Henriette Meyer zu Schwabedissen

Henriette Meyer zu Schwabedissen

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Henriette Meyer zu Schwabedissen

Henriette Meyer zu Schwabedissen

Publications by authors named "Henriette Meyer zu Schwabedissen"

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OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids.

Am J Physiol Gastrointest Liver Physiol 2019 Dec 11;317(6):G751-G762. Epub 2019 Sep 11.

Biopharmacy, Department of Pharmaceutical Sciences, University Basel, 4056 Basel, Switzerland.

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https://www.physiology.org/doi/10.1152/ajpgi.00330.2018
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http://dx.doi.org/10.1152/ajpgi.00330.2018DOI Listing
December 2019

Clinical relevance of St. John's wort drug interactions revisited.

Br J Pharmacol 2019 Nov 19. Epub 2019 Nov 19.

Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1111/bph.14936DOI Listing
November 2019

PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism.

Materials (Basel) 2019 Sep 3;12(17). Epub 2019 Sep 3.

Department Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.3390/ma12172836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747961PMC
September 2019

OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects Endoplasmic Reticulum Access and the Metabolism of Ezetimibe.

Mol Pharmacol 2019 08 24;96(2):128-137. Epub 2019 May 24.

Biopharmacy, Department of Pharmaceutical Sciences, University of Basel (V.M., I.S., H.E.M.S.) and Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University of Basel and University Hospital Basel (U.D., S.K.), Basel, Switzerland

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http://dx.doi.org/10.1124/mol.118.114934DOI Listing
August 2019

Role of Serotonin Transporter and Receptor Gene Variations in the Acute Effects of MDMA in Healthy Subjects.

ACS Chem Neurosci 2019 Jul 10;10(7):3120-3131. Epub 2019 Jan 10.

Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research , University Hospital Basel, University of Basel , Basel CH-4056 , Switzerland.

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http://dx.doi.org/10.1021/acschemneuro.8b00590DOI Listing
July 2019

Pharmacokinetics of oxycodone/naloxone and its metabolites in patients with end-stage renal disease during and between haemodialysis sessions.

Nephrol Dial Transplant 2019 04;34(4):692-702

Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1093/ndt/gfy285DOI Listing
April 2019

The nuclear receptors PXR and LXR are regulators of the scaffold protein PDZK1.

Biochim Biophys Acta Gene Regul Mech 2019 04 1;1862(4):447-456. Epub 2019 Mar 1.

Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18749399183028
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http://dx.doi.org/10.1016/j.bbagrm.2019.02.007DOI Listing
April 2019

Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers.

Br J Clin Pharmacol 2019 03 24;85(3):626-633. Epub 2019 Jan 24.

Division of Clinical Pharmacology & Toxicology, University Hospital Basel, Switzerland.

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http://dx.doi.org/10.1111/bcp.13840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379217PMC
March 2019

Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1.

Mol Pharmacol 2019 03 20;95(3):313-323. Epub 2018 Dec 20.

Laboratories of origin: Biopharmacy (A.M.S., I.S., H.E.M.z.S.) and Pharmaceutical Biology (O.P., O.F.), Department Pharmaceutical Sciences, University of Basel, Basel, Switzerland

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http://dx.doi.org/10.1124/mol.118.114066DOI Listing
March 2019

Establishment and Validation of Competitive Counterflow as a Method To Detect Substrates of the Organic Anion Transporting Polypeptide 2B1.

Mol Pharm 2018 12 9;15(12):5501-5513. Epub 2018 Nov 9.

Biopharmacy, Department Pharmaceutical Sciences , University of Basel , 4056 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00631DOI Listing
December 2018

Synthesis and Characterization of PDMS-PMOXA-Based Polymersomes Sensitive to MMP-9 for Application in Breast Cancer.

Mol Pharm 2018 11 15;15(11):4884-4897. Epub 2018 Oct 15.

Biopharmacy, Department of Pharmaceutical Sciences , University of Basel , Klingelbergstrasse 50 , 4056 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00521DOI Listing
November 2018

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Authors:
Alexander Teumer Layal Chaker Stefan Groeneweg Yong Li Celia Di Munno Caterina Barbieri Ulla T Schultheiss Michela Traglia Tarunveer S Ahluwalia Masato Akiyama Emil Vincent R Appel Dan E Arking Alice Arnold Arne Astrup Marian Beekman John P Beilby Sofie Bekaert Eric Boerwinkle Suzanne J Brown Marc De Buyzere Purdey J Campbell Graziano Ceresini Charlotte Cerqueira Francesco Cucca Ian J Deary Joris Deelen Kai-Uwe Eckardt Arif B Ekici Johan G Eriksson Luigi Ferrrucci Tom Fiers Edoardo Fiorillo Ian Ford Caroline S Fox Christian Fuchsberger Tessel E Galesloot Christian Gieger Martin Gögele Alessandro De Grandi Niels Grarup Karin Halina Greiser Kadri Haljas Torben Hansen Sarah E Harris Diana van Heemst Martin den Heijer Andrew A Hicks Wouter den Hollander Georg Homuth Jennie Hui M Arfan Ikram Till Ittermann Richard A Jensen Jiaojiao Jing J Wouter Jukema Eero Kajantie Yoichiro Kamatani Elisa Kasbohm Jean-Marc Kaufman Lambertus A Kiemeney Margreet Kloppenburg Florian Kronenberg Michiaki Kubo Jari Lahti Bruno Lapauw Shuo Li David C M Liewald Ee Mun Lim Allan Linneberg Michela Marina Deborah Mascalzoni Koichi Matsuda Daniel Medenwald Christa Meisinger Ingrid Meulenbelt Tim De Meyer Henriette E Meyer Zu Schwabedissen Rafael Mikolajczyk Matthijs Moed Romana T Netea-Maier Ilja M Nolte Yukinori Okada Mauro Pala Cristian Pattaro Oluf Pedersen Astrid Petersmann Eleonora Porcu Iris Postmus Peter P Pramstaller Bruce M Psaty Yolande F M Ramos Rajesh Rawal Paul Redmond J Brent Richards Ernst R Rietzschel Fernando Rivadeneira Greet Roef Jerome I Rotter Cinzia F Sala David Schlessinger Elizabeth Selvin P Eline Slagboom Nicole Soranzo Thorkild I A Sørensen Timothy D Spector John M Starr David J Stott Youri Taes Daniel Taliun Toshiko Tanaka Betina Thuesen Daniel Tiller Daniela Toniolo Andre G Uitterlinden W Edward Visser John P Walsh Scott G Wilson Bruce H R Wolffenbuttel Qiong Yang Hou-Feng Zheng Anne Cappola Robin P Peeters Silvia Naitza Henry Völzke Serena Sanna Anna Köttgen Theo J Visser Marco Medici

Nat Commun 2018 10 26;9(1):4455. Epub 2018 Oct 26.

Erasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-06356-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203810PMC
October 2018

Childhood Trauma and Functional Variants of 5-HTTLPR Are Independently Associated with Alexithymia in 5,283 Subjects from the General Population.

Psychother Psychosom 2018 6;87(1):58-61. Epub 2018 Jan 6.

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hanseklinikum Stralsund, Stralsund, Germany.

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http://dx.doi.org/10.1159/000484143DOI Listing
September 2018

Thyroid Hormones Are Transport Substrates and Transcriptional Regulators of Organic Anion Transporting Polypeptide 2B1.

Mol Pharmacol 2018 07 7;94(1):700-712. Epub 2018 May 7.

Biopharmacy (H.E.M.z.S., C.F., A.M.S., I.S.), and Pharmaceutical Biology (M.O., M.H.), Department Pharmaceutical Sciences, University of Basel, Basel, Switzerland; and Departments of Physiology and Pharmacology and Medicine, University of Western Ontario, London, Ontario, Canada (A.M.S., R.G.T.).

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http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
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http://dx.doi.org/10.1124/mol.117.111161DOI Listing
July 2018

The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1.

Eur J Pharm Sci 2018 Jul 9;120:181-190. Epub 2018 May 9.

Department of Pharmaceutical Sciences, Biopharmacy, University of Basel, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2018.05.006DOI Listing
July 2018

No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.

Eur J Clin Pharmacol 2018 Mar 2;74(3):275-283. Epub 2017 Dec 2.

Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Department of Clinical Research, University Hospital Basel, University of Basel, Schanzenstrasse 55, 4056, Basel, Switzerland.

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http://dx.doi.org/10.1007/s00228-017-2392-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808057PMC
March 2018

PDZ domain containing protein 1 (PDZK1), a modulator of membrane proteins, is regulated by the nuclear receptor THRβ.

Mol Cell Endocrinol 2018 02 18;461:215-225. Epub 2017 Sep 18.

Department of Pharmaceutical Sciences, Biopharmacy, University of Basel, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2017.09.017DOI Listing
February 2018

LST-3TM12 is a member of the OATP1B family and a functional transporter.

Biochem Pharmacol 2018 02 15;148:75-87. Epub 2017 Dec 15.

Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952173072
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http://dx.doi.org/10.1016/j.bcp.2017.12.012DOI Listing
February 2018

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters.

Biochem Pharmacol 2017 11 12;144:108-119. Epub 2017 Aug 12.

Dept. of Pharmacology at the Center of Drug Absorption and Transport (C_DAT), University Medicine, Greifswald, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.08.008DOI Listing
November 2017

Functional assessment of genetic variants located in the promoter of SHP1 (NR0B2).

Pharmacogenet Genomics 2017 Nov;27(11):410-415

aDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland bC_DAT Center of Drug Absorption and Transport; Institute of Pharmacology cInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1097/FPC.0000000000000310DOI Listing
November 2017

Characterization of OATP1B3 and OATP2B1 transporter expression in the islet of the adult human pancreas.

Histochem Cell Biol 2017 Oct 10;148(4):345-357. Epub 2017 May 10.

Department of Physiology and Pharmacology, University of Western Ontario, London, Canada.

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http://dx.doi.org/10.1007/s00418-017-1580-6DOI Listing
October 2017

Regulation of PDZ domain-containing 1 (PDZK1) expression by hepatocyte nuclear factor-1α (HNF1α) in human kidney.

Am J Physiol Renal Physiol 2017 Oct 19;313(4):F973-F983. Epub 2017 Jul 19.

Department of Pharmaceutical Sciences, Biopharmacy, University of Basel, Basel, Switzerland; and

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http://www.physiology.org/doi/10.1152/ajprenal.00650.2016
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http://dx.doi.org/10.1152/ajprenal.00650.2016DOI Listing
October 2017

Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 08 2;8:16140. Epub 2017 Aug 2.

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http://dx.doi.org/10.1038/ncomms16140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543301PMC
August 2017

Genetic loci associated with heart rate variability and their effects on cardiac disease risk.

Authors:
Ilja M Nolte M Loretto Munoz Vinicius Tragante Azmeraw T Amare Rick Jansen Ahmad Vaez Benedikt von der Heyde Christy L Avery Joshua C Bis Bram Dierckx Jenny van Dongen Stephanie M Gogarten Philippe Goyette Jussi Hernesniemi Ville Huikari Shih-Jen Hwang Deepali Jaju Kathleen F Kerr Alexander Kluttig Bouwe P Krijthe Jitender Kumar Sander W van der Laan Leo-Pekka Lyytikäinen Adam X Maihofer Arpi Minassian Peter J van der Most Martina Müller-Nurasyid Michel Nivard Erika Salvi James D Stewart Julian F Thayer Niek Verweij Andrew Wong Delilah Zabaneh Mohammad H Zafarmand Abdel Abdellaoui Sulayma Albarwani Christine Albert Alvaro Alonso Foram Ashar Juha Auvinen Tomas Axelsson Dewleen G Baker Paul I W de Bakker Matteo Barcella Riad Bayoumi Rob J Bieringa Dorret Boomsma Gabrielle Boucher Annie R Britton Ingrid Christophersen Andrea Dietrich George B Ehret Patrick T Ellinor Markku Eskola Janine F Felix John S Floras Oscar H Franco Peter Friberg Maaike G J Gademan Mark A Geyer Vilmantas Giedraitis Catharina A Hartman Daiane Hemerich Albert Hofman Jouke-Jan Hottenga Heikki Huikuri Nina Hutri-Kähönen Xavier Jouven Juhani Junttila Markus Juonala Antti M Kiviniemi Jan A Kors Meena Kumari Tatiana Kuznetsova Cathy C Laurie Joop D Lefrandt Yong Li Yun Li Duanping Liao Marian C Limacher Henry J Lin Cecilia M Lindgren Steven A Lubitz Anubha Mahajan Barbara McKnight Henriette Meyer Zu Schwabedissen Yuri Milaneschi Nina Mononen Andrew P Morris Mike A Nalls Gerjan Navis Melanie Neijts Kjell Nikus Kari E North Daniel T O'Connor Johan Ormel Siegfried Perz Annette Peters Bruce M Psaty Olli T Raitakari Victoria B Risbrough Moritz F Sinner David Siscovick Johannes H Smit Nicholas L Smith Elsayed Z Soliman Nona Sotoodehnia Jan A Staessen Phyllis K Stein Adrienne M Stilp Katarzyna Stolarz-Skrzypek Konstantin Strauch Johan Sundström Cees A Swenne Ann-Christine Syvänen Jean-Claude Tardif Kent D Taylor Alexander Teumer Timothy A Thornton Lesley E Tinker André G Uitterlinden Jessica van Setten Andreas Voss Melanie Waldenberger Kirk C Wilhelmsen Gonneke Willemsen Quenna Wong Zhu-Ming Zhang Alan B Zonderman Daniele Cusi Michele K Evans Halina K Greiser Pim van der Harst Mohammad Hassan Erik Ingelsson Marjo-Riitta Järvelin Stefan Kääb Mika Kähönen Mika Kivimaki Charles Kooperberg Diana Kuh Terho Lehtimäki Lars Lind Caroline M Nievergelt Chris J O'Donnell Albertine J Oldehinkel Brenda Penninx Alexander P Reiner Harriëtte Riese Arie M van Roon John D Rioux Jerome I Rotter Tamar Sofer Bruno H Stricker Henning Tiemeier Tanja G M Vrijkotte Folkert W Asselbergs Bianca J J M Brundel Susan R Heckbert Eric A Whitsel Marcel den Hoed Harold Snieder Eco J C de Geus

Nat Commun 2017 06 14;8:15805. Epub 2017 Jun 14.

Department of Biological Psychology, Behavioral and Movement Sciences, VU University, Amsterdam 1081 BT, The Netherlands.

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http://dx.doi.org/10.1038/ncomms15805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474732PMC
June 2017

Pharmacogenetics of ecstasy: CYP1A2, CYP2C19, and CYP2B6 polymorphisms moderate pharmacokinetics of MDMA in healthy subjects.

Eur Neuropsychopharmacol 2017 03 20;27(3):232-238. Epub 2017 Jan 20.

Psychopharmacology Research, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Clinical Research, University Hospital Basel, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2017.01.008DOI Listing
March 2017

CYP2D6 function moderates the pharmacokinetics and pharmacodynamics of 3,4-methylene-dioxymethamphetamine in a controlled study in healthy individuals.

Pharmacogenet Genomics 2016 08;26(8):397-401

aDivision of Clinical Pharmacology and Toxicology, Departments of Biomedicine and Clinical Research, University Hospital Basel bDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1097/FPC.0000000000000231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949007PMC
August 2016

Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery.

Vascul Pharmacol 2015 Sep 16;72:25-34. Epub 2015 Jun 16.

University of Basel, Department of Pharmaceutical Sciences, Biopharmacy, Basel, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15371891150013
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http://dx.doi.org/10.1016/j.vph.2015.06.006DOI Listing
September 2015

Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.

Neuro Oncol 2015 Feb 25;17(2):223-42. Epub 2014 Aug 25.

Department of Pharmacology/C_DAT (S.H., M.H., M.A.F., T.H., A.B., H.E.M.z.S., H.K.K., B.R., S.B-M.); Institute of Pathology (S.V.); Institute of Pharmacy (C.A.R.); Institute for Community Medicine (K.W., C.H., W.H.); Clinic of Neurosurgery (C.F., M.F., H.S.); Institute of Radiology and Neuroradiology, Universitätsmedizin Greifswald, Greifswald, Germany (S.H., K.K., S.L.); Department of Biomedicine, University of Bergen, Bergen, Norway (E.E., H.M.); Department of Pathology, Haukeland University Hospital, Bergen, Norway (E.E., H.M.).

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http://dx.doi.org/10.1093/neuonc/nou216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288523PMC
February 2015

Function-impairing polymorphisms of the hepatic uptake transporter SLCO1B1 modify the therapeutic efficacy of statins in a population-based cohort.

Pharmacogenet Genomics 2015 Jan;25(1):8-18

aBiopharmacy Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland bInstitute of Pharmacology cInstitute of Community Medicine dInstitute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1097/FPC.0000000000000098DOI Listing
January 2015

Transcriptional regulation of urate transportosome member SLC2A9 by nuclear receptor HNF4α.

Am J Physiol Renal Physiol 2014 Nov 10;307(9):F1041-51. Epub 2014 Sep 10.

University of Basel, Department of Pharmaceutical Sciences, Biopharmacy, Basel, Switzerland;

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http://www.physiology.org/doi/10.1152/ajprenal.00640.2013
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http://dx.doi.org/10.1152/ajprenal.00640.2013DOI Listing
November 2014

Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders.

Eur Arch Psychiatry Clin Neurosci 2014 Nov 12;264 Suppl 1:S45-54. Epub 2014 Sep 12.

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany,

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http://dx.doi.org/10.1007/s00406-014-0536-2DOI Listing
November 2014

Creatine kinase elevation caused by a combination of fluvastatin and telmisartan in a patient heterozygous for the CYP2C9*3 and ABCC2 -24C > T variants: a case report.

BMC Res Notes 2014 Oct 3;7:688. Epub 2014 Oct 3.

Institute for Neurorehabilitational Research (InFo), BDH-Clinic, Hessisch Old- endorf, Germany, Teaching Hospital of Hannover Medical School (MHH), Germany.

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http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0
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http://dx.doi.org/10.1186/1756-0500-7-688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192324PMC
October 2014

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:
Dan E Arking Sara L Pulit Lia Crotti Pim van der Harst Patricia B Munroe Tamara T Koopmann Nona Sotoodehnia Elizabeth J Rossin Michael Morley Xinchen Wang Andrew D Johnson Alicia Lundby Daníel F Gudbjartsson Peter A Noseworthy Mark Eijgelsheim Yuki Bradford Kirill V Tarasov Marcus Dörr Martina Müller-Nurasyid Annukka M Lahtinen Ilja M Nolte Albert Vernon Smith Joshua C Bis Aaron Isaacs Stephen J Newhouse Daniel S Evans Wendy S Post Daryl Waggott Leo-Pekka Lyytikäinen Andrew A Hicks Lewin Eisele David Ellinghaus Caroline Hayward Pau Navarro Sheila Ulivi Toshiko Tanaka David J Tester Stéphanie Chatel Stefan Gustafsson Meena Kumari Richard W Morris Åsa T Naluai Sandosh Padmanabhan Alexander Kluttig Bernhard Strohmer Andrie G Panayiotou Maria Torres Michael Knoflach Jaroslav A Hubacek Kamil Slowikowski Soumya Raychaudhuri Runjun D Kumar Tamara B Harris Lenore J Launer Alan R Shuldiner Alvaro Alonso Joel S Bader Georg Ehret Hailiang Huang W H Linda Kao James B Strait Peter W Macfarlane Morris Brown Mark J Caulfield Nilesh J Samani Florian Kronenberg Johann Willeit J Gustav Smith Karin H Greiser Henriette Meyer Zu Schwabedissen Karl Werdan Massimo Carella Leopoldo Zelante Susan R Heckbert Bruce M Psaty Jerome I Rotter Ivana Kolcic Ozren Polašek Alan F Wright Maura Griffin Mark J Daly David O Arnar Hilma Hólm Unnur Thorsteinsdottir Joshua C Denny Dan M Roden Rebecca L Zuvich Valur Emilsson Andrew S Plump Martin G Larson Christopher J O'Donnell Xiaoyan Yin Marco Bobbo Adamo P D'Adamo Annamaria Iorio Gianfranco Sinagra Angel Carracedo Steven R Cummings Michael A Nalls Antti Jula Kimmo K Kontula Annukka Marjamaa Lasse Oikarinen Markus Perola Kimmo Porthan Raimund Erbel Per Hoffmann Karl-Heinz Jöckel Hagen Kälsch Markus M Nöthen Marcel den Hoed Ruth J F Loos Dag S Thelle Christian Gieger Thomas Meitinger Siegfried Perz Annette Peters Hanna Prucha Moritz F Sinner Melanie Waldenberger Rudolf A de Boer Lude Franke Pieter A van der Vleuten Britt Maria Beckmann Eimo Martens Abdennasser Bardai Nynke Hofman Arthur A M Wilde Elijah R Behr Chrysoula Dalageorgou John R Giudicessi Argelia Medeiros-Domingo Julien Barc Florence Kyndt Vincent Probst Alice Ghidoni Roberto Insolia Robert M Hamilton Stephen W Scherer Jeffrey Brandimarto Kenneth Margulies Christine E Moravec Fabiola del Greco M Christian Fuchsberger Jeffrey R O'Connell Wai K Lee Graham C M Watt Harry Campbell Sarah H Wild Nour E El Mokhtari Norbert Frey Folkert W Asselbergs Irene Mateo Leach Gerjan Navis Maarten P van den Berg Dirk J van Veldhuisen Manolis Kellis Bouwe P Krijthe Oscar H Franco Albert Hofman Jan A Kors André G Uitterlinden Jacqueline C M Witteman Lyudmyla Kedenko Claudia Lamina Ben A Oostra Gonçalo R Abecasis Edward G Lakatta Antonella Mulas Marco Orrú David Schlessinger Manuela Uda Marcello R P Markus Uwe Völker Harold Snieder Timothy D Spector Johan Ärnlöv Lars Lind Johan Sundström Ann-Christine Syvänen Mika Kivimaki Mika Kähönen Nina Mononen Olli T Raitakari Jorma S Viikari Vera Adamkova Stefan Kiechl Maria Brion Andrew N Nicolaides Bernhard Paulweber Johannes Haerting Anna F Dominiczak Fredrik Nyberg Peter H Whincup Aroon D Hingorani Jean-Jacques Schott Connie R Bezzina Erik Ingelsson Luigi Ferrucci Paolo Gasparini James F Wilson Igor Rudan Andre Franke Thomas W Mühleisen Peter P Pramstaller Terho J Lehtimäki Andrew D Paterson Afshin Parsa Yongmei Liu Cornelia M van Duijn David S Siscovick Vilmundur Gudnason Yalda Jamshidi Veikko Salomaa Stephan B Felix Serena Sanna Marylyn D Ritchie Bruno H Stricker Kari Stefansson Laurie A Boyer Thomas P Cappola Jesper V Olsen Kasper Lage Peter J Schwartz Stefan Kääb Aravinda Chakravarti Michael J Ackerman Arne Pfeufer Paul I W de Bakker Christopher Newton-Cheh

Nat Genet 2014 Aug 22;46(8):826-36. Epub 2014 Jun 22.

1] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [5].

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http://dx.doi.org/10.1038/ng.3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124521PMC
August 2014

Positive association of serum prolactin concentrations with all-cause and cardiovascular mortality.

Eur Heart J 2014 May 26;35(18):1215-21. Epub 2012 Jul 26.

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Strasse, Greifswald 17475, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehs233DOI Listing
May 2014

Cell-specific expression of uptake transporters--a potential approach for cardiovascular drug delivery devices.

Mol Pharm 2014 Mar 19;11(3):665-72. Epub 2014 Feb 19.

Biopharmacy, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1021/mp400245gDOI Listing
March 2014

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide.

Diabetes 2014 Feb 22;63(2):775-84. Epub 2013 Oct 22.

Biopharmacy, Department of Pharmaceutical Sciences, University Basel, Basel, Switzerland.

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http://dx.doi.org/10.2337/db13-1005DOI Listing
February 2014

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Authors:
Marco Medici Eleonora Porcu Giorgio Pistis Alexander Teumer Suzanne J Brown Richard A Jensen Rajesh Rawal Greet L Roef Theo S Plantinga Sita H Vermeulen Jari Lahti Matthew J Simmonds Lise Lotte N Husemoen Rachel M Freathy Beverley M Shields Diana Pietzner Rebecca Nagy Linda Broer Layal Chaker Tim I M Korevaar Maria Grazia Plia Cinzia Sala Uwe Völker J Brent Richards Fred C Sweep Christian Gieger Tanguy Corre Eero Kajantie Betina Thuesen Youri E Taes W Edward Visser Andrew T Hattersley Jürgen Kratzsch Alexander Hamilton Wei Li Georg Homuth Monia Lobina Stefano Mariotti Nicole Soranzo Massimiliano Cocca Matthias Nauck Christin Spielhagen Alec Ross Alice Arnold Martijn van de Bunt Sandya Liyanarachchi Margit Heier Hans Jörgen Grabe Corrado Masciullo Tessel E Galesloot Ee M Lim Eva Reischl Peter J Leedman Sandra Lai Alessandro Delitala Alexandra P Bremner David I W Philips John P Beilby Antonella Mulas Matteo Vocale Goncalo Abecasis Tom Forsen Alan James Elisabeth Widen Jennie Hui Holger Prokisch Ernst E Rietzschel Aarno Palotie Peter Feddema Stephen J Fletcher Katharina Schramm Jerome I Rotter Alexander Kluttig Dörte Radke Michela Traglia Gabriela L Surdulescu Huiling He Jayne A Franklyn Daniel Tiller Bijay Vaidya Tim de Meyer Torben Jørgensen Johan G Eriksson Peter C O'Leary Eric Wichmann Ad R Hermus Bruce M Psaty Till Ittermann Albert Hofman Emanuele Bosi David Schlessinger Henri Wallaschofski Nicola Pirastu Yurii S Aulchenko Albert de la Chapelle Romana T Netea-Maier Stephen C L Gough Henriette Meyer Zu Schwabedissen Timothy M Frayling Jean-Marc Kaufman Allan Linneberg Katri Räikkönen Johannes W A Smit Lambertus A Kiemeney Fernando Rivadeneira André G Uitterlinden John P Walsh Christa Meisinger Martin den Heijer Theo J Visser Timothy D Spector Scott G Wilson Henry Völzke Anne Cappola Daniela Toniolo Serena Sanna Silvia Naitza Robin P Peeters

PLoS Genet 2014 Feb 27;10(2):e1004123. Epub 2014 Feb 27.

Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

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February 2014

Personalized cardiovascular medicine: concepts and methodological considerations.

Nat Rev Cardiol 2013 Jun 26;10(6):308-16. Epub 2013 Mar 26.

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. voelzke@ uni-greifswald.de

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June 2013

Heparin inhibits TNF-α signaling in human endometrial stromal cells by interaction with NF-κB.

Mol Hum Reprod 2013 Apr 4;19(4):227-36. Epub 2012 Dec 4.

Department of Obstetrics and Gynecology, University of Greifswald, Sauerbruchstr., 17475 Greifswald, Germany.

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http://dx.doi.org/10.1093/molehr/gas060DOI Listing
April 2013

Current understanding of hepatic and intestinal OATP-mediated drug-drug interactions.

Expert Rev Clin Pharmacol 2011 Nov;4(6):729-42

Institute of Pharmacology, Ernst Moritz Arndt University, Friedrich-Loeffler-Straße 23, 17487 Greifswald, Germany.

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http://dx.doi.org/10.1586/ecp.11.58DOI Listing
November 2011

In vitro and in vivo evidence for the importance of breast cancer resistance protein transporters (BCRP/MXR/ABCP/ABCG2).

Handb Exp Pharmacol 2011 (201):325-71

Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.

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http://dx.doi.org/10.1007/978-3-642-14541-4_9DOI Listing
February 2011

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.

Authors:
Abbas Dehghan Josée Dupuis Maja Barbalic Joshua C Bis Gudny Eiriksdottir Chen Lu Niina Pellikka Henri Wallaschofski Johannes Kettunen Peter Henneman Jens Baumert David P Strachan Christian Fuchsberger Veronique Vitart James F Wilson Guillaume Paré Silvia Naitza Megan E Rudock Ida Surakka Eco J C de Geus Behrooz Z Alizadeh Jack Guralnik Alan Shuldiner Toshiko Tanaka Robert Y L Zee Renate B Schnabel Vijay Nambi Maryam Kavousi Samuli Ripatti Matthias Nauck Nicholas L Smith Albert V Smith Jouko Sundvall Paul Scheet Yongmei Liu Aimo Ruokonen Lynda M Rose Martin G Larson Ron C Hoogeveen Nelson B Freimer Alexander Teumer Russell P Tracy Lenore J Launer Julie E Buring Jennifer F Yamamoto Aaron R Folsom Eric J G Sijbrands James Pankow Paul Elliott John F Keaney Wei Sun Antti-Pekka Sarin João D Fontes Sunita Badola Brad C Astor Albert Hofman Anneli Pouta Karl Werdan Karin H Greiser Oliver Kuss Henriette E Meyer zu Schwabedissen Joachim Thiery Yalda Jamshidi Ilja M Nolte Nicole Soranzo Timothy D Spector Henry Völzke Alexander N Parker Thor Aspelund David Bates Lauren Young Kim Tsui David S Siscovick Xiuqing Guo Jerome I Rotter Manuela Uda David Schlessinger Igor Rudan Andrew A Hicks Brenda W Penninx Barbara Thorand Christian Gieger Joe Coresh Gonneke Willemsen Tamara B Harris Andre G Uitterlinden Marjo-Riitta Järvelin Kenneth Rice Dörte Radke Veikko Salomaa Ko Willems van Dijk Eric Boerwinkle Ramachandran S Vasan Luigi Ferrucci Quince D Gibson Stefania Bandinelli Harold Snieder Dorret I Boomsma Xiangjun Xiao Harry Campbell Caroline Hayward Peter P Pramstaller Cornelia M van Duijn Leena Peltonen Bruce M Psaty Vilmundur Gudnason Paul M Ridker Georg Homuth Wolfgang Koenig Christie M Ballantyne Jacqueline C M Witteman Emelia J Benjamin Markus Perola Daniel I Chasman

Circulation 2011 Feb 7;123(7):731-8. Epub 2011 Feb 7.

Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam, Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147232PMC
February 2011

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1.

Hepatology 2010 Nov;52(5):1797-807

Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/hep.23876DOI Listing
November 2010

Identification, expression, and functional characterization of full-length and splice variants of murine organic anion transporting polypeptide 1b2.

Mol Pharm 2009 Nov-Dec;6(6):1790-7

Division of Clinical Pharmacology, Department of Medicine, University of Western Ontario, London, Ontario, Canada.

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February 2010

Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

Mol Pharm 2009 Nov-Dec;6(6):1644-61

Department of Pharmacology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.

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February 2010

Direct mass spectrometric identification of ABCB1 (P-glycoprotein/MDR1) from the apical membrane fraction of human placenta using fourier transform ion cyclotron mass spectrometry.

Pharmacogenet Genomics 2006 Jun;16(6):385-9

Department of Pharmacology, Peter-Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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June 2006

Epidermal growth factor-mediated activation of the map kinase cascade results in altered expression and function of ABCG2 (BCRP).

Drug Metab Dispos 2006 Apr 13;34(4):524-33. Epub 2006 Jan 13.

Department of Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, Greifswald, Germany.

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April 2006

The ATP-binding cassette transporter ABCG2 (BCRP), a marker for side population stem cells, is expressed in human heart.

J Histochem Cytochem 2006 Feb 22;54(2):215-21. Epub 2005 Aug 22.

Institut für Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald, Friedrich-Loeffler-Str. 23d, D-17487 Greifswald, Germany.

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February 2006

Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

Circulation 2006 Feb 20;113(8):1114-22. Epub 2006 Feb 20.

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February 2006

Variable expression of MRP2 (ABCC2) in human placenta: influence of gestational age and cellular differentiation.

Drug Metab Dispos 2005 Jul 8;33(7):896-904. Epub 2005 Apr 8.

Department of Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany.

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July 2005

Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5).

Drug Metab Rev 2005 ;37(1):253-78

Department of Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.

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June 2005

Expression, localization, and function of the carnitine transporter octn2 (slc22a5) in human placenta.

Drug Metab Dispos 2005 Jan 14;33(1):31-7. Epub 2004 Oct 14.

Department of Pharmacology, Friedrich Loefflerstr. 23d, 17487 Greifswald, Germany.

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January 2005