Dr. Heung-Chin Cheng, PhD - University of Melbourne - Associate Professor

Dr. Heung-Chin Cheng

PhD

University of Melbourne

Associate Professor

Melbourne, Victoria | Australia

Main Specialties: Biology

Additional Specialties: Biochemistry & Molecular Biology

ORCID logohttps://orcid.org/0000-0002-4965-7148

Dr. Heung-Chin Cheng, PhD - University of Melbourne - Associate Professor

Dr. Heung-Chin Cheng

PhD

Introduction

Primary Affiliation: University of Melbourne - Melbourne, Victoria , Australia

Specialties:

Additional Specialties:

Research Interests:

Education

Sep 1981 - Dec 1986
University of California Davis
PhD
Endocrinology
Sep 1977 - Jul 1981
Chinese University of Hong Kong
B.Sc. (Hon)
Biology

Experience

Jan 1993 - Jan 1993
University of Melbourne
Associate Professor
Biochemistry
Oct 1988 - Dec 1992
University of Calgary
Postdoctoral fellow
Biochemistry & Molecular Biology
Apr 1987 - Nov 1988
University of California San Francisco
Postdoctoral fellow
Laboratory of Molecular Endocrinology

Publications

34Publications

298Reads

34Profile Views

285PubMed Central Citations

Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death.

Cell Death Dis 2019 Mar 1;10(3):213. Epub 2019 Mar 1.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC, 3010, Australia.

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http://www.nature.com/articles/s41419-019-1445-0
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http://dx.doi.org/10.1038/s41419-019-1445-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397184PMC
March 2019
14 Reads
5.014 Impact Factor

The Roc-COR tandem domain of leucine-rich repeat kinase 2 forms dimers and exhibits conventional Ras-like GTPase properties.

J Neurochem 2018 Nov;147(3):409-428

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/jnc.14566DOI Listing
November 2018
39 Reads
4.281 Impact Factor

A beacon of hope in stroke therapy-Blockade of pathologically activated cellular events in excitotoxic neuronal death as potential neuroprotective strategies.

Pharmacol Ther 2016 Apr 17;160:159-79. Epub 2016 Feb 17.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.02.009DOI Listing
April 2016
15 Reads
9.723 Impact Factor

Modulating Astrocyte Transition after Stroke to Promote Brain Rescue and Functional Recovery: Emerging Targets Include Rho Kinase.

Int J Mol Sci 2016 Feb 26;17(3):288. Epub 2016 Feb 26.

Neurotrauma Research, Department of Medicine, St Vincent's Campus, University of Melbourne, Parkville, VIC 3065, Australia.

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http://dx.doi.org/10.3390/ijms17030288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813152PMC
February 2016
3 Reads
2.862 Impact Factor

The C-terminal tail inhibitory phosphorylation sites of PTEN regulate its intrinsic catalytic activity and the kinetics of its binding to phosphatidylinositol-4,5-bisphosphate.

Arch Biochem Biophys 2015 Dec 22;587:48-60. Epub 2015 Oct 22.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia; Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.10.004DOI Listing
December 2015
5 Reads
3.017 Impact Factor

Src family kinases and their role in hematological malignancies.

Leuk Lymphoma 2015 Mar 21;56(3):577-86. Epub 2015 Jan 21.

Haematology Department and Victorian Cancer Cytogenetics Service, St Vincent's Hospital , Fitzroy , Australia.

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http://dx.doi.org/10.3109/10428194.2014.907897DOI Listing
March 2015
30 Reads
3 Citations

Dual role of Src kinase in governing neuronal survival.

Brain Res 2015 Jan 31;1594:1-14. Epub 2014 Oct 31.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3010, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2014.10.040DOI Listing
January 2015
28 Reads
3 Citations
2.843 Impact Factor

Global analysis of human nonreceptor tyrosine kinase specificity using high-density peptide microarrays.

J Proteome Res 2014 Oct 28;13(10):4339-46. Epub 2014 Aug 28.

Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520, United States.

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http://dx.doi.org/10.1021/pr500503qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184454PMC
October 2014
18 Reads
12 Citations
4.250 Impact Factor

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

Hum Mutat 2014 Apr 24;35(4):395-412. Epub 2014 Feb 24.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/humu.22515DOI Listing
April 2014
4 Reads
8 Citations
5.144 Impact Factor

Activation of Src family tyrosine kinases by ferric ions.

Biochim Biophys Acta 2014 Mar 12;1844(3):487-96. Epub 2013 Dec 12.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.bbapap.2013.12.004DOI Listing
March 2014
3 Reads
1 Citation

A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.

J Biol Chem 2013 Apr 11;288(14):9696-709. Epub 2013 Feb 11.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1074/jbc.M112.419713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617272PMC
April 2013
2 Reads
9 Citations
4.573 Impact Factor

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations.

Biochem Soc Trans 2012 Oct;40(5):1086-9

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.1042/BST20120088DOI Listing
October 2012
3 Reads
7 Citations
3.194 Impact Factor

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1).

Hum Mutat 2012 Oct 5;33(10):1408-22. Epub 2012 Jul 5.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/humu.22127DOI Listing
October 2012
4 Reads
11 Citations
5.144 Impact Factor

Aberrant regulation and function of Src family tyrosine kinases: their potential contributions to glutamate-induced neurotoxicity.

Clin Exp Pharmacol Physiol 2012 Aug;39(8):684-91

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1440-1681.2011.05621.xDOI Listing
August 2012
2 Reads
6 Citations

Regulation and function of protein kinases and phosphatases.

Enzyme Res 2011 13;2011:794089. Epub 2011 Dec 13.

Department of Biochemistry & Molecular Biology, Bio21 Molecular Sciences and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.4061/2011/794089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238372PMC
August 2012
6 Reads
12 Citations

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide.

Biochem J 2011 Mar;434(3):399-413

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://www.biochemj.org/content/ppbiochemj/434/3/399.full.pd
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http://biochemj.org/lookup/doi/10.1042/BJ20101244
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http://dx.doi.org/10.1042/BJ20101244DOI Listing
March 2011
3 Reads
6 Citations
4.400 Impact Factor

A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases.

Bioorg Med Chem Lett 2011 Jan 5;21(1):329-31. Epub 2010 Nov 5.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 3010 Victoria, Australia.

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http://dx.doi.org/10.1016/j.bmcl.2010.11.005DOI Listing
January 2011
7 Reads
2 Citations
2.420 Impact Factor

Development of the procedures for high-yield expression and rapid purification of active recombinant Csk-homologous kinase (CHK): comparison of the catalytic activities of CHK and CSK.

Protein Expr Purif 2010 Dec 25;74(2):139-47. Epub 2010 Jul 25.

Department of Biochemistry & Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.pep.2010.07.007DOI Listing
December 2010
3 Reads
3 Citations
1.700 Impact Factor

Structural elements and allosteric mechanisms governing regulation and catalysis of CSK-family kinases and their inhibition of Src-family kinases.

Growth Factors 2010 Oct;28(5):329-50

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, 3010, Australia.

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http://dx.doi.org/10.3109/08977194.2010.484424DOI Listing
October 2010
5 Reads
10 Citations
3.390 Impact Factor

Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN.

Biochim Biophys Acta 2010 Sep 27;1804(9):1785-95. Epub 2010 May 27.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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https://linkinghub.elsevier.com/retrieve/pii/S15709639100013
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http://dx.doi.org/10.1016/j.bbapap.2010.05.009DOI Listing
September 2010
6 Reads
3 Citations

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: implications for disease-associated kinases.

Clin Exp Pharmacol Physiol 2010 Jan 29;37(1):93-101. Epub 2009 Jun 29.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1440-1681.2009.05237.xDOI Listing
January 2010
13 Reads
2 Citations

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1).

J Neurochem 2008 Apr 23;105(1):18-33. Epub 2008 Jan 23.

Department of Biochemistry & Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05249.xDOI Listing
April 2008
2 Reads
32 Citations
4.281 Impact Factor

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).

Nucleic Acids Res 2008 Jan 19;36(1):203-16. Epub 2007 Nov 19.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1093/nar/gkm1002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248764PMC
January 2008
1 Read
9 Citations
9.112 Impact Factor

Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase.

Protein Expr Purif 2007 Oct 10;55(2):334-42. Epub 2007 May 10.

Department of Biochemistry & Molecular Biology, The University of Melbourne, Parkville, Vic. 3010, Australia.

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http://dx.doi.org/10.1016/j.pep.2007.04.024DOI Listing
October 2007
8 Reads
1 Citation
1.700 Impact Factor

PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.

Cell Signal 2007 Jul 25;19(7):1434-45. Epub 2007 Jan 25.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.cellsig.2007.01.021DOI Listing
July 2007
2 Reads
5 Citations
4.320 Impact Factor

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases.

J Biol Chem 2006 Nov 7;281(44):32988-99. Epub 2006 Sep 7.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1074/jbc.M602951200DOI Listing
November 2006
20 Reads
10 Citations
4.573 Impact Factor

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

Hum Mol Genet 2006 Nov 25;15(21):3251-62. Epub 2006 Sep 25.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1093/hmg/ddl398DOI Listing
November 2006
21 Reads
46 Citations
6.393 Impact Factor

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.

Neurosci Lett 2006 Sep 20;405(1-2):120-5. Epub 2006 Jul 20.

Departments of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Blk MD7, 8 Medical Drive, Singapore 117597, Singapore.

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http://dx.doi.org/10.1016/j.neulet.2006.06.037DOI Listing
September 2006
3 Citations
2.060 Impact Factor

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases.

Biochim Biophys Acta 2005 Dec 8;1754(1-2):210-20. Epub 2005 Sep 8.

Department of Biochemistry and Molecular Biology, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.bbapap.2005.07.027DOI Listing
December 2005
2 Reads
35 Citations

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.

Growth Factors 2005 Sep;23(3):233-44

Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Department of Biochemistry and Molecular Biology, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1080/08977190500178877DOI Listing
September 2005
5 Reads
29 Citations
3.390 Impact Factor

A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity.

J Biol Chem 2004 May 25;279(20):20752-66. Epub 2004 Feb 25.

Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1074/jbc.M309865200DOI Listing
May 2004
9 Reads
11 Citations
4.573 Impact Factor

1H, 13C and 15N chemical shift assignments of the SH2 domain of the Csk homologous kinase.

J Biomol NMR 2002 Dec;24(4):363-4

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December 2002
3 Reads
3 Citations
3.141 Impact Factor

Top co-authors

Terrence D Mulhern
Terrence D Mulhern

The University of Melbourne

10
Janetta G Culvenor
Janetta G Culvenor

The University of Melbourne

8
Ryan D Mills
Ryan D Mills

Bio21 Molecular Science and Biotechnology Institute

7
Hong-Jian Zhu
Hong-Jian Zhu

Ludwig Institute for Cancer Research

7
Yuh-Ping Chong
Yuh-Ping Chong

University of Melbourne

5
Bruno Catimel
Bruno Catimel

Ludwig Institute for Cancer Research

4
Daisy Sio-Seng Lio
Daisy Sio-Seng Lio

University of Melbourne

4
Nicholas A Williamson
Nicholas A Williamson

University of Melbourne

4