Hellmut Merkle

Hellmut Merkle

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Hellmut Merkle

Hellmut Merkle

Publications by authors named "Hellmut Merkle"

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Magnetic resonance measurements of cellular and sub-cellular membrane structures in live and fixed neural tissue.

Elife 2019 Dec 12;8. Epub 2019 Dec 12.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.

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http://dx.doi.org/10.7554/eLife.51101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977971PMC
December 2019

An Albumin-Binding T- T Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging.

Bioconjug Chem 2019 06 31;30(6):1821-1829. Epub 2019 May 31.

Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering , National Institutes of Health , Bethesda , Maryland 20892 , United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00349DOI Listing
June 2019

Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus).

NMR Biomed 2018 03 29;31(3). Epub 2017 Dec 29.

Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/nbm.3864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841465PMC
March 2018

Optically controlled switch-mode current-source amplifiers for on-coil implementation in high-field parallel transmission.

Magn Reson Med 2016 07 10;76(1):340-9. Epub 2015 Aug 10.

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mrm.25857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749483PMC
July 2016

Sensory and optogenetically driven single-vessel fMRI.

Nat Methods 2016 Apr 8;13(4):337-40. Epub 2016 Feb 8.

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nmeth.3765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298439PMC
April 2016

Simultaneous calcium fluorescence imaging and MR of ex vivo organotypic cortical cultures: a new test bed for functional MRI.

NMR Biomed 2015 Dec 29;28(12):1726-38. Epub 2015 Oct 29.

Section on Tissue Biophysics and Biomimetics, PPITS, NICHD, National Institutes of Health, Bethesda, Maryland, USA.

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http://doi.wiley.com/10.1002/nbm.3424
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http://dx.doi.org/10.1002/nbm.3424DOI Listing
December 2015

A 7T spine array based on electric dipole transmitters.

Magn Reson Med 2015 Oct 20;74(4):1189-97. Epub 2015 Jul 20.

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mrm.25817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575257PMC
October 2015

Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex.

Contrast Media Mol Imaging 2014 Jan-Feb;9(1):71-82

Department for Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.

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http://dx.doi.org/10.1002/cmmi.1535DOI Listing
September 2014

An embedded four-channel receive-only RF coil array for fMRI experiments of the somatosensory pathway in conscious awake marmosets.

NMR Biomed 2013 Nov 22;26(11):1395-402. Epub 2013 May 22.

Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/nbm.2965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200535PMC
November 2013

Micro-compartment specific T2* relaxation in the brain.

Neuroimage 2013 Aug 22;77:268-78. Epub 2013 Mar 22.

Translational Neuroradiology Unit, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2013.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816634PMC
August 2013

High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses.

Neuron 2012 Nov;76(3):629-39

Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.neuron.2012.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234326PMC
November 2012

Chronic multiple sclerosis lesions: characterization with high-field-strength MR imaging.

Radiology 2012 Jan 14;262(1):206-15. Epub 2011 Nov 14.

Advanced MRI Section, Laboratory of Functional Molecular Imaging, and Neuroimmunology Branch, Neurologic Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Bethesda, MD 20892-1065, USA.

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http://dx.doi.org/10.1148/radiol.11110601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244667PMC
January 2012

Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla.

Brain 2011 Dec;134(Pt 12):3602-15

National Institutes of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/brain/awr278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235560PMC
December 2011

Transmit B1-field correction at 7 T using actively tuned coupled inner elements.

Magn Reson Med 2011 Sep 24;66(3):901-10. Epub 2011 Mar 24.

National Institutes of Health, National Institute of Neurological Disorders and Stroke, Laboratory for Functional and Molecular Imaging, Bethesda, Maryland 20892-1065, USA.

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http://dx.doi.org/10.1002/mrm.22864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128196PMC
September 2011

T2*-based fiber orientation mapping.

Neuroimage 2011 Jul 22;57(1):225-234. Epub 2011 Apr 22.

Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2011.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119254PMC
July 2011

Longitudinal functional magnetic resonance imaging in animal models.

Methods Mol Biol 2011 ;711:281-302

Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-61737-992-5_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748954PMC
May 2011

Flexible, phase-matched, linear receive arrays for high-field MRI in monkeys.

Magn Reson Imaging 2010 Oct 24;28(8):1183-91. Epub 2010 Apr 24.

Department of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.mri.2010.03.026DOI Listing
October 2010

The effects of electrical microstimulation on cortical signal propagation.

Nat Neurosci 2010 Oct 5;13(10):1283-91. Epub 2010 Sep 5.

Max Planck Institute for Biological Cybernetics, Tübingen, Germany.

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http://dx.doi.org/10.1038/nn.2631DOI Listing
October 2010

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure.

Proc Natl Acad Sci U S A 2010 Mar 2;107(11):5130-5. Epub 2010 Mar 2.

Advanced MRI Section and Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0910222107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841900PMC
March 2010

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast.

Proc Natl Acad Sci U S A 2010 Feb 3;107(8):3834-9. Epub 2010 Feb 3.

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0911177107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840419PMC
February 2010

Characterization of T(2)* heterogeneity in human brain white matter.

Magn Reson Med 2009 Dec;62(6):1652-7

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/mrm.22156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508464PMC
December 2009

Multisequence-imaging protocols to detect cortical lesions of patients with multiple sclerosis: observations from a post-mortem 3 Tesla imaging study.

J Neurol Sci 2009 Jul 23;282(1-2):80-5. Epub 2009 Apr 23.

Neuroimmunology Branch (NIB), National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD 20892-1400, USA.

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http://dx.doi.org/10.1016/j.jns.2009.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504465PMC
July 2009

B1 homogenization in MRI by multilayer coupled coils.

IEEE Trans Med Imaging 2009 Apr;28(4):551-4

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 USA.

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http://dx.doi.org/10.1109/TMI.2008.2006523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197805PMC
April 2009

Functional MRI evidence for LTP-induced neural network reorganization.

Curr Biol 2009 Mar 19;19(5):398-403. Epub 2009 Feb 19.

Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822090060
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http://dx.doi.org/10.1016/j.cub.2009.01.037DOI Listing
March 2009

The effect of labeling parameters on perfusion-based fMRI in nonhuman primates.

J Cereb Blood Flow Metab 2008 Mar 24;28(3):640-52. Epub 2007 Oct 24.

Department Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, Tübingen, Germany.

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http://dx.doi.org/10.1038/sj.jcbfm.9600564DOI Listing
March 2008

fMRI of the temporal lobe of the awake monkey at 7 T.

Neuroimage 2008 Feb 29;39(3):1081-93. Epub 2007 Sep 29.

Max-Planck Institute for Biological Cybernetics, Department of Physiology of Cognitive Processes, Spemannstrasse 38, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2007.09.038DOI Listing
February 2008

Functional MR imaging in the awake monkey: effects of motion on dynamic off-resonance and processing strategies.

Magn Reson Imaging 2007 Jul 23;25(6):869-82. Epub 2007 Apr 23.

Max-Planck Institute for Biological Cybernetics, Department Physiology of Cognitive Processes, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.mri.2007.03.002DOI Listing
July 2007

In vivo detection of gray and white matter differences in GABA concentration in the human brain.

Neuroimage 2006 Oct 1;33(1):85-93. Epub 2006 Aug 1.

The Nathan Kline Institute, Medical Physics, Orangeburg, NY 10962, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2006.06.016DOI Listing
October 2006

Extensive heterogeneity in white matter intensity in high-resolution T2*-weighted MRI of the human brain at 7.0 T.

Neuroimage 2006 Sep 18;32(3):1032-40. Epub 2006 Jul 18.

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S105381190600632
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http://dx.doi.org/10.1016/j.neuroimage.2006.05.053DOI Listing
September 2006

BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system.

Magn Reson Med 2006 Feb;55(2):316-24

Emory University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1002/mrm.20744DOI Listing
February 2006

Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast.

Magn Reson Med 2005 Mar;53(3):640-8

Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/mrm.20368DOI Listing
March 2005

Anatomical and functional MR imaging in the macaque monkey using a vertical large-bore 7 Tesla setup.

Magn Reson Imaging 2004 Dec;22(10):1343-59

Department Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, 72012 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.mri.2004.10.004DOI Listing
December 2004

High-field localized 1H NMR spectroscopy in the anesthetized and in the awake monkey.

Magn Reson Imaging 2004 Dec;22(10):1361-72

Department of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.mri.2004.10.002DOI Listing
December 2004

Region and volume dependencies in spectral line width assessed by 1H 2D MR chemical shift imaging in the monkey brain at 7 T.

Magn Reson Imaging 2004 Dec;22(10):1373-83

Department of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany.

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http://dx.doi.org/10.1016/j.mri.2004.10.005DOI Listing
December 2004

Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging.

Magn Reson Med 2004 Jul;52(1):89-99

Laboratory of Functional and Molecular Imaging, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1002/mrm.20114DOI Listing
July 2004

Single-shot two-echo technique for simultaneous measurement of GABA and creatine in the human brain in vivo.

Magn Reson Med 2004 Jun;51(6):1115-21

Nathan Kline Institute, Medical Physics, Orangeburg, New York 10962, USA.

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http://dx.doi.org/10.1002/mrm.20082DOI Listing
June 2004

Measurement of arterial input function of 17O water tracer in rat carotid artery by using a region-defined (REDE) implanted vascular RF coil.

MAGMA 2003 Jul 4;16(2):77-85. Epub 2003 Jul 4.

Center for Magnetic Resonance Research, University of Minnesota School of Medicine, 2021 6th Street S.E., Department of Radiology, Minneapolis, Minnesota, USA.

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http://link.springer.com/10.1007/s10334-003-0013-9
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http://dx.doi.org/10.1007/s10334-003-0013-9DOI Listing
July 2003

Development of (17)O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field.

Proc Natl Acad Sci U S A 2002 Oct 19;99(20):13194-9. Epub 2002 Sep 19.

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, 2021 6th Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1073/pnas.202471399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130609PMC
October 2002

High-resolution, spin-echo BOLD, and CBF fMRI at 4 and 7 T.

Magn Reson Med 2002 Oct;48(4):589-93

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, USA.

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http://dx.doi.org/10.1002/mrm.10252DOI Listing
October 2002

Zoomed functional imaging in the human brain at 7 Tesla with simultaneous high spatial and high temporal resolution.

Neuroimage 2002 Sep;17(1):272-86

Center for Magnetic Resonance Research, University of Minnesota Medical School, 2021 6th Street S.E., Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1006/nimg.2002.1103DOI Listing
September 2002

Eliminating spurious lipid sidebands in 1H MRS of breast lesions.

Magn Reson Med 2002 Aug;48(2):215-22

Center for Magnetic Resonance Research, University of Minnesota School of Medicine, Minneapolis 55455, USA.

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http://dx.doi.org/10.1002/mrm.10224DOI Listing
August 2002

Ultra high-resolution fMRI in monkeys with implanted RF coils.

Neuron 2002 Jul;35(2):227-42

Max Planck Institute for Biological Cybernetics, Spemannstr. 38, Tuebingen, Germany.

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http://dx.doi.org/10.1016/s0896-6273(02)00775-4DOI Listing
July 2002

Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T.

Magn Reson Med 2002 Apr;47(4):629-33

Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1002/mrm.10135DOI Listing
April 2002

In vivo 1H2O T2+ measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast.

Magn Reson Med 2002 Apr;47(4):742-50

The Center for Magnetic Resonance Research and Department of Radiology, The University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1002/mrm.10112DOI Listing
April 2002