Henri Brunengraber

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Henri Brunengraber

Publications by authors named "Henri Brunengraber"

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59Publications

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Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.

Am J Physiol Endocrinol Metab 2017 10 20;313(4):E413-E428. Epub 2017 Jun 20.

Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke Molecular Physiology Institute, Duke University, Durham, North Carolina.

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October 2017

Glutathione species and metabolomic prints in subjects with liver disease as biological markers for the detection of hepatocellular carcinoma.

HPB (Oxford) 2016 12 27;18(12):979-990. Epub 2016 Oct 27.

Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Department of Metabolomics and Proteomics Core Facilities, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

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December 2016

New mechanisms by which statins lower plasma cholesterol.

J Lipid Res 2016 08 23;57(8):1325-6. Epub 2016 Jun 23.

Department of Nutrition, Case Western Reserve University, Cleveland, OH 44109

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August 2016

Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4.

Cell Rep 2016 07 23;16(2):323-332. Epub 2016 Jun 23.

Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA; Division of Cardiology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address:

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July 2016

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis.

J Lipid Res 2016 Feb 2;57(2):258-64. Epub 2015 Dec 2.

Department of Ophthalmology and Visual Sciences,Case Western Reserve University, Cleveland, OH 44106

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February 2016

Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.

Mol Genet Metab 2015 Dec 24;116(4):260-8. Epub 2015 Oct 24.

Departments of Nutrition and Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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December 2015

Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE.

J Biol Chem 2015 Jul 12;290(30):18671-7. Epub 2015 Jun 12.

From the Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106 and

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July 2015

Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):18572-7. Epub 2014 Dec 15.

Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH 44106; Departments of Medicine and Harrington Discovery Institute, University Hospitals Case Medical Center, Cleveland, OH 44106

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December 2014

A role for cytosolic isocitrate dehydrogenase as a negative regulator of glucose signaling for insulin secretion in pancreatic ß-cells.

PLoS One 2013 10;8(10):e77097. Epub 2013 Oct 10.

Molecular Nutrition Unit and the Montreal Diabetes Research Center at the Centre de Recherche du Centre Hospitalier de l'Université de Montréal, CR-CHUM, Montreal, Quebec, Canada.

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June 2014

Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancer.

BMC Syst Biol 2014 Jun 23;8:72. Epub 2014 Jun 23.

Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

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June 2014

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.

Am J Physiol Regul Integr Comp Physiol 2013 May 3;304(10):R829-36. Epub 2013 Apr 3.

Department of Molecular Pharmacology and Physiology, Hyperbaric Biomedical Research Laboratory, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

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May 2013

Metabolism of γ-hydroxybutyrate in perfused rat livers.

Biochem J 2012 Jun;444(2):333-41

Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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June 2012

What is the proper precursor-to-product labeling relationship for calculating the fractional synthetic rate of muscle triglyceride?

J Lipid Res 2012 Jan 9;53(1):1-3. Epub 2011 Nov 9.

Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.

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January 2012

Metabolomics, pathway regulation, and pathway discovery.

J Biol Chem 2011 Jul 12;286(27):23631-5. Epub 2011 May 12.

Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

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July 2011

Analysis of the citric acid cycle intermediates using gas chromatography-mass spectrometry.

Methods Mol Biol 2011 ;708:147-57

Department of Nutrition, Mouse Metabolic Phenotyping Center, Case Western Reserve University, Cleveland, OH, USA.

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April 2011

Delineation of substrate selection and anaplerosis in tricarboxylic acid cycle of the heart by 13C NMR spectroscopy and mass spectrometry.

NMR Biomed 2011 Feb 19;24(2):176-87. Epub 2010 Oct 19.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

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February 2011

Polyethylene glycol modified-albumin enhances the cold preservation properties of University of Wisconsin solution in rat liver and a hepatocyte cell line.

J Surg Res 2010 Nov 23;164(1):95-104. Epub 2009 Apr 23.

Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5047, USA.

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November 2010

Using isotopic tools to dissect and quantitate parallel metabolic pathways.

J Am Chem Soc 2010 May;132(18):6309-11

Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.

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May 2010

Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile.

Am J Physiol Endocrinol Metab 2010 Feb 10;298(2):E362-71. Epub 2009 Nov 10.

Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106-4954, USA.

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February 2010

Dipropionylcysteine ethyl ester compensates for loss of citric acid cycle intermediates during post ischemia reperfusion in the pig heart.

Cardiovasc Drugs Ther 2009 Dec;23(6):459-69

Department Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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December 2009

Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs.

J Biol Chem 2009 Nov 15;284(48):33521-34. Epub 2009 Sep 15.

Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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November 2009

Interrelations between C4 ketogenesis, C5 ketogenesis, and anaplerosis in the perfused rat liver.

J Biol Chem 2009 Oct 8;284(41):27799-807. Epub 2009 Aug 8.

Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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October 2009

Is there glucose production outside of the liver and kidney?

Annu Rev Nutr 2009 ;29:43-57

Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA.

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September 2009

Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.

Am J Physiol Endocrinol Metab 2009 Jul 28;297(1):E260-9. Epub 2009 Apr 28.

Department of Nutrition, Case Western Reserve University, School of Medicine, 10900 Euclid Ave., W-G48, Cleveland, OH 44106-4954, USA.

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July 2009

Alpha-ketoglutarate is the precursor of L-2-hydroxyglutarate.

J Inherit Metab Dis 2007 Oct;30(5):628

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October 2007

Mass isotopomer study of anaplerosis from propionate in the perfused rat heart.

Arch Biochem Biophys 2007 Jul 12;463(1):110-7. Epub 2007 Mar 12.

Department of Nutrition, Case Western Reserve University, School of Medicine - WG 48, 10900 Euclid Avenue, Cleveland, OH 44106-4954, USA.

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July 2007

Assay of the activity of malonyl-coenzyme A decarboxylase by gas chromatography-mass spectrometry.

Anal Biochem 2007 Apr 13;363(2):169-74. Epub 2007 Jan 13.

Department of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA.

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April 2007

Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes.

Histochem Cell Biol 2007 Mar 19;127(3):273-90. Epub 2006 Dec 19.

Department of Biology, San Diego State University, San Diego, CA, USA.

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March 2007

Anaplerotic molecules: current and future.

J Inherit Metab Dis 2006 Apr-Jun;29(2-3):327-31

Department of Nutrition, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4906, USA.

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January 2007

Competition between acetate and oleate for the formation of malonyl-CoA and mitochondrial acetyl-CoA in the perfused rat heart.

J Mol Cell Cardiol 2006 Nov 3;41(5):868-75. Epub 2006 Oct 3.

Department of Nutrition, Case Western Reserve University, 2109 Adelbert Road, Room BRB923, Cleveland, OH 44106-4906, USA.

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November 2006

Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats.

Am J Physiol Endocrinol Metab 2006 Oct 16;291(4):E860-6. Epub 2006 May 16.

Department of Pediatrics, Case Western Reserve University, Euclid Ave., Cleveland, OH 44106-4954, USA.

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October 2006

Differential effects of heptanoate and hexanoate on myocardial citric acid cycle intermediates following ischemia-reperfusion.

J Appl Physiol (1985) 2006 Jan 1;100(1):76-82. Epub 2005 Sep 1.

Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106-4970, USA.

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January 2006

Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy.

Mol Genet Metab 2005 Apr;84(4):305-12

Metabolic Unit, Departments of Pediatrics and Biochemistry, Hospital Necker-Enfants Malades, Paris, France.

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April 2005

Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis.

J Biol Chem 2004 Oct 28;279(41):43207-16. Epub 2004 Jul 28.

Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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October 2004

In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver.

J Biol Chem 2004 Oct 28;279(41):43217-26. Epub 2004 Jul 28.

Department of Nutrition and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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October 2004

Regulation of malonyl-CoA concentration and turnover in the normal heart.

J Biol Chem 2004 Aug 4;279(33):34298-301. Epub 2004 Jun 4.

Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

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August 2004

Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart.

J Biol Chem 2004 May 24;279(19):19574-9. Epub 2004 Feb 24.

Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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May 2004

Quantifying rates of protein synthesis in humans by use of 2H2O: application to patients with end-stage renal disease.

Am J Physiol Endocrinol Metab 2004 Apr 23;286(4):E665-72. Epub 2003 Dec 23.

Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106-4951, USA.

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April 2004

New secondary metabolites of phenylbutyrate in humans and rats.

Drug Metab Dispos 2004 Jan;32(1):10-9

Department of Nutrition, Room 280, Case Western Reserve University, 11000 Cedar Rd., Cleveland, OH 44106-7139, USA.

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January 2004

Investigations by mass isotopomer analysis of the formation of D-2-hydroxyglutarate by cultured lymphoblasts from two patients with D-2-hydroxyglutaric aciduria.

FEBS Lett 2004 Jan;557(1-3):115-20

Department of Clinical Chemistry, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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January 2004

Assessing the reversibility of the anaplerotic reactions of the propionyl-CoA pathway in heart and liver.

J Biol Chem 2003 Sep 24;278(37):34959-65. Epub 2003 Jun 24.

Department of Biochemistry, Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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September 2003

Post-ischemic treatment with dipyruvyl-acetyl-glycerol decreases myocardial infarct size in the pig.

Cardiovasc Drugs Ther 2003 May;17(3):209-16

Departments of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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May 2003

Quantitative assessment of anaplerosis from propionate in pig heart in vivo.

Am J Physiol Endocrinol Metab 2003 Feb 8;284(2):E351-6. Epub 2002 Oct 8.

Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-7139, USA.

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February 2003

Probing the link between citrate and malonyl-CoA in perfused rat hearts.

Am J Physiol Heart Circ Physiol 2002 Oct 13;283(4):H1379-86. Epub 2002 Jun 13.

Department of Biochemistry, University of Montreal, Québec, Canada H3C 3J7.

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October 2002

Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride.

J Clin Invest 2002 Jul;110(2):259-69

Institute of Metabolic Disease, Baylor University Medical Center, Dallas, Texas 75226, USA.

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July 2002