Helene Blons

Helene Blons

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Helene Blons

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DNAshell Protects DNA Stored at Room Temperature for Downstream Next-Generation Sequencing Studies.

Biopreserv Biobank 2019 Aug 26;17(4):352-354. Epub 2019 Mar 26.

1Laboratoire de Pathologie Clinique et Experimentale, Biobanque BB-0033-00025, FHU OncoAge, Université Côte d'Azur, Nice, France.

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http://dx.doi.org/10.1089/bio.2018.0129DOI Listing
August 2019

Plasma clearance of RAS mutation under therapeutic pressure is a rare event in metastatic colorectal cancer.

Int J Cancer 2019 Aug 31. Epub 2019 Aug 31.

Centre de Recherche des Cordeliers, INSERM, CNRS, Sorbonne Université, USPC, Université Paris Descartes, Université Paris Diderot, Paris, France.

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http://dx.doi.org/10.1002/ijc.32657DOI Listing
August 2019

Clinical Characteristics, Molecular Phenotyping, and Management of Isolated Adrenal Metastases From Lung Cancer.

Clin Lung Cancer 2019 Jun 13. Epub 2019 Jun 13.

Thoracic Surgery Department, Paris Center University Hospital, Assistance Publique - Hôpitaux de Paris, Paris Descartes University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2019.06.003DOI Listing
June 2019

Clinical Relevance of EGFR- or KRAS-mutated Subclones in Patients With Advanced Non-small-cell Lung Cancer Receiving Erlotinib in a French Prospective Cohort (IFCT ERMETIC2 Cohort - Part 2).

Clin Lung Cancer 2019 May 19;20(3):222-230. Epub 2018 Dec 19.

Intergroupe Francophone de Cancérologie Thoracique (IFCT), Paris, France; Service de Pneumologie, Assistance Publique Hôpitaux de Paris, Hôpital Tenon, GRC-04 Theranoscan, Université Paris VI, 75970 Paris, France.

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http://dx.doi.org/10.1016/j.cllc.2018.12.012DOI Listing
May 2019

Proposal for a Combined Histomolecular Algorithm to Distinguish Multiple Primary Adenocarcinomas from Intrapulmonary Metastasis in Patients with Multiple Lung Tumors.

J Thorac Oncol 2019 May 2;14(5):844-856. Epub 2019 Feb 2.

Department of Biochemistry, Unit of Pharmacogenetic and Molecular Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; INSERM UMR-S1147, Paris Sorbonne Cite University, Paris, France.

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http://dx.doi.org/10.1016/j.jtho.2019.01.017DOI Listing
May 2019

Mutational Diversity of Lung Cancer and Associated Lymph Nodes. An Exploratory Prospective Study of 4 Resected cIIIA-N2.

Pathol Oncol Res 2019 Jan 6;25(1):319-325. Epub 2017 Nov 6.

Thoracic Surgery and Lung Transplantation Department, Georges Pompidou European Hospital, Assistance Publique Hôpitaux de Paris, 20 rue Leblanc, 75908, Paris Cedex 15, France.

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http://dx.doi.org/10.1007/s12253-017-0352-xDOI Listing
January 2019

Molecular markers and prediction of response to immunotherapy in non-small cell lung cancer, an update.

J Thorac Dis 2019 Jan;11(Suppl 1):S25-S36

Department of Biochemistry, Unit of Pharmacogenetics and Molecular Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

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http://dx.doi.org/10.21037/jtd.2018.12.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353739PMC
January 2019

How apoptosis and epithelial-to-mesenchymal transition are nested in EGFR inhibitors resistance in lung cancer.

J Thorac Dis 2019 Jan;11(1):47-49

INSERM UMR-S1147, CNRS SNC 5014, Saints-Pères Research Center, 45 rue des Saints-Pères Paris-Descartes University, Sorbonne Paris Cité University, Paris 75006, France.

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http://dx.doi.org/10.21037/jtd.2018.12.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384333PMC
January 2019

Role of circulating tumor DNA in the management of patients with colorectal cancer.

Clin Res Hepatol Gastroenterol 2018 10 5;42(5):396-402. Epub 2018 Apr 5.

INSERM UMR-S1147, CNRS SNC5014, Paris Descartes University, Equipe labellisée Ligue Nationale contre le cancer, Paris, France; Department of Gastroenterology and Digestive Oncology, European Georges Pompidou Hospital, AP-HP, Paris Descartes University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2018.03.002DOI Listing
October 2018

Vemurafenib and cobimetinib overcome resistance to vemurafenib in -mutant ganglioglioma.

Neurology 2018 09 17;91(11):523-525. Epub 2018 Aug 17.

From Sorbonne Université (M.T., A.I., M.S., A.L.D.S.), Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris, France; Department of Oncologic Pathology (M.T., K.L.L.), Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA; Department of Neuroradiology (J.G., S.C.A.), Pharmacy Department (K.S.), and Departments of Neurosurgery (S.A.), Pathology (C.V.), and Neurology (A.L.D.S.), Hôpital Foch, Suresnes; Department of Radiology (J.S.), Fondation Ophtalmologique Adolphe de Rothschild, Paris; Département de Génétique (G.P., A.-P.G.-R., P.L.-P.), and Service de Biochimie, UF de Pharmacogénétique et Oncologie Moléculaire (H.B.), Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Paris; INSERM (G.P., H.B., P.L.-P.), UMR S 1147, Paris; Drug Development Department (A.H.), Gustave Roussy, Université Paris-Saclay, Villejuif; INSERM (A.-P.G.-R.), UMR970, Paris-Cardiovascular Research Center, Equipe Labellisée par la Ligue contre le Cancer, Paris; and Université Paris Descartes (H.B., A.-P.G.-R., P.L.-P.), Sorbonne Paris Cité, Faculté de Médecine, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000006171DOI Listing
September 2018

Validity of Targeted Next-Generation Sequencing in Routine Care for Identifying Clinically Relevant Molecular Profiles in Non-Small-Cell Lung Cancer: Results of a 2-Year Experience on 1343 Samples.

J Mol Diagn 2018 07 19;20(4):550-564. Epub 2018 May 19.

INSERM UMR-S1147, Sorbonne Paris Cité University, Paris, France; Department of Biochemistry, Unit of Pharmacogenetic and Molecular Oncology, Georges Pompidou European Hospital, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15251578173052
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http://dx.doi.org/10.1016/j.jmoldx.2018.04.002DOI Listing
July 2018

Current and Future Molecular Testing in NSCLC, What Can We Expect from New Sequencing Technologies?

J Clin Med 2018 Jun 9;7(6). Epub 2018 Jun 9.

Department of Biochemistry, Unit of Pharmacogenetics and Molecular Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France.

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http://dx.doi.org/10.3390/jcm7060144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024886PMC
June 2018

Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction.

J Am Coll Cardiol 2018 01;71(4):429-438

Cell Therapy Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Louis, Paris, France; INSERM, Clinical Investigation Center in Biotherapies (CBT-501) and U1160, Institut Universitaire d'Hématologie, Hôpital Saint-Louis, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.jacc.2017.11.047DOI Listing
January 2018

[Lynch syndrome and endometrial cancer].

Bull Cancer 2017 Dec 21;104(12):1013-1021. Epub 2017 Oct 21.

Université Paris Descartes, Sorbonne Paris cité, faculté de médecine, 15, rue de l'École-de-médecine, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, hôpital européen Georges-Pompidou, chirurgie cancérologique gynécologique et du sein, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Inserm UMR-S 1124, 45, rue des Saints-Pères, 75006 Paris, France.

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http://dx.doi.org/10.1016/j.bulcan.2017.06.018DOI Listing
December 2017

Early Evaluation of Circulating Tumor DNA as Marker of Therapeutic Efficacy in Metastatic Colorectal Cancer Patients (PLACOL Study).

Clin Cancer Res 2017 Sep 2;23(18):5416-5425. Epub 2017 Jun 2.

INSERM UMR-S1147, CNRS SNC5014; Paris Descartes University, Equipe Labellisée Ligue Nationale Contre le Cancer, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3155DOI Listing
September 2017

Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer.

Cancers (Basel) 2017 Aug 3;9(8). Epub 2017 Aug 3.

INSERM UMR-S1147, CNRS SNC 5014, Saints-Pères Research Center, 45 rue des Saints-Pères Paris-Descartes University, Sorbonne Paris Cité University, 75006 Paris, France.

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http://dx.doi.org/10.3390/cancers9080101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575604PMC
August 2017

Morphologic and molecular study of lung cancers associated with idiopathic pulmonary fibrosis and other pulmonary fibroses.

Respir Res 2017 06 15;18(1):120. Epub 2017 Jun 15.

Département de Pathologie, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris, 46 rue Henri Huchard, 75018, Paris, France.

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http://dx.doi.org/10.1186/s12931-017-0605-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472872PMC
June 2017

Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab: A Post Hoc Analysis of the PETACC-8 Trial.

JAMA Oncol 2016 May;2(5):643-653

Centre de Recherché UMR-S 1147, Médecine Personnalisée, Pharmacogénomique, Optimisation Thérapeutique, Institut National de la Santé et de la Recherche Médicale, Paris, France6Paris Descartes University, Department of Biology, European Georges Pompidou Ho.

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http://dx.doi.org/10.1001/jamaoncol.2015.5225DOI Listing
May 2016

[What future for circulating tumor DNA? Current data and prospects in colorectal, non-small cell lung and pancreatic cancers].

Bull Cancer 2016 Jan 11;103(1):55-65. Epub 2016 Jan 11.

Université Paris Sorbonne Cité, centre universitaire des Saints-Pères, CNRS SNC5014, Inserm UMR-S1147 MEPPOT, 75006 Paris, France; Assistance publique-Hôpitaux de Paris, groupe hospitalier Pitié-Salpêtrière, pôle 3I, service d'hépatogastroentérologie, 75013 Paris, France; Université Sorbonne, université Pierre-et-Marie-Curie, Paris 06, 75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.bulcan.2015.10.017DOI Listing
January 2016

[Lung cancer molecular testing, what role for Next Generation Sequencing and circulating tumor DNA].

Ann Pathol 2016 Jan 20;36(1):80-93. Epub 2016 Jan 20.

Inserm UMR-S1147, université Paris Sorbonne Cité, 75006 Paris, France; Unité de pharmacogénétique et oncologie moléculaire, service de biochimie, hôpital européen Georges-Pompidou (HEGP), Assistance publique-Hôpitaux de Paris, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.annpat.2015.11.012DOI Listing
January 2016

Sustained response to vemurafenib in a low grade serous ovarian cancer with a BRAF V600E mutation.

Invest New Drugs 2015 Dec 21;33(6):1267-70. Epub 2015 Oct 21.

Centre des cancers de la femme et recherche clinique, GH Paris Centre, site Hôtel-Dieu, 1 place du Parvis Notre-Dame, 75181, Paris cedex 04, France.

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http://dx.doi.org/10.1007/s10637-015-0297-4DOI Listing
December 2015

French multicentric validation of ALK rearrangement diagnostic in 547 lung adenocarcinomas.

Eur Respir J 2015 Jul 30;46(1):207-18. Epub 2015 Apr 30.

Département d'Anatomie et de Cytologie Pathologiques, Pôle de Biologie et de Pathologie, CHU A. Michallon, and Université Joseph Fourier, INSERM U823, Institut Albert Bonniot, Grenoble, France.

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http://dx.doi.org/10.1183/09031936.00119914DOI Listing
July 2015

The new histologic classification of lung primary adenocarcinoma subtypes is a reliable prognostic marker and identifies tumors with different mutation status: the experience of a French cohort.

Chest 2014 Sep;146(3):633-643

INSERM, U1138, Team Cancer, Immune Control, and Escape, Centre de Recherche des Cordeliers, Paris, France; Université Pierre et Marie Curie-Paris 6, Paris, France; Université Paris Descartes-Paris 5, Paris, France; Université Denis Diderot-Paris 7, Paris, France; Service de Pathologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1378/chest.13-2499DOI Listing
September 2014

ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma.

Eur J Cancer 2014 Jul 2;50(10):1740-1746. Epub 2014 May 2.

Université Paris Descartes, Sorbone Paris Cité, Paris, France; Inserm UMR-S775 Bases Moléculaires de la réponse aux xénobiotiques, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.04.007DOI Listing
July 2014

Microsatellite instability analysis in uterine cavity washings to detect endometrial cancer in Lynch syndrome.

Anticancer Res 2014 Jun;34(6):3211-5

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France INSERM UMR-S 747, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://link.springer.com/content/pdf/10.1007/s10689-011-9470
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http://ar.iiarjournals.org/content/33/9/3977.full.pdf
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June 2014

Beyond KRAS status and response to anti-EGFR therapy in metastatic colorectal cancer.

Pharmacogenomics 2014 May;15(7):1043-52

Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche (UMR)-S1147, Personalized Medicine, Pharmacogenomics, Therapeutic Optimization, University Paris Descartes, 45 rue des Saints Pères, Paris 75006, France.

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https://www.futuremedicine.com/doi/10.2217/pgs.14.66
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http://dx.doi.org/10.2217/pgs.14.66DOI Listing
May 2014

Microsatellite instability analysis for the screening of synchronous endometrial and ovarian cancer in Lynch syndrome.

Anticancer Res 2013 Sep;33(9):3977-81

Service de Chirurgie Cancérologique Gynécologique et du Sein, Hôpital Européen Georges-Pompidou, 20-40 rue Leblanc, 75015 Paris, France.

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September 2013

Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.

Lung Cancer 2012 Jun 6;76(3):309-15. Epub 2011 Dec 6.

APHP, Université Paris Descartes, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Service d'anatomie et de cytologie pathologiques, Paris, F-75014, France.

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http://dx.doi.org/10.1016/j.lungcan.2011.11.004DOI Listing
June 2012

Prediction of response to anticancer treatment as simple as the resolution of ordinary differential equations?

Gut 2012 May 26;61(5):637-8. Epub 2011 Dec 26.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1136/gutjnl-2011-301767DOI Listing
May 2012

Dual blockade of epidermal growth factor receptor-induced pathways: a new avenue to treat metastatic colorectal cancer.

J Clin Oncol 2012 May 12;30(13):1550-2. Epub 2012 Mar 12.

Université Paris Descartes, Sorbonne Paris Cité, France.

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http://ascopubs.org/doi/10.1200/JCO.2011.40.1190
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http://dx.doi.org/10.1200/JCO.2011.40.1190DOI Listing
May 2012

MicroRNA and colorectal cancer.

Dig Liver Dis 2012 Mar 21;44(3):195-200. Epub 2011 Nov 21.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.dld.2011.10.010DOI Listing
March 2012

[p16: molecular mechanisms involved in the carcinogenesis of various organs].

Ann Pathol 2010 Nov 29;30(5 Suppl 1):100-2. Epub 2010 Sep 29.

Université Paris-Descartes, UMR-S775, INSERM, Paris, France.

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http://dx.doi.org/10.1016/j.annpat.2010.07.031DOI Listing
November 2010

Beyond the KRAS test.

Eur J Cancer 2009 Sep;45 Suppl 1:398-9

Paris Descartes University, INSERM U775, Paris, France.

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http://dx.doi.org/10.1016/S0959-8049(09)70063-2DOI Listing
September 2009

Mutations and response to epidermal growth factor receptor inhibitors.

Clin Cancer Res 2009 Feb;15(4):1133-9

Université Paris Descartes and INSERM, U775, Bases moléculaires de la réponse aux xénobiotiques, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0905DOI Listing
February 2009

Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation.

Am J Surg Pathol 2006 Oct;30(10):1309-15

Department of Biochemistry, Hôpital Européen Georges Pompidou, Université Paris V, 75015 Paris, France.

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http://dx.doi.org/10.1097/01.pas.0000213285.65907.31DOI Listing
October 2006

Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.

Clin Cancer Res 2005 Jan;11(2 Pt 1):594-9

INSERM U490, Laboratoire de toxicologie Moléculaire, 45 rue des Saintes Pères, 75006 Paris, France.

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January 2005

Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma.

Anticancer Res 2004 May-Jun;24(3b):2021-6

U490 INSERM, Laboratoire de Toxicologie Moléculaire, 45 rue des Saints Pères, 75006 Paris, France.

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September 2004

TP53 and head and neck neoplasms.

Hum Mutat 2003 Mar;21(3):252-7

U490 INSERM Laboratoire de Toxicologie Moléculaire, Paris, France.

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http://dx.doi.org/10.1002/humu.10171DOI Listing
March 2003