Helmut E Meyer

Helmut E Meyer

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Helmut E Meyer

Helmut E Meyer

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Next-Generation Trapping of Protease Substrates by Label-Free Proteomics.

Methods Mol Biol 2018 ;1841:189-206

Lehrstuhl für Biologie der Mikroorganismen, Ruhr-Universität Bochum, Bochum, Germany.

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http://link.springer.com/10.1007/978-1-4939-8695-8_14
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http://dx.doi.org/10.1007/978-1-4939-8695-8_14DOI Listing
April 2019

The deubiquitination of the PTS1-import receptor Pex5p is required for peroxisomal matrix protein import.

Biochim Biophys Acta Mol Cell Res 2019 02 6;1866(2):199-213. Epub 2018 Nov 6.

Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, 44801 Bochum, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01674889183050
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http://dx.doi.org/10.1016/j.bbamcr.2018.11.002DOI Listing
February 2019

An Integrated Proteomic Approach Uncovers Novel Substrates and Functions of the Lon Protease in Escherichia coli.

Proteomics 2018 07 6;18(13):e1800080. Epub 2018 Jun 6.

Department of Microbial Biology, Ruhr University Bochum, Universitätsstraße 150, D-44801, Bochum, Germany.

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http://dx.doi.org/10.1002/pmic.201800080DOI Listing
July 2018

Identification of new channels by systematic analysis of the mitochondrial outer membrane.

J Cell Biol 2017 11 15;216(11):3485-3495. Epub 2017 Sep 15.

Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1083/jcb.201706043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674900PMC
November 2017

Altered mitochondrial and peroxisomal integrity in lipocalin-2-deficient mice with hepatic steatosis.

Biochim Biophys Acta Mol Basis Dis 2017 09 7;1863(9):2093-2110. Epub 2017 Apr 7.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.04.006DOI Listing
September 2017

Molecular profiles of thyroid cancer subtypes: Classification based on features of tissue revealed by mass spectrometry imaging.

Biochim Biophys Acta Proteins Proteom 2017 Jul 17;1865(7):837-845. Epub 2016 Oct 17.

Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, ul. Wybrzeze Armii Krajowej 15, 44101 Gliwice, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2016.10.006DOI Listing
July 2017

Strategies in relative and absolute quantitative mass spectrometry based proteomics.

Biol Chem 2017 05;398(5-6):687-699

Ruhr-University Bochum, Medizinisches Proteom-Center, Universitätsstraße 150, D-44801 Bochum.

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http://dx.doi.org/10.1515/hsz-2017-0104DOI Listing
May 2017

Tissue MALDI Mass Spectrometry Imaging (MALDI MSI) of Peptides.

Methods Mol Biol 2016 ;1394:129-150

Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3341-9_10DOI Listing
October 2016

Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.

J Proteome Res 2016 07 9;15(7):2178-86. Epub 2016 Jun 9.

Department of Pediatric Hematology/Oncology/Stem Cell Transplantation Charité - Universitätsmedizin Berlin , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1021/acs.jproteome.6b00134DOI Listing
July 2016

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?

Sarcoidosis Vasc Diffuse Lung Dis 2016 Mar 29;33(1):41-50. Epub 2016 Mar 29.

Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany.

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March 2016

ProCon - PROteomics CONversion tool.

J Proteomics 2015 Nov 13;129:56-62. Epub 2015 Jul 13.

Medizinisches Proteom Center (MPC), Ruhr-Universität Bochum, D-44801 Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2015.06.015DOI Listing
November 2015

Identification and validation of potential new biomarkers for prostate cancer diagnosis and prognosis using 2D-DIGE and MS.

Biomed Res Int 2015 15;2015:454256. Epub 2015 Jan 15.

Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany ; Medizinisches Proteom-Center, Ruhr-University Bochum, 44801 Bochum, Germany ; Leibniz-Institut für Analytische Wissenschaften ISAS e.V., 44139 Dortmund, Germany.

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http://dx.doi.org/10.1155/2015/454256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312578PMC
October 2015

Characterization of Regenerative Phenotype of Unrestricted Somatic Stem Cells (USSC) from Human Umbilical Cord Blood (hUCB) by Functional Secretome Analysis.

Mol Cell Proteomics 2015 Oct 16;14(10):2630-43. Epub 2015 Jul 16.

From the ‡Molecular Proteomics Laboratory (MPL), Institute for Molecular Medicine, Heinrich Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany; **Biologisch-Medizinisches Forschungszentrum (BMFZ), Heinrich Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany

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http://dx.doi.org/10.1074/mcp.M115.049312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597141PMC
October 2015

Differential proteomic and tissue expression analyses identify valuable diagnostic biomarkers of hepatocellular differentiation and hepatoid adenocarcinomas.

Pathology 2015 Oct;47(6):543-50

1Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Essen 2Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum 3Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen 4Institute of Pathology, Klinikum Dortmund gGmbH, Dortmund 5Department of General, Visceral and Transplantation Surgery, University Hospital of Essen, University of Duisburg-Essen, Essen 6West German Cancer Centre Essen, University Hospital of Essen, University of Duisburg-Essen, Essen 7Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen 8Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany *contributed equally as senior authors.

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http://dx.doi.org/10.1097/PAT.0000000000000298DOI Listing
October 2015

A Long Journey from Childhood to Senility: The 23rd HUPO BPP Workshop: 16-17 April 2015, São Paulo, Brazil.

Proteomics 2015 Sep;15(17):2895-7

Department of Pathology, University of São Paulo Medical School, Brazil.

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http://dx.doi.org/10.1002/pmic.201570154DOI Listing
September 2015

IGFBP1 in epithelial circulating tumor cells as a potential response marker to selective internal radiation therapy in hepatocellular carcinoma.

Biomark Med 2014 ;8(5):687-98

Department of Medical Oncology, Molecular Oncology Risk-Profile Evaluation, West German Cancer Center, University Hospital of Essen, Essen, Germany.

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http://dx.doi.org/10.2217/bmm.14.23DOI Listing
August 2015

Improved preparation of nasal lavage fluid (NLF) as a noninvasive sample for proteomic biomarker discovery.

Biochim Biophys Acta 2015 Jul 10;1854(7):741-5. Epub 2015 Feb 10.

Abteilung für Funktionelle Proteomik, Medizinisches Proteom-Center, Ruhr-Universitaet Bochum, 44801 Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.01.015DOI Listing
July 2015

PIA: An Intuitive Protein Inference Engine with a Web-Based User Interface.

J Proteome Res 2015 Jul 10;14(7):2988-97. Epub 2015 Jun 10.

Medizinisches Proteom-Center, Ruhr-Universität Bochum, 44801 Bochum, Germany.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.5b00121
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http://dx.doi.org/10.1021/acs.jproteome.5b00121DOI Listing
July 2015

Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells.

Biochim Biophys Acta 2015 Jun 9;1854(6):632-40. Epub 2014 Sep 9.

Department of Biochemistry and Functional Proteomics, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestr. 1, 79104 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2014.09.002DOI Listing
June 2015

Editorial medical proteomics.

Biochim Biophys Acta 2015 Jun 18;1854(6):517-8. Epub 2015 Feb 18.

National Cancer Center (NCC), Tokyo, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S15709639150004
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http://dx.doi.org/10.1016/j.bbapap.2015.02.006DOI Listing
June 2015

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets.

Transfusion 2015 Mar 21;55(3):507-21. Epub 2014 Oct 21.

Institute for Clinical Chemistry and Laboratory Medicine, University Clinic of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1111/trf.12874DOI Listing
March 2015

New milestones in the development of characterization tools for neurodegenerative diseases in proteomics: 22nd HUPO BPP Workshop 7 October 2014, Madrid, Spain.

Proteomics 2015 Feb;15(4):627-9

Leibniz-Institut für Analytische Wissenschaften -ISAS- e. V, Biomedical Research, Dortmund, Germany; Leibniz-Institut für Analytische Wissenschaften -ISAS- e. V, Human Brain Proteomics I, Dortmund, Germany.

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http://dx.doi.org/10.1002/pmic.201570035DOI Listing
February 2015

Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO.

Cancers (Basel) 2014 Dec 23;7(1):1-29. Epub 2014 Dec 23.

Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, Bochum 44801, Germany.

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http://dx.doi.org/10.3390/cancers7010001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381249PMC
December 2014

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts.

Aging (Albany NY) 2014 Oct;6(10):856-78

Institute for Molecular Medicine, Heinrich-Heine-University, Düsseldorf, Germany. Molecular Proteomics Laboratory, Biomedical Research Centre (BMFZ), Heinrich-Heine-University, Düsseldorf, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247387PMC
http://dx.doi.org/10.18632/aging.100698DOI Listing
October 2014

Intestinal amino acid availability via PEPT-1 affects TORC1/2 signaling and the unfolded protein response.

J Proteome Res 2014 Aug 16;13(8):3685-92. Epub 2014 Jul 16.

ZIEL Research Center of Nutrition and Food Sciences, Molecular Nutrition and Biochemistry Unit, Technische Universität München , Gregor-Mendel-Str. 2, 85350 Freising, Germany.

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http://pubs.acs.org/doi/10.1021/pr5002669
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http://dx.doi.org/10.1021/pr5002669DOI Listing
August 2014

The membrane proteome of sensory cilia to the depth of olfactory receptors.

Mol Cell Proteomics 2014 Jul 18;13(7):1828-43. Epub 2014 Apr 18.

the ¶Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 1, 79104 Freiburg,

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http://www.mcponline.org/content/early/2014/04/18/mcp.M113.0
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http://www.mcponline.org/cgi/doi/10.1074/mcp.M113.035378
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http://dx.doi.org/10.1074/mcp.M113.035378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083118PMC
July 2014

Proteome analysis of a hepatocyte-specific BIRC5 (survivin)-knockout mouse model during liver regeneration.

J Proteome Res 2014 Jun 27;13(6):2771-82. Epub 2014 May 27.

Medizinisches Proteom-Center, Ruhr Universität Bochum , Bochum, Germany.

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http://dx.doi.org/10.1021/pr401188rDOI Listing
June 2014

Comparison of label-free and label-based strategies for proteome analysis of hepatoma cell lines.

Biochim Biophys Acta 2014 May 14;1844(5):967-76. Epub 2013 Aug 14.

Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2013.07.017DOI Listing
May 2014

Long-term incubation with mifepristone (MLTI) increases the spine density in developing Purkinje cells: new insights into progesterone receptor mechanisms.

Cell Mol Life Sci 2014 May 28;71(9):1723-40. Epub 2013 Aug 28.

Institute of Anatomy and Molecular Embryology, Ruhr-University Bochum, Universitätsstraße 150, 44780, Bochum, Germany.

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http://dx.doi.org/10.1007/s00018-013-1448-4DOI Listing
May 2014

Autoimmune profiling with protein microarrays in clinical applications.

Biochim Biophys Acta 2014 May 7;1844(5):977-87. Epub 2014 Mar 7.

Department of Medical Proteomics/Bioanalytics, Medizinisches Proteom-Center, Ruhr-Universität Bochum, 44801 Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2014.02.023DOI Listing
May 2014

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

J Proteome Res 2014 May 28;13(5):2339-51. Epub 2014 Mar 28.

Heinrich-Heine-Universität Düsseldorf , Molecular Proteomics Laboratory, Biomedizinisches Forschungszentrum (BMFZ), Düsseldorf, Germany.

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http://dx.doi.org/10.1021/pr401157kDOI Listing
May 2014

Proteome Analyses of Hepatocellular Carcinoma.

J Clin Transl Hepatol 2014 Mar 15;2(1):23-30. Epub 2014 Mar 15.

Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.14218/JCTH.2013.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521250PMC
March 2014

Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization.

J Proteome Res 2014 Feb 3;13(2):1128-37. Epub 2014 Jan 3.

Faculty of Biology, Functional Proteomics, University of Freiburg , 79104 Freiburg, Germany.

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http://dx.doi.org/10.1021/pr400402sDOI Listing
February 2014

A practical data processing workflow for multi-OMICS projects.

Biochim Biophys Acta 2014 Jan 15;1844(1 Pt A):52-62. Epub 2013 Mar 15.

Medizinisches Proteom-Center, Ruhr-Universitaet Bochum, Universitaetsstrasse 150, D-44801 Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2013.02.029DOI Listing
January 2014

The fate of b-ions in the two worlds of collision-induced dissociation.

Biochim Biophys Acta 2013 Dec 28;1834(12):2843-8. Epub 2013 Aug 28.

Molecular Proteomics Laboratory, Biologisch-Medizinisches Forschungszentrum (BMFZ), Heinrich-Heine-Universität, Düsseldorf, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2013.08.007DOI Listing
December 2013

Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p.

Traffic 2013 Dec 7;14(12):1290-301. Epub 2013 Oct 7.

Biochemie Intrazellulärer Transportprozesse, Ruhr-Universität Bochum, Bochum, 44780, Germany; Systembiochemie, Ruhr-Universität Bochum, Bochum, 44780, Germany; Medizinische Proteomik/Bioanalytik, AG Neuro Proteomics, Medizinisches Proteom-Center, Bochum, 44801, Germany.

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http://dx.doi.org/10.1111/tra.12120DOI Listing
December 2013

Label-free quantification in clinical proteomics.

Biochim Biophys Acta 2013 Aug 6;1834(8):1581-90. Epub 2013 Apr 6.

Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2013.04.001DOI Listing
August 2013

Individual profiling of circulating tumor cell composition and therapeutic outcome in patients with hepatocellular carcinoma.

Transl Oncol 2013 Aug 1;6(4):420-8. Epub 2013 Aug 1.

Department of Medical Oncology, Molecular Oncology Risk-Profile Evaluation, West German Cancer Center, University Hospital of Essen, Essen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730017PMC
http://dx.doi.org/10.1593/tlo.13271DOI Listing
August 2013

Nonnative disulfide bond formation activates the σ32-dependent heat shock response in Escherichia coli.

J Bacteriol 2013 Jun 12;195(12):2807-16. Epub 2013 Apr 12.

Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1128/JB.00127-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697257PMC
June 2013

Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2).

J Cell Sci 2013 Jun 19;126(Pt 12):2629-40. Epub 2013 Apr 19.

Institute of Physiology, Faculty of Medicine, University Duisburg-Essen, 45147 Essen, Germany.

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http://dx.doi.org/10.1242/jcs.117564DOI Listing
June 2013

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts.

Nephrol Dial Transplant 2013 Apr 9;28(4):889-900. Epub 2012 Dec 9.

Division of Nephrology and Clinical Immunology, RWTH Aachen University Hospital, Aachen, Germany.

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http://dx.doi.org/10.1093/ndt/gfs509DOI Listing
April 2013

Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study.

FEBS Lett 2013 Feb 16;587(4):328-38. Epub 2013 Jan 16.

Department of Molecular Genetics and Cell Biology, Ulm University, Germany.

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http://dx.doi.org/10.1016/j.febslet.2012.12.025DOI Listing
February 2013

A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1.

Biochim Biophys Acta 2013 Jan 7;1834(1):387-94. Epub 2012 Aug 7.

Functional Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum, D-44801 Bochum, Germany.

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http://dx.doi.org/10.1016/j.bbapap.2012.07.017DOI Listing
January 2013

Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA.

Proteomics 2013 Jan;13(2):217-8

Medizinisches Proteom-Center (MPC), Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1002/pmic.201370024DOI Listing
January 2013

Stepwise isolation of human peripheral erythrocytes, T lymphocytes, and monocytes for blood cell proteomics.

Proteomics Clin Appl 2012 Oct 24;6(9-10):497-501. Epub 2012 Sep 24.

Abteilung für Funktionelle Proteomik, Medizinisches Proteom-Center, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1002/prca.201200032DOI Listing
October 2012

Proteome analysis with classical 2D-PAGE.

Methods Mol Biol 2012 ;893:37-46

Department of Medical Proteomics/Bionalaytics, Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1007/978-1-61779-885-6_3DOI Listing
September 2012

Differential proteome analysis using 2D-DIGE.

Methods Mol Biol 2012 ;893:75-82

Department of Medical Proteomics/Bionalaytics, Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1007/978-1-61779-885-6_6DOI Listing
September 2012

Application of label-free proteomics for differential analysis of lung carcinoma cell line A549.

Methods Mol Biol 2012 ;893:241-8

Department of Medical Proteomics/Bioanalytics, Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1007/978-1-61779-885-6_16DOI Listing
September 2012

Dynamic changes of the Caenorhabditis elegans proteome during ontogenesis assessed by quantitative analysis with 15N metabolic labeling.

J Proteome Res 2012 Sep 24;11(9):4594-604. Epub 2012 Aug 24.

ZIEL Research Center of Nutrition and Food Sciences, Abteilung Biochemie, Technische Universität München, Gregor-Mendel-Strasse 2, 85350 Freising, Germany.

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http://pubs.acs.org/doi/10.1021/pr300385v
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http://dx.doi.org/10.1021/pr300385vDOI Listing
September 2012

Find pairs: the module for protein quantification of the PeakQuant software suite.

OMICS 2012 Sep 21;16(9):457-67. Epub 2012 Aug 21.

Medizinisches Proteom-Center, Ruhr-Universitaet Bochum, Bochum, Germany.

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http://dx.doi.org/10.1089/omi.2011.0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437042PMC
September 2012

Translational proteomics in neurodegenerative diseases--16th HUPO BPP workshop September 5, 2011 Geneva, Switzerland.

Proteomics 2012 Feb;12(3):356-8

Medizinisches Proteom-Center (MPC), Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1002/pmic.201290017DOI Listing
February 2012

Sense and nonsense of pathway analysis software in proteomics.

J Proteome Res 2011 Dec 14;10(12):5398-408. Epub 2011 Nov 14.

Functional Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum, D-44780 Bochum, Germany.

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http://pubs.acs.org/doi/abs/10.1021/pr200654k
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http://dx.doi.org/10.1021/pr200654kDOI Listing
December 2011