Publications by authors named "Henry D Herce"

23Publications

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening.

Authors:
Christoph Gorgulla Krishna M Padmanabha Das Kendra E Leigh Marco Cespugli Patrick D Fischer Zi-Fu Wang Guilhem Tesseyre Shreya Pandita Alec Shnapir Anthony Calderaio Minko Gechev Alexander Rose Noam Lewis Colin Hutcheson Erez Yaffe Roni Luxenburg Henry D Herce Vedat Durmaz Thanos D Halazonetis Konstantin Fackeldey Justin J Patten Alexander Chuprina Igor Dziuba Alla Plekhova Yurii Moroz Dmytro Radchenko Olga Tarkhanova Irina Yavnyuk Christian Gruber Ryan Yust Dave Payne Anders M Näär Mark N Namchuk Robert A Davey Gerhard Wagner Jamie Kinney Haribabu Arthanari

iScience 2021 Jan 5:102021. Epub 2021 Jan 5.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.

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January 2021

A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening.

Authors:
Christoph Gorgulla Krishna M Padmanabha Das Kendra E Leigh Marco Cespugli Patrick D Fischer Zi-Fu Wang Guilhem Tesseyre Shreya Pandita Alec Shnapir Anthony Calderaio Minko Gechev Alexander Rose Noam Lewis Colin Hutcheson Erez Yaffe Roni Luxenburg Henry D Herce Vedat Durmaz Thanos D Halazonetis Konstantin Fackeldey Justin J Patten Alexander Chuprina Igor Dziuba Alla Plekhova Yurii Moroz Dmytro Radchenko Olga Tarkhanova Irina Yavnyuk Christian Gruber Ryan Yust Dave Payne Anders M Näär Mark N Namchuk Robert A Davey Gerhard Wagner Jamie Kinney Haribabu Arthanari

ChemRxiv 2020 Jul 24. Epub 2020 Jul 24.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University, Boston, USA.

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July 2020

Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer.

Authors:
Ann M Cathcart Gregory H Bird Thomas E Wales Henry D Herce Edward P Harvey Zachary J Hauseman Catherine E Newman Utsarga Adhikary Michelle S Prew Tun Oo Susan Lee John R Engen Loren D Walensky

Nat Chem Biol 2020 11 17;16(11):1218-1226. Epub 2020 Aug 17.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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November 2020

Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.

Authors:
Zachary J Hauseman Edward P Harvey Catherine E Newman Thomas E Wales Joel C Bucci Julian Mintseris Devin K Schweppe Liron David Lixin Fan Daniel T Cohen Henry D Herce Rida Mourtada Yael Ben-Nun Noah B Bloch Scott B Hansen Hao Wu Steven P Gygi John R Engen Loren D Walensky

Mol Cell 2020 07 12;79(1):68-83.e7. Epub 2020 Jun 12.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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July 2020

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

Authors:
Rida Mourtada Henry D Herce Daniel J Yin Jamie A Moroco Thomas E Wales John R Engen Loren D Walensky

Nat Biotechnol 2019 10 19;37(10):1186-1197. Epub 2019 Aug 19.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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October 2019

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.

Authors:
Henry D Herce Dominik Schumacher Anselm F L Schneider Anne K Ludwig Florian A Mann Marion Fillies Marc-André Kasper Stefan Reinke Eberhard Krause Heinrich Leonhardt M Cristina Cardoso Christian P R Hackenberger

Nat Chem 2017 08 17;9(8):762-771. Epub 2017 Jul 17.

Chemical Biology Department, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

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August 2017

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise.

Authors:
Anne K Ludwig Peng Zhang Florian D Hastert Stephanie Meyer Cathia Rausch Henry D Herce Udo Müller Anne Lehmkuhl Ines Hellmann Carina Trummer Christian Storm Heinrich Leonhardt M Cristina Cardoso

Nucleic Acids Res 2017 03;45(5):2438-2457

Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

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March 2017

Visualization of the Nucleolus in Living Cells with Cell-Penetrating Fluorescent Peptides.

Authors:
Robert M Martin Henry D Herce Anne K Ludwig M Cristina Cardoso

Methods Mol Biol 2016 ;1455:71-82

Department of Biology, Technische Universität Darmstadt, Schnittspahnstr. 10, 64287, Darmstadt, Germany.

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January 2018

Can Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor?

Authors:
Chris Neale Henry D Herce Régis Pomès Angel E García

Biophys J 2015 Oct;109(8):1652-62

Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, Troy, New York; Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York. Electronic address:

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October 2015

Principles of protein targeting to the nucleolus.

Authors:
Robert M Martin Gohar Ter-Avetisyan Henry D Herce Anne K Ludwig Gisela Lättig-Tünnemann M Cristina Cardoso

Nucleus 2015 ;6(4):314-25

a Instituto de Medicina Molecular ; Faculdade de Medicina ; Universidade de Lisboa ; Lisboa , Portugal.

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June 2016

Complete topology of the RNF complex from Vibrio cholerae.

Authors:
Teri N Hreha Katherine G Mezic Henry D Herce Ellen B Duffy Anais Bourges Sergey Pryshchep Oscar Juarez Blanca Barquera

Biochemistry 2015 Apr 10;54(15):2443-55. Epub 2015 Apr 10.

§University of Montpellier 2, Montpellier, France.

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April 2015

Covalent attachment of cyclic TAT peptides to GFP results in protein delivery into live cells with immediate bioavailability.

Authors:
Nicole Nischan Henry D Herce Francesco Natale Nina Bohlke Nediljko Budisa M Cristina Cardoso Christian P R Hackenberger

Angew Chem Int Ed Engl 2015 Feb 17;54(6):1950-3. Epub 2014 Dec 17.

Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10, 13125 Berlin (Germany); Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195 Berlin (Germany).

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February 2015

A novel cell permeable DNA replication and repair marker.

Authors:
Henry D Herce Malini Rajan Gisela Lättig-Tünnemann Marion Fillies M Cristina Cardoso

Nucleus 2014 31;5(6):590-600. Epub 2014 Oct 31.

a Department of Biology , Technische Universität Darmstadt ; Darmstadt , Germany.

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September 2015

Fundamental molecular mechanism for the cellular uptake of guanidinium-rich molecules.

Authors:
Henry D Herce Angel E Garcia M Cristina Cardoso

J Am Chem Soc 2014 Dec 1;136(50):17459-67. Epub 2014 Dec 1.

Department of Physics, Applied Physics and Astronomy and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute , Troy, New York 12180, United States.

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December 2014

Altered spatio-temporal dynamics of RNase H2 complex assembly at replication and repair sites in Aicardi-Goutières syndrome.

Authors:
Barbara Kind Britta Muster Wolfgang Staroske Henry D Herce René Sachse Alexander Rapp Franziska Schmidt Sarah Koss M Cristina Cardoso Min Ae Lee-Kirsch

Hum Mol Genet 2014 Nov 30;23(22):5950-60. Epub 2014 Jun 30.

Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus and

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November 2014

Visualization and targeted disruption of protein interactions in living cells.

Authors:
Henry D Herce Wen Deng Jonas Helma Heinrich Leonhardt M Cristina Cardoso

Nat Commun 2013 ;4:2660

1] Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany [2].

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June 2014

Direct homo- and hetero-interactions of MeCP2 and MBD2.

Authors:
Annette Becker Lena Allmann Maria Hofstätter Valentina Casà Patrick Weber Anne Lehmkuhl Henry D Herce M Cristina Cardoso

PLoS One 2013 15;8(1):e53730. Epub 2013 Jan 15.

Department of Biology, Technische Universität Darmstadt, Darmstadt, Germany.

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June 2013

Cube-octameric silsesquioxane-mediated cargo peptide delivery into living cancer cells.

Authors:
Sebastian Hörner Sebastian Fabritz Henry D Herce Olga Avrutina Christian Dietz Robert W Stark M Cristina Cardoso Harald Kolmar

Org Biomol Chem 2013 Apr;11(14):2258-65

Clemens-Schöpf Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstr. 22, 64287 Darmstadt, Germany.

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April 2013

Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin.

Authors:
Corella S Casas-Delucchi Joke G van Bemmel Sebastian Haase Henry D Herce Danny Nowak Daniela Meilinger Jeffrey H Stear Heinrich Leonhardt M Cristina Cardoso

Nucleic Acids Res 2012 Jan 8;40(1):159-69. Epub 2011 Sep 8.

Department of Biology, Technische Universität Darmstadt, 64287 Darmstadt, Germany.

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January 2012

Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.

Authors:
Gisela Lättig-Tünnemann Manuel Prinz Daniel Hoffmann Joachim Behlke Caroline Palm-Apergi Ingo Morano Henry D Herce M Cristina Cardoso

Nat Commun 2011 Aug 30;2:453. Epub 2011 Aug 30.

Max Delbrueck Center for Molecular Medicine, Berlin, Germany.

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August 2011