Publications by authors named "Heymut Omran"

100Publications

A novel hypomorphic allele of causes primary ciliary dyskinesia phenotypes in mice.

Dis Model Mech 2020 Oct 30;13(10). Epub 2020 Oct 30.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA

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http://dx.doi.org/10.1242/dmm.045344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648611PMC
October 2020

Motile ciliopathies.

Nat Rev Dis Primers 2020 09 17;6(1):77. Epub 2020 Sep 17.

Department of General Pediatrics, University Children's Hospital Muenster, Muenster, Germany.

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http://dx.doi.org/10.1038/s41572-020-0209-6DOI Listing
September 2020

Generation of induced pluripotent stem cell lines from a Crisponi/Cold induced sweating syndrome type 1 individual.

Stem Cell Res 2020 07 28;46:101820. Epub 2020 May 28.

Department of General Pediatrics, Muenster University Children's Hospital, Muenster, Germany.

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http://dx.doi.org/10.1016/j.scr.2020.101820DOI Listing
July 2020

Efficacy and safety of azithromycin maintenance therapy in primary ciliary dyskinesia (BESTCILIA): a multicentre, double-blind, randomised, placebo-controlled phase 3 trial.

Lancet Respir Med 2020 05;8(5):493-505

Danish Primary Ciliary Dyskinesia Centre, Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(20)30058-8DOI Listing
May 2020

Errors in Methodology Affect Diagnostic Accuracy of High-Speed Videomicroscopy Analysis in Primary Ciliary Dyskinesia.

Chest 2019 11;156(5):1032-1033

Department of Medicine, Marsico Lung Institute, University of North Carolina School of Medicine, Chapel Hill, NC.

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http://dx.doi.org/10.1016/j.chest.2019.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339238PMC
November 2019

Primary ciliary dyskinesia in the genomics age.

Lancet Respir Med 2020 02 14;8(2):202-216. Epub 2019 Oct 14.

Division of Molecular and Clinical Medicine, University of Dundee, Dundee, UK; Department of Paediatrics, Royal Brompton and Harefield NHS Trust, London, UK.

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http://dx.doi.org/10.1016/S2213-2600(19)30374-1DOI Listing
February 2020

Acinetobacter baumannii Is a Risk Factor for Lower Respiratory Tract Infections in Children and Adolescents With a Tracheostomy.

Pediatr Infect Dis J 2019 10;38(10):1005-1009

From the Department of General Pediatrics, Pediatric Respiratory Medicine Unit, University Hospital Muenster, Muenster.

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http://dx.doi.org/10.1097/INF.0000000000002421DOI Listing
October 2019

A retrospective analysis of the pathogens in the airways of patients with primary ciliary dyskinesia.

Respir Med 2019 09 15;156:69-77. Epub 2019 Aug 15.

Institute of Medical Microbiology, University Hospital Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2019.08.009DOI Listing
September 2019

Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis.

J Clin Invest 2019 05 16;129(7):2841-2855. Epub 2019 May 16.

Department of Experimental and Clinical Pharmacology and Pharmacogenomics, University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1172/JCI98890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597216PMC
May 2019

Recessive DNAH9 Loss-of-Function Mutations Cause Laterality Defects and Subtle Respiratory Ciliary-Beating Defects.

Am J Hum Genet 2018 12 21;103(6):995-1008. Epub 2018 Nov 21.

Genome Research Division, Human Genetics Department, Radboud University Medical Center and Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 10, 6525KL Nijmegen, the Netherlands; Center for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg University Faculty of Medicine, Mathildenstrasse 1, 79112 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288205PMC
December 2018

Comparison of Nocturnal Cough Analysis in Healthy Subjects and in Patients with Cystic Fibrosis and Primary Ciliary Dyskinesia: A Prospective Observational Study.

Respiration 2019;97(1):60-69. Epub 2018 Nov 8.

Pediatric Respiratory Medicine Unit, Department of General Pediatrics, University Hospital Münster, Münster, Germany,

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https://www.karger.com/Article/FullText/493323
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http://dx.doi.org/10.1159/000493323DOI Listing
April 2020

Exploring the Art of Ciliary Beating: The Benefits of High-Speed Video Analysis.

Chest 2017 12;152(6):1348-1349

Primary Ciliary Dyskinesia Centre, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and Academic Unit of Clinical and Experimental Medicine, University of Southampton, Southampton, England.

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http://dx.doi.org/10.1016/j.chest.2017.06.053DOI Listing
December 2017

Mutation of serine/threonine protein kinase 36 (STK36) causes primary ciliary dyskinesia with a central pair defect.

Hum Mutat 2017 08 15;38(8):964-969. Epub 2017 Jun 15.

Department of General Pediatrics, University Children's Hospital Muenster, Muenster, Germany.

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http://dx.doi.org/10.1002/humu.23261DOI Listing
August 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

DYNC2H1 mutation causes Jeune syndrome and recurrent lung infections associated with ciliopathy.

Clin Respir J 2018 Mar 12;12(3):1017-1020. Epub 2017 Mar 12.

Department of Pediatric Pulmonology, Hacettepe University School of Medicine, Ankara, Turkey.

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http://dx.doi.org/10.1111/crj.12620DOI Listing
March 2018

Tyrosine kinase 2 is not limiting human antiviral type III interferon responses.

Eur J Immunol 2016 11 5;46(11):2639-2649. Epub 2016 Oct 5.

Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.201646519DOI Listing
November 2016

The atypical cadherin Dachsous1 localizes to the base of the ciliary apparatus in airway epithelia.

Biochem Biophys Res Commun 2016 05 10;473(4):1177-1184. Epub 2016 Apr 10.

Division of Nephrology and Immunology, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2016.04.036DOI Listing
May 2016

Effect of TH2 cytokines and interferon gamma on beat frequency of human respiratory cilia.

Pediatr Res 2016 05 13;79(5):731-5. Epub 2016 Jan 13.

Department of General Paediatrics, University Children´s Hospital Muenster, Muenster, Germany.

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http://www.nature.com/articles/pr20168
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http://dx.doi.org/10.1038/pr.2016.8DOI Listing
May 2016

Ciliary function and motor protein composition of human fallopian tubes.

Hum Reprod 2015 Dec 15;30(12):2871-80. Epub 2015 Sep 15.

Pediatric Pulmonology Unit, Department of General Pediatrics, University Children's Hospital Muenster, Albert-Schweitzer-Campus 1, Geb. A1, D-48149 Muenster, Germany.

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http://dx.doi.org/10.1093/humrep/dev227DOI Listing
December 2015

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.

Nat Cell Biol 2015 Aug 13;17(8):1074-1087. Epub 2015 Jul 13.

Section of Ophthalmology and Neuroscience, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, UK.

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http://www.nature.com/articles/ncb3201
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http://dx.doi.org/10.1038/ncb3201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536769PMC
August 2015

Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.

EMBO J 2015 Apr 23;34(8):1078-89. Epub 2015 Feb 23.

University Medical Centre, Renal Department, Centre for Clinical Research, Freiburg, Germany BIOSS Centre of Biological Signalling Studies, Albert-Ludwigs-University, Freiburg, Germany

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http://dx.doi.org/10.15252/embj.201490805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406653PMC
April 2015

Diagnosis and management of primary ciliary dyskinesia.

Cilia 2015 22;4(1). Epub 2015 Jan 22.

Department of General Pediatrics, Pediatric Pulmonology Unit, University Children's Hospital Muenster, Albert-Schweitzer-Campus 1, Geb. A1, D-48149 Münster, Germany.

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http://www.ciliajournal.com/content/4/1/2
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http://dx.doi.org/10.1186/s13630-014-0011-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300728PMC
January 2015

Ciliary beat pattern and frequency in genetic variants of primary ciliary dyskinesia.

Eur Respir J 2014 Dec 3;44(6):1579-88. Epub 2014 Sep 3.

University Children's Hospital Münster, Dept of General Pediatrics, Pediatric Pulmonology Unit, Münster, Germany

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http://dx.doi.org/10.1183/09031936.00052014DOI Listing
December 2014

Multicilin drives centriole biogenesis via E2f proteins.

Genes Dev 2014 Jul 16;28(13):1461-71. Epub 2014 Jun 16.

The Salk Institute for Biological Studies, La Jolla 92037, California, USA;

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http://dx.doi.org/10.1101/gad.243832.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083089PMC
July 2014

A bumpy road to the diagnosis of a Kytococcus schroeteri shunt infection.

J Med Microbiol 2013 Jan 20;62(Pt 1):165-168. Epub 2012 Sep 20.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

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http://dx.doi.org/10.1099/jmm.0.045351-0DOI Listing
January 2013

RPGR mutations might cause reduced orientation of respiratory cilia.

Pediatr Pulmonol 2013 Apr 6;48(4):352-63. Epub 2012 Aug 6.

Department of Molecular and Clinical Genetics, Institute of Human Genetics Polish Academy of Sciences, Poznań, Poland.

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http://dx.doi.org/10.1002/ppul.22632DOI Listing
April 2013

Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

Cell 2012 Aug;150(3):533-48

Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.cell.2012.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433835PMC
August 2012

The emerging genetics of primary ciliary dyskinesia.

Proc Am Thorac Soc 2011 Sep;8(5):430-3

Department of Pathology/Lab Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1513/pats.201103-023SDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209577PMC
September 2011

Lethal phenotype of mice carrying a Sept11 null mutation.

Biol Chem 2011 Aug;392(8-9):779-81

Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1515/BC.2011.093DOI Listing
August 2011

U1 snRNA-mediated gene therapeutic correction of splice defects caused by an exceptionally mild BBS mutation.

Hum Mutat 2011 Jul;32(7):815-24

University of Zurich, Institute of Medical Molecular Genetics, Schorenstrasse 16, Schwerzenbach, Switzerland.

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http://dx.doi.org/10.1002/humu.21509DOI Listing
July 2011

The molecular basis of aminoacylase 1 deficiency.

Biochim Biophys Acta 2011 Jun 23;1812(6):685-90. Epub 2011 Mar 23.

Labor für Klinische Biochemie & Stoffwechsel, Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.bbadis.2011.03.005DOI Listing
June 2011

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.

Int J Cancer 2011 Nov 25;129(9):2297-303. Epub 2011 Jul 25.

Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University, Freiburg, Germany.

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http://dx.doi.org/10.1002/ijc.25893DOI Listing
November 2011

NPHP proteins: gatekeepers of the ciliary compartment.

Authors:
Heymut Omran

J Cell Biol 2010 Sep;190(5):715-7

Klinik und Poliklinik für Kinder- und Jugendmedizin, Allgemeine Pädiatrie, Universitätsklinikum Münster 48149, Germany.

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http://dx.doi.org/10.1083/jcb.201008080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935579PMC
September 2010

ENT manifestations in patients with primary ciliary dyskinesia: prevalence and significance of otorhinolaryngologic co-morbidities.

Eur Arch Otorhinolaryngol 2011 Mar 22;268(3):383-8. Epub 2010 Jul 22.

Department of Otorhinolaryngology Head and Neck Surgery, University Hospital Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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http://dx.doi.org/10.1007/s00405-010-1341-9DOI Listing
March 2011

Aminoacylase 1 deficiency associated with autistic behavior.

J Inherit Metab Dis 2010 Dec 18;33 Suppl 3:S211-4. Epub 2010 May 18.

Department of Metabolic Diseases, Endocrinology and Diabetology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

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http://dx.doi.org/10.1007/s10545-010-9089-3DOI Listing
December 2010