Publications by authors named "Helen McIlleron"

100Publications

Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review.

J Antimicrob Chemother 2020 Dec;75(12):3433-3457

Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands.

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December 2020

Rifapentine Population Pharmacokinetics and Dosing Recommendations for Latent Tuberculosis Infection.

Am J Respir Crit Care Med 2020 09;202(6):866-877

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California.

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September 2020

Abacavir Exposure in Children Cotreated for Tuberculosis with Rifampin and Superboosted Lopinavir-Ritonavir.

Antimicrob Agents Chemother 2020 04 21;64(5). Epub 2020 Apr 21.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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April 2020

Pharmacokinetic profile and safety of adjusted doses of darunavir/ritonavir with rifampicin in people living with HIV.

J Antimicrob Chemother 2020 Apr;75(4):1019-1025

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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April 2020

Early antituberculosis drug exposure in hospitalized patients with human immunodeficiency virus-associated tuberculosis.

Br J Clin Pharmacol 2020 05 17;86(5):966-978. Epub 2020 Feb 17.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa.

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May 2020

Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis.

Antimicrob Agents Chemother 2020 02 21;64(3). Epub 2020 Feb 21.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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February 2020

Quantitative assessment of the activity of antituberculosis drugs and regimens.

Expert Rev Anti Infect Ther 2019 06 30;17(6):449-457. Epub 2019 May 30.

a Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Rondebosch , South Africa.

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June 2019

Pharmacokinetics of adjusted-dose 8-hourly lopinavir/ritonavir in HIV-infected children co-treated with rifampicin.

J Antimicrob Chemother 2019 08;74(8):2347-2351

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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August 2019

Current research toward optimizing dosing of first-line antituberculosis treatment.

Expert Rev Anti Infect Ther 2019 01 12;17(1):27-38. Epub 2018 Dec 12.

a Division of Clinical Pharmacology, Department of Medicine , University of Cape Town , Cape Town , South Africa.

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January 2019

Artificial intelligence-derived 3-Way Concentration-dependent Antagonism of Gatifloxacin, Pyrazinamide, and Rifampicin During Treatment of Pulmonary Tuberculosis.

Clin Infect Dis 2018 11;67(suppl_3):S284-S292

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

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November 2018

Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol.

BMC Infect Dis 2018 Sep 29;18(1):488. Epub 2018 Sep 29.

Section of Infectious Diseases, Boston University School of Medicine, 801 Massachusetts Avenue, 2nd floor, Crosstown Center, Boston, MA, 02118, USA.

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September 2018

Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid.

J Antimicrob Chemother 2019 01;74(1):139-148

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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January 2019

Effect of Coadministration of Lidocaine on the Pain and Pharmacokinetics of Intramuscular Amikacin in Children With Multidrug-Resistant Tuberculosis: A Randomized Crossover Trial.

Pediatr Infect Dis J 2018 12;37(12):1199-1203

From the Department of Paediatrics and Child Health, Desmond Tutu TB Centre, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

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December 2018

Effect of genetic variation in UGT1A and ABCB1 on moxifloxacin pharmacokinetics in South African patients with tuberculosis.

Pharmacogenomics 2018 Jan 6;19(1):17-29. Epub 2017 Dec 6.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.

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January 2018

Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis.

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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February 2018

A Review of Moxifloxacin for the Treatment of Drug-Susceptible Tuberculosis.

J Clin Pharmacol 2017 Nov 24;57(11):1369-1386. Epub 2017 Jul 24.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

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November 2017

Pharmacokinetics of Pyrazinamide and Optimal Dosing Regimens for Drug-Sensitive and -Resistant Tuberculosis.

Antimicrob Agents Chemother 2017 08 25;61(8). Epub 2017 Jul 25.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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August 2017

Determinants of virological outcome and adverse events in African children treated with paediatric nevirapine fixed-dose-combination tablets.

AIDS 2017 04;31(7):905-915

aDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa bMRC Clinical Trials Unit at University College London, London, United Kingdom cDepartment of Paediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia dJoint Clinical Research Centre eBaylor College of Medicine Bristol Myers Squibb Children's Clinical Centre of Excellence, Kampala, Uganda fGulu Regional Centre of Excellence, Gulu, Uganda gDepartment of Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands. *Ann S. Walker and Helen McIlleron contributed equally to the article.

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April 2017

Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children.

J Antimicrob Chemother 2017 01 5;72(1):190-199. Epub 2016 Oct 5.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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January 2017

Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children.

Pediatr Infect Dis J 2016 12;35(12):e378-e383

From the *Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; †Centre for Infectious Diseases Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; ‡Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; §Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; ¶ICAP, Mailman School of Public Health, and College of Physicians & Surgeons, Columbia University, New York, NY; and ‖Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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December 2016

HIV-1 Coinfection Does Not Reduce Exposure to Rifampin, Isoniazid, and Pyrazinamide in South African Tuberculosis Outpatients.

Antimicrob Agents Chemother 2016 10 23;60(10):6050-9. Epub 2016 Sep 23.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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October 2016

Plasma Efavirenz Exposure, Sex, and Age Predict Virological Response in HIV-Infected African Children.

J Acquir Immune Defic Syndr 2016 10;73(2):161-8

*Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; †MRC Clinical Trials Unit, University College London, London, United Kingdom; ‡Department of Paediatrics and Child Health, University Teaching Hospital, Lusaka, Zambia; §Joint Clinical Research Centre, Kampala, Uganda; ‖Baylor College of Medicine Bristol Myers Squibb Children's Clinical Centre of Excellence, Kampala, Uganda/Gulu Regional Centre of Excellence, Gulu, Uganda; and ¶Department of Pharmacy, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

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October 2016

The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children.

Br J Clin Pharmacol 2016 07 25;82(1):185-98. Epub 2016 Apr 25.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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July 2016

Poor Penetration of Antibiotics Into Pericardium in Pericardial Tuberculosis.

EBioMedicine 2015 Nov 16;2(11):1640-9. Epub 2015 Sep 16.

Divisions of Cardiology, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa; Department of Medicine, Groote Schuur Hospital, University of Cape Town, Observatory, South Africa.

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November 2015

Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations.

Medicine (Baltimore) 2016 Jan;95(2):e2385

From the Division of Clinical Pharmacology, Department of Medicine, University of Cape Town (PZS, HMM, PJS, GM); Division of Endocrinology and Diabetic Medicine, Department of Medicine, University of Cape Town. Cape Town, South Africa (JAD, NSL); Vanderbilt University School of Medicine, Departments of Medicine, Pharmacology, Pathology, Microbiology & Immunology (DWH); Meharry Medical College, Department of Internal Medicine, Nashville, TN, United States of America (DWH).

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January 2016

Drug-drug interactions between bedaquiline and the antiretrovirals lopinavir/ritonavir and nevirapine in HIV-infected patients with drug-resistant TB.

J Antimicrob Chemother 2016 Apr 7;71(4):1037-40. Epub 2016 Jan 7.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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April 2016

Model-Based Evaluation of Higher Doses of Rifampin Using a Semimechanistic Model Incorporating Autoinduction and Saturation of Hepatic Extraction.

Antimicrob Agents Chemother 2016 01 9;60(1):487-94. Epub 2015 Nov 9.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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January 2016

Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis.

Antimicrob Agents Chemother 2016 01 19;60(1):617-20. Epub 2015 Oct 19.

TB Research Unit, Medical Research Council, Durban, South Africa KwaZulu-Natal Research Institute for Tuberculosis & HIV (K-RITH), Nelson Mandela School of Medicine, Durban, South Africa.

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January 2016

Treatment Failure, Drug Resistance, and CD4 T-Cell Count Decline Among Postpartum Women on Antiretroviral Therapy in South Africa.

J Acquir Immune Defic Syndr 2016 Jan;71(1):31-7

*Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;†Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Soweto, South Africa;‡Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa; and§Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.

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January 2016

Pharmacokinetics and Safety of Ofloxacin in Children with Drug-Resistant Tuberculosis.

Antimicrob Agents Chemother 2015 Oct 20;59(10):6073-9. Epub 2015 Jul 20.

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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October 2015

Special populations and pharmacogenetic issues in tuberculosis drug development and clinical research.

J Infect Dis 2015 Jun;211 Suppl 3:S115-25

Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, United Kingdom.

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June 2015

Reply to "breakpoints and drug exposure are inevitably closely linked".

Antimicrob Agents Chemother 2015 Feb;59(2):1385

Division of Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa

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February 2015

Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.

Br J Clin Pharmacol 2015 Jul 28;80(1):146-56. Epub 2015 May 28.

Vanderbilt University School of Medicine, Department of Medicine, Nashville, Tennessee, United States of America.

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July 2015

Pharmacokinetics and safety of moxifloxacin in children with multidrug-resistant tuberculosis.

Clin Infect Dis 2015 Feb 30;60(4):549-56. Epub 2014 Oct 30.

Desmond Tutu Tuberculosis Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

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February 2015

High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.

N Engl J Med 2014 Oct;371(17):1599-608

From St. George's, University of London (A.J., D.A.M., T.S.H., D.C., P.D.B.), Medical Research Council Clinical Trials Unit at University College London (A.J.N., P.P.J.P., H.E.C.), and University College London Centre for Clinical Biology, University College London (A.L.E.B., T.D.M.), London; Aurum Institute (G.J.C., S.C.) and School of Public Health, University of the Witwatersrand (G.J.C.), Johannesburg, and South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health (M.H., H.G.) and Division of Clinical Pharmacology, Department of Medicine (H.M.M., S.P.Z.), University of Cape Town, Cape Town - all in South Africa; Harare City Health Department, Harare (S.M., N.A.S.S.), and Medical Directorate of Mashonaland East, Marondera (S.Z., L.M.) - both in Zimbabwe; CDC, Gaborone, Botswana (J.S., S.N.); and Macha Research Trust, Macha, Zambia (J.H.D.).

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October 2014

Impact of nonlinear interactions of pharmacokinetics and MICs on sputum bacillary kill rates as a marker of sterilizing effect in tuberculosis.

Antimicrob Agents Chemother 2015 Jan 13;59(1):38-45. Epub 2014 Oct 13.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

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January 2015

Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir.

J Antimicrob Chemother 2015 Feb 3;70(2):543-9. Epub 2014 Oct 3.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

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February 2015

Redefining multidrug-resistant tuberculosis based on clinical response to combination therapy.

Antimicrob Agents Chemother 2014 Oct 4;58(10):6111-5. Epub 2014 Aug 4.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa

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October 2014

Research capacity. Enabling the genomic revolution in Africa.

Authors:
Charles Rotimi Akin Abayomi Alash'le Abimiku Victoria May Adabayeri Clement Adebamowo Ezekiel Adebiyi Adebowale D Ademola Adebowale Adeyemo Dwomoa Adu Dissou Affolabi Godfred Agongo Samuel Ajayi Sally Akarolo-Anthony Rufus Akinyemi Albert Akpalu Marianne Alberts Orlando Alonso Betancourt Ahmed Mansour Alzohairy Gobena Ameni Olukemi Amodu Gabriel Anabwani Kristian Andersen Fatiu Arogundade Oyedunni Arulogun Danny Asogun Rasheed Bakare Naby Balde Mary Lynn Baniecki Christine Beiswanger Alia Benkahla Lara Bethke Micheal Boehnke Vincent Boima James Brandful Andrew I Brooks Frank C Brosius Chester Brown Bruno Bucheton David T Burke Barrington G Burnett Stacy Carrington-Lawrence Nadia Carstens John Chisi Alan Christoffels Richard Cooper Heather Cordell Nigel Crowther Talishiea Croxton Jantina de Vries Leslie Derr Peter Donkor Seydou Doumbia Audrey Duncanson Ivy Ekem Ahmed El Sayed Mark E Engel John C K Enyaru Dean Everett Faisal M Fadlelmola Eyitayo Fakunle Kenneth H Fischbeck Anne Fischer Onikepe Folarin Junaid Gamieldien Robert F Garry Simani Gaseitsiwe Rasheed Gbadegesin Anita Ghansah Maria Giovanni Parham Goesbeck F Xavier Gomez-Olive Donald S Grant Ravnit Grewal Mark Guyer Neil A Hanchard Christian T Happi Scott Hazelhurst Branwen J Hennig Christiane Hertz- Fowler Winston Hide Friedhelm Hilderbrandt Christopher Hugo-Hamman Muntaser E Ibrahim Regina James Yasmina Jaufeerally-Fakim Carolyn Jenkins Ute Jentsch Pan-Pan Jiang Moses Joloba Victor Jongeneel Fourie Joubert Mukthar Kader Kathleen Kahn Pontiano Kaleebu Saidi H Kapiga Samar Kamal Kassim Ishmael Kasvosve Jonathan Kayondo Bernard Keavney Adeodata Kekitiinwa Sheik Humarr Khan Paul Kimmel Mary-Claire King Robert Kleta Mathurin Koffi Jeffrey Kopp Matthias Kretzler Judit Kumuthini Samuel Kyobe Catherine Kyobutungi Daniel T Lackland Karen A Lacourciere Guida Landouré Rita Lawlor Thomas Lehner Maia Lesosky Naomi Levitt Katherine Littler Zane Lombard Jeanne F Loring Sylvester Lyantagaye Annette Macleod Ebony B Madden Chengetai R Mahomva Julie Makani Manmak Mamven Marape Marape Graeme Mardon Patricia Marshall Darren P Martin Daniel Masiga Robin Mason Michael Mate-Kole Enock Matovu Mary Mayige Bongani M Mayosi Jean Claude Mbanya Sheryl A McCurdy Mark I McCarthy Helen McIlleron S O Mc'Ligeyo Corrine Merle Ana Olga Mocumbi Charles Mondo John V Moran Ayesha Motala Marva Moxey-Mims Wata Sununguko Mpoloka Chisomo L Msefula Thuli Mthiyane Nicola Mulder Gebregziab her Mulugeta Dieuodonne Mumba John Musuku Mo Nagdee Oyekanmi Nash Daouda Ndiaye Anh Quynh Nguyen Mark Nicol Oathokwa Nkomazana Shane Norris Betty Nsangi Alexander Nyarko Moffat Nyirenda Eileen Obe Reginald Obiakor Abraham Oduro Solomon F Ofori-Acquah Okechukwu Ogah Stephen Ogendo Kwaku Ohene-Frempong Akinlolu Ojo Timothy Olanrewaju John Oli Charlotte Osafo Odile Ouwe Missi Oukem-Boyer Bruce Ovbiagele Andrew Owen Mayowa Ojo Owolabi Lukman Owolabi Ellis Owusu-Dabo Guillaume Pare Rulan Parekh Hugh G Patterton Margaret B Penno Jane Peterson Rembert Pieper Jacob Plange-Rhule Martin Pollak Julia Puzak Rajkumar S Ramesar Michele Ramsay Rebekah Rasooly Shiksha Reddy Pardis C Sabeti Kwamena Sagoe Tunde Salako Oumar Samassékou Manjinder S Sandhu Osman Sankoh Fred Stephen Sarfo Marie Sarr Gasnat Shaboodien Issa Sidibe Gustave Simo Martin Simuunza Liam Smeeth Eugene Sobngwi Himla Soodyall Hermann Sorgho Oumou Sow Bah Sudha Srinivasan Dan J Stein Ezra S Susser Carmen Swanepoel Godfred Tangwa Andrew Tareila Ozlem Tastan Bishop Bamidele Tayo Nicki Tiffin Halidou Tinto Ekaete Tobin Stephen Meir Tollman Mahamadou Traoré Marsha J Treadwell Jennifer Troyer Masego Tsimako-Johnstone Vincent Tukei Ifeoma Ulasi Nzovu Ulenga Beverley van Rooyen Ablo Prudence Wachinou Salina P Waddy Alisha Wade Misaki Wayengera James Whitworth Louise Wideroff Cheryl A Winkler Sarah Winnicki Ambroise Wonkam Mengistu Yewondwos Tadase sen Nathan Yozwiak Heather Zar

Science 2014 Jun;344(6190):1346-8

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June 2014

Nevirapine concentrations in preterm and low birth weight HIV-exposed infants: implications for dosing recommendations.

Pediatr Infect Dis J 2014 Dec;33(12):1231-3

From the *Division of Clinical Pharmacology, Department of Medicine, and †Department of Paediatrics, University of Cape Town, Cape Town; and ‡Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa.

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December 2014

Evaluation of an immunoassay for determination of plasma efavirenz concentrations in resource-limited settings.

J Int AIDS Soc 2014 5;17:18979. Epub 2014 Jun 5.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.

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September 2014

The pyrazinamide susceptibility breakpoint above which combination therapy fails.

J Antimicrob Chemother 2014 Sep 12;69(9):2420-5. Epub 2014 May 12.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, Cape Town, South Africa

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September 2014

Principles for designing future regimens for multidrug-resistant tuberculosis.

Bull World Health Organ 2014 Jan 25;92(1):68-74. Epub 2013 Oct 25.

Access Campaign, Médecins Sans Frontières, 78 Rue de Lausanne, PO Box 116, Geneva, CH1211, Switzerland .

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January 2014

Management of HIV-associated tuberculosis in resource-limited settings: a state-of-the-art review.

BMC Med 2013 Dec 2;11:253. Epub 2013 Dec 2.

Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.

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December 2013

Serum drug concentrations predictive of pulmonary tuberculosis outcomes.

J Infect Dis 2013 Nov 29;208(9):1464-73. Epub 2013 Jul 29.

Office of Global Health, University of Texas Southwestern Medical Center, Dallas, Texas.

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November 2013

Model-based evaluation of the pharmacokinetic differences between adults and children for lopinavir and ritonavir in combination with rifampicin.

Br J Clin Pharmacol 2013 Nov;76(5):741-51

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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November 2013

Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study.

AIDS Res Ther 2012 Oct 26;9(1):32. Epub 2012 Oct 26.

Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa.

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October 2012

Population pharmacokinetic model for adherence evaluation using lamivudine concentration monitoring.

Ther Drug Monit 2012 Aug;34(4):481-4

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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August 2012

Population pharmacokinetics and pharmacodynamics of ofloxacin in South African patients with multidrug-resistant tuberculosis.

Antimicrob Agents Chemother 2012 Jul 7;56(7):3857-63. Epub 2012 May 7.

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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July 2012

The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy.

PLoS One 2012 7;7(3):e32173. Epub 2012 Mar 7.

Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

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August 2012

Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin.

Br J Clin Pharmacol 2012 May;73(5):758-67

Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.

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May 2012

Paediatric use of second-line anti-tuberculosis agents: a review.

Tuberculosis (Edinb) 2012 Jan 25;92(1):9-17. Epub 2011 Nov 25.

Desmond Tutu TB Centre, Faculty of Health Sciences, Stellenbosch University, South Africa.

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January 2012

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

Antimicrob Agents Chemother 2011 Sep 27;55(9):4122-7. Epub 2011 Jun 27.

Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, K-45 Old Main Building, Groote Schuur Hospital, Observatory, 7925 Cape Town, South Africa.

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September 2011