Herbert Y Meltzer

Herbert Y Meltzer

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Herbert Y Meltzer

Herbert Y Meltzer

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A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugs.

Pharmacogenomics J 2020 Apr 21;20(2):260-270. Epub 2019 Oct 21.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1038/s41397-019-0101-5DOI Listing
April 2020

Effects of NBI-98782, a selective vesicular monoamine transporter 2 (VMAT2) inhibitor, on neurotransmitter efflux and phencyclidine-induced locomotor activity: Relevance to tardive dyskinesia and antipsychotic action.

Pharmacol Biochem Behav 2020 Mar 18;190:172872. Epub 2020 Feb 18.

Departments of Psychiatry and Behavioral Sciences, Pharmacology, and Physiology, School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2020.172872DOI Listing
March 2020

The effect of high vs. low dose lurasidone on eye movement biomarkers of prefrontal abilities in treatment-resistant schizophrenia.

Schizophr Res 2020 Jan 6;215:314-321. Epub 2019 Nov 6.

Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, 710 N Lake Shore Drive, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1016/j.schres.2019.10.008DOI Listing
January 2020

The Role of Dopamine D Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.

J Pharmacol Exp Ther 2019 Nov 11;371(2):517-525. Epub 2019 Sep 11.

Department of Psychiatry and Behavior Science, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (M.H., W.H., H.Y.M.); Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary (B.K., B.F.); and Allergan, Madison, New Jersey (N.A.)

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http://dx.doi.org/10.1124/jpet.119.259879DOI Listing
November 2019

Genome-wide association study on antipsychotic-induced weight gain in Europeans and African-Americans.

Schizophr Res 2019 10 22;212:204-212. Epub 2019 Aug 22.

Pharmacogenetic Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2019.07.022DOI Listing
October 2019

Impact of histamine receptors H1 and H3 polymorphisms on antipsychotic-induced weight gain.

World J Biol Psychiatry 2018 15;19(sup3):S97-S105. Epub 2016 Dec 15.

a Neurogenetics Section, Neuroscience Department , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/15622975.2016.1262061DOI Listing
September 2019

New Trends in the Treatment of Schizophrenia.

CNS Neurol Disord Drug Targets 2017 ;16(8):900-906

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 303 East Chicago Ave, Ward Building 7-101, Chicago, Il 60611, United States.

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http://dx.doi.org/10.2174/1871527316666170728165355DOI Listing
March 2019

Association of Serotonin Receptor Polymorphisms With Antipsychotic Drug Response in Schizophrenia.

Front Psychiatry 2019 15;10:58. Epub 2019 Feb 15.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Evanston, IL, United States.

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00058
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http://dx.doi.org/10.3389/fpsyt.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384235PMC
February 2019

Genetic study of neuregulin 1 and receptor tyrosine-protein kinase erbB-4 in tardive dyskinesia.

World J Biol Psychiatry 2019 01 10;20(1):91-95. Epub 2017 Apr 10.

a Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada.

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http://dx.doi.org/10.1080/15622975.2017.1301681DOI Listing
January 2019

Genetic validation study of protein tyrosine phosphatase receptor type D (PTPRD) gene variants and risk for antipsychotic-induced weight gain.

J Neural Transm (Vienna) 2019 01 18;126(1):27-33. Epub 2018 Sep 18.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, R-132, Toronto, ON, M5T1R8, Canada.

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http://dx.doi.org/10.1007/s00702-018-1921-1DOI Listing
January 2019

TPA-023 attenuates subchronic phencyclidine-induced declarative and reversal learning deficits via GABA receptor agonist mechanism: possible therapeutic target for cognitive deficit in schizophrenia.

Neuropsychopharmacology 2018 11 23;43(12):2468-2477. Epub 2018 Jul 23.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://www.nature.com/articles/s41386-018-0160-3
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http://dx.doi.org/10.1038/s41386-018-0160-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180114PMC
November 2018

Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia.

Neurosci Lett 2018 11 15;686:17-22. Epub 2018 Aug 15.

Neurogenetics Section, Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, CAMH, Canada; Institute of Medical Science, University of Toronto, Canada; Department of Psychiatry, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada. Electronic address:

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https://www.sciencedirect.com/journal/neuroscience-letters/v
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https://academic.oup.com/ntr/article-abstract/11/4/404/11007
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https://academic.oup.com/schizophreniabulletin/article/21/2/
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https://linkinghub.elsevier.com/retrieve/pii/S03043940183053
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http://dx.doi.org/10.1016/j.neulet.2018.08.007DOI Listing
November 2018

5-HT parital agonism and 5-HT antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA.

Psychopharmacology (Berl) 2018 Oct 31;235(10):2795-2808. Epub 2018 Jul 31.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave., Ward Building 7-014, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s00213-018-4972-yDOI Listing
October 2018

Identifying the genetic risk factors for treatment response to lurasidone by genome-wide association study: A meta-analysis of samples from three independent clinical trials.

Schizophr Res 2018 09 2;199:203-213. Epub 2018 May 2.

Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09209964183019
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http://dx.doi.org/10.1016/j.schres.2018.04.006DOI Listing
September 2018

Hippocampal GABA antagonism reverses the novel object recognition deficit in sub-chronic phencyclidine-treated rats.

Behav Brain Res 2018 04 28;342:11-18. Epub 2017 Dec 28.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 303 East Chicago Ave #7-101, Chicago, IL, 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.12.033DOI Listing
April 2018

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology.

Cell Stem Cell 2018 04 15;22(4):559-574.e9. Epub 2018 Mar 15.

The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535433PMC
April 2018

Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes.

Schizophr Res 2018 02 19;192:194-204. Epub 2017 Apr 19.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2017.04.009DOI Listing
February 2018

Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain.

Neuropsychobiology 2016 23;74(3):169-175. Epub 2017 May 23.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1159/000457903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653224PMC
February 2018

Muscarinic receptor signaling contributes to atypical antipsychotic drug reversal of the phencyclidine-induced deficit in novel object recognition in rats.

J Psychopharmacol 2017 12 25;31(12):1588-1604. Epub 2017 Sep 25.

1 Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, USA.

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http://dx.doi.org/10.1177/0269881117731278DOI Listing
December 2017

New Trends in the Treatment of Schizophrenia.

CNS Neurol Disord Drug Targets 2017 ;16(8):900-906

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 303 East Chicago Ave, Ward Building 7-101, Chicago, Il 60611, United States.

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http://dx.doi.org/10.2174/1871527316666170728165355DOI Listing
March 2019

5-HT Agonists Modulate Schizophrenia-Like Behaviors in Mice.

Neuropsychopharmacology 2017 Oct 15;42(11):2163-2177. Epub 2017 Mar 15.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1038/npp.2017.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603814PMC
October 2017

RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia.

Behav Brain Res 2017 08 31;332:180-199. Epub 2017 Mar 31.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01664328163094
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http://dx.doi.org/10.1016/j.bbr.2017.02.036DOI Listing
August 2017

Δ9-tetrahydrocannabinol (Δ9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice.

Pharmacol Biochem Behav 2017 08 23;159:6-11. Epub 2017 Jun 23.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2017.06.010DOI Listing
August 2017

Neurochemical arguments for the use of dopamine D receptor stimulation to improve cognitive impairment associated with schizophrenia.

Pharmacol Biochem Behav 2017 06 25;157:16-23. Epub 2017 Apr 25.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00913057163026
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http://dx.doi.org/10.1016/j.pbb.2017.04.010DOI Listing
June 2017

Randomized controlled trial of deutetrabenazine for tardive dyskinesia: The ARM-TD study.

Neurology 2017 May 26;88(21):2003-2010. Epub 2017 Apr 26.

From the Cleveland Clinic (H.H.F.), Center for Neurological Restoration, Cleveland, OH; Emory University (S.A.F.), Atlanta, GA; University of South Florida Parkinson's Disease and Movement Disorders Center (R.A.H.), Tampa, FL; Baylor College of Medicine (J.J.-S.), Houston, TX; Methodist Neurological Institute (W.G.O.), Houston, TX; University of North Carolina School of Medicine (L.F.J.), Chapel Hill, NC; Northwestern University Feinberg School of Medicine (H.Y.M., D.B.), Chicago, IL; Yale School of Medicine (S.W.W.), New Haven, CT; University of Tennessee Health Science Center (M.S.L.), Memphis, TN; University of Utah Health Care (D.R.S.), Salt Lake City, UT; Banner Sun Health Research Institute (D.R.S.), Sun City, AZ; CSD Biostatistics (C.D.), Tucson, AZ; Teva Pharmaceutical Industries (M.D.D.), Frazer, PA; Teva Pharmaceuticals (D.S.), La Jolla, CA; and Georgetown University (K.E.A.), Washington, DC.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000003960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440239PMC
May 2017

Dopamine D receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia.

J Psychopharmacol 2017 04 1;31(4):442-452. Epub 2017 Feb 1.

1 Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, USA.

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http://journals.sagepub.com/doi/10.1177/0269881117693746
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http://dx.doi.org/10.1177/0269881117693746DOI Listing
April 2017

GSK-3β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.

CNS Neurosci Ther 2017 Feb 20;23(2):174-187. Epub 2016 Dec 20.

Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Soochow University, Suzhou, Jiangsu, China.

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http://dx.doi.org/10.1111/cns.12664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492711PMC
February 2017

Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine.

Mol Neuropsychiatry 2017 Feb 12;2(4):185-197. Epub 2016 Oct 12.

Neuroscience Research Department, Campbell Family Research Institute, Toronto, Ont., Canada; Institute of Medical Science, Toronto, Ont., Canada; Department of Psychiatry, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000449224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318922PMC
February 2017

Association study between the neurexin-1 gene and tardive dyskinesia.

Hum Psychopharmacol 2017 01;32(1)

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/hup.2568DOI Listing
January 2017

Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U.

Biol Psychiatry 2016 12 8;80(11):878-887. Epub 2016 Mar 8.

Center for Addiction Research, Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016225PMC
December 2016

Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response.

Pharmacogenomics 2016 15;17(2):103-9. Epub 2015 Dec 15.

250 College Street, Pharmacogenetic Research Clinic, Centre for Addiction & Mental Health, Toronto, ON, M5T 1R8, Canada.

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http://dx.doi.org/10.2217/pgs.15.155DOI Listing
September 2016

The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia.

Curr Pharm Des 2014 ;20(31):5104-14

Psychiatry and Behavioral Science, Northwestern University, Feinberg School of Medicine, 303E Chicago Ave, Ward Building 12-014, Chicago, IL 60611.

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http://dx.doi.org/10.2174/1381612819666131216114240DOI Listing
May 2016

Catechol-O-Methyltransferase Val158Met Polymorphism and Clinical Response to Antipsychotic Treatment in Schizophrenia and Schizo-Affective Disorder Patients: a Meta-Analysis.

Int J Neuropsychopharmacol 2016 05 29;19(5). Epub 2016 Apr 29.

Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada (Mr Huang, Dr Zai, Ms Lisoway, Dr Maciukiewicz, Mr Felsky, Dr Tiwari, Dr Müller, and Dr Kennedy); Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN (Dr Bishop); Department of Psychiatry, Fujita Health University, Toyoake, Aichi, Japan (Dr Ikeda); Departamento de Psiquiatria, Clinica Universidad de Navarra, Pamplona, Spain (Drs Molero and Ortuno); Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy (Dr Porcelli); Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland (Dr Samochowiec); Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, Poland (Dr Mierzejewski); Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, China (Dr Gao); Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla- IDIVAL, School of Medicine, University of Cantabria, Santander, Spain (Dr Pelayo-Terán); Institute of Genomics and Integrative Biology, Delhi, India (Drs Kaur and Kukreti); Feinberg School of Medicine, Northwestern University, Chicago, IL (Dr Meltzer); Department of Psychiatry, Columbia University Medical Center, New York, NY (Dr Lieberman); Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA (Dr Potkin).

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http://dx.doi.org/10.1093/ijnp/pyv132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886669PMC
May 2016

Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.

World J Biol Psychiatry 2016 04 8;17(3):221-9. Epub 2015 Oct 8.

a Pharmacogenetics Research Clinic, Neurogenetics Section , Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto , ON , Canada .

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http://dx.doi.org/10.3109/15622975.2015.1076173DOI Listing
April 2016

A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells.

PLoS One 2015 31;10(3):e0121707. Epub 2015 Mar 31.

Cancer Biology and Epigenomics Program, Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States of America; Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America; Division of Hematology/Oncology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121707PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380339PMC
March 2016

Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism.

Behav Brain Res 2016 Mar 3;301:132-41. Epub 2015 Sep 3.

Division of Psychiatry and Behavioural Sciences, Northwestern University Feinberg School of Medicine, Chicago IL 60611, USA; Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville TN 37212, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.08.040DOI Listing
March 2016

Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition.

Behav Brain Res 2016 Mar 28;301:204-12. Epub 2015 Oct 28.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 303 East Chicago Ave #7-101, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.10.044DOI Listing
March 2016

Genetic association analysis of N-methyl-D-aspartate receptor subunit gene GRIN2B and clinical response to clozapine.

Hum Psychopharmacol 2016 Mar 15;31(2):121-34. Epub 2016 Feb 15.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/hup.2519DOI Listing
March 2016

Serotonin (5-HT)1A receptor agonism and 5-HT7 receptor antagonism ameliorate the subchronic phencyclidine-induced deficit in executive functioning in mice.

Psychopharmacology (Berl) 2016 Feb 12;233(4):649-60. Epub 2015 Nov 12.

Department of Psychiatry and Behavioral Science, Northwestern University, Feinberg School of Medicine, 303E Chicago Ave, Ward Building 7-101, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s00213-015-4137-1DOI Listing
February 2016

GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice.

Behav Brain Res 2016 Feb 26;299:105-10. Epub 2015 Nov 26.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 303 E Chicago Ave., 7-101, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2015.10.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721234PMC
February 2016

Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus.

Neuropharmacology 2016 Jan 30;100:90-7. Epub 2015 Apr 30.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584174PMC
January 2016

Cariprazine in acute exacerbation of schizophrenia: a fixed-dose, phase 3, randomized, double-blind, placebo- and active-controlled trial.

J Clin Psychiatry 2015 Dec;76(12):e1574-82

Clinical Development, Forest Research Institute, an Allergan affiliate, Harborside Financial Center, Plaza V, Jersey City, NJ 07311

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http://dx.doi.org/10.4088/JCP.15m09997DOI Listing
December 2015

Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement.

Pharmacol Biochem Behav 2015 Nov 14;138:49-57. Epub 2015 Sep 14.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pbb.2015.09.011DOI Listing
November 2015

Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis.

Angew Chem Int Ed Engl 2015 Jun 27;54(23):6900-4. Epub 2015 Apr 27.

Department of Chemistry Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (USA).

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http://dx.doi.org/10.1002/anie.201502011DOI Listing
June 2015

Attention Must Be Paid: The Association of Plasma Clozapine/NDMC Ratio With Working Memory.

Am J Psychiatry 2015 Jun;172(6):502-4

From the Departments of Psychiatry and Pharmacology, Northwestern University Feinberg School of Medicine, Chicago.

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http://dx.doi.org/10.1176/appi.ajp.2015.15030338DOI Listing
June 2015

Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats.

Behav Brain Res 2015 May 16;285:165-75. Epub 2014 Oct 16.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 303 East Chicago Ave #12-013, Chicago, IL 60611, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01664328140063
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http://dx.doi.org/10.1016/j.bbr.2014.09.040DOI Listing
May 2015

Involvement of cholinergic system in hyperactivity in dopamine-deficient mice.

Neuropsychopharmacology 2015 Mar 13;40(5):1141-50. Epub 2015 Mar 13.

Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1038/npp.2014.295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367456PMC
March 2015

Decreased serotonin2C receptor responses in male patients with schizophrenia.

Psychiatry Res 2015 Mar 15;226(1):308-15. Epub 2015 Jan 15.

Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2015.01.007DOI Listing
March 2015

Association study of GABAA α2 receptor subunit gene variants in antipsychotic-associated weight gain.

J Clin Psychopharmacol 2015 Feb;35(1):7-12

From the *Neurogenetics Section, Centre for Addiction and Mental Health; †Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; ‡Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, Berlin, Germany; §Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York State Psychiatric Institute, Lieber Center for Schizophrenia Research, New York Presbyterian Hospital & Columbia University Medical Center, New York, NY; and ║Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.

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http://dx.doi.org/10.1097/JCP.0000000000000261DOI Listing
February 2015

Fat mass- and obesity-associated (FTO) gene and antipsychotic-induced weight gain: an association study.

Neuropsychobiology 2014 30;69(1):59-63. Epub 2014 Jan 30.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ont., Canada.

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http://dx.doi.org/10.1159/000356231DOI Listing
January 2015

Genetic variation in CYP3A43 is associated with response to antipsychotic medication.

J Neural Transm (Vienna) 2015 Jan 24;122(1):29-34. Epub 2014 Aug 24.

Pharmacogenetics Research Clinic, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, 250 College Street, Toronto, ON, M5T1R8, Canada,

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http://dx.doi.org/10.1007/s00702-014-1298-8DOI Listing
January 2015

The role of genetic variation across IL-1β, IL-2, IL-6, and BDNF in antipsychotic-induced weight gain.

World J Biol Psychiatry 2015 Jan;16(1):45-56

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health & Department of Psychiatry, University of Toronto , Toronto, ON , Canada.

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http://dx.doi.org/10.3109/15622975.2014.984631DOI Listing
January 2015

The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens.

Psychopharmacology (Berl) 2014 Dec 9;231(23):4541-51. Epub 2014 May 9.

Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.

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http://dx.doi.org/10.1007/s00213-014-3596-0DOI Listing
December 2014

Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.

Psychopharmacology (Berl) 2014 Dec 27;231(24):4711-22. Epub 2014 May 27.

Department of Psychiatry and Behavioral Sciences, Feinberg School Medicine, Northwestern University, 303 E. Chicago Ave, Chicago, IL, 60611, USA,

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http://link.springer.com/10.1007/s00213-014-3629-8
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http://dx.doi.org/10.1007/s00213-014-3629-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233002PMC
December 2014

A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.

Schizophr Res 2014 Nov 13;159(2-3):333-9. Epub 2014 Sep 13.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, United States. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.08.018DOI Listing
November 2014

No evidence for a role of the peroxisome proliferator-activated receptor gamma (PPARG) and adiponectin (ADIPOQ) genes in antipsychotic-induced weight gain.

Psychiatry Res 2014 Oct 28;219(2):255-60. Epub 2014 May 28.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01651781140040
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http://dx.doi.org/10.1016/j.psychres.2014.05.031DOI Listing
October 2014

Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt.

Neuropsychopharmacology 2014 Jul 17;39(8):1902-13. Epub 2014 Feb 17.

Department of Molecular Therapeutics and Neuroscience, Scripps Research Institute, Jupiter, FL, USA.

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http://dx.doi.org/10.1038/npp.2014.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059899PMC
July 2014

Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain.

Hum Psychopharmacol 2014 Jul 16;29(4):330-5. Epub 2014 Apr 16.

Neurogenetics Section, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/hup.2407
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http://dx.doi.org/10.1002/hup.2407DOI Listing
July 2014

A hypothesis-driven association study of 28 nuclear-encoded mitochondrial genes with antipsychotic-induced weight gain in schizophrenia.

Neuropsychopharmacology 2014 May 7;39(6):1347-54. Epub 2013 Nov 7.

1] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [2] Neuroscience Section, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/npp.2013.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988538PMC
May 2014

The alpha-7 nicotinic receptor partial agonist/5-HT3 antagonist RG3487 enhances cortical and hippocampal dopamine and acetylcholine release.

Psychopharmacology (Berl) 2014 May 7;231(10):2199-210. Epub 2013 Dec 7.

Division of Psychopharmacology, Vanderbilt University School of Medicine, Nashville, TN, 37212, USA.

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http://link.springer.com/10.1007/s00213-013-3373-5
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May 2014

Investigation of melanocortin system gene variants in antipsychotic-induced weight gain.

World J Biol Psychiatry 2014 Apr 24;15(3):251-8. Epub 2014 Feb 24.

Neurogenetics Section, Neuroscience Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health , Toronto, ON , Canada.

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http://dx.doi.org/10.3109/15622975.2013.858827DOI Listing
April 2014

Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism.

J Neurochem 2014 Mar 14;128(6):938-49. Epub 2013 Nov 14.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1111/jnc.12512DOI Listing
March 2014

Genetic variation in the GCG and in the GLP1R genes and antipsychotic-induced weight gain.

Pharmacogenomics 2014 Mar;15(4):423-31

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction & Mental Health, Toronto, ON, Canada.

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https://www.futuremedicine.com/doi/10.2217/pgs.13.247
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http://dx.doi.org/10.2217/pgs.13.247DOI Listing
March 2014

Language-dependent performance on the letter fluency task in patients with schizophrenia.

Schizophr Res 2014 Feb 17;152(2-3):421-9. Epub 2014 Jan 17.

National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, 187-8551 Tokyo, Japan.

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http://dx.doi.org/10.1016/j.schres.2013.12.009DOI Listing
February 2014

Translating the N-methyl-D-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia.

Int J Neuropsychopharmacol 2013 Nov;16(10):2181-94

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Il 60611, USA.

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http://dx.doi.org/10.1017/S1461145713000928DOI Listing
November 2013

Role of ethnicity in antipsychotic-induced weight gain and tardive dyskinesia: genes or environment?

Pharmacogenomics 2013 Aug;14(11):1273-81

Centre for Addiction & Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2217/pgs.13.127DOI Listing
August 2013

Update on typical and atypical antipsychotic drugs.

Annu Rev Med 2013 27;64:393-406. Epub 2012 Sep 27.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://www.annualreviews.org/doi/10.1146/annurev-med-050911-
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http://dx.doi.org/10.1146/annurev-med-050911-161504DOI Listing
July 2013

Augmentation of antipsychotic drug action by azapirone 5-HT1A receptor partial agonists: a meta-analysis.

Int J Neuropsychopharmacol 2013 Jul 3;16(6):1259-66. Epub 2013 Apr 3.

Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

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http://dx.doi.org/10.1017/S1461145713000151DOI Listing
July 2013

Serotonergic mechanisms as targets for existing and novel antipsychotics.

Handb Exp Pharmacol 2012 (212):87-124

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1007/978-3-642-25761-2_4DOI Listing
April 2013

Exploratory study on association of genetic variation in TBC1D1 with antipsychotic-induced weight gain.

Hum Psychopharmacol 2013 Mar 30;28(2):183-7. Epub 2013 Jan 30.

Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://doi.wiley.com/10.1002/hup.2288
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March 2013

D(1) receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats.

Behav Brain Res 2013 Feb 24;238:36-43. Epub 2012 Sep 24.

Division of Psychopharmacology, Vanderbilt University Medical Center, Nashville, TN 37212, USA.

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http://dx.doi.org/10.1016/j.bbr.2012.09.030DOI Listing
February 2013

Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients.

J Clin Psychopharmacol 2013 Feb;33(1):11-7

Neurogenetics Section, Neuroscience Department, Centre forAddiction and Mental Health & Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JCP.0b013e31827d145aDOI Listing
February 2013

Pimavanserin, a selective serotonin (5-HT)2A-inverse agonist, enhances the efficacy and safety of risperidone, 2mg/day, but does not enhance efficacy of haloperidol, 2mg/day: comparison with reference dose risperidone, 6mg/day.

Schizophr Res 2012 Nov 4;141(2-3):144-52. Epub 2012 Sep 4.

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Ward Bldg 12-104, 303 East Chicago Ave. Chicago, Il 60611, USA.

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http://dx.doi.org/10.1016/j.schres.2012.07.029DOI Listing
November 2012

The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain.

Prog Neuropsychopharmacol Biol Psychiatry 2012 Oct 27;39(1):96-101. Epub 2012 May 27.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2012.05.014DOI Listing
October 2012

Clozapine: balancing safety with superior antipsychotic efficacy.

Clin Schizophr Relat Psychoses 2012 Oct;6(3):134-44

Northwestern Feinberg School of Medicine, Ward Building-12-104, 303 East Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.3371/CSRP.6.3.5DOI Listing
October 2012

Sulfotransferase 4A1 Haplotype 1 (SULT4A1-1) Is Associated With Decreased Hospitalization Events in Antipsychotic-Treated Patients With Schizophrenia.

Prim Care Companion CNS Disord 2012 24;14(3). Epub 2012 Jun 24.

SureGene, LLC, Louisville, Kentucky (Drs Liu, Massey, and Brennan; Mr Ramsey; and Ms Padmanabhan); and Department of Psychiatry, Vanderbilt University, Nashville, Tennessee (Dr Meltzer).

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http://www.psychiatrist.com/pcc/article/pages/2012/v14n03/11
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http://dx.doi.org/10.4088/PCC.11m01293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466036PMC
October 2012

Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia.

Psychiatry Res 2012 Jul 12;198(2):202-6. Epub 2012 Mar 12.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.psychres.2011.12.035DOI Listing
July 2012

Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies.

Hum Psychopharmacol 2012 Jul 22;27(4):345-51. Epub 2012 Jun 22.

Neurogenetics Section, Center for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/hup.2233DOI Listing
July 2012

Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice.

Behav Pharmacol 2012 Jun;23(3):262-70

Department of Psychology, Virginia Commonwealth University, Richmond, Virginia 23284-2018, USA.

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http://dx.doi.org/10.1097/FBP.0b013e3283534332DOI Listing
June 2012

5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux.

Neuroreport 2012 May;23(7):436-40

Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WNR.0b013e328352de40DOI Listing
May 2012

Dopamine D4 and D5 receptor gene variant effects on clozapine response in schizophrenia: replication and exploration.

Prog Neuropsychopharmacol Biol Psychiatry 2012 Apr 8;37(1):62-75. Epub 2011 Dec 8.

Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.pnpbp.2011.11.018DOI Listing
April 2012

Association study between variants of AMP-activated protein kinase catalytic and regulatory subunit genes with antipsychotic-induced weight gain.

J Psychiatr Res 2012 Apr 2;46(4):462-8. Epub 2012 Feb 2.

Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.jpsychires.2012.01.010DOI Listing
April 2012

Tying comparative effectiveness information to decision-making and the future of comparative effectiveness research designs: the case for antipsychotic drugs.

J Comp Eff Res 2012 Mar;1(2):171-80

Department of Health Services, PORPP, University of Washington, 1959 NE Pacific St, Box-357660, Seattle, WA 98195-7660, USA.

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http://dx.doi.org/10.2217/cer.12.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237158PMC
March 2012

The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responses.

Mol Pharmacol 2012 Feb 9;81(2):113-9. Epub 2011 Nov 9.

Department of Physiology and Biophysics, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14214, USA.

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http://dx.doi.org/10.1124/mol.111.076141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263951PMC
February 2012