Herve Galons

Herve Galons

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Herve Galons

Herve Galons

Publications by authors named "Herve Galons"

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Recent advances in the development of cyclin-dependent kinase 7 inhibitors.

Eur J Med Chem 2019 Dec 22;183:111641. Epub 2019 Aug 22.

Unité de Technologies Chimiques et Biologiques pour la Santé, Université Paris Descartes UMR-S 1022 Inserm, 4 avenue de l'Observatoire, Paris, 75006, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111641DOI Listing
December 2019

Composition design and medical application of liposomes.

Eur J Med Chem 2019 Feb 7;164:640-653. Epub 2019 Jan 7.

China International Science and Technology, Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Tianjin International Cooperation Research Centre of Food Nutrition/ Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.01.007DOI Listing
February 2019

A β-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy.

Eur J Med Chem 2018 Oct 3;158:1-6. Epub 2018 Sep 3.

Institut de Chimie des Milieux et des Matériaux de Poitiers (IC2MP), Université de Poitiers, CNRS, Groupe "Systèmes Moléculaires Programmés", 4 rue Michel Brunet, TSA 51106, F-86073, Poitiers, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183077
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http://dx.doi.org/10.1016/j.ejmech.2018.08.100DOI Listing
October 2018

One-pot synthesis of β-lactams by the Ugi and Michael addition cascade reaction.

Org Biomol Chem 2018 08;16(33):6096-6105

China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Tianjin International Cooperation Research Centre of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin, 300457, China.

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http://xlink.rsc.org/?DOI=C8OB01176A
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http://dx.doi.org/10.1039/c8ob01176aDOI Listing
August 2018

Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor.

Eur J Med Chem 2017 Jan 22;125:696-709. Epub 2016 Sep 22.

ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, Bretagne, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.09.064DOI Listing
January 2017

Therapeutic approaches of diseases related to misfolded proteins.

Eur J Med Chem 2016 Oct;121:773

Scripps Florida, USA.

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http://dx.doi.org/10.1016/j.ejmech.2016.07.036DOI Listing
October 2016

Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines.

J Biomed Sci 2015 Jul 17;22:57. Epub 2015 Jul 17.

Laboratoire de Thérapie Cellulaire et Immunobiologie du Cancer, Université de Bretagne Occidentale, CHRU Morvan, 5 avenue Foch, 29609, Brest Cedex, France.

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http://dx.doi.org/10.1186/s12929-015-0163-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504225PMC
July 2015

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents.

Molecules 2014 Sep 23;19(9):15237-57. Epub 2014 Sep 23.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (LCBPT), UMR 8601 CNRS, Université Paris Descartes, Sorbonne Paris Cité, UFR Biomédicale des Saints Pères, 45 rue des Saints-Pères, Paris 75270, France.

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http://dx.doi.org/10.3390/molecules190915237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271241PMC
September 2014

Cyclin-dependent kinase inhibitors closer to market launch?

Expert Opin Ther Pat 2013 Aug 22;23(8):945-63. Epub 2013 Apr 22.

Laboratoire de Chimie Organique 2, INSERM U 1022, Université Paris - Descartes, 4 avenue de l'Observatoire, 75270 Paris cedex 06, France.

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http://dx.doi.org/10.1517/13543776.2013.789861DOI Listing
August 2013

Introduction for the special issue on kinase inhibitors.

Authors:
Hervé Galons

Eur J Med Chem 2013 Mar 5;61. Epub 2012 Dec 5.

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http://dx.doi.org/10.1016/j.ejmech.2012.12.001DOI Listing
March 2013

Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.

Bioorg Med Chem Lett 2013 Jan 10;23(1):125-31. Epub 2012 Nov 10.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, Sorbonne Paris Cité, UFR Biomédicale des Saints Pères, 45 rue des Saints Pères, 75270 Paris cedex 06, France.

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http://dx.doi.org/10.1016/j.bmcl.2012.10.141DOI Listing
January 2013

Small-molecule inducers of Aβ-42 peptide production share a common mechanism of action.

FASEB J 2012 Dec 12;26(12):5115-23. Epub 2012 Sep 12.

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA.

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http://dx.doi.org/10.1096/fj.12-212985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509055PMC
December 2012

Use of ATP analogs to inhibit HIV-1 transcription.

Virology 2012 Oct 6;432(1):219-31. Epub 2012 Jul 6.

National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA.

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http://dx.doi.org/10.1016/j.virol.2012.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431923PMC
October 2012

A sweet origin for the key congocidine precursor 4-acetamidopyrrole-2-carboxylate.

Angew Chem Int Ed Engl 2012 Jul 15;51(30):7454-8. Epub 2012 Jun 15.

Institut de Génétique et Microbiologie, Université Paris-Sud, CNRS, UMR8621, 91405 Orsay, France.

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http://dx.doi.org/10.1002/anie.201201445DOI Listing
July 2012

Targeting low molecular weight cyclin E (LMW-E) in breast cancer.

Breast Cancer Res Treat 2012 Apr 22;132(2):575-88. Epub 2011 Jun 22.

Department of Experimental Radiation Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s10549-011-1638-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855283PMC
April 2012

The FAF-Drugs2 server: a multistep engine to prepare electronic chemical compound collections.

Bioinformatics 2011 Jul 2;27(14):2018-20. Epub 2011 Jun 2.

MTi, Ressource Parisienne en Bioinformatique Structurale, Institut National de Santé et de Recherche Médicale (INSERM), UMR-S 973 - Paris Diderot University, 75205 Paris, Cedex 13, France.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btr333DOI Listing
July 2011

Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding.

Biochimie 2011 Jun 17;93(6):1047-54. Epub 2011 Mar 17.

Department of Cell and Molecular Biology, Uppsala University, Box-596, BMC, 75124 Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.biochi.2011.03.002DOI Listing
June 2011

Cyclin-dependent kinase inhibitors: a survey of recent patent literature.

Expert Opin Ther Pat 2010 Mar;20(3):377-404

INSERM U648, Université Paris Descartes, 4 avenue de l'observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1517/13543770903524284DOI Listing
March 2010

Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography.

Bioconjug Chem 2010 Feb;21(2):279-88

Laboratoire de Chimie Organique 2, INSERM U648, Universite Paris-Descartes, 4 avenue de l'Observatoire, 75270 Paris cedex 06, France.

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http://dx.doi.org/10.1021/bc900314nDOI Listing
February 2010

Antiprion drugs as chemical tools to uncover mechanisms of prion propagation.

Prion 2007 Jan-Mar;1(1):48-52. Epub 2007 Jan 20.

INSERM U613, CHU de Brest, Faculté de Médecine de l'Université de Bretagne Occidentale, 46 rue Félix Le Dantec, Brest, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633708PMC
http://dx.doi.org/10.4161/pri.1.1.4053DOI Listing
March 2009

Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application.

Bioorg Med Chem Lett 2009 Feb 7;19(3):878-81. Epub 2008 Dec 7.

Université d'Avignon, Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, 33 rue Louis Pasteur, 84000 Avignon, France.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.118DOI Listing
February 2009

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

J Med Chem 2008 Sep 13;51(17):5229-42. Epub 2008 Aug 13.

Laboratoire de Chimie Organique 2, INSERM U 648, Universite Paris-Descartes, 4 avenue de l'Observatoire, 75270 Paris cedex 06, France.

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http://dx.doi.org/10.1021/jm800109eDOI Listing
September 2008

FAF-Drugs2: free ADME/tox filtering tool to assist drug discovery and chemical biology projects.

BMC Bioinformatics 2008 Sep 24;9:396. Epub 2008 Sep 24.

INSERM U648, MTi team, Paris Descartes University, Paris Diderot University, Paris, France.

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http://dx.doi.org/10.1186/1471-2105-9-396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561050PMC
September 2008

Estrone sulfate (E1S), a prognosis marker for tumor aggressiveness in prostate cancer (PCa).

J Steroid Biochem Mol Biol 2008 Mar 8;109(1-2):158-67. Epub 2008 Feb 8.

AP-HP CIB INSERM IMRB U841eq07, Henri Mondor, Faculté de Médecine, 94010 Créteil, France.

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http://dx.doi.org/10.1016/j.jsbmb.2007.10.005DOI Listing
March 2008

Investigation of N-hydroxythalidomide in vitro stability and comparison to other N-substituted derivatives.

J Pharm Biomed Anal 2007 Oct 14;45(2):237-42. Epub 2007 Jun 14.

UMR 6014 CNRS, Université de Rouen, Equipe de chimie Pharmaceutique, Faculté de Médecine et de Pharmacie, 22 Boulevard Gambetta, 76183 Rouen Cedex 1, France.

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http://dx.doi.org/10.1016/j.jpba.2007.06.010DOI Listing
October 2007

Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography.

Biotechnol J 2007 Jan;2(1):68-75

CNRS, Molecules and Therapeutic Targets Laboratory, Station Biologique, Roscoff, France.

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http://dx.doi.org/10.1002/biot.200600223DOI Listing
January 2007

A yeast-based assay to isolate drugs active against mammalian prions.

Methods 2006 May;39(1):72-7

CNRS, Station Biologique, UPS2682, Place G. Teissier, 29680 Roscoff, Bretagne, France.

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http://dx.doi.org/10.1016/j.ymeth.2006.04.005DOI Listing
May 2006

Development of murine monoclonal antibodies to methamphetamine and methamphetamine analogues.

J Immunol Methods 2006 Feb 20;309(1-2):1-10. Epub 2005 Dec 20.

Etablissement Français du Sang, Laboratoire de Biotechnologie, 34 bd J Monnet, BP 91115, 44011 Nantes cedex 01, France.

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http://dx.doi.org/10.1016/j.jim.2005.10.017DOI Listing
February 2006

Design of cocaethylene and cocaine conjugates to produce highly selective polyclonal antibodies.

Int J Biomed Sci 2006 Feb;2(1):53-8

Laboratoires de chimie organique et de Pharmacocinétique, 4, avenue de L'observatoire, Paris, France;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614565PMC
February 2006

Using budding yeast to screen for anti-prion drugs.

Biotechnol J 2006 Jan;1(1):58-67

CNRS UMR7150, Amyloids and Cell Division Cycle Laboratory, Station Biologique, Roscoff, Bretagne, France.

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http://dx.doi.org/10.1002/biot.200500001DOI Listing
January 2006

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.

J Biol Chem 2005 Sep 28;280(35):31220-9. Epub 2005 Jun 28.

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China.

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http://dx.doi.org/10.1074/jbc.M500805200DOI Listing
September 2005

Role of GABA-ergic and serotonergic systems in the anxiolytic-like mechanism of action of a 5-HT-moduline antagonist in the mouse elevated plus maze.

Behav Brain Res 2005 Mar;158(2):339-48

EA 3256, Neurobiologie de l'anxiété et de la dépression, Faculté de Médecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes Cedex 01, France.

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http://dx.doi.org/10.1016/j.bbr.2004.09.015DOI Listing
March 2005

Anxiolytic profile of HG1, a 5-HT-moduline antagonist, in three mouse models of anxiety.

Eur Neuropsychopharmacol 2004 Dec;14(6):449-56

EA 3256 Neurobiologie de l'anxiété et de la dépression, Faculté de Médecine, BP 53508, 1 rue Gaston Veil, 44035 Nantes cedex 01, France.

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http://dx.doi.org/10.1016/j.euroneuro.2003.12.004DOI Listing
December 2004

Development of monoclonal antibodies directed against cocaine and cocaethylene: potential new tools for immunotherapy.

Hybrid Hybridomics 2004 Aug;23(4):212-8

Etablissement Français du Sang, Laboratoire de Biotechnologie, Nantes, France.

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http://dx.doi.org/10.1089/1536859041651286DOI Listing
August 2004

Development of a highly sensitive and specific new testosterone time-resolved fluoroimmunoassay in human serum.

Steroids 2004 Jul;69(7):461-71

Emi Inserm 03-37, Centre de Recherche Chirurgicale CHU Henri Mondor, Faculté de Médecine, 8 rue du Général Sarrail 94010 Créteil France.

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http://dx.doi.org/10.1016/j.steroids.2004.04.008DOI Listing
July 2004

Isolation of drugs active against mammalian prions using a yeast-based screening assay.

Nat Biotechnol 2003 Sep 10;21(9):1075-81. Epub 2003 Aug 10.

C.N.R.S., Station Biologique, Cell Cycle Laboratory, place Georges Teissier, 29680 ROSCOFF, Bretagne, France.

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http://dx.doi.org/10.1038/nbt855DOI Listing
September 2003

Plasma 11beta-hydroxy-4-androstene-3,17-dione: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunoassay using a tritiated tracer.

J Steroid Biochem Mol Biol 2003 Apr;84(5):563-8

Laboratoire d'Hormonologie, Hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Cedex 10, Paris, France

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http://dx.doi.org/10.1016/s0960-0760(03)00077-3DOI Listing
April 2003

Development of a new sensitive and specific time-resolved fluoroimmunoassay (TR-FIA) of chlormadinone acetate in the serum of treated menopausal women.

Steroids 2002 Dec;67(13-14):1045-55

Laboratoire de Biologie Hormonale, Hôpital Saint-Louis, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France.

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http://dx.doi.org/10.1016/s0039-128x(02)00050-8DOI Listing
December 2002

Separation of oxazepam, lorazepam, and temazepam enantiomers by HPLC on a derivatized cyclodextrin-bonded phase: application to the determination of oxazepam in plasma.

J Biochem Biophys Methods 2002 Dec;54(1-3):287-99

Laboratory of Toxicology, Faculty of Pharmacy, University of Paris V, 4 avenue de l'Observatoire, 75006 Paris, France.

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http://dx.doi.org/10.1016/s0165-022x(02)00123-9DOI Listing
December 2002

Specific radioimmunoassay of estrone sulfate. Application to measurement in male plasma.

J Steroid Biochem Mol Biol 2002 May;81(1):85-94

Laboratoire de Biologie Hormonale, Hôpital Saint-Louis, Paris, France.

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http://dx.doi.org/10.1016/s0960-0760(02)00051-1DOI Listing
May 2002