Publications by authors named "Helena Vihinen"

36Publications

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage.

Cell 2020 05 16;181(4):800-817.e22. Epub 2020 Apr 16.

Helsinki Institute of Life Science, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, 00290 Helsinki, Finland; Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, 00290 Helsinki, Finland; Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; Cologne Excellence Cluster for Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany. Electronic address:

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May 2020

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 11 13;144(5):1364-1376. Epub 2019 Jun 13.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

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November 2019

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.

Dev Cell 2019 08 6;50(4):478-493.e9. Epub 2019 Jun 6.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland. Electronic address:

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August 2019

Secretion of Tau via an Unconventional Non-vesicular Mechanism.

Cell Rep 2018 11;25(8):2027-2035.e4

Neuroscience Center, HiLIFE, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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November 2018

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization.

J Pathol 2018 06 6;245(2):172-185. Epub 2018 Apr 6.

Research Programmes Unit, Genome-Scale Biology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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June 2018

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties.

Am J Pathol 2018 02 14;188(2):525-538. Epub 2017 Nov 14.

Atherosclerosis Research Laboratory, Wihuri Research Institute, Helsinki, Finland; Helsinki University Lipidomics Unit, Department of Biosciences, University of Helsinki, Helsinki, Finland. Electronic address:

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February 2018

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra.

eNeuro 2017 Jan-Feb;4(1). Epub 2017 Feb 20.

Program in Developmental Biology, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland; Department of Gene Technology, Tallinn University of Technology, 12618 Tallinn, Estonia.

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July 2018

FYCO1 and autophagy control the integrity of the haploid male germ cell-specific RNP granules.

Autophagy 2017 Feb 8;13(2):302-321. Epub 2016 Dec 8.

a Institute of Biomedicine, Department of Physiology , University of Turku , Turku , Finland.

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February 2017

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

J Allergy Clin Immunol 2017 04 29;139(4):1391-1393.e11. Epub 2016 Nov 29.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland; Center for Innovative Medicine, Karolinska Institutet, Huddinge, Sweden.

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April 2017

Seipin regulates ER-lipid droplet contacts and cargo delivery.

EMBO J 2016 12 22;35(24):2699-2716. Epub 2016 Nov 22.

Department of Anatomy, Faculty of Medicine, University of Helsinki, Helsinki, Finland

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December 2016

Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets.

PLoS Biol 2016 Jan 4;14(1):e1002340. Epub 2016 Jan 4.

Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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January 2016

Membrane protrusion powers clathrin-independent endocytosis of interleukin-2 receptor.

EMBO J 2015 Aug 29;34(16):2147-61. Epub 2015 Jun 29.

Unité de Biologie des Interactions Cellulaires, Institut Pasteur, Paris, France CNRS UMR3691, Paris, France

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August 2015

Correlative light and electron microscopy enables viral replication studies at the ultrastructural level.

Methods 2015 Nov 24;90:49-56. Epub 2015 Apr 24.

Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland. Electronic address:

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November 2015

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy.

Acta Ophthalmol 2015 Sep 21;93(6):512-23. Epub 2015 Apr 21.

Research Programs Unit, Genome-Scale Biology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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September 2015

Ultrastructural relationship of the phagophore with surrounding organelles.

Autophagy 2015 ;11(3):439-51

a Department of Biosciences ; Division of Biochemistry and Biotechnology; University of Helsinki ; Helsinki , Finland.

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March 2016

The versatile electron microscope: an ultrastructural overview of autophagy.

Methods 2015 Mar 26;75:44-53. Epub 2014 Nov 26.

Department of Biosciences, Division of Biochemistry and Biotechnology, University of Helsinki, Finland. Electronic address:

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March 2015

ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays.

Mol Biol Cell 2014 Apr 12;25(7):1111-26. Epub 2014 Feb 12.

Cell and Molecular Biology Program, Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland Electron Microscopy Unit, Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, United Kingdom.

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April 2014

Interactions between ICAM-5 and β1 integrins regulate neuronal synapse formation.

J Cell Sci 2013 Jan 26;126(Pt 1):77-89. Epub 2012 Sep 26.

Division of Biochemistry and Biotechnology, Faculty of Biological and Environmental Sciences, University of Helsinki, Finland.

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January 2013

Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells.

Mol Biol Cell 2012 Jul 9;23(13):2424-32. Epub 2012 May 9.

Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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July 2012

3D tomography reveals connections between the phagophore and endoplasmic reticulum.

Autophagy 2009 Nov 8;5(8):1180-5. Epub 2009 Nov 8.

University of Helsinki, Department of Biological and Environmental Sciences, Division of Biochemistry, Helsinki, Finland.

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November 2009

Monitoring autophagy by electron microscopy in Mammalian cells.

Methods Enzymol 2009 ;452:143-64

Department of Biological and Environmental Sciences, Division of Biochemistry, University of Helsinki, Helsinki, Finland.

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April 2009

Endoplasmic reticulum remains continuous and undergoes sheet-to-tubule transformation during cell division in mammalian cells.

J Cell Biol 2007 Dec;179(5):895-909

Electron Microscopy Unit, Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland.

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December 2007