Hengli Tang

Hengli Tang

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Hengli Tang

Publications by authors named "Hengli Tang"

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High-Throughput Zika Viral Titer Assay for Rapid Screening of Antiviral Drugs.

Assay Drug Dev Technol 2019 Apr;17(3):128-139

2 National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1089/adt.2018.881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479255PMC
April 2019

Multiplexed Biomarker Panels Discriminate Zika and Dengue Virus Infection in Humans.

Mol Cell Proteomics 2018 02 15;17(2):349-356. Epub 2017 Nov 15.

From the ‡Department of Pharmacology & Molecular Sciences; Johns Hopkins School of Medicine, Baltimore, Maryland 21205;

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http://dx.doi.org/10.1074/mcp.RA117.000310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795396PMC
February 2018

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins.

Cell Stem Cell 2017 09 17;21(3):349-358.e6. Epub 2017 Aug 17.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Bioengineering Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, Perelman School for Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600197PMC
September 2017

Racing to Uncover the Link between Zika Virus and Microcephaly.

Cell Stem Cell 2017 06;20(6):749-753

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http://dx.doi.org/10.1016/j.stem.2017.05.010DOI Listing
June 2017

Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities.

Cell Stem Cell 2016 12;19(6):690-702

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(16)30415-5
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http://dx.doi.org/10.1016/j.stem.2016.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218815PMC
December 2016

Modeling Dengue Virus-Hepatic Cell Interactions Using Human Pluripotent Stem Cell-Derived Hepatocyte-like Cells.

Stem Cell Reports 2016 09 18;7(3):341-354. Epub 2016 Aug 18.

Department of Biological Science, Florida State University, 319 Stadium Drive, Tallahassee, FL 32306-4295, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031989PMC
September 2016

Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny.

Methods 2016 05 2;101:11-20. Epub 2015 Dec 2.

The Gladstone Institute of Cardiovascular Disease, San Francisco, CA, United States; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2015.11.027DOI Listing
May 2016

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth.

Cell Stem Cell 2016 05 4;18(5):587-90. Epub 2016 Mar 4.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Cellular and Molecular Medicine Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909160010
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http://dx.doi.org/10.1016/j.stem.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299540PMC
May 2016

Zika virus and neural developmental defects: building a case for a cause.

Sci China Life Sci 2016 May 11;59(5):536-8. Epub 2016 Apr 11.

Department of Biological Science, Florida State University, Tallahassee, FL32306, USA.

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http://link.springer.com/10.1007/s11427-016-5053-2
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http://dx.doi.org/10.1007/s11427-016-5053-2DOI Listing
May 2016

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.

Cell 2016 May 22;165(5):1238-1254. Epub 2016 Apr 22.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://www.cell.com/cell/pdf/S0092-8674(16)30467-6.pdf
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http://www.cell.com/cms/attachment/2054161004/2060541246/mmc
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http://dx.doi.org/10.1016/j.cell.2016.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900885PMC
May 2016

The missing pieces of the HCV entry puzzle.

Future Virol 2015;10(4):415-428

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA ; Institute of Health Sciences, Anhui University, Hefei, 230601, PR China.

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http://dx.doi.org/10.2217/FVL.15.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423549PMC
January 2015

Suppression of the DHX9 helicase induces premature senescence in human diploid fibroblasts in a p53-dependent manner.

J Biol Chem 2014 Aug 2;289(33):22798-814. Epub 2014 Jul 2.

From the Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada, the Department of Oncology, The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada, and

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http://dx.doi.org/10.1074/jbc.M114.568535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132785PMC
August 2014

Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors.

Eur J Med Chem 2014 Apr 7;77:258-68. Epub 2014 Mar 7.

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.03.017DOI Listing
April 2014

Apolipoprotein E mediates attachment of clinical hepatitis C virus to hepatocytes by binding to cell surface heparan sulfate proteoglycan receptors.

PLoS One 2013 2;8(7):e67982. Epub 2013 Jul 2.

Department of Microbiology, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067982PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699494PMC
February 2014

The interaction between claudin-1 and dengue viral prM/M protein for its entry.

Virology 2013 Nov 7;446(1-2):303-13. Epub 2013 Sep 7.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States; University of Alabama at Birmingham, Department of Medicine, Division of Infectious Diseases, BBRB 562, 845 19th Street South, Birmingham, AL 35294, United States.

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http://dx.doi.org/10.1016/j.virol.2013.08.009DOI Listing
November 2013

Cyclophilins as modulators of viral replication.

Viruses 2013 Jul 11;5(7):1684-701. Epub 2013 Jul 11.

Department of Biological Science, The Florida State University, Tallahassee, FL 32306, USA.

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http://dx.doi.org/10.3390/v5071684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738956PMC
July 2013

Combining ligand design with photoligation to provide compact, colloidally stable, and easy to conjugate quantum dots.

ACS Appl Mater Interfaces 2013 Apr 19;5(8):2861-9. Epub 2013 Feb 19.

Department of Chemistry and Biochemistry, Florida State University, 95 Chieftan Way, Tallahassee, Florida 32306, USA.

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http://dx.doi.org/10.1021/am302788qDOI Listing
April 2013

Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors.

J Virol 2012 Dec 12;86(23):12616-24. Epub 2012 Sep 12.

Department of Biological Science, Florida State University, Tallahassee, Florida, USA.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.01351-12
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http://dx.doi.org/10.1128/JVI.01351-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497644PMC
December 2012

Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate.

J Virol 2012 Jul 24;86(13):7256-67. Epub 2012 Apr 24.

Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1128/JVI.07222-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416335PMC
July 2012

A conserved tandem cyclophilin-binding site in hepatitis C virus nonstructural protein 5A regulates Alisporivir susceptibility.

J Virol 2012 May 15;86(9):4811-22. Epub 2012 Feb 15.

Department of Biological Science, Florida State University, Tallahassee, Florida, USA.

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http://dx.doi.org/10.1128/JVI.06641-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347344PMC
May 2012

Cyclophilin inhibitors as a novel HCV therapy.

Authors:
Hengli Tang

Viruses 2010 Aug 5;2(8):1621-34. Epub 2010 Aug 5.

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA; E-Mail: ; Tel.: +1-850-645-2402;

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http://dx.doi.org/10.3390/v2081621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185723PMC
August 2010

Simultaneous reduction and digestion of proteins with disulfide bonds for hydrogen/deuterium exchange monitored by mass spectrometry.

Anal Chem 2010 Feb;82(4):1450-4

Ion Cyclotron Resonance Program, National High Magnetic Field Laboratory, Florida State University, 1800 East Paul Dirac Drive, Tallahassee, Florida 32310-4005, USA.

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http://dx.doi.org/10.1021/ac902550nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825376PMC
February 2010

Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation.

Nucleic Acids Res 2009 Oct 3;37(19):6587-99. Epub 2009 Sep 3.

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkp714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770676PMC
October 2009

Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein.

Antimicrob Agents Chemother 2009 Aug 18;53(8):3226-35. Epub 2009 May 18.

State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.

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http://dx.doi.org/10.1128/AAC.00189-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715601PMC
August 2009

Critical role of cyclophilin A and its prolyl-peptidyl isomerase activity in the structure and function of the hepatitis C virus replication complex.

J Virol 2009 Jul 22;83(13):6554-65. Epub 2009 Apr 22.

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.

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http://dx.doi.org/10.1128/JVI.02550-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698523PMC
July 2009

Cellular and molecular biology of HCV infection and hepatitis.

Clin Sci (Lond) 2009 Jun 15;117(2):49-65. Epub 2009 Jun 15.

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA.

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http://dx.doi.org/10.1042/CS20080631DOI Listing
June 2009

Selection and characterization of drug-resistant HCV replicons in vitro with a flow cytometry-based assay.

Methods Mol Biol 2009 ;510:227-42

Department of Biological Science, Florida State University, Tallahassee, FL, USA.

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http://dx.doi.org/10.1007/978-1-59745-394-3_17DOI Listing
March 2009

Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro.

J Virol 2008 Jun 2;82(11):5269-78. Epub 2008 Apr 2.

Department of Biological Science, Florida State University, Tallahassee, Florida 32306-4370, USA.

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http://dx.doi.org/10.1128/JVI.02614-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395199PMC
June 2008

Molecular determinants of nucleolar translocation of RNA helicase A.

Exp Cell Res 2007 Oct 14;313(17):3743-54. Epub 2007 Aug 14.

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4370, USA.

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http://dx.doi.org/10.1016/j.yexcr.2007.07.037DOI Listing
October 2007

Characterization of hepatitis C virus subgenomic replicon resistance to cyclosporine in vitro.

J Virol 2007 Jun 21;81(11):5829-40. Epub 2007 Mar 21.

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4370, USA.

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http://dx.doi.org/10.1128/JVI.02524-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900250PMC
June 2007

Effect of cell growth on hepatitis C virus (HCV) replication and a mechanism of cell confluence-based inhibition of HCV RNA and protein expression.

J Virol 2006 Feb;80(3):1181-90

Bio Unit I, Chieftan Way, Department of Biological Science, Florida State University, Tallahassee, FL 32306-4370, USA.

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http://dx.doi.org/10.1128/JVI.80.3.1181-1190.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346944PMC
February 2006

Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach.

J Virol 2004 Dec;78(23):12829-37

Department of Biological Sciences, Biology Unit 1, Florida State University, Tallahassee, FL 32306-4370, USA.

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http://dx.doi.org/10.1128/JVI.78.23.12829-12837.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524980PMC
December 2004

Novel technologies for studying virus-host interaction and discovering new drug targets for HCV and HIV.

Curr Opin Pharmacol 2002 Oct;2(5):541-7

Immusol Inc., San Diego, CA 92121, USA.

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October 2002