Publications by authors named "Hermann Gram"

39Publications

Combination Therapy for Treating Advanced Drug-Resistant Acute Lymphoblastic Leukemia.

Cancer Immunol Res 2019 07 28;7(7):1106-1119. Epub 2019 May 28.

Division of Hematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, Ohio.

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July 2019

The long and winding road in pharmaceutical development of canakinumab from rare genetic autoinflammatory syndromes to myocardial infarction and cancer.

Authors:
Hermann Gram

Pharmacol Res 2020 04 14;154:104139. Epub 2019 Jan 14.

Novartis Institutes for BioMedical Research, Forum 1, CH-4002 Basel, Switzerland. Electronic address:

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April 2020

Neutralization of Interleukin-1β following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes.

J Neurotrauma 2018 12 30;35(23):2837-2849. Epub 2018 Jul 30.

1 Department of Neuroscience, Section of Neurosurgery, Uppsala University , Uppsala, Sweden .

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December 2018

Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis.

Shock 2016 11;46(5):566-574

*Center for Infection and Immunity Amsterdam (CINIMA)/Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands †Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands ‡Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand §Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK ||Novartis Institutes for BioMedical Research, Basel, Switzerland ¶Department of Internal medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands.

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November 2016

Preclinical characterization and clinical development of ILARIS(®) (canakinumab) for the treatment of autoinflammatory diseases.

Authors:
Hermann Gram

Curr Opin Chem Biol 2016 06 23;32:1-9. Epub 2015 Dec 23.

Novartis Institutes of BioMedical Research, Forum 1, CH-4002 Basel, Switzerland. Electronic address:

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June 2016

Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.

J Biol Chem 2016 Feb 14;291(7):3455-67. Epub 2015 Dec 14.

Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, and.

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February 2016

The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β.

MAbs 2015 18;7(6):1151-60. Epub 2015 Aug 18.

a Novartis Institutes for BioMedical Research ; Basel , Switzerland.

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August 2016

Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes.

Curr Opin Rheumatol 2014 Sep;26(5):543-52

aNovartis Institutes for Biomedical Research, Cambridge, Massachusetts bChildren's Hospital Medical Center, Cincinnati, Ohio, USA cNovartis Institutes for Biomedical Research, Basel, Switzerland.

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September 2014

Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R.

Mol Cancer Ther 2014 Jun 13;13(6):1567-77. Epub 2014 May 13.

Authors' Affiliations: Section of Molecular Carcinogenesis; Division of Hematology/Oncology and Bone Marrow Transplantation, The Saban Research Institute, Children's Hospital Los Angeles; Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California; Oncology Translational Medicine and Oncology Research, Novartis Institutes for Biomedical Research, Novartis Pharmaceuticals, Cambridge, Massachusetts; and Autoimmunity, Transplantation and Inflammation, Novartis Institute for Biomedical Research, Basel, SwitzerlandAuthors' Affiliations: Section of Molecular Carcinogenesis; Division of Hematology/Oncology and Bone Marrow Transplantation, The Saban Research Institute, Children's Hospital Los Angeles; Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California; Oncology Translational Medicine and Oncology Research, Novartis Institutes for Biomedical Research, Novartis Pharmaceuticals, Cambridge, Massachusetts; and Autoimmunity, Transplantation and Inflammation, Novartis Institute for Biomedical Research, Basel, SwitzerlandAuthors' Affiliations: Section of Molecular Carcinogenesis; Division of Hematology/Oncology and Bone Marrow Transplantation, The Saban Research Institute, Children's Hospital Los Angeles; Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California; Oncology Translational Medicine and Oncology Research, Novartis Institutes for Biomedical Research, Novartis Pharmaceuticals, Cambridge, Massachusetts; and Autoimmunity, Transplantation and Inflammation, Novartis Institute for Biomedical Research, Basel, Switzerland

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June 2014

Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis.

J Am Heart Assoc 2012 Jun 22;1(3):e002006. Epub 2012 Jun 22.

Faculty of Life Sciences, University of Manchester, Manchester, UK (A.D., C.D., S.M.A., N.J.R.).

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June 2012

Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.

Eur J Neurosci 2011 Jul 30;34(1):110-23. Epub 2011 May 30.

Department of Neuroscience, Section for Neurosurgery, Uppsala University, Entrance 85, 2nd floor, Uppsala University Hospital, S-75185 Uppsala, Sweden.

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July 2011