Hendrik Wesseling

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.

Cell 2020 Dec 13;183(6):1699-1713.e13. Epub 2020 Nov 13.

F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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December 2020

Cell-Type-Specific Profiling of Alternative Translation Identifies Regulated Protein Isoform Variation in the Mouse Brain.

Authors:

Darshan Sapkota Allison M Lake Wei Yang Chengran Yang Hendrik Wesseling Amanda Guise Ceren Uncu Jasbir S Dalal Andrew W Kraft Jin-Moo Lee Mark S Sands Judith A Steen Joseph D Dougherty

Cell Rep 2019 01;26(3):594-607.e7

Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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January 2019

Fetal regional brain protein signature in FASD rat model.

Authors:

Katie L Davis-Anderson Hendrik Wesseling Lara M Siebert Emilie R Lunde-Young Vishal D Naik Hanno Steen Jayanth Ramadoss

Reprod Toxicol 2018 03 1;76:84-92. Epub 2018 Feb 1.

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4466, USA. Electronic address:

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March 2018

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.

Authors:

Jasmin Lalonde Surya A Reis Sudhir Sivakumaran Carl S Holland Hendrik Wesseling John F Sauld Begum Alural Wen-Ning Zhao Judith A Steen Stephen J Haggarty

Nat Commun 2017 11 21;8(1):1659. Epub 2017 Nov 21.

Chemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.

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November 2017

A brain proteomic investigation of rapamycin effects in the mouse model.

Authors:

Hendrik Wesseling Ype Elgersma Sabine Bahn

Mol Autism 2017 1;8:41. Epub 2017 Aug 1.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT UK.

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April 2018

Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems approach.

Authors:

David Alan Cox Michael Gerd Gottschalk Viktoria Stelzhammer Hendrik Wesseling Jason David Cooper Sabine Bahn

World J Biol Psychiatry 2018 25;19(sup2):S63-S74. Epub 2016 Nov 25.

a Department of Chemical Engineering and Biotechnology , University of Cambridge , Cambridge , United Kingdom.

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June 2019

Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology.

Authors:

David A Cox Michael G Gottschalk Hendrik Wesseling Agnes Ernst Jason D Cooper Sabine Bahn

Schizophr Res 2016 11 19;177(1-3):98-107. Epub 2016 Jun 19.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB2 1QT, United Kingdom. Electronic address:

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November 2016

Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model.

Authors:

Hendrik Wesseling Elizabeth J Want Paul C Guest Hassan Rahmoune Elaine Holmes Sabine Bahn

J Proteome Res 2015 Aug 30;14(8):3174-87. Epub 2015 Jun 30.

†Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1QT, U.K.

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August 2015

Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia.

Authors:

Julian A Jaros Hassan Rahmoune Hendrik Wesseling F Markus Leweke Sureyya Ozcan Paul C Guest Sabine Bahn

Proteomics Clin Appl 2015 Oct 15;9(9-10):907-16. Epub 2015 May 15.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

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October 2015

Proteomic enrichment analysis of psychotic and affective disorders reveals common signatures in presynaptic glutamatergic signaling and energy metabolism.

Authors:

Michael G Gottschalk Hendrik Wesseling Paul C Guest Sabine Bahn

Int J Neuropsychopharmacol 2014 Oct 31;18(2). Epub 2014 Oct 31.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK (Drs Gottschalk, Wesseling, and Drs Guest and Bahn); Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands (Dr Bahn).

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October 2014

Targeted multiplexed selected reaction monitoring analysis evaluates protein expression changes of molecular risk factors for major psychiatric disorders.

Authors:

Hendrik Wesseling Michael G Gottschalk Sabine Bahn

Int J Neuropsychopharmacol 2014 Oct 31;18(1). Epub 2014 Oct 31.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom (Wesseling, Gottschalk, and Bahn); Department of Neuroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands (Dr Bahn).H.W. and M.G.G. contributed equally to this work.

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October 2014

A targeted multiplexed proteomic investigation identifies ketamine-induced changes in immune markers in rat serum and expression changes in protein kinases/phosphatases in rat brain.

Authors:

Hendrik Wesseling Hassan Rahmoune Mark Tricklebank Paul C Guest Sabine Bahn

J Proteome Res 2015 Jan 19;14(1):411-21. Epub 2014 Nov 19.

Department of Chemical Engineering and Biotechnology, University of Cambridge , Cambridge CB2 1QT, United Kingdom.

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January 2015

Integrative proteomic analysis of the NMDA NR1 knockdown mouse model reveals effects on central and peripheral pathways associated with schizophrenia and autism spectrum disorders.

Authors:

Hendrik Wesseling Paul C Guest Chi-Ming Lee Erik Hf Wong Hassan Rahmoune Sabine Bahn

Mol Autism 2014 4;5:38. Epub 2014 Jul 4.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT, UK ; Department of Neuroscience, Erasmus Medical Center, Rotterdam, CA, 3000, The Netherlands.

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July 2014