Helena Erlandsson Harris

Helena Erlandsson Harris

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Helena Erlandsson Harris

Helena Erlandsson Harris

Publications by authors named "Helena Erlandsson Harris"

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55Publications

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Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study.

Ann Neurol 2020 Mar 25;87(3):370-382. Epub 2020 Jan 25.

Department of Physiology and Pharmacology, Section of Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.25678DOI Listing
March 2020

Expression of concern to: High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome.

Mol Med 2020 02 3;26(1):17. Epub 2020 Feb 3.

Unit of Pediatric Rheumatology, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s10020-020-0142-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998297PMC
February 2020

Juvenile idiopathic arthritis patients have a distinct cartilage and bone biomarker profile that differs from healthy and knee-injured children.

Clin Exp Rheumatol 2019 Oct 30. Epub 2019 Oct 30.

Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, and Division of Rheumatology, Karolinska University Hospital, Stockholm, Sweden.

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October 2019

Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms.

J Innate Immun 2018 23;10(3):215-227. Epub 2018 Feb 23.

Department of Medicine Solna, Rheumatology Unit, Centre for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000487056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050639PMC
September 2019

The immune response of the human brain to abdominal surgery.

Ann Neurol 2017 Apr 11;81(4):572-582. Epub 2017 Apr 11.

Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.24909DOI Listing
April 2017

Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis.

Int J Rheum Dis 2017 Jan 5;20(1):25-32. Epub 2014 Apr 5.

Department of Medicine, Center for molecular medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/1756-185X.12353DOI Listing
January 2017

High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome.

Mol Med 2015 Jan 27;20:538-47. Epub 2015 Jan 27.

Unit of Pediatric Rheumatology, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2119/molmed.2014.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365070PMC
January 2015

HMGB1 levels are increased in patients with juvenile idiopathic arthritis, correlate with early onset of disease, and are independent of disease duration.

J Rheumatol 2013 Sep 15;40(9):1604-13. Epub 2013 Jul 15.

Department of Women's and Children's Health, Clinical Paediatrics, and the Department of Medicine, Rheumatology Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3899/jrheum.120987DOI Listing
September 2013

TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis.

EMBO J 2013 Jan 7;32(1):86-99. Epub 2012 Dec 7.

Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1038/emboj.2012.328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545309PMC
January 2013

Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models.

Mol Med 2011 Sep-Oct;17(9-10):1039-44. Epub 2011 Jun 7.

Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.2119/molmed.2010.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188862PMC
March 2012

Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1).

Mol Med 2012 Mar 30;18:250-9. Epub 2012 Mar 30.

Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.

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http://dx.doi.org/10.2119/molmed.2011.00389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324950PMC
March 2012

Suppression of pain and joint destruction by inhibition of the proteasome system in experimental osteoarthritis.

Pain 2012 Jan 22;153(1):18-26. Epub 2011 Oct 22.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm 17176, Sweden.

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http://dx.doi.org/10.1016/j.pain.2011.08.001DOI Listing
January 2012

HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease.

Nat Rev Rheumatol 2012 Jan 31;8(4):195-202. Epub 2012 Jan 31.

Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrrheum.2011.222DOI Listing
January 2012

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.

Arthritis Res Ther 2011 Aug 26;13(4):R136. Epub 2011 Aug 26.

Department of Women's and Children's Health, Pediatric Rheumatology Research Unit Karolinska Institutet, Astrid Lindgren Children Hospital/Karolinska University Hospital, Stockholm, 17176, Sweden.

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http://dx.doi.org/10.1186/ar3450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239379PMC
August 2011

Immunomodulatory drugs regulate HMGB1 release from activated human monocytes.

Mol Med 2010 Sep-Oct;16(9-10):343-51. Epub 2010 Apr 9.

Department of Women's and Children's Health, Pediatric Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2119/molmed.2010.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935946PMC
December 2010

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model.

Arthritis Rheum 2010 Oct;62(10):2963-72

Astrid Lindgren Children's Hospital, Karolinska Hospital, and Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/art.27590DOI Listing
October 2010

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.

Proc Natl Acad Sci U S A 2010 Jun 14;107(26):11942-7. Epub 2010 Jun 14.

Laboratory of Biomedical Science and Department of Medicinal Chemistry, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA.

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http://dx.doi.org/10.1073/pnas.1003893107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900689PMC
June 2010

The role of HMGB1 in the pathogenesis of rheumatic disease.

Biochim Biophys Acta 2010 Jan-Feb;1799(1-2):141-8

Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital at Solna, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbagrm.2009.11.003DOI Listing
April 2010

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

J Leukoc Biol 2009 Sep 29;86(3):655-62. Epub 2009 Jun 29.

Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Karolinska Institutet, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1189/jlb.0908548DOI Listing
September 2009

Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.

Eur J Pharmacol 2009 Jun 7;613(1-3):155-62. Epub 2009 Apr 7.

Karolinska Institutet, Department of Medicine, Rheumatology Unit, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.ejphar.2009.03.074DOI Listing
June 2009

TLR activation induces TNF-alpha production from adult neural stem/progenitor cells.

J Immunol 2009 Jun;182(11):6889-95

Department of Clinical Neurosciences, Division of Neuroimmunology, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.4049/jimmunol.0802907DOI Listing
June 2009

High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes.

Immunobiology 2009 25;214(4):303-9. Epub 2008 Oct 25.

Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, L 8:04 CMM, S-17176 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.imbio.2008.09.006DOI Listing
May 2009

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease.

Arthritis Res Ther 2008 30;10(3):209. Epub 2008 Jun 30.

Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1186/ar2440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483460PMC
December 2008

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients--a prospective clinical study.

Arthritis Res Ther 2008 17;10(2):R33. Epub 2008 Mar 17.

Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1186/ar2387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2452983PMC
September 2008

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.

Arthritis Res Ther 2008 7;10(1):R1. Epub 2008 Jan 7.

Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, 171 176 Stockholm, Sweden.

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http://dx.doi.org/10.1186/ar2347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2374449PMC
July 2008

Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate.

J Leukoc Biol 2008 Jan 3;83(1):31-8. Epub 2007 Oct 3.

Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1189/jlb.0507323DOI Listing
January 2008

Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis.

Arthritis Res Ther 2007 ;9(2):R35

Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1186/ar2155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906813PMC
November 2007

HMGB1-secreting capacity of multiple cell lineages revealed by a novel HMGB1 ELISPOT assay.

J Leukoc Biol 2007 Jan 15;81(1):129-36. Epub 2006 Sep 15.

Rheumatology Unit, Department of Medicine, Karolinska Institutet CMM L8:04, Karolinska Sjukhuset, Stockholm, Sweden.

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http://dx.doi.org/10.1189/jlb.0506349DOI Listing
January 2007

Alarmin(g) news about danger: workshop on innate danger signals and HMGB1.

EMBO Rep 2006 Aug 21;7(8):774-8. Epub 2006 Jul 21.

Department of Medicine, Rheumatology Unit, Karolinska Institutet CMM L8:04, Karolinska Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/sj.embor.7400759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525157PMC
August 2006

HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages.

Cytokine 2006 Apr 11;34(1-2):17-23. Epub 2006 May 11.

Division of Clinical Virology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cyto.2006.03.010DOI Listing
April 2006

Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility.

J Leukoc Biol 2004 Dec 15;76(6):1118-24. Epub 2004 Sep 15.

Department of Clinical Neurosciences, CMM L8:04, Karolinska Sjukhuset, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1189/jlb.0704385DOI Listing
December 2004

A pH-induced modification of CII increases its arthritogenic properties.

J Autoimmun 2004 Sep;23(2):95-102

Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska Hospital, CMM L8:04, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jaut.2004.05.002DOI Listing
September 2004

Mini-review: The nuclear protein HMGB1 as a proinflammatory mediator.

Eur J Immunol 2004 Jun;34(6):1503-12

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.200424916DOI Listing
June 2004

High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis.

Arthritis Rheum 2003 Jun;48(6):1693-700

Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, University of Göteborg, Gothenburg, Sweden.

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http://dx.doi.org/10.1002/art.11028DOI Listing
June 2003

HMGB1 as a DNA-binding cytokine.

J Leukoc Biol 2002 Dec;72(6):1084-91

Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Stockholm, Sweden.

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December 2002

High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid.

Pediatr Res 2002 Aug;52(2):148-54

Pediatric Endocrinology Unit, Department of Woman and Child Health, Astrid Lindgren Children's Hospital, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1203/00006450-200208000-00004DOI Listing
August 2002