bakker Lyudmyla Kedenko Bernhard Paulweber Stefan Coassin Karlhans Endlich Heyo K Kroemer Reiner Biffar Sylvia Stracke Henry Völzke Michael Stumvoll Reedik Mägi Harry Campbell Veronique Vitart Nicholas D Hastie Vilmundur Gudnason Sharon L R Kardia Yongmei Liu Ozren Polasek Gary Curhan Florian Kronenberg Inga Prokopenko Igor Rudan Johan Arnlöv Stein Hallan Gerjan Navis Afshin Parsa Luigi Ferrucci Josef Coresh Michael G Shlipak Shelley B Bull Nicholas J Paterson H-Erich Wichmann Nicholas J Wareham Ruth J F Loos Jerome I Rotter Peter P Pramstaller L Adrienne Cupples Jacques S Beckmann Qiong Yang Iris M Heid Rainer Rettig Albert W Dreisbach Murielle Bochud Caroline S Fox W H L Kao

J Am Soc Nephrol 2011 Mar;22(3):555-70

Department of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1681/ASN.2010060598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060449PMC
March 2011

MTHFR 677C>T polymorphism and cluster headache.

Headache 2011 Feb 14;51(2):201-7. Epub 2010 Oct 14.

Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA.

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http://dx.doi.org/10.1111/j.1526-4610.2010.01780.xDOI Listing
February 2011

In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2).

Handb Exp Pharmacol 2011 (201):325-71

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1007/978-3-642-14541-4_9DOI Listing
February 2011

Pharmacogenomics: will the promise be fulfilled?

Nat Rev Genet 2011 01 30;12(1):69-73. Epub 2010 Nov 30.

Department of Bioengineering, Stanford University, 318 Campus Drive, S172, MC, 5444 Stanford, California 94305-5444, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098748PMC
January 2011

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.

Authors:
Nona Sotoodehnia Aaron Isaacs Paul I W de Bakker Marcus Dörr Christopher Newton-Cheh Ilja M Nolte Pim van der Harst Martina Müller Mark Eijgelsheim Alvaro Alonso Andrew A Hicks Sandosh Padmanabhan Caroline Hayward Albert Vernon Smith Ozren Polasek Steven Giovannone Jingyuan Fu Jared W Magnani Kristin D Marciante Arne Pfeufer Sina A Gharib Alexander Teumer Man Li Joshua C Bis Fernando Rivadeneira Thor Aspelund Anna Köttgen Toby Johnson Kenneth Rice Mark P S Sie Ying A Wang Norman Klopp Christian Fuchsberger Sarah H Wild Irene Mateo Leach Karol Estrada Uwe Völker Alan F Wright Folkert W Asselbergs Jiaxiang Qu Aravinda Chakravarti Moritz F Sinner Jan A Kors Astrid Petersmann Tamara B Harris Elsayed Z Soliman Patricia B Munroe Bruce M Psaty Ben A Oostra L Adrienne Cupples Siegfried Perz Rudolf A de Boer André G Uitterlinden Henry Völzke Timothy D Spector Fang-Yu Liu Eric Boerwinkle Anna F Dominiczak Jerome I Rotter Gé van Herpen Daniel Levy H-Erich Wichmann Wiek H van Gilst Jacqueline C M Witteman Heyo K Kroemer W H Linda Kao Susan R Heckbert Thomas Meitinger Albert Hofman Harry Campbell Aaron R Folsom Dirk J van Veldhuisen Christine Schwienbacher Christopher J O'Donnell Claudia Beu Volpato Mark J Caulfield John M Connell Lenore Launer Xiaowen Lu Lude Franke Rudolf S N Fehrmann Gerard te Meerman Harry J M Groen Rinse K Weersma Leonard H van den Berg Cisca Wijmenga Roel A Ophoff Gerjan Navis Igor Rudan Harold Snieder James F Wilson Peter P Pramstaller David S Siscovick Thomas J Wang Vilmundur Gudnason Cornelia M van Duijn Stephan B Felix Glenn I Fishman Yalda Jamshidi Bruno H Ch Stricker Nilesh J Samani Stefan Kääb Dan E Arking

Nat Genet 2010 Dec 14;42(12):1068-76. Epub 2010 Nov 14.

Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/ng.716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338195PMC
December 2010

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.

Hepatology 2010 Nov;52(5):1797-807

Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/hep.23876DOI Listing
November 2010

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

Authors:
Iris M Heid Anne U Jackson Joshua C Randall Thomas W Winkler Lu Qi Valgerdur Steinthorsdottir Gudmar Thorleifsson M Carola Zillikens Elizabeth K Speliotes Reedik Mägi Tsegaselassie Workalemahu Charles C White Nabila Bouatia-Naji Tamara B Harris Sonja I Berndt Erik Ingelsson Cristen J Willer Michael N Weedon Jian'an Luan Sailaja Vedantam Tõnu Esko Tuomas O Kilpeläinen Zoltán Kutalik Shengxu Li Keri L Monda Anna L Dixon Christopher C Holmes Lee M Kaplan Liming Liang Josine L Min Miriam F Moffatt Cliona Molony George Nicholson Eric E Schadt Krina T Zondervan Mary F Feitosa Teresa Ferreira Hana Lango Allen Robert J Weyant Eleanor Wheeler Andrew R Wood Karol Estrada Michael E Goddard Guillaume Lettre Massimo Mangino Dale R Nyholt Shaun Purcell Albert Vernon Smith Peter M Visscher Jian Yang Steven A McCarroll James Nemesh Benjamin F Voight Devin Absher Najaf Amin Thor Aspelund Lachlan Coin Nicole L Glazer Caroline Hayward Nancy L Heard-Costa Jouke-Jan Hottenga Asa Johansson Toby Johnson Marika Kaakinen Karen Kapur Shamika Ketkar Joshua W Knowles Peter Kraft Aldi T Kraja Claudia Lamina Michael F Leitzmann Barbara McKnight Andrew P Morris Ken K Ong John R B Perry Marjolein J Peters Ozren Polasek Inga Prokopenko Nigel W Rayner Samuli Ripatti Fernando Rivadeneira Neil R Robertson Serena Sanna Ulla Sovio Ida Surakka Alexander Teumer Sophie van Wingerden Veronique Vitart Jing Hua Zhao Christine Cavalcanti-Proença Peter S Chines Eva Fisher Jennifer R Kulzer Cecile Lecoeur Narisu Narisu Camilla Sandholt Laura J Scott Kaisa Silander Klaus Stark Mari-Liis Tammesoo Tanya M Teslovich Nicholas John Timpson Richard M Watanabe Ryan Welch Daniel I Chasman Matthew N Cooper John-Olov Jansson Johannes Kettunen Robert W Lawrence Niina Pellikka Markus Perola Liesbeth Vandenput Helene Alavere Peter Almgren Larry D Atwood Amanda J Bennett Reiner Biffar Lori L Bonnycastle Stefan R Bornstein Thomas A Buchanan Harry Campbell Ian N M Day Mariano Dei Marcus Dörr Paul Elliott Michael R Erdos Johan G Eriksson Nelson B Freimer Mao Fu Stefan Gaget Eco J C Geus Anette P Gjesing Harald Grallert Jürgen Grässler Christopher J Groves Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Aki S Havulinna Karl-Heinz Herzig Andrew A Hicks Jennie Hui Wilmar Igl Pekka Jousilahti Antti Jula Eero Kajantie Leena Kinnunen Ivana Kolcic Seppo Koskinen Peter Kovacs Heyo K Kroemer Vjekoslav Krzelj Johanna Kuusisto Kirsti Kvaloy Jaana Laitinen Olivier Lantieri G Mark Lathrop Marja-Liisa Lokki Robert N Luben Barbara Ludwig Wendy L McArdle Anne McCarthy Mario A Morken Mari Nelis Matt J Neville Guillaume Paré Alex N Parker John F Peden Irene Pichler Kirsi H Pietiläinen Carl G P Platou Anneli Pouta Martin Ridderstråle Nilesh J Samani Jouko Saramies Juha Sinisalo Jan H Smit Rona J Strawbridge Heather M Stringham Amy J Swift Maris Teder-Laving Brian Thomson Gianluca Usala Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Claudia B Volpato Henri Wallaschofski G Bragi Walters Elisabeth Widen Sarah H Wild Gonneke Willemsen Daniel R Witte Lina Zgaga Paavo Zitting John P Beilby Alan L James Mika Kähönen Terho Lehtimäki Markku S Nieminen Claes Ohlsson Lyle J Palmer Olli Raitakari Paul M Ridker Michael Stumvoll Anke Tönjes Jorma Viikari Beverley Balkau Yoav Ben-Shlomo Richard N Bergman Heiner Boeing George Davey Smith Shah Ebrahim Philippe Froguel Torben Hansen Christian Hengstenberg Kristian Hveem Bo Isomaa Torben Jørgensen Fredrik Karpe Kay-Tee Khaw Markku Laakso Debbie A Lawlor Michel Marre Thomas Meitinger Andres Metspalu Kristian Midthjell Oluf Pedersen Veikko Salomaa Peter E H Schwarz Tiinamaija Tuomi Jaakko Tuomilehto Timo T Valle Nicholas J Wareham Alice M Arnold Jacques S Beckmann Sven Bergmann Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Francis S Collins Gudny Eiriksdottir Vilmundur Gudnason Ulf Gyllensten Anders Hamsten Andrew T Hattersley Albert Hofman Frank B Hu Thomas Illig Carlos Iribarren Marjo-Riitta Jarvelin W H Linda Kao Jaakko Kaprio Lenore J Launer Patricia B Munroe Ben Oostra Brenda W Penninx Peter P Pramstaller Bruce M Psaty Thomas Quertermous Aila Rissanen Igor Rudan Alan R Shuldiner Nicole Soranzo Timothy D Spector Ann-Christine Syvanen Manuela Uda André Uitterlinden Henry Völzke Peter Vollenweider James F Wilson Jacqueline C Witteman Alan F Wright Gonçalo R Abecasis Michael Boehnke Ingrid B Borecki Panos Deloukas Timothy M Frayling Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Kari E North Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Joel N Hirschhorn Themistocles L Assimes H-Erich Wichmann Unnur Thorsteinsdottir Cornelia M van Duijn Kari Stefansson L Adrienne Cupples Ruth J F Loos Inês Barroso Mark I McCarthy Caroline S Fox Karen L Mohlke Cecilia M Lindgren

Nat Genet 2010 Nov 10;42(11):949-60. Epub 2010 Oct 10.

Regensburg University Medical Center, Department of Epidemiology and Preventive Medicine, Regensburg, Germany.

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http://dx.doi.org/10.1038/ng.685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000924PMC
November 2010

Genome-wide association analysis identifies multiple loci related to resting heart rate.

Hum Mol Genet 2010 Oct 16;19(19):3885-94. Epub 2010 Jul 16.

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddq303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657480PMC
October 2010

Expression of ABC-type transport proteins in human platelets.

Pharmacogenet Genomics 2010 Jun;20(6):396-400

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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http://dx.doi.org/10.1097/FPC.0b013e32833997b0DOI Listing
June 2010

Viral myocarditis induced by Coxsackievirus B3 in A.BY/SnJ mice: analysis of changes in the myocardial proteome.

Proteomics 2010 May;10(9):1802-18

Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1002/pmic.200900734DOI Listing
May 2010

New loci associated with kidney function and chronic kidney disease.

Authors:
Anna Köttgen Cristian Pattaro Carsten A Böger Christian Fuchsberger Matthias Olden Nicole L Glazer Afshin Parsa Xiaoyi Gao Qiong Yang Albert V Smith Jeffrey R O'Connell Man Li Helena Schmidt Toshiko Tanaka Aaron Isaacs Shamika Ketkar Shih-Jen Hwang Andrew D Johnson Abbas Dehghan Alexander Teumer Guillaume Paré Elizabeth J Atkinson Tanja Zeller Kurt Lohman Marilyn C Cornelis Nicole M Probst-Hensch Florian Kronenberg Anke Tönjes Caroline Hayward Thor Aspelund Gudny Eiriksdottir Lenore J Launer Tamara B Harris Evadnie Rampersaud Braxton D Mitchell Dan E Arking Eric Boerwinkle Maksim Struchalin Margherita Cavalieri Andrew Singleton Francesco Giallauria Jeffrey Metter Ian H de Boer Talin Haritunians Thomas Lumley David Siscovick Bruce M Psaty M Carola Zillikens Ben A Oostra Mary Feitosa Michael Province Mariza de Andrade Stephen T Turner Arne Schillert Andreas Ziegler Philipp S Wild Renate B Schnabel Sandra Wilde Thomas F Munzel Tennille S Leak Thomas Illig Norman Klopp Christa Meisinger H-Erich Wichmann Wolfgang Koenig Lina Zgaga Tatijana Zemunik Ivana Kolcic Cosetta Minelli Frank B Hu Asa Johansson Wilmar Igl Ghazal Zaboli Sarah H Wild Alan F Wright Harry Campbell David Ellinghaus Stefan Schreiber Yurii S Aulchenko Janine F Felix Fernando Rivadeneira Andre G Uitterlinden Albert Hofman Medea Imboden Dorothea Nitsch Anita Brandstätter Barbara Kollerits Lyudmyla Kedenko Reedik Mägi Michael Stumvoll Peter Kovacs Mladen Boban Susan Campbell Karlhans Endlich Henry Völzke Heyo K Kroemer Matthias Nauck Uwe Völker Ozren Polasek Veronique Vitart Sunita Badola Alexander N Parker Paul M Ridker Sharon L R Kardia Stefan Blankenberg Yongmei Liu Gary C Curhan Andre Franke Thierry Rochat Bernhard Paulweber Inga Prokopenko Wei Wang Vilmundur Gudnason Alan R Shuldiner Josef Coresh Reinhold Schmidt Luigi Ferrucci Michael G Shlipak Cornelia M van Duijn Ingrid Borecki Bernhard K Krämer Igor Rudan Ulf Gyllensten James F Wilson Jacqueline C Witteman Peter P Pramstaller Rainer Rettig Nick Hastie Daniel I Chasman W H Kao Iris M Heid Caroline S Fox

Nat Genet 2010 May 11;42(5):376-84. Epub 2010 Apr 11.

Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ng.568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997674PMC
May 2010

Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.

J Biol Chem 2010 Apr 16;285(15):11336-47. Epub 2010 Feb 16.

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, 17487 Greifswald, Germany.

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http://dx.doi.org/10.1074/jbc.M109.056457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857012PMC
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Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies.

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Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Institut für Pharmakologie, Ernst-Moritz-Arndt-University, Friedrich-Loeffler-Str. 23d, D-17487, Greifswald, Germany.

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http://dx.doi.org/10.2353/ajpath.2010.090425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832132PMC
March 2010

Isolation of platelet granules.

Curr Protoc Cell Biol 2010 Mar;Chapter 3:Unit 3.35

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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http://dx.doi.org/10.1002/0471143030.cb0335s46DOI Listing
March 2010

Concentration of the macrolide antibiotic tulathromycin in broncho-alveolar cells is influenced by comedication of rifampicin in foals.

Naunyn Schmiedebergs Arch Pharmacol 2010 Feb 15;381(2):161-9. Epub 2009 Dec 15.

Clinic for Horses, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.

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http://dx.doi.org/10.1007/s00210-009-0481-1DOI Listing
February 2010

Rac1-induced connective tissue growth factor regulates connexin 43 and N-cadherin expression in atrial fibrillation.

J Am Coll Cardiol 2010 Feb;55(5):469-80

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarland, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/j.jacc.2009.08.064DOI Listing
February 2010

Common variants in the G protein beta3 subunit gene and thyroid disorders in a formerly iodine-deficient population.

Thyroid 2009 Oct;19(10):1115-9

Study of Health in Pomerania (SHIP)/Clinical-Epidemiological Research, Institute of Community Medicine, Ernst-Moritz-Arndt University, Greifswald D-17487, Germany.

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http://dx.doi.org/10.1089/thy.2009.0134DOI Listing
October 2009

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.

JAMA 2009 Jul;302(2):168-78

Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702-5827, USA.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975567PMC
July 2009

Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin.

Drug Metab Dispos 2009 May 23;37(5):1129-37. Epub 2009 Feb 23.

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Friedrich-Loeffler-Str. 23 D, D-17487 Greifswald, Germany.

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http://dx.doi.org/10.1124/dmd.108.024570DOI Listing
May 2009

Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice.

Cancer Res 2009 Jan;69(2):695-9

Department of Cardiology and Pulmology, Charite-Universitätsmedizin Berlin, Campus Benjamin Franklin, Med Klinik II, Berlin, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3076DOI Listing
January 2009

The adhesion and spreading of thrombocyte vesicles on electrode surfaces.

Bioelectrochemistry 2008 Nov 19;74(1):210-6. Epub 2008 Aug 19.

Institut für Biochemie, Universität Greifswald, Felix-Hausdorff-Str. 4, D-17487, Greifswald, Germany.

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http://dx.doi.org/10.1016/j.bioelechem.2008.08.003DOI Listing
November 2008

Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents.

J Control Release 2008 Aug 19;130(1):2-8. Epub 2008 May 19.

Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Friedrich-Ludwig-Jahn-Strasse 17, 17487 Greifswald, Germany.

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http://dx.doi.org/10.1016/j.jconrel.2008.05.012DOI Listing
August 2008

Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1.

Pharmacogenet Genomics 2008 Jul;18(7):559-68

Department of Clinical Pharmacology, University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1097/FPC.0b013e3282fe9a2cDOI Listing
July 2008