Helle Margrete Meltzer

Helle Margrete Meltzer

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Helle Margrete Meltzer

Helle Margrete Meltzer

Publications by authors named "Helle Margrete Meltzer"

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Language delay and poorer school performance in children of mothers with inadequate iodine intake in pregnancy: results from follow-up at 8 years in the Norwegian Mother and Child Cohort Study.

Eur J Nutr 2019 Dec 12;58(8):3047-3058. Epub 2018 Nov 12.

Division of Infection Control and Environmental Health, Department of Exposure and Environmental Epidemiology, Norwegian Institute of Public Health, Skøyen, P.O. Box 222, 0213, Oslo, Norway.

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http://dx.doi.org/10.1007/s00394-018-1850-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842354PMC
December 2019

Maternal probiotic milk intake during pregnancy and breastfeeding complications in the Norwegian Mother and Child Cohort Study.

Eur J Nutr 2019 Sep 10. Epub 2019 Sep 10.

Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Gothenburg, Sweden.

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http://dx.doi.org/10.1007/s00394-019-02072-8DOI Listing
September 2019

Environmental Sustainability Perspectives of the Nordic Diet.

Nutrients 2019 Sep 18;11(9). Epub 2019 Sep 18.

Unit for Nutrition Research, Faculty of Food Science and Nutrition, University of Iceland and Landspitali-University Hospital, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.3390/nu11092248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769495PMC
September 2019

Caffeine exposure during pregnancy, small for gestational age birth and neonatal outcome - results from the Norwegian Mother and Child Cohort Study.

BMC Pregnancy Childbirth 2019 Feb 26;19(1):80. Epub 2019 Feb 26.

Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, SE-416 85, Gothenburg, Sweden.

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http://dx.doi.org/10.1186/s12884-019-2215-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390347PMC
February 2019

K.L. Iversen and co-workers respond

Tidsskr Nor Laegeforen 2018 10 30;138(17). Epub 2018 Oct 30.

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http://dx.doi.org/10.4045/tidsskr.18.0774DOI Listing
October 2018

Dietary acrylamide intake during pregnancy and postnatal growth and obesity: Results from the Norwegian Mother and Child Cohort Study (MoBa).

Environ Int 2018 04 3;113:325-334. Epub 2018 Feb 3.

Department of Environmental Exposure and Epidemiology, Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1016/j.envint.2018.01.004DOI Listing
April 2018

Suboptimal Iodine Concentration in Breastmilk and Inadequate Iodine Intake among Lactating Women in Norway.

Nutrients 2017 Jun 22;9(7). Epub 2017 Jun 22.

Division of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo 0403, Norway.

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http://dx.doi.org/10.3390/nu9070643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537763PMC
June 2017

Organic Food in the Diet: Exposure and Health Implications.

Annu Rev Public Health 2017 Mar 15;38:295-313. Epub 2016 Dec 15.

Domain of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, 0403 Norway; email: , ,

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http://dx.doi.org/10.1146/annurev-publhealth-031816-044437DOI Listing
March 2017

Erratum to: Maternal intake of seafood and supplementary long chain n-3 poly-unsaturated fatty acids and preterm delivery.

BMC Pregnancy Childbirth 2017 02 10;17(1):61. Epub 2017 Feb 10.

Department of Environmental Exposure and Epidemiology, Domain of Infection Control and Environmental Health, Norwegian Institute of Public Health, P.O. Box 4404Nydalen, NO-0403, Oslo, Norway.

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http://dx.doi.org/10.1186/s12884-017-1243-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303207PMC
February 2017

Maternal intake of seafood and supplementary long chain n-3 poly-unsaturated fatty acids and preterm delivery.

BMC Pregnancy Childbirth 2017 Jan 19;17(1):41. Epub 2017 Jan 19.

Department of Environmental Exposure and Epidemiology, Domain of Infection Control and Environmental Health, Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, NO-0403, Oslo, Norway.

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http://dx.doi.org/10.1186/s12884-017-1225-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248483PMC
January 2017

Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa).

Environ Health Perspect 2016 Mar 9;124(3):357-64. Epub 2015 Jul 9.

Division of Environmental Medicine, Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1289/ehp.1409518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786987PMC
March 2016

Arsenic in the human food chain, biotransformation and toxicology--Review focusing on seafood arsenic.

J Trace Elem Med Biol 2015 28;31:249-59. Epub 2015 Jan 28.

Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, N-0403 Oslo, Norway.

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http://dx.doi.org/10.1016/j.jtemb.2015.01.010DOI Listing
February 2016

A model to secure a stable iodine concentration in milk.

Food Nutr Res 2015 18;59:29829. Epub 2015 Dec 18.

Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Ås, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685975PMC
http://dx.doi.org/10.3402/fnr.v59.29829DOI Listing
December 2015

Tracking of body size from birth to 7 years of age and factors associated with maintenance of a high body size from birth to 7 years of age--the Norwegian Mother and Child Cohort study (MoBa).

Public Health Nutr 2015 Jul 10;18(10):1746-55. Epub 2014 Nov 10.

1Department of Nutrition,Institute of Basic Medical Sciences,University of Oslo,PO Box 1046 Blindern,0316 Oslo,Norway.

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http://dx.doi.org/10.1017/S1368980014002419DOI Listing
July 2015

Possibilities and considerations when merging dietary data from the world's two largest pregnancy cohorts: the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study.

Acta Obstet Gynecol Scand 2014 Nov 16;93(11):1131-40. Epub 2014 Oct 16.

Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1111/aogs.12513DOI Listing
November 2014

The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study.

Mutagenesis 2014 Nov 8;29(6):393-400. Epub 2014 Oct 8.

Laboratory of Cell Genetics, Faculty of Science and Bio-engineering, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium, National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Vassileos Constantinou Avenue 48, 11635 Athens, Greece, Division of Medical Science, School of Life Science, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK, Department of Histology and Department of Social Medicine, School of Medicine, University of Crete, PO Box 2208, 71003 Heraklion, Greece, Centre for Research in Environmental Epidemiology (CREAL), Dr. Aiguader 88, 08003 Barcelona, Spain, Grup de Mutagenesi, Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, Placa Civica, 08193 Cerdanyola del Vallès, Ellaterra, Spain, Hospital del Mar Medical Research Institute, Dr. Aiguader 88, 08003 Barcelona, Spain, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, 0403 Oslo, Norway, Department of Public Health, University of Copenhagen, Norregade 10, 1165 Copenhagen, Denmark, Laboratory of Antropogenetics, Faculty of Science and Bio-engineering, Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium, Epidemiology, Biostatistics, and Clinical Trials, IRCCS AOU San Martino-IST-National Cancer Research Institute, R. Benzi 10, 16132 Genoa, Italy, Department of Toxicogenomics, University of Maastricht, Minderbroedersberg 4-6, 6211 LK Maastricht, the Netherlands, Municipal Institute of Medical Research, Dr. Aiguader 88, 08003 Barcelona, Spain, CIBER Epidemiologia y Salud Pública (CIBERESP), Casanova 143, 08036 Barcelona, Spain and National School of Public Health, Alexandras Avenue 196, 11521 Athens, Greece.

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http://dx.doi.org/10.1093/mutage/geu052DOI Listing
November 2014

Breast-feeding in relation to weight retention up to 36 months postpartum in the Norwegian Mother and Child Cohort Study: modification by socio-economic status?

Public Health Nutr 2014 Jul 6;17(7):1514-23. Epub 2013 Aug 6.

1Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy,University of Gothenburg,PO Box 459,SE-405 30 Göteborg,Gothenburg,Sweden.

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http://dx.doi.org/10.1017/S1368980013001869DOI Listing
July 2014

Folic acid supplementation and interpregnancy interval.

Paediatr Perinat Epidemiol 2014 May 10;28(3):270-4. Epub 2014 Feb 10.

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Alessandra Lisi International Centre on Birth Defects and Prematurity, Rome, Italy.

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http://dx.doi.org/10.1111/ppe.12111DOI Listing
May 2014

Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies.

Am J Clin Nutr 2014 Mar 11;99(3):506-16. Epub 2013 Dec 11.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece (VL, TR, and LC); the Centre for Research in Environmental Epidemiology, Barcelona, Spain (DM, MC, JS, MK, and MV); the Hospital del Mar Medical Research Institute, Barcelona, Spain (DM, MC, JS, MK, and MV); the Department of Clinical Epidemiology, Predictive Medicine and Public Health and Cardiovascular Research & Development Unit, University of Porto Medical School, Porto, Portugal (HB and AO); the Public Health Institute, University of Porto, Portugal (HB and AO); the Department for Genes and Environment (ME) and Department of Chronic Diseases (HS), Division of Epidemiology, and the Division of Environmental Medicine (A-LB, MH, and HMH), Norwegian Institute of Public Health, Oslo, Norway; the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain (MC, M Murcia, JS, MK, and MV); the Institut National de la Santé et de la Recherche Médicale (INSERM), Centre for Research in Epidemiology and Population Health, U1018, Lifelong Epidemiology of Obesity, Diabetes and Renal Disease Team, Villejuif, France (M-AC and BH); the University Paris-Sud, UMRS 1018, le Kremlin Bicêtre, France (M-AC and BH); the INSERM UMR 1085, Institut de Recherche Santé Environnement & Travail, Université de Rennes 1, Rennes Cedex, France (SC and, FP); the Public Health Service Amsterdam, Department of Epidemiology, Documentation and Health Promotion, Amsterdam, Netherlands (MvE); the Department of Epidemiology, Lazio Regional health System, Rome, Italy (FF and DP); the Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands (UG); the Environmental Risk and Health, Flemish Institute for Technological Research, Mol, Belgium (EG); the Maternal Nutrition Group, Centre for Fetal Programming, Statens Serum Institut, Copenhagen, Denmark (TIH, SFO, and MS); the Faculty of Food Science and Nutrition, University of Ice

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http://dx.doi.org/10.3945/ajcn.113.067421DOI Listing
March 2014

Maternal dietary patterns and preterm delivery: results from large prospective cohort study.

BMJ 2014 Mar 4;348:g1446. Epub 2014 Mar 4.

Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, SE-41685 Gothenburg, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942565PMC
http://dx.doi.org/10.1136/bmj.g1446DOI Listing
March 2014

Maternal dietary intake of dioxins and polychlorinated biphenyls and birth size in the Norwegian Mother and Child Cohort Study (MoBa).

Environ Int 2013 Oct 23;60:209-16. Epub 2013 Sep 23.

Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; Pompeu Fabra University, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2013.08.017DOI Listing
October 2013

Dietary benzo(a)pyrene intake during pregnancy and birth weight: associations modified by vitamin C intakes in the Norwegian Mother and Child Cohort Study (MoBa).

Environ Int 2013 Oct 24;60:217-23. Epub 2013 Sep 24.

Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2013.08.016DOI Listing
October 2013

Maternal and early postnatal nutrition and mental health of offspring by age 5 years: a prospective cohort study.

J Am Acad Child Adolesc Psychiatry 2013 Oct 17;52(10):1038-47. Epub 2013 Aug 17.

IMPACT Strategic Research Centre, Deakin University, and the University of Melbourne. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2013.07.002DOI Listing
October 2013

Early life nutritional programming of obesity: mother-child cohort studies.

Ann Nutr Metab 2013 5;62(2):137-45. Epub 2013 Feb 5.

Early Life Nutrition Research Unit, Academic Division of Child Health School of Medicine, Queen's Medical Centre, University Hospital, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1159/000345598DOI Listing
September 2013

Intakes of garlic and dried fruits are associated with lower risk of spontaneous preterm delivery.

J Nutr 2013 Jul 22;143(7):1100-8. Epub 2013 May 22.

Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.3945/jn.112.173229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681545PMC
July 2013

Risk of suboptimal iodine intake in pregnant Norwegian women.

Nutrients 2013 Feb 6;5(2):424-40. Epub 2013 Feb 6.

Department of Exposure and Risk Assessment, Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, Norway.

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http://dx.doi.org/10.3390/nu5020424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635203PMC
February 2013

Effect of dietary factors in pregnancy on risk of pregnancy complications: results from the Norwegian Mother and Child Cohort Study.

Am J Clin Nutr 2011 Dec 4;94(6 Suppl):1970S-1974S. Epub 2011 May 4.

Divisions of Environmental Medicine and Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.3945/ajcn.110.001248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364075PMC
December 2011

Diet before pregnancy and the risk of hyperemesis gravidarum.

Br J Nutr 2011 Aug 18;106(4):596-602. Epub 2011 Apr 18.

Division of Environmental Medicine, Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1017/S0007114511000675DOI Listing
August 2011

Gestational weight gain of women with eating disorders in the Norwegian pregnancy cohort.

Int J Eat Disord 2011 Jul 7;44(5):428-34. Epub 2010 May 7.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/eat.20835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683584PMC
July 2011

Intake of probiotic food and risk of spontaneous preterm delivery.

Am J Clin Nutr 2011 Jan 27;93(1):151-7. Epub 2010 Oct 27.

Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.3945/ajcn.110.004085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001603PMC
January 2011

Prevalence of breast-feeding in the Norwegian Mother and Child Cohort Study and health service-related correlates of cessation of full breast-feeding.

Public Health Nutr 2010 Dec 25;13(12):2076-86. Epub 2010 Jun 25.

Department of Food Safety and Nutrition, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO-0403 Oslo, Norway.

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http://www.journals.cambridge.org/abstract_S1368980010001771
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http://dx.doi.org/10.1017/S1368980010001771DOI Listing
December 2010

Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study.

Environ Res 2010 Jul 8;110(5):497-504. Epub 2010 Apr 8.

Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N-0403 Oslo, Norway.

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http://linkinghub.elsevier.com/retrieve/pii/S001393511000048
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http://dx.doi.org/10.1016/j.envres.2010.03.006DOI Listing
July 2010

Exploration of biomarkers for total fish intake in pregnant Norwegian women.

Public Health Nutr 2010 Jan 3;13(1):54-62. Epub 2009 Jun 3.

Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO-04030 Oslo, Norway.

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http://dx.doi.org/10.1017/S1368980009005904DOI Listing
January 2010

Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa).

Int J Hyg Environ Health 2009 Sep 24;212(5):481-91. Epub 2009 Apr 24.

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), MD A3-05, PO Box 12233, Research Triangle Park, NC 27709, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S143846390900044
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http://dx.doi.org/10.1016/j.ijheh.2009.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756471PMC
September 2009

Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women.

Epidemiology 2009 Sep;20(5):720-6

Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1097/EDE.0b013e3181a70f08DOI Listing
September 2009

Dietary supplements contribute substantially to the total nutrient intake in pregnant Norwegian women.

Ann Nutr Metab 2008 22;52(4):272-80. Epub 2008 Jul 22.

Department of Food Safety and Nutrition, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway.

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http://dx.doi.org/10.1159/000146274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2813797PMC
December 2008

Exploration of different methods to assess dietary acrylamide exposure in pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa).

Food Chem Toxicol 2008 Aug 29;46(8):2808-14. Epub 2008 May 29.

Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, P.O. Box 4404, Nydalen, N-0403 Oslo, Norway.

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http://dx.doi.org/10.1016/j.fct.2008.05.020DOI Listing
August 2008

Mediterranean-type diet and risk of preterm birth among women in the Norwegian Mother and Child Cohort Study (MoBa): a prospective cohort study.

Acta Obstet Gynecol Scand 2008 ;87(3):319-24

Division of Environmental Medicine, Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Nydalen, Norway.

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http://doi.wiley.com/10.1080/00016340801899123
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http://dx.doi.org/10.1080/00016340801899123DOI Listing
March 2008

Methodological challenges when monitoring the diet of pregnant women in a large study: experiences from the Norwegian Mother and Child Cohort Study (MoBa).

Matern Child Nutr 2008 Jan;4(1):14-27

Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, Nydalen, Oslo, Norway.

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http://dx.doi.org/10.1111/j.1740-8709.2007.00104.xDOI Listing
January 2008

Validity of a new food frequency questionnaire for pregnant women in the Norwegian Mother and Child Cohort Study (MoBa).

Matern Child Nutr 2008 Jan;4(1):28-43

Division of Environmental Medicine, Department of Food Safety and Nutrition, Norwegian Institute of Public Health, Oslo, Norway.

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http://doi.wiley.com/10.1111/j.1740-8709.2007.00103.x
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http://dx.doi.org/10.1111/j.1740-8709.2007.00103.xDOI Listing
January 2008

Urine flavonoids and plasma carotenoids in the validation of fruit, vegetable and tea intake during pregnancy in the Norwegian Mother and Child Cohort Study (MoBa).

Public Health Nutr 2007 Aug 11;10(8):838-47. Epub 2007 May 11.

Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N-0403 Oslo, Norway.

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http://www.journals.cambridge.org/abstract_S1368980007339037
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http://dx.doi.org/10.1017/S1368980007339037DOI Listing
August 2007

Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa).

Ann Nutr Metab 2007 29;51(2):146-54. Epub 2007 May 29.

Division of Environmental Medicine, Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway.

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https://www.karger.com/Article/FullText/103275
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http://dx.doi.org/10.1159/000103275DOI Listing
July 2007

The iodine content of Norwegian foods and diets.

Public Health Nutr 2004 Jun;7(4):569-76

National Institute of Nutrition and Seafood Research (NIFES), PO Box 176 Sentrum, N-5804 Bergen, Norway.

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http://dx.doi.org/10.1079/PHN2003554DOI Listing
June 2004

[Vitamin and minerals supplements--required for good health?].

Tidsskr Nor Laegeforen 2004 Jun;124(12):1646-9

Avdeling for naeringsmiddeltoksikologi, Divisjon for miljømedisin, Nasjonalt folkehelseinstitutt, Postboks 4404 Nydalen, 0403 Oslo.

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June 2004

[From a hypothesis to dietary advice--roads, short cuts and dead-end roads].

Tidsskr Nor Laegeforen 2004 May;124(9):1248-50

Avdeling for naeringsmiddeltoksikologi, Divisjon for miljømedisin, Nasjonalt folkehelseinstitutt, Oslo.

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May 2004

[Blood type diet--visionary science or nonsense?].

Tidsskr Nor Laegeforen 2002 May;122(14):1402-5

Divisjon for miljømedisin Nasjonalt folkehelseinstitutt Postboks 4404 Nydalen 0403 Oslo.

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May 2002