Helen McIlleron

Helen McIlleron

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Helen McIlleron

Helen McIlleron

Publications by authors named "Helen McIlleron"

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Early antituberculosis drug exposure in hospitalized patients with human immunodeficiency virus associated tuberculosis.

Authors:
Charlotte Schutz Maxwell Chirehwa David Barr Amy Ward Saskia Janssen Rosie Burton Robert J Wilkinson Muki Shey Lubbe Wiesner Paolo Denti Helen McIlleron Gary Maartens Graeme Meintjes

Br J Clin Pharmacol 2020 Jan 7. Epub 2020 Jan 7.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1111/bcp.14207DOI Listing
January 2020

Pharmacokinetic profile and safety of adjusted doses of darunavir/ritonavir with rifampicin in people living with HIV.

Authors:
Ismaeel Ebrahim Gary Maartens Lubbe Wiesner Catherine Orrell Wynand Smythe Helen McIlleron

J Antimicrob Chemother 2020 Jan 13. Epub 2020 Jan 13.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/jac/dkz522DOI Listing
January 2020

N-acetyltransferase 2 genotypes amongst Zulu Speaking South Africans and isoniazid/-acetyl-isoniazid pharmacokinetics during anti-tuberculosis treatment.

Authors:
Thuli Mthiyane James Millard John Adamson Yusentha Balakrishna Cathy Connolly Andrew Owen Roxana Rustomjee Keertan Dheda Helen McIlleron Alexander S Pym

Antimicrob Agents Chemother 2020 Jan 21. Epub 2020 Jan 21.

South African Medical Research Council, Durban, South Africa.

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http://dx.doi.org/10.1128/AAC.02376-19DOI Listing
January 2020

Population Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in South African Pregnant Women with Tuberculosis and HIV.

Authors:
Mahmoud Tareq Abdelwahab Rory Leisegang Kelly E Dooley Jyoti S Mathad Lubbe Wiesner Helen McIlleron Neil Martinson Ziyaad Waja Matebogo Letutu Richard E Chaisson Paolo Denti

Antimicrob Agents Chemother 2019 Dec 16. Epub 2019 Dec 16.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.01978-19DOI Listing
December 2019

Population pharmacokinetics and dosing of ethionamide in children with tuberculosis.

Authors:
Henrik Bjugård Nyberg Heather R Draper Anthony J Garcia-Prats Stephanie Thee Adrie Bekker Heather J Zar Andrew C Hooker H Simon Schaaf Helen McIlleron Anneke C Hesseling Paolo Denti

Antimicrob Agents Chemother 2019 Dec 23. Epub 2019 Dec 23.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.01984-19DOI Listing
December 2019

Correction to: Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy.

Authors:
Elin M Svensson Gunnar Yngman Paolo Denti Helen McIlleron Maria C Kjellsson Mats O Karlsson

Clin Pharmacokinet 2019 Nov 2. Epub 2019 Nov 2.

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s40262-019-00835-4DOI Listing
November 2019

Pharmacokinetics and other risk factors for kanamycin-induced hearing loss in patients with multi-drug resistant tuberculosis.

Authors:
Nazanin Ghafari Richard Court Maxwell Tawanda Chirehwa Lubbe Wiesner Lucretia Petersen Gary Maartens Tawanda Gumbo Helen McIlleron Lebogang Ramma

Int J Audiol 2019 Nov 18:1-5. Epub 2019 Nov 18.

Department of Health & Rehabilitation Sciences, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1080/14992027.2019.1690170DOI Listing
November 2019

Integrating pharmacokinetics and pharmacodynamics in operational research to End TB.

Authors:
Jan-Willem C Alffenaar Tawanda Gumbo Kelly E Dooley Charles A Peloquin Helen McIlleron Andre Zagorski Daniela M Cirillo Scott K Heysell Denise Rossato Silva Giovanni Battista Migliori

Clin Infect Dis 2019 Sep 27. Epub 2019 Sep 27.

Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.

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http://dx.doi.org/10.1093/cid/ciz942DOI Listing
September 2019

Pharmacokinetics of adjusted-dose 8-hourly lopinavir/ritonavir in HIV-infected children co-treated with rifampicin.

Authors:
Helena Rabie Holly Rawizza Peter Zuidewind Jana Winckler Heather Zar Annelies Van Rie Lubbe Wiesner Helen McIlleron

J Antimicrob Chemother 2019 Aug;74(8):2347-2351

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/jac/dkz171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640304PMC
August 2019

A Systematic Review on the Effect of HIV Infection on the Pharmacokinetics of First-Line Tuberculosis Drugs.

Authors:
Alper Daskapan Lusiana R Idrus Maarten J Postma Bob Wilffert Jos G W Kosterink Ymkje Stienstra Daniel J Touw Aase B Andersen Adrie Bekker Paolo Denti Agibothu K Hemanth Kumar Kidola Jeremiah Awewura Kwara Helen McIlleron Graeme Meintjes Joep J van Oosterhout Geetha Ramachandran Neesha Rockwood Robert J Wilkinson Tjip S van der Werf Jan-Willem C Alffenaar

Clin Pharmacokinet 2019 Jun;58(6):747-766

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

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http://link.springer.com/10.1007/s40262-018-0716-8
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http://dx.doi.org/10.1007/s40262-018-0716-8DOI Listing
June 2019

Quantitative assessment of the activity of antituberculosis drugs and regimens.

Authors:
Maxwell T Chirehwa Gustavo E Velásquez Tawanda Gumbo Helen McIlleron

Expert Rev Anti Infect Ther 2019 Jun 30;17(6):449-457. Epub 2019 May 30.

a Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Rondebosch , South Africa.

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http://dx.doi.org/10.1080/14787210.2019.1621747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581212PMC
June 2019

A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine.

Authors:
Jose Francis Simbarashe P Zvada Paolo Denti Mark Hatherill Salome Charalambous Stanley Mungofa Rodney Dawson Susan Dorman Nikhil Gupte Lubbe Wiesner Amina Jindani Thomas S Harrison Adeniyi Olagunju Deirdre Egan Andrew Owen Helen M McIlleron

Antimicrob Agents Chemother 2019 04 27;63(4). Epub 2019 Mar 27.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.01964-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437540PMC
April 2019

Effects of genetic variability on rifampicin and isoniazid pharmacokinetics in South African patients with recurrent tuberculosis.

Authors:
Anushka Naidoo Maxwell Chirehwa Veron Ramsuran Helen McIlleron Kogieleum Naidoo Nonhlanhla Yende-Zuma Ravesh Singh Sinaye Ncgapu John Adamson Katya Govender Paolo Denti Nesri Padayatchi

Pharmacogenomics 2019 03 15;20(4):225-240. Epub 2019 Feb 15.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.2217/pgs-2018-0166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562923PMC
March 2019

Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid.

Authors:
Maxwell T Chirehwa Helen McIlleron Lubbe Wiesner Dissou Affolabi Oumou Bah-Sow Corinne Merle Paolo Denti

J Antimicrob Chemother 2019 01;74(1):139-148

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/jac/dky378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293084PMC
January 2019

Current research toward optimizing dosing of first-line antituberculosis treatment.

Authors:
Helen McIlleron Maxwell T Chirehwa

Expert Rev Anti Infect Ther 2019 01 12;17(1):27-38. Epub 2018 Dec 12.

a Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Cape Town , South Africa.

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http://dx.doi.org/10.1080/14787210.2019.1555031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364307PMC
January 2019

Effect of Coadministration of Lidocaine on the Pain and Pharmacokinetics of Intramuscular Amikacin in Children With Multidrug-Resistant Tuberculosis: A Randomized Crossover Trial.

Authors:
Anthony J Garcia-Prats Penelope C Rose Heather R Draper James A Seddon Jennifer Norman Helen M McIlleron Anneke C Hesseling H Simon Schaaf

Pediatr Infect Dis J 2018 12;37(12):1199-1203

From the Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

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http://dx.doi.org/10.1097/INF.0000000000001983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138584PMC
December 2018

Lopinavir-ritonavir super-boosting in young HIV-infected children on rifampicin-based tuberculosis therapy compared with lopinavir-ritonavir without rifampicin: a pharmacokinetic modelling and clinical study.

Authors:
Helena Rabie Paolo Denti Janice Lee Mhleli Masango Ashraf Coovadia Sandy Pillay Afaaf Liberty François Simon Helen McIlleron Mark F Cotton Marc Lallemant

Lancet HIV 2018 Dec 6. Epub 2018 Dec 6.

Drugs for Neglected Diseases Initiative, Geneva, Switzerland.

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https://linkinghub.elsevier.com/retrieve/pii/S23523018183029
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http://dx.doi.org/10.1016/S2352-3018(18)30293-5DOI Listing
December 2018

Artificial intelligence-derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis.

Authors:
Jotam G Pasipanodya Wynand Smythe Corinne S Merle Piero L Olliaro Devyani Deshpande Gesham Magombedze Helen McIlleron Tawanda Gumbo

Clin Infect Dis 2018 11;67(suppl_3):S284-S292

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1093/cid/ciy610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904294PMC
November 2018

Gatifloxacin Pharmacokinetics/Pharmacodynamics-based Optimal Dosing for Pulmonary and Meningeal Multidrug-resistant Tuberculosis.

Authors:
Devyani Deshpande Jotam G Pasipanodya Shashikant Srivastava Paula Bendet Thearith Koeuth Sujata M Bhavnani Paul G Ambrose Wynand Smythe Helen McIlleron Guy Thwaites Mourad Gumusboga Armand Van Deun Tawanda Gumbo

Clin Infect Dis 2018 11;67(suppl_3):S274-S283

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/cid/ciy618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904296PMC
November 2018

d-Cycloserine Pharmacokinetics/Pharmacodynamics, Susceptibility, and Dosing Implications in Multidrug-resistant Tuberculosis: A Faustian Deal.

Authors:
Devyani Deshpande Jan-Willem C Alffenaar Claudio U Köser Keertan Dheda Moti L Chapagain Noviana Simbar Thomas Schön Marieke G G Sturkenboom Helen McIlleron Pooi S Lee Thearith Koeuth Stellah G Mpagama Sayera Banu Suporn Foongladda Oleg Ogarkov Suporn Pholwat Eric R Houpt Scott K Heysell Tawanda Gumbo

Clin Infect Dis 2018 11;67(suppl_3):S308-S316

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1093/cid/ciy624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260153PMC
November 2018

Transformation Morphisms and Time-to-Extinction Analysis That Map Therapy Duration From Preclinical Models to Patients With Tuberculosis: Translating From Apples to Oranges.

Authors:
Gesham Magombedze Jotam G Pasipanodya Shashikant Srivastava Devyani Deshpande Marianne E Visser Emmanuel Chigutsa Helen McIlleron Tawanda Gumbo

Clin Infect Dis 2018 11;67(suppl_3):S349-S358

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Dallas, Texas.

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http://dx.doi.org/10.1093/cid/ciy623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260172PMC
November 2018

Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol.

Authors:
Bronwyn Myers Tara C Bouton Elizabeth J Ragan Laura F White Helen McIlleron Danie Theron Charles D H Parry C Robert Horsburgh Robin M Warren Karen R Jacobson

BMC Infect Dis 2018 Sep 29;18(1):488. Epub 2018 Sep 29.

Section of Infectious Diseases, Boston University School of Medicine, 801 Massachusetts Avenue, 2nd floor, Crosstown Center, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1186/s12879-018-3396-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162918PMC
September 2018

Evidence-Based Design of Fixed-Dose Combinations: Principles and Application to Pediatric Anti-Tuberculosis Therapy.

Authors:
Elin M Svensson Gunnar Yngman Paolo Denti Helen McIlleron Maria C Kjellsson Mats O Karlsson

Clin Pharmacokinet 2018 05;57(5):591-599

Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1007/s40262-017-0577-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904239PMC
May 2018

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial.

Authors:
Chishala Chabala Anna Turkova Margaret J Thomason Eric Wobudeya Syed Hissar Vidya Mave Marieke van der Zalm Megan Palmer Monica Kapasa Perumal K Bhavani Sarath Balaji Priyanka A Raichur Anne-Marie Demers Graeme Hoddinott Ellen Owen-Powell Aarti Kinikar Philippa Musoke Veronica Mulenga Rob Aarnoutse Helen McIlleron Anneke Hesseling Angela M Crook Mark Cotton Diana M Gibb

Trials 2018 Apr 19;19(1):237. Epub 2018 Apr 19.

Medical Research Council Clinical Trials Unit at University College London, Institute of Clinical Trials and Methodology, High Holborn, London, WC1V 6LJ, UK.

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-018-2608-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909210PMC
April 2018

Pharmacokinetics and Drug-Drug Interactions of Lopinavir-Ritonavir Administered with First- and Second-Line Antituberculosis Drugs in HIV-Infected Children Treated for Multidrug-Resistant Tuberculosis.

Authors:
Louvina E van der Laan Anthony J Garcia-Prats H Simon Schaaf Tjokosela Tikiso Lubbe Wiesner Mine de Kock Jana Winckler Jennifer Norman Helen McIlleron Paolo Denti Anneke C Hesseling

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://aac.asm.org/lookup/doi/10.1128/AAC.00420-17
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http://dx.doi.org/10.1128/AAC.00420-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786799PMC
February 2018

Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis.

Authors:
Paolo Denti Anthony J Garcia-Prats Heather R Draper Lubbe Wiesner Jana Winckler Stephanie Thee Kelly E Dooley Rada M Savic Helen M McIlleron H Simon Schaaf Anneke C Hesseling

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://aac.asm.org/lookup/doi/10.1128/AAC.01521-17
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http://dx.doi.org/10.1128/AAC.01521-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786780PMC
February 2018

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.

Authors:
Anushka Naidoo Veron Ramsuran Maxwell Chirehwa Paolo Denti Helen McIlleron Kogieleum Naidoo Nonhlanhla Yende-Zuma Ravesh Singh Sinaye Ngcapu Mamoonah Chaudhry Michael S Pepper Nesri Padayatchi

Pharmacogenomics 2018 Jan 6;19(1):17-29. Epub 2017 Dec 6.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.

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http://dx.doi.org/10.2217/pgs-2017-0144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753622PMC
January 2018

A Review of Moxifloxacin for the Treatment of Drug-Susceptible Tuberculosis.

Authors:
Anushka Naidoo Kogieleum Naidoo Helen McIlleron Sabiha Essack Nesri Padayatchi

J Clin Pharmacol 2017 Nov 24;57(11):1369-1386. Epub 2017 Jul 24.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

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http://doi.wiley.com/10.1002/jcph.968
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http://dx.doi.org/10.1002/jcph.968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663285PMC
November 2017

Pharmacokinetics of Pyrazinamide and Optimal Dosing Regimens for Drug-Sensitive and -Resistant Tuberculosis.

Authors:
Maxwell T Chirehwa Helen McIlleron Roxana Rustomjee Thuli Mthiyane Philip Onyebujoh Peter Smith Paolo Denti

Antimicrob Agents Chemother 2017 08 25;61(8). Epub 2017 Jul 25.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.00490-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527644PMC
August 2017

Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants.

Authors:
Helen McIlleron Paolo Denti Silvia Cohn Fildah Mashabela Jennifer D Hoffmann Saba Shembe Regina Msandiwa Lubbe Wiesner Sithembiso Velaphi Sanjay G Lala Richard E Chaisson Neil Martinson Kelly E Dooley

J Antimicrob Chemother 2017 07;72(7):2028-2034

Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/jac/dkx112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890683PMC
July 2017

Effects on the QT Interval of a Gatifloxacin-Containing Regimen versus Standard Treatment of Pulmonary Tuberculosis.

Authors:
Piero L Olliaro Corinne Merle Thuli Mthiyane Boubacar Bah Ferdinand Kassa Evans Amukoye Alimatou N Diaye Christian Perronne Christian Lienhardt Helen McIlleron Katherine Fielding

Antimicrob Agents Chemother 2017 07 27;61(7). Epub 2017 Jun 27.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.1128/AAC.01834-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487672PMC
July 2017

Effect of rifampicin and efavirenz on moxifloxacin concentrations when co-administered in patients with drug-susceptible TB.

Authors:
Anushka Naidoo Maxwell Chirehwa Helen McIlleron Kogieleum Naidoo Sabiha Essack Nonhlanhla Yende-Zuma Eddy Kimba-Phongi John Adamson Katya Govender Nesri Padayatchi Paolo Denti

J Antimicrob Chemother 2017 05;72(5):1441-1449

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa.

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https://academic.oup.com/jac/article/72/5/1441/2975595
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http://dx.doi.org/10.1093/jac/dkx004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890691PMC
May 2017

Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis.

Authors:
Neesha Rockwood Jotam G Pasipanodya Paolo Denti Frederick Sirgel Maia Lesosky Tawanda Gumbo Graeme Meintjes Helen McIlleron Robert J Wilkinson

Clin Infect Dis 2017 May;64(10):1350-1359

Department of Medicine, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1093/cid/cix158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411399PMC
May 2017

Determinants of virological outcome and adverse events in African children treated with paediatric nevirapine fixed-dose-combination tablets.

Authors:
Andrzej Bienczak Paolo Denti Adrian Cook Lubbe Wiesner Veronica Mulenga Cissy Kityo Addy Kekitiinwa Diana M Gibb David Burger Ann S Walker Helen McIlleron

AIDS 2017 04;31(7):905-915

aDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa bMRC Clinical Trials Unit at University College London, London, United Kingdom cDepartment of Paediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia dJoint Clinical Research Centre eBaylor College of Medicine Bristol Myers Squibb Children's Clinical Centre of Excellence, Kampala, Uganda fGulu Regional Centre of Excellence, Gulu, Uganda gDepartment of Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands. *Ann S. Walker and Helen McIlleron contributed equally to the article.

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http://Insights.ovid.com/crossref?an=00002030-201704240-0000
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http://dx.doi.org/10.1097/QAD.0000000000001376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572624PMC
April 2017

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.

Authors:
Keertan Dheda Tawanda Gumbo Gary Maartens Kelly E Dooley Ruth McNerney Megan Murray Jennifer Furin Edward A Nardell Leslie London Erica Lessem Grant Theron Paul van Helden Stefan Niemann Matthias Merker David Dowdy Annelies Van Rie Gilman K H Siu Jotam G Pasipanodya Camilla Rodrigues Taane G Clark Frik A Sirgel Aliasgar Esmail Hsien-Ho Lin Sachin R Atre H Simon Schaaf Kwok Chiu Chang Christoph Lange Payam Nahid Zarir F Udwadia C Robert Horsburgh Gavin J Churchyard Dick Menzies Anneke C Hesseling Eric Nuermberger Helen McIlleron Kevin P Fennelly Eric Goemaere Ernesto Jaramillo Marcus Low Carolina Morán Jara Nesri Padayatchi Robin M Warren

Lancet Respir Med 2017 Mar 15. Epub 2017 Mar 15.

SA MRC Centre for Tuberculosis Research/DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1016/S2213-2600(17)30079-6DOI Listing
March 2017

Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients.

Authors:
Naïm Bouazza Tim R Cressey Frantz Foissac Andrzej Bienczak Paolo Denti Helen McIlleron David Burger Martina Penazzato Marc Lallemant Edmund V Capparelli Jean-Marc Treluyer Saïk Urien

J Antimicrob Chemother 2017 02 24;72(2):490-495. Epub 2016 Oct 24.

EA7323, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1093/jac/dkw444DOI Listing
February 2017

Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies.

Authors:
Ben J Marais Anna D Heemskerk Suzaan S Marais Reinout van Crevel Ursula Rohlwink Maxine Caws Graeme Meintjes Usha K Misra Nguyen T H Mai Rovina Ruslami James A Seddon Regan Solomons Ronald van Toorn Anthony Figaji Helen McIlleron Robert Aarnoutse Johan F Schoeman Robert J Wilkinson Guy E Thwaites

Clin Infect Dis 2017 02;64(4):501-509

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1093/cid/ciw757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399942PMC
February 2017

Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children.

Authors:
Andrzej Bienczak Adrian Cook Lubbe Wiesner Veronica Mulenga Cissy Kityo Addy Kekitiinwa A Sarah Walker Andrew Owen Diana M Gibb David Burger Helen McIlleron Paolo Denti

J Antimicrob Chemother 2017 01 5;72(1):190-199. Epub 2016 Oct 5.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/
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http://dx.doi.org/10.1093/jac/dkw388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161049PMC
January 2017

Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children.

Authors:
Retsilisitsoe R Moholisa Michael Schomaker Louise Kuhn Sandra Castel Lubbe Wiesner Ashraf Coovadia Renate Strehlau Faeezah Patel Francoise Pinillos Elaine J Abrams Gary Maartens Helen McIlleron

Pediatr Infect Dis J 2016 12;35(12):e378-e383

From the *Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; †Centre for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; ‡Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; §Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; ¶ICAP, Mailman School of Public Health, and College of Physicians & Surgeons, Columbia University, New York, NY; and ‖Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166428PMC
December 2016

Plasma Efavirenz Exposure, Sex, and Age Predict Virological Response in HIV-Infected African Children.

Authors:
Andrzej Bienczak Paolo Denti Adrian Cook Lubbe Wiesner Veronica Mulenga Cissy Kityo Addy Kekitiinwa Diana M Gibb David Burger A Sarah Walker Helen McIlleron

J Acquir Immune Defic Syndr 2016 10;73(2):161-8

*Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; †MRC Clinical Trials Unit, University College London, London, United Kingdom; ‡Department of Paediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia; §Joint Clinical Research Centre, Kampala, Uganda; ‖Baylor College of Medicine Bristol Myers Squibb Children's Clinical Centre of Excellence, Kampala, Uganda/Gulu Regional Centre of Excellence, Gulu, Uganda; and ¶Department of Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1097/QAI.0000000000001032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172513PMC
October 2016

HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients.

Authors:
Neesha Rockwood Graeme Meintjes Maxwell Chirehwa Lubbe Wiesner Helen McIlleron Robert J Wilkinson Paolo Denti

Antimicrob Agents Chemother 2016 10 23;60(10):6050-9. Epub 2016 Sep 23.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038257PMC
October 2016

The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children.

Authors:
Andrzej Bienczak Adrian Cook Lubbe Wiesner Adeniyi Olagunju Veronica Mulenga Cissy Kityo Addy Kekitiinwa Andrew Owen A Sarah Walker Diana M Gibb Helen McIlleron David Burger Paolo Denti

Br J Clin Pharmacol 2016 07 25;82(1):185-98. Epub 2016 Apr 25.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://doi.wiley.com/10.1111/bcp.12934
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917805PMC
July 2016

Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.

Authors:
Paolo Denti Kidola Jeremiah Emmanuel Chigutsa Daniel Faurholt-Jepsen George PrayGod Nyagosya Range Sandra Castel Lubbe Wiesner Christian Munch Hagen Michael Christiansen John Changalucha Helen McIlleron Henrik Friis Aase Bengaard Andersen

PLoS One 2015 26;10(10):e0141002. Epub 2015 Oct 26.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark; Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4621059PMC
June 2016

Population pharmacokinetic drug-drug interaction pooled analysis of existing data for rifabutin and HIV PIs.

Authors:
Stefanie Hennig Elin M Svensson Ronald Niebecker P Bernard Fourie Marc H Weiner Stefano Bonora Charles A Peloquin Keith Gallicano Charles Flexner Alex Pym Peter Vis Piero L Olliaro Helen McIlleron Mats O Karlsson

J Antimicrob Chemother 2016 May 31;71(5):1330-40. Epub 2016 Jan 31.

Department of Pharmaceutical Bioscience, Uppsala University, Uppsala, Sweden.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830412PMC
May 2016

Erratum for Chirehwa et al., Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction.

Authors:
Maxwell T Chirehwa Roxana Rustomjee Thuli Mthiyane Philip Onyebujoh Peter Smith Helen McIlleron Paolo Denti

Antimicrob Agents Chemother 2016 05 22;60(5):3262. Epub 2016 Apr 22.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.00483-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862483PMC
May 2016

Drug-drug interactions between bedaquiline and the antiretrovirals lopinavir/ritonavir and nevirapine in HIV-infected patients with drug-resistant TB.

Authors:
Mishal Pandie Lubbe Wiesner Helen McIlleron Jennifer Hughes Sweetness Siwendu Francesca Conradie Ebrahim Variava Gary Maartens

J Antimicrob Chemother 2016 Apr 7;71(4):1037-40. Epub 2016 Jan 7.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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April 2016

Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial.

Authors:
Veronica Mulenga Victor Musiime Adeodata Kekitiinwa Adrian D Cook George Abongomera Julia Kenny Chisala Chabala Grace Mirembe Alice Asiimwe Ellen Owen-Powell David Burger Helen McIlleron Nigel Klein Chifumbe Chintu Margaret J Thomason Cissy Kityo A Sarah Walker Diana M Gibb

Lancet Infect Dis 2016 Feb 5;16(2):169-79. Epub 2015 Oct 5.

Medical Research Council Clinical Trials Unit at University College London, London, UK. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726762PMC
February 2016

Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline Among Postpartum Women on Antiretroviral Therapy in South Africa.

Authors:
Christopher J Hoffmann Silvia Cohn Fildah Mashabela Jennifer D Hoffmann Helen McIlleron Paolo Denti David W Haas Kelly E Dooley Neil A Martinson Richard E Chaisson

J Acquir Immune Defic Syndr 2016 Jan;71(1):31-7

*Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;†Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Soweto, South Africa;‡Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; and§Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713347PMC
January 2016

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.

Authors:
Stefanie Hennig Suhashni Naiker Tarylee Reddy Deirdre Egan Tracy Kellerman Lubbe Wiesner Andrew Owen Helen McIlleron Alexander Pym

Antimicrob Agents Chemother 2016 01 19;60(1):617-20. Epub 2015 Oct 19.

TB Research Unit, Medical Research Council, Durban, South Africa KwaZulu-Natal Research Institute for Tuberculosis & HIV (K-RITH), Nelson Mandela School of Medicine, Durban, South Africa.

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http://dx.doi.org/10.1128/AAC.01195-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704238PMC
January 2016

Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction.

Authors:
Maxwell T Chirehwa Roxana Rustomjee Thuli Mthiyane Philip Onyebujoh Peter Smith Helen McIlleron Paolo Denti

Antimicrob Agents Chemother 2016 01 9;60(1):487-94. Epub 2015 Nov 9.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://dx.doi.org/10.1128/AAC.01830-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704145PMC
January 2016

Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations.

Authors:
Phumla Zuleika Sinxadi Helen Margaret McIlleron Joel Alex Dave Peter John Smith Naomi Sharlene Levitt David William Haas Gary Maartens

Medicine (Baltimore) 2016 Jan;95(2):e2385

From the Division of Clinical Pharmacology, Department of Medicine, University of Cape Town (PZS, HMM, PJS, GM); Division of Endocrinology and Diabetic Medicine, Department of Medicine, University of Cape Town. Cape Town, South Africa (JAD, NSL); Vanderbilt University School of Medicine, Departments of Medicine, Pharmacology, Pathology, Microbiology & Immunology (DWH); Meharry Medical College, Department of Internal Medicine, Nashville, TN, United States of America (DWH).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718242PMC
January 2016

Population Pharmacokinetics of Rifampin in Pregnant Women with Tuberculosis and HIV Coinfection in Soweto, South Africa.

Authors:
Paolo Denti Neil Martinson Silvia Cohn Fildah Mashabela Jennifer Hoffmann Reginah Msandiwa Sandra Castel Lubbe Wiesner Richard E Chaisson Helen McIlleron Kelly E Dooley

Antimicrob Agents Chemother 2015 Dec 7;60(3):1234-41. Epub 2015 Dec 7.

Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776013PMC
December 2015

Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis.

Authors:
Justin Shenje F Ifeoma Adimora-Nweke Ian L Ross Mpiko Ntsekhe Lubbe Wiesner Armin Deffur Helen M McIlleron Jotam Pasipanodya Tawanda Gumbo Bongani M Mayosi

EBioMedicine 2015 Nov 16;2(11):1640-9. Epub 2015 Sep 16.

Divisions of Cardiology, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa; Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa.

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http://dx.doi.org/10.1016/j.ebiom.2015.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740291PMC
November 2015

Pharmacokinetics and Safety of Ofloxacin in Children with Drug-Resistant Tuberculosis.

Authors:
Anthony J Garcia-Prats Heather R Draper Stephanie Thee Kelly E Dooley Helen M McIlleron James A Seddon Lubbe Wiesner Sandra Castel H Simon Schaaf Anneke C Hesseling

Antimicrob Agents Chemother 2015 Oct 20;59(10):6073-9. Epub 2015 Jul 20.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1128/AAC.01404-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576031PMC
October 2015

Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.

Authors:
Phumla Z Sinxadi Paul D Leger Helen M McIlleron Peter J Smith Joel A Dave Naomi S Levitt Gary Maartens David W Haas

Br J Clin Pharmacol 2015 Jul 28;80(1):146-56. Epub 2015 May 28.

Vanderbilt University School of Medicine, Department of Medicine, Nashville, Tennessee, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500334PMC
July 2015

Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.

Authors:
Anne F Luetkemeyer Susan L Rosenkranz Darlene Lu Beatriz Grinsztejn Jorge Sanchez Michael Ssemmanda Ian Sanne Helen McIlleron Diane V Havlir David W Haas

Clin Infect Dis 2015 Jun 26;60(12):1860-3. Epub 2015 Feb 26.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542662PMC
June 2015

Towards early inclusion of children in tuberculosis drugs trials: a consensus statement.

Authors:
Sharon Nachman Amina Ahmed Farhana Amanullah Mercedes C Becerra Radu Botgros Grania Brigden Renee Browning Elizabeth Gardiner Richard Hafner Anneke Hesseling Cleotilde How Patrick Jean-Philippe Erica Lessem Mamodikoe Makhene Nontombi Mbelle Ben Marais Helen McIlleron David F McNeeley Carl Mendel Stephen Murray Eileen Navarro E Gloria Anyalechi Ariel R Porcalla Clydette Powell Mair Powell Mona Rigaud Vanessa Rouzier Pearl Samson H Simon Schaaf Seema Shah Jeff Starke Soumya Swaminathan Eric Wobudeya Carol Worrell

Lancet Infect Dis 2015 Jun 6;15(6):711-20. Epub 2015 May 6.

Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471052PMC
June 2015

Special populations and pharmacogenetic issues in tuberculosis drug development and clinical research.

Authors:
Helen McIlleron Susan Abdel-Rahman Joel Alex Dave Marc Blockman Andrew Owen

J Infect Dis 2015 Jun;211 Suppl 3:S115-25

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1093/infdis/jiu600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551115PMC
June 2015

Plasma lopinavir concentrations predict virological failure in a cohort of South African children initiating a protease-inhibitor-based regimen.

Authors:
Retsilisitsoe R Moholisa Michael Schomaker Louise Kuhn Sandra Meredith Lubbe Wiesner Ashraf Coovadia Renate Strehlau Leigh Martens Elaine J Abrams Gary Maartens Helen McIlleron

Antivir Ther 2014 12;19(4):399-406. Epub 2014 Feb 12.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3851/IMP2749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229495PMC
May 2015

Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir.

Authors:
Harry Moultrie Helen McIlleron Shobna Sawry Tracy Kellermann Lubbe Wiesner Gurpreet Kindra Hermien Gous Annelies Van Rie

J Antimicrob Chemother 2015 Feb 3;70(2):543-9. Epub 2014 Oct 3.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/jac/dku382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291235PMC
February 2015

Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis.

Authors:
Stephanie Thee Anthony J Garcia-Prats Heather R Draper Helen M McIlleron Lubbe Wiesner Sandra Castel H Simon Schaaf Anneke C Hesseling

Clin Infect Dis 2015 Feb 30;60(4):549-56. Epub 2014 Oct 30.

Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

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http://dx.doi.org/10.1093/cid/ciu868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366580PMC
February 2015

Reply to "breakpoints and drug exposure are inevitably closely linked".

Authors:
Tawanda Gumbo Jotam G Pasipanodya Peter Wash André Burger Helen McIlleron

Antimicrob Agents Chemother 2015 Feb;59(2):1385

Division of Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa

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http://dx.doi.org/10.1128/AAC.04688-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335911PMC
February 2015

Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection.

Authors:
Kelly E Dooley Paolo Denti Neil Martinson Silvia Cohn Fildah Mashabela Jennifer Hoffmann David W Haas Jennifer Hull Regina Msandiwa Sandra Castel Lubbe Wiesner Richard E Chaisson Helen McIlleron

J Infect Dis 2015 Jan 31;211(2):197-205. Epub 2014 Jul 31.

Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1093/infdis/jiu429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334832PMC
January 2015

Impact of nonlinear interactions of pharmacokinetics and MICs on sputum bacillary kill rates as a marker of sterilizing effect in tuberculosis.

Authors:
Emmanuel Chigutsa Jotam G Pasipanodya Marianne E Visser Paul D van Helden Peter J Smith Frederick A Sirgel Tawanda Gumbo Helen McIlleron

Antimicrob Agents Chemother 2015 Jan 13;59(1):38-45. Epub 2014 Oct 13.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291375PMC
January 2015

Nevirapine concentrations in preterm and low birth weight HIV-exposed infants: implications for dosing recommendations.

Authors:
Reneé de Waal S Max Kroon Sandi L Holgate Alan R Horn Lloyd J Tooke Jennifer Norman Peter Smith Marc Blockman Mark F Cotton Helen M McIlleron Karen Cohen

Pediatr Infect Dis J 2014 Dec;33(12):1231-3

From the *Division of Clinical Pharmacology, Department of Medicine, and †Department of Paediatrics, University of Cape Town, Cape Town; and ‡Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa.

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December 2014

Randomized pharmacokinetic evaluation of different rifabutin doses in African HIV- infected tuberculosis patients on lopinavir/ritonavir-based antiretroviral therapy.

Authors:
Suhashni Naiker Cathy Connolly Lubbe Wiesner Tracey Kellerman Tarylee Reddy Anthony Harries Helen McIlleron Christian Lienhardt Alexander Pym

BMC Pharmacol Toxicol 2014 Nov 19;15:61. Epub 2014 Nov 19.

TB Research Unit, Medical Research Council, Durban, South Africa.

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http://dx.doi.org/10.1186/2050-6511-15-61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277828PMC
November 2014

Redefining multidrug-resistant tuberculosis based on clinical response to combination therapy.

Authors:
Tawanda Gumbo Jotam G Pasipanodya Peter Wash André Burger Helen McIlleron

Antimicrob Agents Chemother 2014 Oct 4;58(10):6111-5. Epub 2014 Aug 4.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa

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http://dx.doi.org/10.1128/AAC.03549-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187940PMC
October 2014

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.

Authors:
Amina Jindani Thomas S Harrison Andrew J Nunn Patrick P J Phillips Gavin J Churchyard Salome Charalambous Mark Hatherill Hennie Geldenhuys Helen M McIlleron Simbarashe P Zvada Stanley Mungofa Nasir A Shah Simukai Zizhou Lloyd Magweta James Shepherd Sambayawo Nyirenda Janneke H van Dijk Heather E Clouting David Coleman Anna L E Bateson Timothy D McHugh Philip D Butcher Denny A Mitchison

N Engl J Med 2014 Oct;371(17):1599-608

From St. George's, University of London (A.J., D.A.M., T.S.H., D.C., P.D.B.), Medical Research Council Clinical Trials Unit at University College London (A.J.N., P.P.J.P., H.E.C.), and University College London Centre for Clinical Biology, University College London (A.L.E.B., T.D.M.), London; Aurum Institute (G.J.C., S.C.) and School of Public Health, University of the Witwatersrand (G.J.C.), Johannesburg, and South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health (M.H., H.G.) and Division of Clinical Pharmacology, Department of Medicine (H.M.M., S.P.Z.), University of Cape Town, Cape Town - all in South Africa; Harare City Health Department, Harare (S.M., N.A.S.S.), and Medical Directorate of Mashonaland East, Marondera (S.Z., L.M.) - both in Zimbabwe; CDC, Gaborone, Botswana (J.S., S.N.); and Macha Research Trust, Macha, Zambia (J.H.D.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233406PMC
October 2014

Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients.

Authors:
Simbarashe P Zvada Paolo Denti Frederick A Sirgel Emmanuel Chigutsa Mark Hatherill Salome Charalambous Stanley Mungofa Lubbe Wiesner Ulrika S H Simonsson Amina Jindani Thomas Harrison Helen M McIlleron

Antimicrob Agents Chemother 2014 4;58(1):503-10. Epub 2013 Nov 4.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910772PMC
September 2014

The pyrazinamide susceptibility breakpoint above which combination therapy fails.

Authors:
Tawanda Gumbo Emmanuel Chigutsa Jotam Pasipanodya Marianne Visser Paul D van Helden Frederick A Sirgel Helen McIlleron

J Antimicrob Chemother 2014 Sep 12;69(9):2420-5. Epub 2014 May 12.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town, South Africa

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http://dx.doi.org/10.1093/jac/dku136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130380PMC
September 2014

Evaluation of an immunoassay for determination of plasma efavirenz concentrations in resource-limited settings.

Authors:
Alemseged Abdissa Lubbe Wiesner Helen McIlleron Henrik Friis Ase Bengård Andersen Pernille Kaestel

J Int AIDS Soc 2014 5;17:18979. Epub 2014 Jun 5.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.7448/IAS.17.1.18979DOI Listing
September 2014

Nutritional supplementation increases rifampin exposure among tuberculosis patients coinfected with HIV.

Authors:
Kidola Jeremiah Paolo Denti Emmanuel Chigutsa Daniel Faurholt-Jepsen George PrayGod Nyagosya Range Sandra Castel Lubbe Wiesner Christian Munch Hagen Michael Christiansen John Changalucha Helen McIlleron Henrik Friis Aase Bengaard Andersen

Antimicrob Agents Chemother 2014 Jun 7;58(6):3468-74. Epub 2014 Apr 7.

Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068463PMC
June 2014

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138491PMC
June 2014

Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses.

Authors:
Simbarashe P Zvada Paolo Denti Peter R Donald H Simon Schaaf Stephanie Thee James A Seddon Heiner I Seifart Peter J Smith Helen M McIlleron Ulrika S H Simonsson

J Antimicrob Chemother 2014 May 31;69(5):1339-49. Epub 2014 Jan 31.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1093/jac/dkt524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977610PMC
May 2014

Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment.

Authors:
Stephanie Shiau Louise Kuhn Renate Strehlau Leigh Martens Helen McIlleron Sandra Meredith Lubbe Wiesner Ashraf Coovadia Elaine J Abrams Stephen M Arpadi

BMC Pediatr 2014 Feb 12;14:39. Epub 2014 Feb 12.

Gertrude H, Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA.

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http://dx.doi.org/10.1186/1471-2431-14-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927631PMC
February 2014

Principles for designing future regimens for multidrug-resistant tuberculosis.

Authors:
Grania Brigden Bern-Thomas Nyang'wa Philipp du Cros Francis Varaine Jennifer Hughes Michael Rich C Robert Horsburgh Carole D Mitnick Eric Nuermberger Helen McIlleron Patrick P J Phillips Manica Balasegaram

Bull World Health Organ 2014 Jan 25;92(1):68-74. Epub 2013 Oct 25.

Access Campaign, Médecins Sans Frontières, 78 Rue de Lausanne, PO Box 116, Geneva, CH1211, Switzerland .

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http://dx.doi.org/10.2471/BLT.13.122028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865549PMC
January 2014

Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review.

Authors:
Stephen D Lawn Graeme Meintjes Helen McIlleron Anthony D Harries Robin Wood

BMC Med 2013 Dec 2;11:253. Epub 2013 Dec 2.

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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http://dx.doi.org/10.1186/1741-7015-11-253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220801PMC
December 2013

Model-based evaluation of the pharmacokinetic differences between adults and children for lopinavir and ritonavir in combination with rifampicin.

Authors:
Chao Zhang Paolo Denti Eric H Decloedt Yuan Ren Mats O Karlsson Helen McIlleron

Br J Clin Pharmacol 2013 Nov;76(5):741-51

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/bcp.12101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853533PMC
November 2013

Serum drug concentrations predictive of pulmonary tuberculosis outcomes.

Authors:
Jotam G Pasipanodya Helen McIlleron André Burger Peter A Wash Peter Smith Tawanda Gumbo

J Infect Dis 2013 Nov 29;208(9):1464-73. Epub 2013 Jul 29.

Office of Global Health, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1093/infdis/jit352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789573PMC
November 2013

Evaluation of initial and steady-state gatifloxacin pharmacokinetics and dose in pulmonary tuberculosis patients by using monte carlo simulations.

Authors:
Wynand Smythe Corinne S Merle Roxana Rustomjee Martin Gninafon Mame Bocar Lo Oumou Bah-Sow Piero L Olliaro Christian Lienhardt John Horton Peter Smith Helen McIlleron Ulrika S H Simonsson

Antimicrob Agents Chemother 2013 Sep 17;57(9):4164-71. Epub 2013 Jun 17.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.00479-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754315PMC
September 2013

Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype.

Authors:
Helen M McIlleron Michael Schomaker Yuan Ren Phumla Sinxadi James J C Nuttall Hermien Gous Harry Moultrie Brian Eley Concepta Merry Peter Smith David W Haas Gary Maartens

AIDS 2013 Jul;27(12):1933-40

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http://dx.doi.org/10.1097/qad.0b013e328360dbb4DOI Listing
July 2013

Population pharmacokinetics of lopinavir and ritonavir in combination with rifampicin-based antitubercular treatment in HIV-infected children.

Authors:
Chao Zhang Helen McIlleron Yuan Ren Jan-Stefan van der Walt Mats O Karlsson Ulrika S H Simonsson Paolo Denti

Antivir Ther 2012 ;17(1):25-33

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.3851/IMP1915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743021PMC
February 2013

A time-to-event pharmacodynamic model describing treatment response in patients with pulmonary tuberculosis using days to positivity in automated liquid mycobacterial culture.

Authors:
Emmanuel Chigutsa Kashyap Patel Paolo Denti Marianne Visser Gary Maartens Carl M J Kirkpatrick Helen McIlleron Mats O Karlsson

Antimicrob Agents Chemother 2013 Feb 26;57(2):789-95. Epub 2012 Nov 26.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.01876-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553722PMC
February 2013

Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study.

Authors:
Phumla Z Sinxadi Helen M McIlleron Joel A Dave Peter J Smith Naomi S Levitt Gary Maartens

AIDS Res Ther 2012 Oct 26;9(1):32. Epub 2012 Oct 26.

Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1186/1742-6405-9-32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533776PMC
October 2012

The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy.

Authors:
Eric H Decloedt Gary Maartens Peter Smith Concepta Merry Funeka Bango Helen McIlleron

PLoS One 2012 7;7(3):e32173. Epub 2012 Mar 7.

Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296695PMC
August 2012

Moxifloxacin population pharmacokinetics in patients with pulmonary tuberculosis and the effect of intermittent high-dose rifapentine.

Authors:
Simbarashe P Zvada Paolo Denti Hennie Geldenhuys Sandra Meredith Danelle van As Mark Hatherill Willem Hanekom Lubbe Wiesner Ulrika S H Simonsson Amina Jindani Thomas Harrison Helen M McIlleron

Antimicrob Agents Chemother 2012 Aug 14;56(8):4471-3. Epub 2012 May 14.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.00404-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421597PMC
August 2012

Population pharmacokinetic model for adherence evaluation using lamivudine concentration monitoring.

Authors:
Chao Zhang Paolo Denti Jan-Stefan van der Walt Yuan Ren Peter Smith Mats O Karlsson Helen McIlleron

Ther Drug Monit 2012 Aug;34(4):481-4

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/FTD.0b013e31825c6067DOI Listing
August 2012

Pharmacokinetics of nevirapine in HIV-infected children under 3 years on rifampicin-based antituberculosis treatment.

Authors:
J Mirjam Oudijk Helen McIlleron Veronica Mulenga Chifumbe Chintu Concepta Merry A Sarah Walker Adrian Cook Diana M Gibb David M Burger

AIDS 2012 Jul;26(12):1523-8

Department of Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1097/QAD.0b013e3283550e20DOI Listing
July 2012

Population pharmacokinetics and pharmacodynamics of ofloxacin in South African patients with multidrug-resistant tuberculosis.

Authors:
Emmanuel Chigutsa Sandra Meredith Lubbe Wiesner Nesri Padayatchi Joe Harding Prashini Moodley William R Mac Kenzie Marc Weiner Helen McIlleron Carl M J Kirkpatrick

Antimicrob Agents Chemother 2012 Jul 7;56(7):3857-63. Epub 2012 May 7.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.00048-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393408PMC
July 2012

Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines.

Authors:
Helen McIlleron Roxana Rustomjee Mahnaz Vahedi Thuli Mthiyane Paolo Denti Catherine Connolly Wasima Rida Alexander Pym Peter J Smith Philip C Onyebujoh

Antimicrob Agents Chemother 2012 Jun 12;56(6):3232-8. Epub 2012 Mar 12.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.05526-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370773PMC
June 2012

Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin.

Authors:
Chao Zhang Paolo Denti Eric Decloedt Gary Maartens Mats O Karlsson Ulrika S H Simonsson Helen McIlleron

Br J Clin Pharmacol 2012 May;73(5):758-67

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1111/j.1365-2125.2011.04154.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403203PMC
May 2012

A semimechanistic pharmacokinetic-enzyme turnover model for rifampin autoinduction in adult tuberculosis patients.

Authors:
Wynand Smythe Akash Khandelwal Corinne Merle Roxana Rustomjee Martin Gninafon Mame Bocar Lo Oumou Bah Sow Piero L Olliaro Christian Lienhardt John Horton Peter Smith Helen McIlleron Ulrika S H Simonsson

Antimicrob Agents Chemother 2012 Apr 17;56(4):2091-8. Epub 2012 Jan 17.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05792-11
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http://dx.doi.org/10.1128/AAC.05792-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318330PMC
April 2012

Paediatric use of second-line anti-tuberculosis agents: a review.

Authors:
James A Seddon Anneke C Hesseling Ben J Marais Helen McIlleron Charles A Peloquin Peter R Donald H Simon Schaaf

Tuberculosis (Edinb) 2012 Jan 25;92(1):9-17. Epub 2011 Nov 25.

Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa.

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http://dx.doi.org/10.1016/j.tube.2011.11.001DOI Listing
January 2012

Lopinavir exposure is insufficient in children given double doses of lopinavir/ritonavir during rifampicin-based treatment for tuberculosis.

Authors:
Helen McIlleron Yuan Ren James Nuttall Lee Fairlie Helena Rabie Mark Cotton Brian Eley Tammy Meyers Peter J Smith Concepta Merry Gary Maartens

Antivir Ther 2011 ;16(3):417-21

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa.

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September 2011

Population pharmacokinetics of ethambutol in South African tuberculosis patients.

Authors:
Siv Jönsson Alistair Davidse Justin Wilkins Jan-Stefan Van der Walt Ulrika S H Simonsson Mats O Karlsson Peter Smith Helen McIlleron

Antimicrob Agents Chemother 2011 Sep 20;55(9):4230-7. Epub 2011 Jun 20.

Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1128/AAC.00274-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165318PMC
September 2011

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

Authors:
Emmanuel Chigutsa Marianne E Visser Elizabeth C Swart Paolo Denti Sudeep Pushpakom Deirdre Egan Nicholas H G Holford Peter J Smith Gary Maartens Andrew Owen Helen McIlleron

Antimicrob Agents Chemother 2011 Sep 27;55(9):4122-7. Epub 2011 Jun 27.

Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, K-45 Old Main Building, Groote Schuur Hospital, Observatory, 7925 Cape Town, South Africa.

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http://dx.doi.org/10.1128/AAC.01833-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165308PMC
September 2011

Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients.

Authors:
Justin J Wilkins Grant Langdon Helen McIlleron Goonaseelan Pillai Peter J Smith Ulrika S H Simonsson

Br J Clin Pharmacol 2011 Jul;72(1):51-62

Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

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http://doi.wiley.com/10.1111/j.1365-2125.2011.03940.x
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http://dx.doi.org/10.1111/j.1365-2125.2011.03940.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141186PMC
July 2011

Pharmacokinetics of lopinavir in HIV-infected adults receiving rifampin with adjusted doses of lopinavir-ritonavir tablets.

Authors:
Eric H Decloedt Helen McIlleron Peter Smith Concepta Merry Catherine Orrell Gary Maartens

Antimicrob Agents Chemother 2011 Jul 2;55(7):3195-200. Epub 2011 May 2.

Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

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http://aac.asm.org/lookup/doi/10.1128/AAC.01598-10
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http://dx.doi.org/10.1128/AAC.01598-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122443PMC
July 2011

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting.

Authors:
Gert Uves van Zyl Thijs E van Mens Helen McIlleron Michele Zeier Jean B Nachega Eric Decloedt Carolina Malavazzi Peter Smith Yong Huang Lize van der Merwe Monica Gandhi Gary Maartens

J Acquir Immune Defic Syndr 2011 Apr;56(4):333-9

Division of Medical Virology, Department of Pathology, NHLS Tygerberg and Stellenbosch University, Tygerberg, South Africa.

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https://insights.ovid.com/crossref?an=00126334-201104010-000
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http://dx.doi.org/10.1097/QAI.0b013e31820dc0ccDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073814PMC
April 2011

Pyrazinamide plasma concentrations in young children with tuberculosis.

Authors:
Helen McIlleron Marianne Willemse Hendrik Simon Schaaf Peter John Smith Peter Roderick Donald

Pediatr Infect Dis J 2011 Mar;30(3):262-5

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1097/inf.0b013e3181fbefe1DOI Listing
March 2011