Hendrik Neubert

Hendrik Neubert

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Hendrik Neubert

Hendrik Neubert

Publications by authors named "Hendrik Neubert"

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Bioanalysis of adeno-associated virus gene therapy therapeutics: regulatory expectations.

Bioanalysis 2019 Nov 25;11(21):2011-2024. Epub 2019 Oct 25.

Pfizer, Inc., Biomedicine Design, 1 Burtt Rd, Andover, MA 01810, USA.

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http://dx.doi.org/10.4155/bio-2019-0135DOI Listing
November 2019

Human FcRn Tissue Expression Profile and Half-Life in PBMCs.

Biomolecules 2019 08 15;9(8). Epub 2019 Aug 15.

Biomedicine Design, Pfizer Worldwide Research & Development, Andover, MA 01810, USA.

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http://dx.doi.org/10.3390/biom9080373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722552PMC
August 2019

Characterization and Quantification of an Fc-FGF21 Fusion Protein in Rat Serum Using Immunoaffinity LC-MS.

AAPS J 2019 07 8;21(5):84. Epub 2019 Jul 8.

BioMedicine Design, Pfizer Inc., 1 Burtt Road, Andover, Massachusetts, 01810, USA.

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http://dx.doi.org/10.1208/s12248-019-0356-4DOI Listing
July 2019

Measuring the Turnover Rate of Clinically Important Plasma Proteins using an Automated SISCAPA Workflow.

Clin Chem 2019 03 9;65(3):492-494. Epub 2019 Jan 9.

Biomedicine Design, Worldwide Research & Development, Pfizer Inc. Andover, MA.

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http://dx.doi.org/10.1373/clinchem.2018.294892DOI Listing
March 2019

New opportunities with quantification of protein therapeutics by LC-MS.

Bioanalysis 2018 Jul;10(13):971-973

Genentech Inc., 1 DNA Way, San Francisco, CA 94080, USA.

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https://www.future-science.com/doi/10.4155/bio-2018-0151
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http://dx.doi.org/10.4155/bio-2018-0151DOI Listing
July 2018

Assessing the Feasibility of Neutralizing Osteopontin with Various Therapeutic Antibody Modalities.

Sci Rep 2018 05 17;8(1):7781. Epub 2018 May 17.

Inflammation and Immunology Research Unit, Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts, 02139, USA.

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http://dx.doi.org/10.1038/s41598-018-26187-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958109PMC
May 2018

Protein Turnover Measurements in Human Serum by Serial Immunoaffinity LC-MS/MS.

Clin Chem 2018 02 20;64(2):279-288. Epub 2017 Oct 20.

Biomedicine Design, Worldwide Research & Development, Pfizer, Inc., Andover, MA.

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http://dx.doi.org/10.1373/clinchem.2017.272922DOI Listing
February 2018

Clinical chemoproteomics-Opportunities and obstacles.

Sci Transl Med 2017 04;9(386)

Biomedicine Design, Pfizer, Andover, MA 01810, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf7951DOI Listing
April 2017

The breadth of biomarkers and their assays: part 2.

Bioanalysis 2016 Dec;8(23):2381-2382

Global Biomarker Discovery & Development, Biogen, 225 Binney Street, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.4155/bio-2016-4984DOI Listing
December 2016

The breadth of biomarkers and their assays.

Bioanalysis 2016 Nov;8(22):2283-2285

Angelini Pharma, Pomezia, RM, Italy.

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http://dx.doi.org/10.4155/bio-2016-4990DOI Listing
November 2016

Quantification of protein biomarkers in tissues: new capabilities with pellet digestion peptide immunoaffinity LC-MS/MS.

Bioanalysis 2016 Aug 11;8(15):1551-1555. Epub 2016 Jul 11.

Biomedicine Design, Worldwide Research & Development, Pfizer, Inc., Andover, MA 01810, USA.

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http://dx.doi.org/10.4155/bio-2016-0155DOI Listing
August 2016

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice.

MAbs 2016 07 22;8(5):848-53. Epub 2016 Apr 22.

a Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Worldwide Research & Development , Andover , Massachusetts , USA.

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https://www.tandfonline.com/doi/full/10.1080/19420862.2016.1
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http://dx.doi.org/10.1080/19420862.2016.1178436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968098PMC
July 2016

Quantitative measurements of GDF-8 using immunoaffinity LC-MS/MS.

Proteomics Clin Appl 2016 05 13;10(5):597-604. Epub 2016 Apr 13.

Pfizer Worldwide Research & Development, Andover, MA, USA.

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http://dx.doi.org/10.1002/prca.201500112DOI Listing
May 2016

Large-scale implementation of sequential protein and peptide immunoaffinity enrichment LC/nanoLC-MS/MS for human β-nerve growth factor.

Bioanalysis 2016 Apr 23;8(8):753-64. Epub 2016 Mar 23.

Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Andover, MA 01810, USA.

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http://dx.doi.org/10.4155/bio-2015-0022DOI Listing
April 2016

Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS.

Anal Chem 2016 Apr 4;88(8):4239-47. Epub 2016 Apr 4.

Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., 1 Burtt Road, Andover, Massachusetts 01810, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b03900DOI Listing
April 2016

Quantification of biotherapeutic targets: new opportunities with immunoaffinity LC-MS/MS.

Bioanalysis 2014 ;6(13):1731-3

Pfizer Inc., Pfizer Worldwide Research & Development, Pharmacokinetics Dynamics & Metabolism, 1 Burtt Road, Andover, MA 01810, USA.

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http://www.future-science.com/doi/10.4155/bio.14.138
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http://dx.doi.org/10.4155/bio.14.138DOI Listing
July 2015

Mass cytometry: a highly multiplexed single-cell technology for advancing drug development.

Drug Metab Dispos 2015 Feb 27;43(2):227-33. Epub 2014 Oct 27.

Pharmacokinetics, Dynamics and Metabolism, New Biological Entities, Pfizer, Andover, Massachusetts.

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http://dx.doi.org/10.1124/dmd.114.060798DOI Listing
February 2015

Serum β-nerve growth factor concentrations in pregnant female, nonpregnant female, and male cynomolgus monkeys.

Neuroreport 2014 Aug;25(11):829-832

Pfizer Inc., Pharmacokinetics Dynamics and Metabolism, Groton, Connecticut.

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http://dx.doi.org/10.1097/WNR.0000000000000187DOI Listing
August 2014

Targeted precise quantification of 12 human recombinant uridine-diphosphate glucuronosyl transferase 1A and 2B isoforms using nano-ultra-high-performance liquid chromatography/tandem mass spectrometry with selected reaction monitoring.

Drug Metab Dispos 2013 Dec 17;41(12):2076-80. Epub 2013 Sep 17.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (J.K.F., P.C.S.); and Department. of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc., Andover, Massachusetts, (H.N.) and Groton, Connecticut, (T.C.G.).

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http://dx.doi.org/10.1124/dmd.113.053801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834135PMC
December 2013

Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring.

J Proteome Res 2013 Oct 26;12(10):4402-13. Epub 2013 Sep 26.

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/pr4004213DOI Listing
October 2013

Highly specific and sensitive measurements of human and monkey interleukin 21 using sequential protein and tryptic peptide immunoaffinity LC-MS/MS.

Anal Chem 2013 Jun 16;85(11):5522-9. Epub 2013 May 16.

Pfizer Worldwide Research & Development, Andover, MA 01810, USA.

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http://dx.doi.org/10.1021/ac4006765DOI Listing
June 2013

Sequential protein and peptide immunoaffinity capture for mass spectrometry-based quantification of total human β-nerve growth factor.

Anal Chem 2013 Feb 7;85(3):1719-26. Epub 2013 Jan 7.

Pfizer Inc., 1 Burtt Road, Andover, Massachusetts 01810, United States.

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http://dx.doi.org/10.1021/ac303031qDOI Listing
February 2013

Clinical pharmacokinetic assessment of an anti-MAdCAM monoclonal antibody therapeutic by LC-MS/MS.

Anal Chem 2012 Jul 5;84(14):5959-67. Epub 2012 Jul 5.

Pharmacokinetics Dynamics & Metabolism, Pfizer, Inc., Andover, Massachusetts 01810, United States.

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http://dx.doi.org/10.1021/ac300600fDOI Listing
July 2012

Online high-flow peptide immunoaffinity enrichment and nanoflow LC-MS/MS: assay development for total salivary pepsin/pepsinogen.

Clin Chem 2010 Sep 14;56(9):1413-23. Epub 2010 May 14.

Pharmacokinetics Dynamics & Metabolism and Biotherapeutics & Translational Research, Pfizer Limited, Kent, UK.

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http://dx.doi.org/10.1373/clinchem.2010.144576DOI Listing
September 2010

An immunoaffinity liquid chromatography-tandem mass spectrometry assay for the quantitation of matrix metalloproteinase 9 in mouse serum.

Anal Biochem 2010 Apr 11;399(2):202-10. Epub 2010 Jan 11.

Experimental Biological Sciences, Pfizer, Kent CT13 9NJ, UK.

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http://dx.doi.org/10.1016/j.ab.2010.01.002DOI Listing
April 2010

Online capillary weak cation exchange enrichment hyphenated to nanospray mass spectrometry for quantitation of a basic pegvisomant derived peptide.

J Chromatogr A 2009 Aug 1;1216(33):6151-4. Epub 2009 Jul 1.

Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S002196730900983
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http://dx.doi.org/10.1016/j.chroma.2009.06.072DOI Listing
August 2009

Assessing immunogenicity in the presence of excess protein therapeutic using immunoprecipitation and quantitative mass spectrometry.

Anal Chem 2008 Sep 15;80(18):6907-14. Epub 2008 Aug 15.

Pfizer Global Research and Development, Sandwich, UK.

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http://dx.doi.org/10.1021/ac8005439DOI Listing
September 2008

Label-free detection of differential protein expression by LC/MALDI mass spectrometry.

J Proteome Res 2008 Jun 16;7(6):2270-9. Epub 2008 Apr 16.

Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom.

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http://dx.doi.org/10.1021/pr700705uDOI Listing
June 2008

MALDI mass spectrometric determination of dendritic iron chelation stoichiometries and conditional affinity constants.

J Mass Spectrom 2008 May;43(5):617-22

Division of Pharmaceutical Science, King's College London, UK.

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http://dx.doi.org/10.1002/jms.1357DOI Listing
May 2008

The fenton activity of iron(III) in the presence of deferiprone.

J Pharm Sci 2008 Apr;97(4):1454-67

Division of Pharmaceutical Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1002/jps.21039DOI Listing
April 2008

Iron binding dendrimers: a novel approach for the treatment of haemochromatosis.

J Med Chem 2006 Jul;49(14):4171-82

Department of Pharmacy and Drug Control Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1021/jm0600949DOI Listing
July 2006

3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: a bidentate or tridentate iron(III) ligand?

J Med Chem 2006 May;49(10):3028-31

Pharmacy Department and Drug Control Centre/Mass Spectrometry Facility, King's College London, Franklin-Wilkins Building, Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1021/jm050905tDOI Listing
May 2006

High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: synthesis and characterization.

Bioorg Med Chem Lett 2005 Nov;15(22):5007-11

Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.008DOI Listing
November 2005

Structural characterization of chelator-terminated dendrimers and their synthetic intermediates by mass spectrometry.

J Mass Spectrom 2005 Sep;40(9):1203-14

Department of Medicinal-Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/jms.899DOI Listing
September 2005

Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques.

Mol Cell Proteomics 2005 Jul 25;4(7):984-92. Epub 2005 Apr 25.

Biomedical Sciences, Institute of Social and Health Research, Middlesex University, Enfield EN3 4SA, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M500085-MCP200DOI Listing
July 2005

C-terminal sequencing by mass spectrometry: application to gelatine-derived proline-rich peptides.

Proteomics 2005 Apr;5(5):1209-16

Centre for Chemical and Bioanalytical Sciences, Royal Holloway, University of London, Egham, UK.

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http://dx.doi.org/10.1002/pmic.200401006DOI Listing
April 2005

Widespread sulfenic acid formation in tissues in response to hydrogen peroxide.

Proc Natl Acad Sci U S A 2004 Dec 16;101(52):17982-7. Epub 2004 Dec 16.

Department of Cardiology, Cardiovascular Division, The Rayne Institute, St. Thomas' Hospital, King's College London, London SE1 7EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0404762101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539740PMC
December 2004

MALDI post-source decay and LIFT-TOF/TOF investigation of alpha-cyano-4-hydroxycinnamic acid cluster interferences.

J Am Soc Mass Spectrom 2004 Mar;15(3):336-43

Drug Control Centre, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jasms.2003.11.002DOI Listing
March 2004

BSE control: detection of gelatine-derived peptides in animal feed by mass spectrometry.

Analyst 2004 Feb 23;129(2):111-5. Epub 2003 Dec 23.

Centre for Chemical and Bioanalytical Sciences, Royal Holloway University of London, Egham, UK W20 0EX.

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http://dx.doi.org/10.1039/b312593aDOI Listing
February 2004

Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G.

Anal Chem 2002 Aug;74(15):3677-83

Drug Control Centre and Department of Pharmacy, King's College London, United Kingdom.

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http://dx.doi.org/10.1021/ac025558zDOI Listing
August 2002