Publications by authors named "Helmut R Salih"

81Publications

Protocol of a prospective, multicentre phase I study to evaluate the safety, tolerability and preliminary efficacy of the bispecific PSMAxCD3 antibody CC-1 in patients with castration-resistant prostate carcinoma.

BMJ Open 2020 10 16;10(10):e039639. Epub 2020 Oct 16.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany

View Article and Find Full Text PDF
October 2020

Genetic Loss of LCK Kinase Leads to Acceleration of Chronic Lymphocytic Leukemia.

Front Immunol 2020 2;11:1995. Epub 2020 Sep 2.

Department of Hematology, Oncology and Clinical Immunology and Rheumatology, University of Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
September 2020

Neutralization of B-Cell Activating Factor (BAFF) by Belimumab Reinforces Small Molecule Inhibitor Treatment in Chronic Lymphocytic Leukemia.

Cancers (Basel) 2020 Sep 23;12(10). Epub 2020 Sep 23.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Department of Internal Medicine, University Hospital Tuebingen, 72076 Tuebingen, Germany.

View Article and Find Full Text PDF
September 2020

Fc gamma receptor expression serves as prognostic and diagnostic factor in AML.

Leuk Lymphoma 2020 10 16;61(10):2466-2474. Epub 2020 Jun 16.

Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), University Hospital Tübingen, Tubingen, Germany.

View Article and Find Full Text PDF
October 2020

hERG K Channels Promote Survival of Irradiated Leukemia Cells.

Front Pharmacol 2020 24;11:489. Epub 2020 Apr 24.

Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
April 2020

CD105 (endoglin) as risk marker in AML patients undergoing stem cell transplantation.

Int J Hematol 2020 Jul 7;112(1):57-64. Epub 2020 Apr 7.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
July 2020

Modulation of Immune Responses by Platelet-Derived ADAM10.

Front Immunol 2020 5;11:44. Epub 2020 Feb 5.

Department of Hematology, Medical Oncology and Pneumology, University Medical Center of Mainz, Mainz, Germany.

View Article and Find Full Text PDF
February 2020

Identification of CD318 (CDCP1) as novel prognostic marker in AML.

Ann Hematol 2020 Mar 21;99(3):477-486. Epub 2020 Jan 21.

Department of Immunology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Interfaculty Institute for Cell Biology, University of Tübingen, Partner Site Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
March 2020

Induction of NK Cell Reactivity against B-Cell Acute Lymphoblastic Leukemia by an Fc-Optimized FLT3 Antibody.

Cancers (Basel) 2019 Dec 6;11(12). Epub 2019 Dec 6.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, 72076 Tübingen, Germany.

View Article and Find Full Text PDF
December 2019

CD105 (Endoglin) as negative prognostic factor in AML.

Sci Rep 2019 12 4;9(1):18337. Epub 2019 Dec 4.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
December 2019

The challenges of translation.

EMBO Mol Med 2019 12 18;11(12):e10874. Epub 2019 Oct 18.

Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.

View Article and Find Full Text PDF
December 2019

An Fc-Optimized CD133 Antibody for Induction of Natural Killer Cell Reactivity against Colorectal Cancer.

Cancers (Basel) 2019 Jun 7;11(6). Epub 2019 Jun 7.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), 72076 Partner site Tuebingen, Germany.

View Article and Find Full Text PDF
June 2019

Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia.

J Immunother Cancer 2019 05 29;7(1):143. Epub 2019 May 29.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner site Tuebingen, Otfried-Mueller-Str. 10, 72076, Tuebingen, Germany.

View Article and Find Full Text PDF
May 2019

Inhibition of NK Reactivity Against Solid Tumors by Platelet-Derived RANKL.

Cancers (Basel) 2019 Feb 26;11(3). Epub 2019 Feb 26.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner site Tuebingen 72076, Germany.

View Article and Find Full Text PDF
February 2019

The novel deubiquitinase inhibitor b-AP15 induces direct and NK cell-mediated antitumor effects in human mantle cell lymphoma.

Cancer Immunol Immunother 2018 06 19;67(6):935-947. Epub 2018 Mar 19.

Clinical Collaboration Unit Translational Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Partner site Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

View Article and Find Full Text PDF
June 2018

The BCR-ABL inhibitor nilotinib influences phenotype and function of monocyte-derived human dendritic cells.

Cancer Immunol Immunother 2018 May 21;67(5):775-783. Epub 2018 Feb 21.

Department of Medical Oncology, Hematology, Immunology, Rheumatology and Pulmology, University Hospital Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany.

View Article and Find Full Text PDF
May 2018

Reply to: "Histone deacetylase inhibitor for the treatment of hepatocellular carcinoma: Chemoimmunotherapeutic perspective and prospects".

J Hepatol 2017 04 9;66(4):867-868. Epub 2017 Jan 9.

Medical University Clinic, Eberhard Karls University, Tübingen, Germany.

View Article and Find Full Text PDF
April 2017

Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction.

Proc Natl Acad Sci U S A 2016 11 10;113(48):13827-13832. Epub 2016 Nov 10.

Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany;

View Article and Find Full Text PDF
November 2016

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial.

J Clin Oncol 2017 Feb 31;35(6):605-612. Epub 2016 Oct 31.

Uwe Platzbecker, Christian Thiede, Christoph Röllig, and Gerhard Ehninger, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden; Uwe Platzbecker and Gerhard Ehninger, Study Alliance Leukemia, Dresden; Walter Fiedler, University Hospital Hamburg-Eppendorf; Norbert Schmitz, Asklepios Klinik St Georg Hamburg, Hamburg; Peter Brossart, Innere Medizin mit deSchwerpunkten Onkologie, Haematollogie un Rheumatologie, Bonn; Bernd Hertenstein, Klinikum Bremen Mitte, Bremen; Helmut R. Salih, University Hospital Tubingen; Mohammed Wattad, Kliniken Essen Süd, Essen; Michael Lübbert, University Medical Center, Freiburg; Christian H. Brandts, Goethe University Frankfurt, Frankfurt; Mathias Hänel, Klinikum Chemnitz gGmbH, Chemnitz; Hartmut Link, Klinik für Innere Medizin I, Westpfalz-Klinikum, Kaiserslautern; Konstanze Döhner, Hartmut Döhner, and Richard F. Schlenk, University Hospital Ulm, Ulm; Arnold Ganser, Hannover Medical School, Hannover, Germany; Giuseppe Avvisati, University Campus Bio-Medico; Laura Cicconi, Mariadomenica Divona, Sergio Amadori, and Francesco Lo-Coco, University Tor Vergata; Francesca Paoloni, Marco Vignetti, Fabio Efficace, Paola Fazi, and Franco Mandelli, Gruppo Italiano Malattie Ematologiche dell'Adulto Central Office; Marco Vignetti and Massimo Breccia, Sapienza University, Rome; Felicetto Ferrara, Cardarelli Hospital, Naples; Francesco Albano, University of Bari, Bari; Marco Sborgia, U.O. di Ematologia Clinica, Pescara; Eros Di Bona, San Bortolo Hospital, Vicenza; Erika Borlenghi, U.O. di Ematologia, Spedali Civili, Brescia; Roberto Cairoli, Ospedale Niguarda, Ca' Granda, SC Ematologia; Agostino Cortelezzi, Foundation Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico and University of Milan, Milano; Alessandro Rambaldi, Azienda Opsedaliera Papa Giovanni XXIII, Bergamo; Lorella Melillo, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo; Giorgio La Nasa, Centro Trapianti Midollo Osseo, Ospedale R. Binaghi, Università di Cagliari, Cagliari; Chiara Frairia, Hematology, Città della Salute e della Scienza, Torino; Enrico Maria Pogliani, Ospedale San Gerardo, Università degli Studi Milano Bicocca, Monza; Claudio Fozza, University of Sassari, Sassari; Alfonso Maria D'Arco, U.O. Medicina Interna e Onco-Ematologica P.O. "Umberto I," Nocera Inferiore, Nocera Inferiore; Nicola Di Renzo, Ospedale Vito Fazzi, Lecce; and Francesco Fabbiano, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.

View Article and Find Full Text PDF
February 2017

Expression of 4-1BB and its ligand on blasts correlates with prognosis of patients with AML.

J Investig Med 2016 12 7;64(8):1252-1260. Epub 2016 Jul 7.

Department for Hematopoetic Cell Transplantation, Medical Department 3, University Hospital of Munich, Munich, Germany.

View Article and Find Full Text PDF
December 2016

Erratum to: The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells.

Cell Commun Signal 2016 05 17;14(1):11. Epub 2016 May 17.

Department of Internal Medicine II, Oncology, Hematology, Immunology, Rheumatology and Pulmology, University of Tübingen, Otfried-Müller-Str. 10, Tübingen, 72076, Germany.

View Article and Find Full Text PDF
May 2016

Cardiac Myeloid Sarcoma: Multimodality Radiologic Imaging Features and Pathologic Correlation.

Am J Med 2016 Aug 18;129(8):e117-20. Epub 2016 Apr 18.

Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Germany. Electronic address:

View Article and Find Full Text PDF
August 2016

Death Receptor Expression on Blasts in AML Is Associated with Unfavorable Prognosis.

Anticancer Res 2015 Jul;35(7):4043-52

Medical Department 3, Department for Hematopoetic Cell Transplantations, University Hospital of Munich, Munich, Germany

View Article and Find Full Text PDF
July 2015

The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells.

Cell Commun Signal 2015 Mar 24;13:19. Epub 2015 Mar 24.

Department of Internal Medicine II, Oncology, Hematology, Immunology, Rheumatology and Pulmology, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

View Article and Find Full Text PDF
March 2015

Characterization of a bispecific FLT3 X CD3 antibody in an improved, recombinant format for the treatment of leukemia.

Mol Ther 2015 Apr 12;23(4):648-55. Epub 2015 Jan 12.

1] Department of Immunology, Eberhard Karls Universität Tübingen, Tübingen, Germany [2] German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

View Article and Find Full Text PDF
April 2015

Fc-optimized NKG2D-Fc constructs induce NK cell antibody-dependent cellular cytotoxicity against breast cancer cells independently of HER2/neu expression status.

J Immunol 2014 Oct 12;193(8):4261-72. Epub 2014 Sep 12.

Department of Hematology and Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany; Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, D-69120 Heidelberg, Germany;

View Article and Find Full Text PDF
October 2014

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Blood 2014 Jul 24;124(1):13-23. Epub 2014 Apr 24.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany;

View Article and Find Full Text PDF
July 2014

Sequential combination of gemtuzumab ozogamicin and standard chemotherapy in older patients with newly diagnosed acute myeloid leukemia: results of a randomized phase III trial by the EORTC and GIMEMA consortium (AML-17).

J Clin Oncol 2013 Dec 14;31(35):4424-30. Epub 2013 Oct 14.

Sergio Amadori and Adriano Venditti, Tor Vergata University Hospital; Paolo De Fabritiis, St Eugenio Hospital; Roberto Latagliata, University Sapienza; Paola Fazi and Marco Vignetti, Gruppo Italiano Malattie Ematologiche dell'Adulto, Roma; Franca Falzetti, University Hospital, Perugia; Domenico Magro, Pugliese Hospital, Catanzaro; Giorgina Specchia, University Hospital, Bari, Italy; Stefan Suciu and Matthias Karrasch, European Organisation for Research and Treatment of Cancer, Brussels; Dominik Selleslag, Algemeen Ziekenhuis St Jan, Brugge; Zwi Berneman, University Hospital, Antwerp, Belgium; Roberto Stasi, St George's Hospital, London, United Kingdom; Helmut R. Salih, University Hospital, Tubingen; Anthony D. Ho, University Hospital, Heidelberg; Michael Lübbert, Albert Ludwigs University, Freiburg, Germany; Petra Muus and Theo de Witte, Radboud University Medical Centre, Nijmegen; Constantijn J.M. Halkes and Roel Willemze, University Medical Center, Leiden, the Netherlands; Xavier Thomas, Edouard Herriot Hospital, Lyon; Jean-Pierre Marie, St. Antoine Hospital, Paris, France; and José E. Guimaraes, University Hospital, Porto, Portugal.

View Article and Find Full Text PDF
December 2013

Kv3.4 potassium channel-mediated electrosignaling controls cell cycle and survival of irradiated leukemia cells.

Pflugers Arch 2013 Aug 27;465(8):1209-21. Epub 2013 Feb 27.

Department of Radiation Oncology, University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

View Article and Find Full Text PDF
August 2013

GITR ligand provided by thrombopoietic cells inhibits NK cell antitumor activity.

J Immunol 2012 Jul 30;189(1):154-60. Epub 2012 May 30.

Department of Hematology/Oncology, Eberhard Karls University, D-72076 Tuebingen, Germany.

View Article and Find Full Text PDF
July 2012

More than just tumor destruction: immunomodulation by thermal ablation of cancer.

Clin Dev Immunol 2011 29;2011:160250. Epub 2011 Dec 29.

Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, Otfried Mueller Straße 10, 72076 Tuebingen, Germany.

View Article and Find Full Text PDF
April 2012

4-1BB ligand modulates direct and Rituximab-induced NK-cell reactivity in chronic lymphocytic leukemia.

Eur J Immunol 2012 Mar 20;42(3):737-48. Epub 2011 Dec 20.

Department of Hematology, Eberhard Karls University of Tuebingen, Tuebingen, Germany.

View Article and Find Full Text PDF
March 2012

The immune inhibitory receptor osteoactivin is upregulated in monocyte-derived dendritic cells by BCR-ABL tyrosine kinase inhibitors.

Cancer Immunol Immunother 2012 Feb 27;61(2):193-202. Epub 2011 Aug 27.

Department of Oncology, Hematology, Immunology, Rheumatology and Pulmology, University of Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

View Article and Find Full Text PDF
February 2012

Acquired coagulopathy caused by intoxication with the superwarfarin-type anticoagulant rodenticide flocoumafen.

Eur J Haematol 2011 Feb 29;86(2):173-5. Epub 2010 Dec 29.

Department of Hematology/Oncology, University of Tuebingen Medical School, Otfried-Mueller-Strasse 10, Tuebingen, Germany.

View Article and Find Full Text PDF
February 2011

Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation.

Int J Cancer 2011 Jun 19;128(12):2911-22. Epub 2010 Oct 19.

Department of Hematology and Oncology, Eberhard Karls University, Tuebingen, Germany.

View Article and Find Full Text PDF
June 2011

Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia.

Blood 2009 Apr 13;113(17):4049-51. Epub 2009 Feb 13.

Department of Hematology/Oncology, University of Tuebingen Medical Center II, Tuebingen, Germany.

View Article and Find Full Text PDF
April 2009

Signaling pathways of the TREM-1- and TLR4-mediated neutrophil oxidative burst.

J Innate Immun 2009 30;1(6):582-91. Epub 2009 Jul 30.

Institute for Immunology, Johannes Gutenberg University, Mainz, Germany.

View Article and Find Full Text PDF
May 2010

Alterations in Fas (CD 95/Apo-1) and Fas ligand (CD178) expression in acute promyelocytic leukemia during treatment with ATRA.

Leuk Lymphoma 2004 Jan;45(1):55-9

Department of Internal Medicine II, University Hospital of the Eberhard-Karls-University, Otfried-Mueller Str. 10, 72076 Tuebingen, Germany.

View Article and Find Full Text PDF
January 2004

Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding.

J Immunol 2002 Oct;169(8):4098-102

Department of Internal Medicine II, University Hospital, Eberhard-Karls-University, Auf der Morgenstelle 15, 72076 Tubingen, Germany.

View Article and Find Full Text PDF
October 2002

Spatial imagery in deductive reasoning: a functional MRI study.

Brain Res Cogn Brain Res 2002 Apr;13(2):203-12

Center for Cognitive Science, University of Freiburg, Friedrichstr. 50, 79098, Freiburg, Germany.

View Article and Find Full Text PDF
April 2002

Differentiation of promyelocytic leukaemia: alterations in Fas (CD95/Apo-1) and Fas ligand (CD178) expression.

Br J Haematol 2002 Apr;117(1):76-85

Department of Immunology, Inflammation and Pulmonary Diseases, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, USA.

View Article and Find Full Text PDF
April 2002