Publications by authors named "Herbert W Virgin"

100Publications

Advances in Genomics for Drug Development.

Genes (Basel) 2020 Aug 15;11(8). Epub 2020 Aug 15.

Vir Biotechnology, Inc., San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11080942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465049PMC
August 2020

Beth Cindy Levine (1960-2020).

Science 2020 Jul;369(6502):378

Broad Institute, Cambridge, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.abd6216DOI Listing
July 2020

Innate immune receptor NOD2 mediates LGR5 intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation.

Proc Natl Acad Sci U S A 2020 01 9;117(4):1994-2003. Epub 2020 Jan 9.

Molecular Microbial Pathogenesis Unit, Institut Pasteur, INSERM U1202, 75015 Paris, France;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1902788117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994981PMC
January 2020

Bile Salts Alter the Mouse Norovirus Capsid Conformation: Possible Implications for Cell Attachment and Immune Evasion.

J Virol 2019 10 12;93(19). Epub 2019 Sep 12.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00970-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744230PMC
October 2019

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis.

Cell Host Microbe 2019 06 23;25(6):845-857.e5. Epub 2019 May 23.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6622463PMC
June 2019

Drowning in Viruses.

Cell 2019 05;177(5):1084-1085

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Vir Biotechnology, San Francisco, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2019.04.045DOI Listing
May 2019

Virome biogeography in the lower gastrointestinal tract of rhesus macaques with chronic diarrhea.

Virology 2019 01 20;527:77-88. Epub 2018 Nov 20.

Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333316PMC
January 2019

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening.

J Virol 2019 01 10;93(1). Epub 2018 Dec 10.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01324-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288323PMC
January 2019

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.

Proc Natl Acad Sci U S A 2018 09 7;115(39):E9201-E9210. Epub 2018 Sep 7.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1805797115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166816PMC
September 2018

Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection.

Nat Microbiol 2018 10 20;3(10):1109-1114. Epub 2018 Aug 20.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-018-0221-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158067PMC
October 2018

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

ACS Infect Dis 2018 10 28;4(10):1499-1507. Epub 2018 Aug 28.

Department of Molecular Microbiology , Washington University in Saint Louis School of Medicine , 660 S. Euclid Avenue , St. Louis , Missouri 63110 , United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00135
Publisher Site
http://dx.doi.org/10.1021/acsinfecdis.8b00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200635PMC
October 2018

Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections.

Cell Rep 2018 03;22(13):3440-3453.e6

Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908250PMC
March 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Differentiation and Protective Capacity of Virus-Specific CD8 T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche.

Immunity 2017 10 11;47(4):723-738.e5. Epub 2017 Oct 11.

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2017.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077984PMC
October 2017

Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine.

Cell Host Microbe 2017 Oct 28;22(4):449-459.e4. Epub 2017 Sep 28.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2017.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679710PMC
October 2017

VirusSeeker, a computational pipeline for virus discovery and virome composition analysis.

Virology 2017 03 18;503:21-30. Epub 2017 Jan 18.

Departments of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326578PMC
March 2017

MHC II+ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes.

J Exp Med 2016 09 22;213(10):1951-9. Epub 2016 Aug 22.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20160486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030807PMC
September 2016

Discovery of a proteinaceous cellular receptor for a norovirus.

Science 2016 08 18;353(6302):933-6. Epub 2016 Aug 18.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aaf1220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484048PMC
August 2016

Impaired autophagy in macrophages promotes inflammatory eye disease.

Autophagy 2016 10 27;12(10):1876-1885. Epub 2016 Jul 27.

a Department of Ophthalmology and Visual Sciences , Washington University School of Medicine , St. Louis , MO , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15548627.2016.1207857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066937PMC
October 2016

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity.

PLoS Pathog 2016 06 21;12(6):e1005684. Epub 2016 Jun 21.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915689PMC
June 2016

Accounting for reciprocal host-microbiome interactions in experimental science.

Nature 2016 06;534(7606):191-9

Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature18285DOI Listing
June 2016

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.

J Cell Biol 2016 Feb;212(5):545-60

Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201507023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772497PMC
February 2016

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):2994-9. Epub 2016 Feb 29.

Department of Internal Medicine, Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX 75390; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1601860113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801257PMC
March 2016

Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine.

Science 2016 Jan 14;351(6270). Epub 2016 Jan 14.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aad5872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751997PMC
January 2016

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.

Nature 2015 Dec 9;528(7583):565-9. Epub 2015 Dec 9.

Department of Molecular Microbiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature16451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842313PMC
December 2015

Gut DNA viromes of Malawian twins discordant for severe acute malnutrition.

Proc Natl Acad Sci U S A 2015 Sep 8;112(38):11941-6. Epub 2015 Sep 8.

Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108; Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63108; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1514285112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586842PMC
September 2015

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells.

mBio 2015 Sep 8;6(5):e01157-15. Epub 2015 Sep 8.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.01157-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600106PMC
September 2015

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.

Cell Host Microbe 2015 Jun 2;17(6):811-819. Epub 2015 Jun 2.

Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466081PMC
June 2015

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation.

Nature 2015 May 16;521(7550):90-93. Epub 2015 Feb 16.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425643PMC
May 2015

Reservoir host immune responses to emerging zoonotic viruses.

Cell 2015 Jan 18;160(1-2):20-35. Epub 2014 Dec 18.

Merck Vaccines, Merck & Co. Inc., West Point, PA 19486, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390999PMC
January 2015

Type I interferons link viral infection to enhanced epithelial turnover and repair.

Cell Host Microbe 2015 Jan 4;17(1):85-97. Epub 2014 Dec 4.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2014.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297260PMC
January 2015

Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection.

Science 2015 Jan 27;347(6219):266-9. Epub 2014 Nov 27.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1258025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409937PMC
January 2015

Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity.

Science 2015 Jan 27;347(6219):269-73. Epub 2014 Nov 27.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1258100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398891PMC
January 2015

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.

Science 2014 Aug 17;345(6196):578-82. Epub 2014 Jul 17.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1256942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548887PMC
August 2014

Advances in norovirus biology.

Cell Host Microbe 2014 Jun;15(6):668-80

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2014.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113907PMC
June 2014

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Proc Natl Acad Sci U S A 2014 May 12;111(21):7741-6. Epub 2014 May 12.

Broad Institute, Cambridge, MA 02142;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114;Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1407001111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040621PMC
May 2014

The virome in mammalian physiology and disease.

Authors:
Herbert W Virgin

Cell 2014 Mar;157(1):142-50

Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO 63110, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2014.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977141PMC
March 2014

Pervasive transcription of a herpesvirus genome generates functionally important RNAs.

mBio 2014 Mar 11;5(2):e01033-13. Epub 2014 Mar 11.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://mbio.asm.org/cgi/doi/10.1128/mBio.01033-13
Publisher Site
http://dx.doi.org/10.1128/mBio.01033-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952160PMC
March 2014

Identification of alternative transcripts encoding the essential murine gammaherpesvirus lytic transactivator RTA.

J Virol 2014 May 26;88(10):5474-90. Epub 2014 Feb 26.

Emory Vaccine Center and Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03110-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019092PMC
May 2014

Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communities.

Gastroenterology 2014 May 5;146(6):1459-69. Epub 2014 Feb 5.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009354PMC
May 2014

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.

Science 2014 Jan 5;343(6168):313-317. Epub 2013 Dec 5.

Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1246829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048998PMC
January 2014

The Francisella O-antigen mediates survival in the macrophage cytosol via autophagy avoidance.

Cell Microbiol 2014 Jun 16;16(6):862-77. Epub 2013 Dec 16.

Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cmi.12246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028363PMC
June 2014

Identification of novel viruses using VirusHunter--an automated data analysis pipeline.

PLoS One 2013 22;8(10):e78470. Epub 2013 Oct 22.

Departments of Pathology & Immunology, Washington University School of Medicine, and the Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078470PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805514PMC
May 2014

Latent gammaherpesvirus 68 infection induces distinct transcriptional changes in different organs.

J Virol 2014 Jan 23;88(1):730-8. Epub 2013 Oct 23.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02708-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911696PMC
January 2014

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Gastroenterology 2013 Dec 21;145(6):1347-57. Epub 2013 Aug 21.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2013.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840157PMC
December 2013

Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against Toxoplasma gondii.

PLoS Pathog 2013 25;9(4):e1003320. Epub 2013 Apr 25.

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635975PMC
January 2014

Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses.

J Virol 2013 Jun 17;87(12):7015-31. Epub 2013 Apr 17.

Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03389-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676130PMC
June 2013

FIP200 regulates targeting of Atg16L1 to the isolation membrane.

EMBO Rep 2013 Mar 8;14(3):284-91. Epub 2013 Feb 8.

Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/embor.2013.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589088PMC
March 2013

ATG5 regulates plasma cell differentiation.

Autophagy 2013 Apr 17;9(4):528-37. Epub 2013 Jan 17.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/auto.23484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627668PMC
April 2013

A single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistence.

J Virol 2013 Jan 17;87(1):327-34. Epub 2012 Oct 17.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01864-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536416PMC
January 2013