Henk-Jan Guchelaar

Henk-Jan Guchelaar

UNVERIFIED PROFILE

Are you Henk-Jan Guchelaar?   Register this Author

Register author
Henk-Jan Guchelaar

Henk-Jan Guchelaar

Publications by authors named "Henk-Jan Guchelaar"

Are you Henk-Jan Guchelaar?   Register this Author

100Publications

2399Reads

32Profile Views

A review of the bioanalytical methods for the quantitative determination of capecitabine and its metabolites in biological matrices.

Biomed Chromatogr 2019 Nov 6:e4732. Epub 2019 Nov 6.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bmc.4732DOI Listing
November 2019

Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.

Pharmacogenomics J 2019 Oct 4;19(5):473-479. Epub 2019 Feb 4.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41397-019-0079-zDOI Listing
October 2019

Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing.

Clin Pharmacol Ther 2019 Oct 12;106(4):866-873. Epub 2019 Jun 12.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771671PMC
October 2019

A pilot study of the implementation of pharmacogenomic pharmacist initiated pre-emptive testing in primary care.

Eur J Hum Genet 2019 Oct 21;27(10):1532-1541. Epub 2019 Jun 21.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-019-0454-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777565PMC
October 2019

A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid Tumors.

CPT Pharmacometrics Syst Pharmacol 2019 Oct 9;8(10):720-737. Epub 2019 Aug 9.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/psp4.12450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813171PMC
October 2019

Predictive genetic biomarkers for the efficacy of methotrexate in rheumatoid arthritis: a systematic review.

Pharmacogenomics J 2019 Oct 17. Epub 2019 Oct 17.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41397-019-0098-9DOI Listing
October 2019

One non-believer: Response to "Obviously Nine Believers: Actionable Germline Genetic Variants for Pre-emptive Pharmacogenetic Testing".

Basic Clin Pharmacol Toxicol 2019 Oct 31. Epub 2019 Oct 31.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcpt.13336DOI Listing
October 2019

Reply to C.L. Braal et al, H. Brauch et al, and M.P. Goetz et al.

J Clin Oncol 2019 Aug 18;37(22):1984-1985. Epub 2019 Jun 18.

Henk-Jan Guchelaar, PharmD, PhD and Anabel Sanchez-Spitman, PharmD, Leiden University Medical Center, Leiden, the Netherlands; Vincent Dezentjé, MD, PhD, Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, the Netherlands; Stefan Böhringer, PhD, MD and Jesse Swen, PharmD, PhD, Leiden University Medical Center, Leiden, the Netherlands; Patrick Neven, MD, PhD, University Hospitals Leuven, Leuven, Belgium; and Hans Gelderblom, MD, PhD, Leiden University Medical Center, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.19.00932DOI Listing
August 2019

Implementation of Pharmacogenomics in Everyday Clinical Settings.

Adv Pharmacol 2018 ;83:219-246

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/bs.apha.2018.04.003DOI Listing
July 2019

Pharmacist-Initiated Pre-Emptive Pharmacogenetic Panel Testing with Clinical Decision Support in Primary Care: Record of PGx Results and Real-World Impact.

Genes (Basel) 2019 05 29;10(6). Epub 2019 May 29.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes10060416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628264PMC
May 2019

Confirmation practice in pharmacogenetic testing; how good is good enough?

Clin Chim Acta 2019 Mar 21;490:77-80. Epub 2018 Dec 21.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2018.12.023DOI Listing
March 2019

Adverse drug reactions on sexual functioning: a systematic overview.

Drug Discov Today 2019 03 25;24(3):890-897. Epub 2019 Jan 25.

Leiden University Medical Center, Department of Clinical Pharmacy & Toxicology, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2019.01.012DOI Listing
March 2019

Transcriptome Signature Reversion as a Method to Reposition Drugs Against Cancer for Precision Oncology.

Cancer J 2019 Mar/Apr;25(2):116-120

Medical Statistics, Leiden University Medical Centre, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PPO.0000000000000370DOI Listing
March 2019

Non-Cancer Drug Repurposing Candidates for Renal Cell Carcinoma.

Cancer J 2019 Mar/Apr;25(2):147-148

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00130404-201903000-0001
Publisher Site
http://dx.doi.org/10.1097/PPO.0000000000000364DOI Listing
March 2019

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy: who and how? - Authors' reply.

Lancet Oncol 2019 Feb;20(2):e67

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(19)30010-5DOI Listing
February 2019

The impact of estimated tumour purity on gene expression-based drug repositioning of Clear Cell Renal Cell Carcinoma samples.

Sci Rep 2019 Feb 21;9(1):2495. Epub 2019 Feb 21.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-39891-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385172PMC
February 2019

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy.

Eur J Cancer 2019 Jan 11;107:60-67. Epub 2018 Dec 11.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09598049183147
Publisher Site
http://dx.doi.org/10.1016/j.ejca.2018.11.010DOI Listing
January 2019

Validation of a clinical pharmacogenetic model to predict methotrexate nonresponse in rheumatoid arthritis patients.

Pharmacogenomics 2019 01 10;20(2):85-93. Epub 2019 Jan 10.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/pgs-2018-0144
Publisher Site
http://dx.doi.org/10.2217/pgs-2018-0144DOI Listing
January 2019

Therapeutic drug monitoring of tacrolimus and mycophenolic acid in outpatient renal transplant recipients using a volumetric dried blood spot sampling device.

Br J Clin Pharmacol 2018 12 15;84(12):2889-2902. Epub 2018 Oct 15.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bcp.13755
Publisher Site
http://dx.doi.org/10.1111/bcp.13755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256056PMC
December 2018

Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy.

Breast Cancer Res Treat 2018 Nov 17;172(2):401-411. Epub 2018 Aug 17.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-018-4923-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208901PMC
November 2018

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

Lancet Oncol 2018 11 19;19(11):1459-1467. Epub 2018 Oct 19.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14702045183068
Publisher Site
http://dx.doi.org/10.1016/S1470-2045(18)30686-7DOI Listing
November 2018

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants.

Genes (Basel) 2018 Nov 28;9(12). Epub 2018 Nov 28.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes9120585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316498PMC
November 2018

Pharmacogenomics, a novel section in the European Journal of Human Genetics.

Eur J Hum Genet 2018 10 2;26(10):1399-1400. Epub 2018 Jul 2.

Dept. Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-018-0205-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138632PMC
October 2018

EU decision-making for marketing authorization of advanced therapy medicinal products: a case study.

Drug Discov Today 2018 07 21;23(7):1328-1333. Epub 2018 Mar 21.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2018.03.008DOI Listing
July 2018

The extent and effects of patient involvement in pictogram design for written drug information: a short systematic review.

Drug Discov Today 2018 06 7;23(6):1312-1318. Epub 2018 May 7.

Clinical Pharmacy & Toxicology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Science Communication & Society, Leiden University, 2333 BE Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2018.05.013DOI Listing
June 2018

Pharmacogenetic Information in Clinical Guidelines: The European Perspective.

Clin Pharmacol Ther 2018 05 30;103(5):795-801. Epub 2018 Mar 30.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1049DOI Listing
May 2018

SLC04A1, SLC22A2 and SLC28A2 variants not related to methotrexate efficacy or toxicity in rheumatoid arthritis patients.

Pharmacogenomics 2018 05 27;19(7):613-619. Epub 2018 Apr 27.

Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2018-0021DOI Listing
May 2018

Clinical Pharmacokinetics and Pharmacodynamics of the Epidermal Growth Factor Receptor Inhibitor Panitumumab in the Treatment of Colorectal Cancer.

Clin Pharmacokinet 2018 04;57(4):455-473

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-017-0590-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856878PMC
April 2018

The possibility of obtaining marketing authorization of orphan pharmaceutical compounding preparations: 3,4-DAP for Lambert-Eaton Myasthenic Syndrome.

Eur J Pharm Sci 2018 Mar 28;114:24-29. Epub 2017 Nov 28.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09280987173065
Publisher Site
http://dx.doi.org/10.1016/j.ejps.2017.11.025DOI Listing
March 2018

A nationwide cross-sectional survey of pharmacy students on pharmacogenetic testing in The Netherlands.

Pharmacogenomics 2018 03 23;19(4):311-319. Epub 2018 Feb 23.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0175DOI Listing
March 2018

Personalised drug repositioning for Clear Cell Renal Cell Carcinoma using gene expression.

Sci Rep 2018 03 27;8(1):5250. Epub 2018 Mar 27.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-23195-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869697PMC
March 2018

Unlicensed pharmaceutical preparations for clinical patient care: Ensuring safety.

Pharmacoepidemiol Drug Saf 2018 01 19;27(1):3-8. Epub 2017 Oct 19.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.4335DOI Listing
January 2018

More Dose-dependent Side Effects with Mercaptopurine over Azathioprine in IBD Treatment Due to Relatively Higher Dosing.

Inflamm Bowel Dis 2017 10;23(10):1873-1881

Departments of *Gastroenterology, †Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; ‡Department of Clinical Pharmacy, Pharmacology and Toxicology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands; §Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; ‖Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht University, Utrecht, the Netherlands; ¶Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, the Netherlands; and **Department of Clinical Pharmacy, Máxima Medical Center, Veldhoven, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MIB.0000000000001163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598908PMC
October 2017

Medical education in pharmacogenomics-results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx).

Eur J Clin Pharmacol 2017 Oct 2;73(10):1247-1252. Epub 2017 Jul 2.

Research Division, Federal Institute for Drugs and Medical Devices, University Bonn Medical School, Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-017-2292-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599468PMC
October 2017

The effect of rs5758550 on CYP2D6*2 phenotype and formation of endoxifen in breast cancer patients using tamoxifen.

Pharmacogenomics 2017 Aug 26;18(12):1125-1132. Epub 2017 Jul 26.

Leiden Network for Personalised Therapeutics, Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0080DOI Listing
August 2017

Pathway analysis to identify genetic variants associated with efficacy of adalimumab in rheumatoid arthritis.

Pharmacogenomics 2017 Jul 22;18(10):945-953. Epub 2017 Jun 22.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0047DOI Listing
July 2017

The Ubiquitous Pharmacogenomics consortium: making effective treatment optimization accessible to every European citizen.

Pharmacogenomics 2017 07 7;18(11):1041-1045. Epub 2017 Jul 7.

Department of Clinical Pharmacy & Toxicology, Leiden Network for Personalised Therapeutics, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0093DOI Listing
July 2017

Evaluation of KDR rs34231037 as a predictor of sunitinib efficacy in patients with metastatic renal cell carcinoma.

Pharmacogenet Genomics 2017 06;27(6):227-231

aHereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO) bOncology Department, Hospital Universitario 12 de Octubre cSpanish Oncology Genitourinary Group (SOGUG) dISCIII Center for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain eDepartment of Clinical Pharmacy and Toxicology fDepartment of Medical Oncology gDepartment of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden hDepartment of Medical Oncology, VU University Medical Center, Amsterdam iDepartment of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands jDepartment of Solid Tumour Oncology, Cleveland Clinic Foundation (CCF) Taussig Cancer Institute, Cleveland, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000280DOI Listing
June 2017

Understanding clinical development of chimeric antigen receptor T cell therapies.

Cytotherapy 2017 06 19;19(6):703-709. Epub 2017 Apr 19.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcyt.2017.03.070DOI Listing
June 2017

Pharmaceutical pictograms for low-literate patients: Understanding, risk of false confidence, and evidence-based design strategies.

Patient Educ Couns 2017 05 19;100(5):966-973. Epub 2016 Dec 19.

Clinical Pharmacy & Toxicology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pec.2016.12.015DOI Listing
May 2017

Assessment of ethnic differences in sunitinib outcome between Caucasian and Asian patients with metastatic renal cell carcinoma: a meta-analysis.

Acta Oncol 2017 Apr 7;56(4):582-589. Epub 2016 Dec 7.

a Department of Clinical Pharmacy and Toxicology , Leiden University Medical Center , Leiden , The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/0284186X.2016.1265666DOI Listing
April 2017

Flexible and Scalable Full-Length CYP2D6 Long Amplicon PacBio Sequencing.

Hum Mutat 2017 03 18;38(3):310-316. Epub 2017 Jan 18.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.23166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324676PMC
March 2017

A nationwide survey of pharmacists' perception of pharmacogenetics in the context of a clinical decision support system containing pharmacogenetics dosing recommendations.

Pharmacogenomics 2017 Feb 23;18(3):215-225. Epub 2017 Jan 23.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Centre, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2016-0138DOI Listing
February 2017

What do we need to make genetic biomarker-guided treatment for renal cell carcinoma a reality?

Pharmacogenomics 2017 01 14;18(1):1-4. Epub 2016 Dec 14.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2016-0168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220441PMC
January 2017

Population pharmacokinetics of lenalidomide in multiple myeloma patients.

Cancer Chemother Pharmacol 2017 Jan 30;79(1):189-200. Epub 2016 Dec 30.

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Valencia, Vicent Andrés Estellés Avenue, 46100, Burjassot, Valencia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-016-3228-yDOI Listing
January 2017

A decade of pharmacogenomics research on tyrosine kinase inhibitors in metastatic renal cell cancer: a systematic review.

Expert Rev Mol Diagn 2016 17;16(5):605-18. Epub 2016 Feb 17.

a Department of Clinical Pharmacy and Toxicology , Leiden University Medical Center , Leiden , Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/14737159.2016.1148601DOI Listing
December 2016

A brighter future for the implementation of pharmacogenomic testing.

Eur J Hum Genet 2016 12 31;24(12):1658-1660. Epub 2016 Aug 31.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ejhg.2016.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117920PMC
December 2016

The role of pharmacogenetics in the treatment of osteosarcoma.

Drug Discov Today 2016 11 25;21(11):1775-1786. Epub 2016 Jun 25.

Dept of Pediatric Hematology and Oncology, Dept of Pediatrics, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2016.06.022DOI Listing
November 2016

Genotypes of CYP2C8 and FGD4 and their association with peripheral neuropathy or early dose reduction in paclitaxel-treated breast cancer patients.

Br J Cancer 2016 Nov 13;115(11):1335-1342. Epub 2016 Oct 13.

Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/bjc.2016.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129817PMC
November 2016

Clinical development of gene- and cell-based therapies: overview of the European landscape.

Mol Ther Methods Clin Dev 2016 30;3:16073. Epub 2016 Nov 30.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center , Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtm.2016.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130079PMC
November 2016

Minimum Effective Doses of Succinylcholine and Rocuronium During Electroconvulsive Therapy: A Prospective, Randomized, Crossover Trial.

Anesth Analg 2016 09;123(3):587-96

From the *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; †Broad Institute of MIT and Harvard, Cambridge, Massachusetts; ‡Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts; §Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands; ‖Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; ¶Patient Care Services/Special Care Nursery, Massachusetts General Hospital, Boston, Massachusetts; and #Clinic for Anesthesiology and Intensive Care, Essen University Hospital, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1213/ANE.0000000000001218DOI Listing
September 2016

Development of cell therapy medicinal products by academic institutes.

Drug Discov Today 2016 08 23;21(8):1206-12. Epub 2016 Apr 23.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2016.04.016DOI Listing
August 2016

Translating DPYD genotype into DPD phenotype: using the DPYD gene activity score.

Pharmacogenomics 2015 12;16(11):1277-86. Epub 2015 Aug 12.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.15.70DOI Listing
June 2016

Hurdles in clinical implementation of academic advanced therapy medicinal products: A national evaluation.

Cytotherapy 2016 06 5;18(6):797-805. Epub 2016 Apr 5.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcyt.2016.02.010DOI Listing
June 2016

Replication of a genetic variant in ACYP2 associated with cisplatin-induced hearing loss in patients with osteosarcoma.

Pharmacogenet Genomics 2016 May;26(5):243-7

aLaboratory of Pediatric Oncology bDepartment of Pediatric Hematology and Oncology, Department of Pediatrics Departments of cHuman Genetics dMedical Oncology, Radboud university medical center, Nijmegen Departments of eClinical Pharmacy & Toxicology fMedical Oncology, Leiden University Medical Center, Leiden gDepartment of Pediatric Hematology and Oncology, University Medical Center Groningen, Groningen hDepartment of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000212DOI Listing
May 2016

Evaluation of clinical implementation of prospective DPYD genotyping in 5-fluorouracil- or capecitabine-treated patients.

Pharmacogenomics 2016 05 16;17(7):721-9. Epub 2016 May 16.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2016-0013DOI Listing
May 2016

Pharmacogenetics in electroconvulsive therapy and adjunctive medications.

Pharmacogenomics 2015 26;16(9):1015-31. Epub 2015 Jun 26.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.15.57DOI Listing
April 2016

Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy.

Br J Clin Pharmacol 2016 Mar 8;81(3):553-61. Epub 2016 Jan 8.

Department of Pharmacy, Isala Diaconessen Hospital, Meppel and Bethesda Hospital,Hoogeveen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.12821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767209PMC
March 2016

Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime time.

Eur J Cancer 2016 Feb 21;54:40-48. Epub 2015 Dec 21.

Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2015.11.008DOI Listing
February 2016

FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis.

Pharmacogenomics 2015 ;16(4):373-81

Department of Clinical Pharmacy, San Cecilio University Hospital, Instituto de Investigación Biosanitaria ibs. Granada, Granada, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs.14.178DOI Listing
January 2016

Dried blood spot analysis for therapeutic drug monitoring of pazopanib.

J Clin Pharmacol 2015 Dec 14;55(12):1344-50. Epub 2015 Jul 14.

Department of Clinical Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcph.558DOI Listing
December 2015

CYP3A5 and ABCB1 polymorphisms as predictors for sunitinib outcome in metastatic renal cell carcinoma.

Eur Urol 2015 Oct 27;68(4):621-9. Epub 2015 Apr 27.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands; Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2015.04.018DOI Listing
October 2015

Sirolimus and everolimus in kidney transplantation.

Drug Discov Today 2015 Oct 4;20(10):1243-9. Epub 2015 Jun 4.

Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2015.05.006DOI Listing
October 2015

Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease.

Gastroenterology 2015 Oct 11;149(4):907-17.e7. Epub 2015 Jun 11.

Department of Human Genetics, Donders Centre for Neuroscience, Radboud university medical center, Nijmegen, The Netherlands; Department of Psychiatry, Donders Centre for Neuroscience, Radboud university medical center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.06.002DOI Listing
October 2015

Aberrant CYP2D6 metabolizer phenotypes do not show increased frequency in patients undergoing ECT after antidepressant therapy.

Pharmacogenet Genomics 2015 Oct;25(10):515-7

aDepartment of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital bDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA cDepartment of Clinical Pharmacy & Toxicology dDepartment of Psychiatry, Leiden University Medical Center, Leiden University, Leiden, The Netherlands eDepartment of Clinical Chemistry, St Jansdal Hospital, Harderwijk, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000167DOI Listing
October 2015

Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients.

Anticancer Drugs 2015 Sep;26(8):872-7

Departments of aClinical Oncology bClinical Pharmacy and Toxicology cPathology, Leiden University Medical Center dDepartment of Internal Medicine, Diaconessenhuis Leiden, Leiden eDepartment of Internal Medicine, Reinier de Graaf Hospital, Delft fDepartment of Internal Medicine and Clinical Oncology, Haga Hospital, The Hague, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CAD.0000000000000255DOI Listing
September 2015

The Effect of Tamoxifen Dose Increment in Patients With Impaired CYP2D6 Activity.

Ther Drug Monit 2015 Aug;37(4):501-7

*Department of Pharmacy, Radboud University Medical Center, Nijmegen; †Department of Clinical Oncology; ‡Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center; §Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam; ¶Department of Medical Oncology, Radboud University Medical Center, Nijmegen; and ‖Department of Medical Oncology, Academic Medical Center, University of Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FTD.0000000000000195DOI Listing
August 2015

Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients.

Cancer Chemother Pharmacol 2015 Jul 10;76(1):47-52. Epub 2015 May 10.

Department of Pharmacy, Treant Healthgroup, Location Scheper, Scheper Hospital Emmen, Boermarkeweg 60, 7824 AA, Emmen, The Netherlands,

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00280-015-2746-3
Publisher Site
http://dx.doi.org/10.1007/s00280-015-2746-3DOI Listing
July 2015

Clinical validation study of genetic markers for capecitabine efficacy in metastatic colorectal cancer patients.

Pharmacogenet Genomics 2015 Jun;25(6):279-88

Departments of aClinical Oncology bClinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden cDepartment of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000119DOI Listing
June 2015

High-quality genotyping data from formalin-fixed, paraffin-embedded tissue on the drug metabolizing enzymes and transporters plus array.

J Mol Diagn 2015 Jan;17(1):4-9

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2014.08.003DOI Listing
January 2015