Hendrik Witt

Hendrik Witt

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Hendrik Witt

Hendrik Witt

Publications by authors named "Hendrik Witt"

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Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Jun 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
June 2019

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Exploiting Laboratory Insights to Improve Outcomes of Pediatric Central Nervous System Tumors.

Am Soc Clin Oncol Educ Book 2016 ;35:e540-6

From the Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Center for Data Driven Discovery in Biomedicine, Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1200/EDBK_159149DOI Listing
January 2017

Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape.

J Clin Oncol 2015 Sep 24;33(27):2986-98. Epub 2015 Aug 24.

Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Daniel C. Bowers, University of Texas Southwestern Medical Center, Dallas, TX; Matthias A. Karajannis, New York University (NYU) Perlmutter Cancer Center and NYU Langone Medical Center, New York, NY; Sarah Leary, University of Washington School of Medicine and Fred Hutchinson Cancer Research Center, Seattle, WA; Hendrik Witt, German Cancer Research Center and University of Heidelberg, Heidelberg, Germany; and Nicholas G. Gottardo, Princess Margaret Hospital for Children and The University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1200/JCO.2014.59.9217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567701PMC
September 2015

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

Clin Cancer Res 2015 Aug 8;21(16):3750-8. Epub 2015 May 8.

Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537825PMC
August 2015

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.

Cancer Cell 2014 Mar;25(3):393-405

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493053PMC
March 2014

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis.

Int J Cancer 2014 Feb 2;134(3):703-16. Epub 2013 Sep 2.

Division of Tumor Virology, Program Infection and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, Heidelberg, Germany; Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.28386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232887PMC
February 2014

Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma.

Acta Neuropathol 2013 Aug 10;126(2):291-301. Epub 2013 May 10.

Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1007/s00401-013-1124-7DOI Listing
August 2013

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Nat Genet 2013 Aug 30;45(8):927-32. Epub 2013 Jun 30.

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:1982973/compon
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http://www.nature.com/doifinder/10.1038/ng.2682
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http://dx.doi.org/10.1038/ng.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951336PMC
August 2013

Cilengitide affects tumor compartment, vascularization and microenvironment in experimental bone metastases as shown by longitudinal ¹⁸F-FDG PET and gene expression analysis.

J Cancer Res Clin Oncol 2013 Apr 11;139(4):573-83. Epub 2012 Dec 11.

Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00432-012-1360-6DOI Listing
April 2013

Emerging insights into the ependymoma epigenome.

Brain Pathol 2013 Mar;23(2):206-9

Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/bpa.12020DOI Listing
March 2013

Molecular approaches to ependymoma: the next step(s).

Curr Opin Neurol 2012 Dec;25(6):745-50

Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany.

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http://pdfs.journals.lww.com/co-neurology/2012/12000/Molecul
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WCO.0b013e328359cdf5DOI Listing
December 2012

Nestin expression identifies ependymoma patients with poor outcome.

Brain Pathol 2012 Nov 30;22(6):848-60. Epub 2012 May 30.

Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00600.xDOI Listing
November 2012

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

Cancer Cell 2012 Oct;22(4):425-37

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2012.08.024DOI Listing
October 2012

Dissecting the genomic complexity underlying medulloblastoma.

Nature 2012 Aug;488(7409):100-5

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

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http://dx.doi.org/10.1038/nature11284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662966PMC
August 2012

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

Oncotarget 2011 Dec;2(12):984-96

Department of Pediatric Oncology / Hematology, Neuro-oncology Research Group, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282104PMC
http://dx.doi.org/10.18632/oncotarget.362DOI Listing
December 2011

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma.

Int J Cancer 2011 Nov 25;129(9):2297-303. Epub 2011 Jul 25.

Centre for Biological Systems Analysis (ZBSA), Albert-Ludwigs-University, Freiburg, Germany.

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http://dx.doi.org/10.1002/ijc.25893DOI Listing
November 2011

The genetics of pediatric brain tumors.

Curr Neurol Neurosci Rep 2010 May;10(3):215-23

Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s11910-010-0103-9DOI Listing
May 2010

DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells.

Aging Cell 2010 Feb 6;9(1):54-63. Epub 2009 Nov 6.

Department of Medicine V, University of Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00535.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814091PMC
February 2010

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

Acta Neuropathol 2009 Sep 19;118(3):401-5. Epub 2009 Jun 19.

Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-Universität Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00401-009-0550-zDOI Listing
September 2009