Hemachandra Reddy

Hemachandra Reddy

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Hemachandra Reddy

Publications by authors named "Hemachandra Reddy"

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DNA repair fidelity in stem cell maintenance, health, and disease.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 4;1866(4):165444. Epub 2019 Apr 4.

Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Centre, Lubbock, TX 79430, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.03.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935429PMC
April 2020

Current status of stem cell research: An editorial.

Biochim Biophys Acta Mol Basis Dis 2020 Apr 17;1866(4):165635. Epub 2019 Dec 17.

Internal Medicine, Texas Tech University Health Sciences Center, 3601 Fourth Street/MS/9410/4B 207, Lubbock, TX 79430, United States; Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, 3601 Fourth Street/MS/9424/4B 207, Lubbock, TX 79430, United States; Neurology, Departments of School of Medicine, Texas Tech University Health Sciences Center, 3601 Fourth Street/MS/9424/4B 207, Lubbock, TX 79430, United States; Public Health Department of Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, 3601 Fourth Street/MS/9424/4B 207, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Department, School Health Professions, Texas Tech University Health Sciences Center, 3601 Fourth Street/MS/9410/4B 207, Lubbock, TX 79430, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.165635DOI Listing
April 2020

Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer's disease.

Hum Mol Genet 2020 Jan;29(1):49-69

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1093/hmg/ddz227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001603PMC
January 2020

Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease.

Front Aging Neurosci 2019 10;11:369. Epub 2020 Jan 10.

Department of Biotechnology and Microbial Biotechnology, Sri Guru Gobind Singh College, Chandigarh, India.

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http://dx.doi.org/10.3389/fnagi.2019.00369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966236PMC
January 2020

Novel miRNA PC-5P-12969 in Ischemic Stroke.

Mol Neurobiol 2019 Oct 5;56(10):6976-6985. Epub 2019 Apr 5.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1007/s12035-019-1562-xDOI Listing
October 2019

Molecular and cellular bases of diabetes: Focus on type 2 diabetes mouse model-TallyHo.

Biochim Biophys Acta Mol Basis Dis 2019 Sep 11;1865(9):2276-2284. Epub 2019 May 11.

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4(th) Street, Lubbock, TX 79430, United States; Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, 3601 4(th) Street, Lubbock, TX 79430, United States; Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Neurology Department, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Department, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Department of Public Health, Graduate School of Biomedical Sciences, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.05.004DOI Listing
September 2019

Novel MicroRNA-455-3p and its protective effects against abnormal APP processing and amyloid beta toxicity in Alzheimer's disease.

Biochim Biophys Acta Mol Basis Dis 2019 Sep 8;1865(9):2428-2440. Epub 2019 Jun 8.

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Neurology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Suite E, MS 7495, Lubbock, TX 79413, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688505PMC
September 2019

Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.

Cells 2019 08 23;8(9). Epub 2019 Aug 23.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3390/cells8090961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769467PMC
August 2019

Corrigendum to "Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal" [Drug Discov. Today 22 (February (2)) (2017) 223-233].

Drug Discov Today 2019 Jul 5;24(7):1423. Epub 2018 Jan 5.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Speech, Language and Hearing Sciences, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Ste. E, MS 7495, Lubbock, TX 79413, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2017.12.003DOI Listing
July 2019

Improvement in Glycemic Control in Mice of Different Age Groups.

Exp Clin Endocrinol Diabetes 2019 Jul 24. Epub 2019 Jul 24.

Department of Nutritional Sciences, Obesity and Metabolic Health Laboratory, Texas Tech University, Lubbock, TX, USA.

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http://dx.doi.org/10.1055/a-0961-7804DOI Listing
July 2019

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease.

J Alzheimers Dis 2018 ;62(4):1549-1565

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-170988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884714PMC
May 2019

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer's Disease.

Cells 2019 05 22;8(5). Epub 2019 May 22.

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3390/cells8050488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562604PMC
May 2019

Amyloid Beta and MicroRNAs in Alzheimer's Disease.

Front Neurosci 2019 3;13:430. Epub 2019 May 3.

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

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http://dx.doi.org/10.3389/fnins.2019.00430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510214PMC
May 2019

Small molecules as therapeutic drugs for Alzheimer's disease.

Mol Cell Neurosci 2019 04 12;96:47-62. Epub 2019 Mar 12.

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, United State; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Suite E, Lubbock, TX 79413, United States; Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, United States; Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, United States; Neurology Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, United States; Department of Public Health, Graduate School of Biomedical Sciences, 3601 4th Street, Lubbock, TX 79430, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510253PMC
April 2019

Corrigendum: Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Hum Mol Genet 2019 Mar;28(5):875-876

Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA.

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http://dx.doi.org/10.1093/hmg/ddy399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381310PMC
March 2019

Potential role of E4orf1 protein in aging-associated impairment in glycemic control.

J Diabetes Complications 2019 03 22;33(3):261-265. Epub 2018 Nov 22.

Obesity and Metabolic Health Laboratory, Nutritional Sciences Department, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183102
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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.006DOI Listing
March 2019

Structure Based Design and Molecular Docking Studies for Phosphorylated Tau Inhibitors in Alzheimer's Disease.

Cells 2019 03 19;8(3). Epub 2019 Mar 19.

Internal Medicine Department, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3390/cells8030260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468864PMC
March 2019

Pharmacophore-based models for therapeutic drugs against phosphorylated tau in Alzheimer's disease.

Drug Discov Today 2019 02 16;24(2):616-623. Epub 2018 Nov 16.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Pharmacology & Neuroscience Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Neurology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Suite E, MS 7495, Lubbock, TX 79413, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397090PMC
February 2019

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity.

Hum Mol Genet 2019 01;28(2):177-199

Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS, Lubbock, TX, USA.

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http://dx.doi.org/10.1093/hmg/ddy335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322070PMC
January 2019

Molecular Basis of Alzheimer's Disease: Focus on Mitochondria.

J Alzheimers Dis 2019 ;72(s1):S95-S116

Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

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http://dx.doi.org/10.3233/JAD-190048DOI Listing
January 2019

Can Healthy Diets, Regular Exercise, and Better Lifestyle Delay the Progression of Dementia in Elderly Individuals?

J Alzheimers Dis 2019 ;72(s1):S37-S58

Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-190232DOI Listing
January 2019

Are TallyHo Mice A True Mouse Model for Type 2 Diabetes and Alzheimer's Disease?

J Alzheimers Dis 2019 ;72(s1):S81-S93

Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-190613DOI Listing
January 2019

A New Discovery of MicroRNA-455-3p in Alzheimer's Disease.

J Alzheimers Dis 2019 ;72(s1):S117-S130

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-190583DOI Listing
January 2019

Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer's Disease?

J Alzheimers Dis 2019 ;72(s1):S71-S79

Internal Medicine, Cell Biology and Biochemistry, Neuroscience/Pharmacology and Neurology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-190808DOI Listing
January 2019

Role of Phosphorylated Tau and Glucose Synthase Kinase 3 Beta in Huntington's Disease Progression.

J Alzheimers Dis 2019 ;72(s1):S177-S191

Internal Medicine Department, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-190851DOI Listing
January 2019

Current Issues in Chronic Diseases: A Focus on Dementia and Hypertension in Rural West Texans.

J Alzheimers Dis 2019 ;72(s1):S59-S69

School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-190893DOI Listing
January 2019

Lifestyle and Risk Factors of Dementia in Rural West Texas.

J Alzheimers Dis 2019 ;72(s1):S1-S10

Professor of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-191280DOI Listing
January 2019

Liquid Crystals: A Novel Approach for Cancer Detection and Treatment.

Cancers (Basel) 2018 Nov 21;10(11). Epub 2018 Nov 21.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.3390/cancers10110462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267481PMC
November 2018

Preface.

Prog Mol Biol Transl Sci 2017 ;146:xvii-xx

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http://dx.doi.org/10.1016/S1877-1173(17)30028-5DOI Listing
July 2018

Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke.

Hum Mol Genet 2018 07;27(13):2318-2329

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1093/hmg/ddy136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005038PMC
July 2018

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons.

J Alzheimers Dis 2017 ;57(4):975-999

Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-160612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793225PMC
February 2018

Role of Glutamate and NMDA Receptors in Alzheimer's Disease.

J Alzheimers Dis 2017 ;57(4):1041-1048

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-160763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791143PMC
February 2018

Therapeutics of Neurotransmitters in Alzheimer's Disease.

J Alzheimers Dis 2017 ;57(4):1049-1069

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-161118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793221PMC
February 2018

Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer's Disease.

J Alzheimers Dis 2017 ;58(1):147-162

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-170051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444307PMC
February 2018

A Critical Assessment of Research on Neurotransmitters in Alzheimer's Disease.

J Alzheimers Dis 2017 ;57(4):969-974

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-170256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791142PMC
February 2018

MicroRNA-455-3p as a Potential Biomarker for Alzheimer's Disease: An Update.

Front Aging Neurosci 2018 23;10:41. Epub 2018 Feb 23.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States.

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http://dx.doi.org/10.3389/fnagi.2018.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829054PMC
February 2018

MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease.

Hum Mol Genet 2017 10;26(19):3808-3822

Biomarker Unit, Garrison Institute on Aging.

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http://dx.doi.org/10.1093/hmg/ddx267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075184PMC
October 2017

Cell cycle activation in p21 dependent pathway: An alternative mechanism of organophosphate induced dopaminergic neurodegeneration.

Biochim Biophys Acta Mol Basis Dis 2017 07 2;1863(7):1858-1866. Epub 2016 Jun 2.

Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.05.014DOI Listing
July 2017

Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.

Biochim Biophys Acta Mol Basis Dis 2017 May 6;1863(5):1037-1045. Epub 2016 May 6.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.1016/j.bbadis.2016.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344771PMC
May 2017

Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal.

Biochim Biophys Acta Mol Basis Dis 2017 05 25;1863(5):1078-1089. Epub 2016 Aug 25.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Departments of Cell Biology & Biochemistry, Neuroscience & Pharmacology and Neurology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States.

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http://dx.doi.org/10.1016/j.bbadis.2016.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344773PMC
May 2017

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies.

Biochim Biophys Acta Mol Basis Dis 2017 05 9;1863(5):1066-1077. Epub 2016 Nov 9.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neuroscience & Pharmacology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neurology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Suite E, MS 7495, Lubbock, TX 79413, United States.

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http://dx.doi.org/10.1016/j.bbadis.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423868PMC
May 2017

Are microRNAs true sensors of ageing and cellular senescence?

Ageing Res Rev 2017 May 27;35:350-363. Epub 2016 Nov 27.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neuroscience & Pharmacology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neurology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Suite E, MS 7495, Lubbock, TX 79413, United States. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357446PMC
May 2017

Methods needed to measure predictive accuracy: A study of diabetic patients.

Biochim Biophys Acta Mol Basis Dis 2017 05 11;1863(5):1046-1053. Epub 2017 Jan 11.

Department of Public Health, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neuroscience & Pharmacology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neurology Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language, and Hearing Sciences Department, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Suite E, MS 7495, Lubbock, TX 79413, United States.

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http://dx.doi.org/10.1016/j.bbadis.2017.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429869PMC
May 2017

Dynamics of diabetes and obesity: Epidemiological perspective.

Biochim Biophys Acta Mol Basis Dis 2017 May 24;1863(5):1026-1036. Epub 2017 Jan 24.

Community Outreach and Education, 6630 S. Quaker Ave., Suite E, Lubbock, TX 79413, United States; Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430-9424, United States; Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430-9424, United States; Department of Pharmacology & Neuroscience, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430-9424, United States; Department of Neurology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430-9424, United States; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430-9424, United States; Department of Public Health, 3601 4th Street, MS 9424, Lubbock, TX 79430-9424, United States.

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http://dx.doi.org/10.1016/j.bbadis.2017.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429876PMC
May 2017

Editorial of the article.

Biochim Biophys Acta Mol Basis Dis 2017 05 14;1863(5):1023-1025. Epub 2017 Feb 14.

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http://dx.doi.org/10.1016/j.bbadis.2017.02.010DOI Listing
May 2017

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.

Hum Mol Genet 2017 04;26(8):1483-1496

Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS 9424 Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1093/hmg/ddx052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075532PMC
April 2017

Mitochondria-targeted small molecule SS31: a potential candidate for the treatment of Alzheimer's disease.

Hum Mol Genet 2017 04;26(8):1597

Garrison Institute on Aging, Texas Tech University Health Sciences Center, MS 9424 Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1093/hmg/ddx129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303436PMC
April 2017

Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts.

Physiol Rep 2017 Mar;5(5)

Cell Biology and Biochemistry and Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas.

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http://dx.doi.org/10.14814/phy2.13184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350185PMC
March 2017

White Matter Deterioration May Foreshadow Impairment of Emotional Valence Determination in Early-Stage Dementia of the Alzheimer Type.

Front Aging Neurosci 2017 1;9:37. Epub 2017 Mar 1.

Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences CenterLubbock, TX, USA; Department of Human Development and Family Studies, Texas Tech UniversityLubbock, TX, USA.

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http://dx.doi.org/10.3389/fnagi.2017.00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331035PMC
March 2017

Can Diabetes Be Controlled by Lifestyle Activities?

Curr Res Diabetes Obes J 2017 Mar 20;1(4). Epub 2017 Mar 20.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792082PMC
March 2017

A critical evaluation of neuroprotective and neurodegenerative MicroRNAs in Alzheimer's disease.

Biochem Biophys Res Commun 2017 02 12;483(4):1156-1165. Epub 2016 Aug 12.

Department of Internal Medicine, Texas Tech University Health Sciences Center, 3601 Fourth Street, MS 9424, Lubbock, TX 79430, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.08.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343756PMC
February 2017

Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.

Drug Discov Today 2017 02 27;22(2):223-233. Epub 2016 Oct 27.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Neurology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Department of Speech, Language and Hearing Sciences, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Ste. E, MS 7495, Lubbock, TX 79413, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344027PMC
February 2017

Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.

Hum Mol Genet 2016 11;25(22):4881-4897

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA.

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http://dx.doi.org/10.1093/hmg/ddw312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078590PMC
November 2016

Peripheral biomarkers of stroke: Focus on circulatory microRNAs.

Biochim Biophys Acta 2016 10 5;1862(10):1984-93. Epub 2016 Aug 5.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neurology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Ste. E, MS 7495, Lubbock, TX 79413, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343760PMC
October 2016

Are circulating microRNAs peripheral biomarkers for Alzheimer's disease?

Biochim Biophys Acta 2016 09 2;1862(9):1617-27. Epub 2016 Jun 2.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Neurology Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Ste. E, MS 7495, Lubbock, TX 79413, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343750PMC
September 2016

Stroke, Vascular Dementia, and Alzheimer's Disease: Molecular Links.

J Alzheimers Dis 2016 09;54(2):427-43

Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://dx.doi.org/10.3233/JAD-160527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793908PMC
September 2016

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.

Hum Mol Genet 2016 05 16;25(9):1739-53. Epub 2016 Feb 16.

Garrison Institute on Aging, Cell Biology and Biochemistry, Neuroscience & Pharmacology, Neurology and Speech, Language and Hearing Sciences Departments, Texas Tech University Health Sciences Center, 3601 4th Street, MS 9424, Lubbock, TX 79430, USA

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http://dx.doi.org/10.1093/hmg/ddw045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986329PMC
May 2016

Impact of Exercise and Education in Adults of Lubbock, Texas: Implications for Better Lifestyle.

Front Aging Neurosci 2016 10;8:85. Epub 2016 May 10.

Garrison Institute on Aging, Southwest Campus, Texas Tech University Health Sciences CenterLubbock, TX, USA; Garrison Institute on Aging, Texas Tech University Health Sciences CenterLubbock, TX, USA; Cell Biology and Biochemistry, Neuroscience/Pharmacology and Neurology Departments, Texas Tech University Health Sciences CenterLubbock, TX, USA.

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http://dx.doi.org/10.3389/fnagi.2016.00085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861719PMC
May 2016

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis.

Biochim Biophys Acta 2016 04 17;1862(4):814-828. Epub 2015 Dec 17.

Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Cell Biology & Biochemistry, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Department of Neuroscience & Pharmacology, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Department of Neurology, Texas Tech University Health Sciences Center, 3601 4(th) Street, MS 9424, Lubbock, TX 79430, United States; Garrison Institute on Aging, South West Campus, Texas Tech University Health Sciences Center, 6630 S. Quaker Ste. E, MS 7495, Lubbock, TX 79413, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343673PMC
April 2016

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.

Hum Mol Genet 2015 Dec 12;24(25):7308-25. Epub 2015 Oct 12.

Garrison Institute on Aging and Cell Biology and Biochemistry, Neuroscience/Pharmacology and Neurology Departments, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA

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http://dx.doi.org/10.1093/hmg/ddv429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664169PMC
December 2015

Garrison Institute on Aging-Lubbock Retired and Senior Volunteer Program (RSVP) Provides Services to South Plains, Texas.

Front Aging Neurosci 2015 8;7:215. Epub 2015 Dec 8.

Garrison Institute on Aging, Texas Tech University Health Sciences Center Lubbock, TX, USA ; Cell Biology and Biochemistry, Texas Tech University Health Sciences Center Lubbock, TX, USA ; Neuroscience/Pharmacology, Texas Tech University Health Sciences Center Lubbock, TX, USA ; Neurology, Texas Tech University Health Sciences Center Lubbock, TX, USA.

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http://dx.doi.org/10.3389/fnagi.2015.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672082PMC
December 2015

Mitochondrial division and fusion in metabolism.

Curr Opin Cell Biol 2015 Apr 19;33:111-8. Epub 2015 Feb 19.

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380865PMC
April 2015

Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction.

J Alzheimers Dis 2014 ;40(2):245-56

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR, USA.

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http://dx.doi.org/10.3233/JAD-132060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972337PMC
January 2015

Misfolded proteins, mitochondrial dysfunction, and neurodegenerative diseases.

Biochim Biophys Acta 2014 Aug 29;1842(8):1167. Epub 2014 Mar 29.

Neurogenetics Laboratory, Neuroscience Division, Oregon National Primate Research Center, West Campus, Oregon Health and Science University, 505 N.W. 185th Avenue Beaverton, OR 97006.

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http://dx.doi.org/10.1016/j.bbadis.2014.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343755PMC
August 2014

Reduced VDAC1 protects against Alzheimer's disease, mitochondria, and synaptic deficiencies.

J Alzheimers Dis 2013 ;37(4):679-90

Neurogenetics Laboratory, Neuroscience Division, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.

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http://dx.doi.org/10.3233/JAD-130761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925364PMC
July 2014

Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission.

Drug Discov Today 2014 Jul 28;19(7):951-5. Epub 2014 Mar 28.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA; Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2014.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191657PMC
July 2014

Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage.

J Alzheimers Dis 2013 ;36(2):285-95

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.3233/JAD-130275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943249PMC
January 2014

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: implications for synaptic dysfunction and neuronal damage.

Biochim Biophys Acta 2013 Dec 28;1832(12):1913-21. Epub 2013 Jun 28.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA; Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2013.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825775PMC
December 2013

MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.

Biochim Biophys Acta 2013 Dec 19;1832(12):2322-31. Epub 2013 Sep 19.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA; Department of Physiology and Pharmacology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.bbadis.2013.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830526PMC
December 2013

RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity.

Biochim Biophys Acta 2013 Dec 21;1832(12):2368-78. Epub 2013 Sep 21.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2013.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830527PMC
December 2013

Mitochondria-Targeted Antioxidant SS31 Prevents Amyloid Beta-Induced Mitochondrial Abnormalities and Synaptic Degeneration in Alzheimer's Disease.

Pharmaceuticals (Basel) 2012 ;5(10):1103-19

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA; (M.M.); (P.H.R.) ; Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.3390/ph5101103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513393PMC
November 2013

Neurotransmitter CART as a New Therapeutic Candidate for Parkinson's Disease.

Pharmaceuticals (Basel) 2013 ;6(1):108-23

Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA ; Department of Public Health and Preventive Medicine, and the Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA ; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.3390/ph6010108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609669PMC
November 2013

Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?

Biochim Biophys Acta 2013 Jan 17;1832(1):67-75. Epub 2012 Sep 17.

Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518645PMC
January 2013

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease.

Hum Mol Genet 2012 Dec 27;21(23):5131-46. Epub 2012 Aug 27.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1093/hmg/dds360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490521PMC
December 2012

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage.

Hum Mol Genet 2012 Jun 24;21(11):2538-47. Epub 2012 Feb 24.

Neurogenetics Laboratory, Neuroscience Division, Oregon National Primate Research Center, West Campus, Oregon Health and Science University, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1093/hmg/dds072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349426PMC
June 2012

Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies.

Biochim Biophys Acta 2012 Jun 23;1822(6):862-74. Epub 2012 Feb 23.

Neurogenetics Laboratory, Neuroscience Division, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2012.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338881PMC
June 2012

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics.

Biochim Biophys Acta 2012 May 19;1822(5):639-49. Epub 2011 Oct 19.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272314PMC
May 2012

CART peptide is a potential endogenous antioxidant and preferentially localized in mitochondria.

PLoS One 2012 3;7(1):e29343. Epub 2012 Jan 3.

The Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250433PMC
May 2012

Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: implications for aging.

Biochim Biophys Acta 2012 Feb 28;1822(2):111-9. Epub 2011 Oct 28.

Neuroscience Division, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249524PMC
February 2012

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease.

Biochim Biophys Acta 2012 Feb 4;1822(2):101-10. Epub 2011 Nov 4.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249480PMC
February 2012

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.

Hum Mol Genet 2012 Jan 13;21(2):406-20. Epub 2011 Oct 13.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1093/hmg/ddr475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276281PMC
January 2012

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.

Hum Mol Genet 2011 Dec 25;20(23):4515-29. Epub 2011 Aug 25.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1093/hmg/ddr381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209824PMC
December 2011

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics.

Biochim Biophys Acta 2011 Nov 18;1812(11):1359-70. Epub 2011 Aug 18.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185172PMC
November 2011

Assessment of newly synthesized mitochondrial DNA using BrdU labeling in primary neurons from Alzheimer's disease mice: Implications for impaired mitochondrial biogenesis and synaptic damage.

Biochim Biophys Acta 2011 Sep 27;1812(9):1182-9. Epub 2011 Apr 27.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.bbadis.2011.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143239PMC
September 2011

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease.

Brain Res 2011 Sep 31;1415:136-48. Epub 2011 Jul 31.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1016/j.brainres.2011.07.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176990PMC
September 2011

A transgenic mouse model for Alzheimer's disease has impaired synaptic gain but normal synaptic dynamics.

Neurosci Lett 2011 Aug 29;500(3):212-5. Epub 2011 Jun 29.

Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Pk Rd., Portland, OR 97239, United States.

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http://dx.doi.org/10.1016/j.neulet.2011.06.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252233PMC
August 2011