Helen Mackay

Helen Mackay

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Helen Mackay

Helen Mackay

Publications by authors named "Helen Mackay"

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HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors.

Int J Gynecol Pathol 2019 Jul 3. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan (G.A.) Departments of Radiation Oncology (M.L.Y., J.C., M.M.) Obstetrics and Gynecology, Division of Gynecologic Oncology (S.F.) Medical Oncology (H.M.) Laboratory Medicine and Pathobiology (S.K.R., I.W., D.G., B.A.C.) Biostatistics (M.P.), Princess Margaret Cancer Centre/University Health Network, and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/PGP.0000000000000620DOI Listing
July 2019

Incidence of Brain Metastases in Nonmetastatic and Metastatic Breast Cancer: Is There a Role for Screening?

Clin Breast Cancer 2019 Jul 11. Epub 2019 Jul 11.

Division of Medical Oncology and Hematology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2019.06.007DOI Listing
July 2019

Endocrine therapy in endometrial cancer: An old dog with new tricks.

Gynecol Oncol 2019 04 5;153(1):175-183. Epub 2019 Jan 5.

Division of Medical Oncology and Hematology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.12.018DOI Listing
April 2019

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.

Cell Death Differ 2018 12 23;25(12):2195-2208. Epub 2018 May 23.

Sunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1038/s41418-018-0115-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261950PMC
December 2018

Prevention of carboplatin-induced hypersensitivity reactions in women with ovarian cancer.

J Oncol Pharm Pract 2018 Mar 17;24(2):83-90. Epub 2016 Nov 17.

1 Division of Medical Oncology and Hematology, Faculty of Medicine, University of Toronto, Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1078155216679028DOI Listing
March 2018

Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.

Clin Colorectal Cancer 2018 03 23;17(1):73-79. Epub 2017 Oct 23.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.010DOI Listing
March 2018

Is hormonal therapy effective in advanced endometrial cancer? A systematic review and meta-analysis.

Gynecol Oncol 2017 10 6;147(1):158-166. Epub 2017 Jul 6.

Division of Medical Oncology and Hematology, Sunnybrook Health Sciences Centre, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2017.07.002DOI Listing
October 2017

Validation of microRNA pathway polymorphisms in esophageal adenocarcinoma survival.

Cancer Med 2017 02 11;6(2):361-373. Epub 2017 Jan 11.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cam4.989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313634PMC
February 2017

HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology.

J Clin Oncol 2017 Feb 14;35(4):446-464. Epub 2016 Nov 14.

Angela N. Bartley, St Joseph Mercy Hospital, Ann Arbor, MI; Mary Kay Washington, Vanderbilt University Medical Center, Nashville, TN; Carol Colasacco and Christina B. Ventura, College of American Pathologists, Northfield; Al B. Benson III, Northwestern University, Chicago, IL; Nofisat Ismaila, American Society of Clinical Oncology, Alexandria, VA; Alfredo Carrato, Ramón y Cajal University Hospital, Madrid, Spain; Margaret L. Gulley, University of North Carolina, Chapel Hill, NC; Dhanpat Jain, Yale University School of Medicine, New Haven, CT; Sanjay Kakar, University of California, San Francisco, CA; Helen J. Mackay, Princess Margaret Cancer Centre; Catherine Streutker, St Michael's Hospital, University of Toronto, Toronto, Canada; Laura Tang, Memorial Sloan Kettering Cancer Center, New York, NY; Megan Troxell, Stanford University Medical Center, Stanford, CA; and Jaffer A. Ajani, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.69.4836DOI Listing
February 2017

Update on Intraperitoneal Chemotherapy for the Treatment of Epithelial Ovarian Cancer.

Am Soc Clin Oncol Educ Book 2016 ;35:143-51

From the Edinburgh Cancer Research Centre, Medical Research Council, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, Oklahoma City, OK; Faculty of Medicine, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1200/EDBK_158927DOI Listing
January 2017

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts.

Br J Cancer 2017 01 22;116(1):50-57. Epub 2016 Nov 22.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario MG5 2M9, Canada.

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http://dx.doi.org/10.1038/bjc.2016.383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220149PMC
January 2017

HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology.

Arch Pathol Lab Med 2016 Dec 14;140(12):1345-1363. Epub 2016 Nov 14.

From the Department of Pathology, St. Joseph Mercy Hospital, Ann Arbor, Michigan (Dr Bartley); the Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Washington); Surveys (Ms Ventura) and Governance (Ms Colasacco), College of American Pathologists, Northfield, Illinois; Quality and Guidelines Department, American Society of Clinical Oncology, Alexandria, Virginia (Dr Ismaila); the Division of Hematology/Oncology, Northwestern University, Chicago, Illinois (Dr Benson); Medical Oncology Department, Ramon y Cajal University Hospital, Madrid, Spain (Dr Carrato); the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill (Dr Gulley); the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Jain); the Department of Pathology and Laboratory Medicine, UCSF, San Francisco, California (Dr Kakar); the Division of Medical Oncology and Hematology, University of Toronto/Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada (Dr Mackay); the Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada (Dr Streutker); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Tang); the Department of Pathology, Stanford University Medical Center, Stanford, California (Dr Troxell); and the Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston (Dr Ajani).

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http://dx.doi.org/10.5858/arpa.2016-0331-CPDOI Listing
December 2016

Ovarian Sex Cord-Stromal Tumors: The Challenge of Rare Gynecologic Malignancies.

J Oncol Pract 2016 10;12(10):947-948

Odette Cancer Centre, Sunnybrook Health Sciences, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JOP.2016.016998DOI Listing
October 2016

Endometrial cancer: Not your grandmother's cancer.

Cancer 2016 09 16;122(18):2787-98. Epub 2016 Jun 16.

Division of Medical Oncology and Hematology, Faculty of Medicine, University of Toronto, Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.30094DOI Listing
September 2016

Retrospective assessment of patterns of recurrence relative to radiotherapy volumes for adjuvant conformal chemoradiotherapy in gastric cancer.

Gastric Cancer 2016 Jul 11;19(3):887-93. Epub 2015 Sep 11.

Department of Radiation Oncology, Princess Margaret Cancer Centre, 610 University Avenue, 5th Floor, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1007/s10120-015-0534-8DOI Listing
July 2016

Current and emerging treatment options in the management of advanced ovarian cancer.

Expert Opin Pharmacother 2016 Jun 16;17(8):1063-76. Epub 2016 Mar 16.

a Division of Medical Oncology and Hematology, Princess Margaret Hospital , University of Toronto , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1517/14656566.2016.1159295DOI Listing
June 2016

Breaking down the evidence for bevacizumab in advanced cervical cancer: past, present and future.

Gynecol Oncol Res Pract 2015 21;2. Epub 2015 Sep 21.

Division of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2 M9 Canada.

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http://dx.doi.org/10.1186/s40661-015-0015-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881045PMC
May 2016

Nonsurgical management of cervical cancer: locally advanced, recurrent, and metastatic disease, survivorship, and beyond.

Am Soc Clin Oncol Educ Book 2015 :e299-309

From the Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre/Deptartment of Medicine, University of Toronto, Ontario, Canada; Department of Medicine and Public Health, University of California, Irvine, Irvine, CA; Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.14694/EdBook_AM.2015.35.e299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920478PMC
February 2016

Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study.

Int J Radiat Oncol Biol Phys 2016 Jan 18;94(1):111-117. Epub 2015 Sep 18.

Department of Medical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2015.09.009DOI Listing
January 2016

Patient-derived xenograft models in gynecologic malignancies.

Am Soc Clin Oncol Educ Book 2014 :e258-66

From The Walter and Eliza Hall Institute of Medical Research and Royal Women's Hospital, Parkville, Victoria, Australia; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Canada; Department of Oncology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156101PMC
November 2015

Discovery and validation of vascular endothelial growth factor (VEGF) pathway polymorphisms in esophageal adenocarcinoma outcome.

Carcinogenesis 2015 Sep 25;36(9):956-62. Epub 2015 May 25.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre and University of Toronto, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1093/carcin/bgv073DOI Listing
September 2015

Stage I granulosa cell tumours: A management conundrum? Results of long-term follow up.

Gynecol Oncol 2015 Aug 21;138(2):285-91. Epub 2015 May 21.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2015.05.011DOI Listing
August 2015

Performance characteristics of a brief Family History Questionnaire to screen for Lynch syndrome in women with newly diagnosed endometrial cancer.

Gynecol Oncol 2015 Feb 19;136(2):311-6. Epub 2014 Dec 19.

Division of Gynecologic Oncology, Princess Margaret Hospital/University Health Network, 610 University Ave., Toronto, Ontario M5G 2M9, Canada; Department of Obstetrics and Gynecology, University of Toronto, 27 King's College Circle, Toronto, Ontario M5S 2J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2014.12.023DOI Listing
February 2015

Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.

Cancer 2014 Dec 31;120(24):3932-9. Epub 2014 Jul 31.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28933DOI Listing
December 2014

Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer.

Gynecol Oncol 2014 Nov 28;135(2):184-9. Epub 2014 Aug 28.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto ON Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258140107
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http://dx.doi.org/10.1016/j.ygyno.2014.06.033DOI Listing
November 2014

State of the science in cervical cancer: where we are today and where we need to go.

Cancer 2014 Aug 15;120(15):2282-8. Epub 2014 Apr 15.

Gillette Center for Gynecologic Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28722DOI Listing
August 2014

Recent and current Phase II clinical trials in endometrial cancer: review of the state of art.

Expert Opin Investig Drugs 2014 Jun 9;23(6):773-92. Epub 2014 Apr 9.

Princess Margaret Hospital, Division of Medical Oncology and Hematology , 610 University Avenue, Toronto, Ontario, M5G 2M9 , Canada

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http://dx.doi.org/10.1517/13543784.2014.907272DOI Listing
June 2014

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.

Nat Genet 2014 May 23;46(5):438-43. Epub 2014 Mar 23.

1] Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada. [2] Department of Medical Genetics, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. [3] Department of Human Genetics, McGill University, Montreal, Quebec, Canada. [4] Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.

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http://www.nature.com/articles/ng.2931
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http://dx.doi.org/10.1038/ng.2931DOI Listing
May 2014

Systemic therapy in squamous cell carcinoma of the vulva: current status and future directions.

Gynecol Oncol 2014 Mar 1;132(3):780-9. Epub 2013 Dec 1.

Division of Medical Oncology and Hematology, University of Toronto, Canada; Princess Margaret Hospital, 610 University Avenue, Toronto, ON M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2013.11.025DOI Listing
March 2014

Uterine adenosarcomas: a dual-institution update on staging, prognosis and survival.

Gynecol Oncol 2013 Dec 14;131(3):634-9. Epub 2013 Oct 14.

Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2013.09.011DOI Listing
December 2013

Current phase II clinical data for ridaforolimus in cancer.

Expert Opin Investig Drugs 2013 Nov 21;22(11):1485-93. Epub 2013 Aug 21.

Princess Margaret Hospital, Division of Medical Oncology and Hematology , 610 University Avenue, Toronto, Ontario, M5G 2M9 , Canada +1 416 846 2253 ; +1 416 946 6546 ;

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http://dx.doi.org/10.1517/13543784.2013.831404DOI Listing
November 2013

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.

Lancet Oncol 2013 Aug 9;14(9):853-62. Epub 2013 Jul 9.

Division of Epidemiology, Department of Health Research and Policy, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1016/S1470-2045(13)70253-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006367PMC
August 2013

Treatment of metastatic cervical cancer: future directions involving targeted agents.

Crit Rev Oncol Hematol 2013 Mar 9;85(3):303-14. Epub 2012 Aug 9.

Division of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.critrevonc.2012.07.006DOI Listing
March 2013

Vascular endothelial growth factor pathway polymorphisms as prognostic and pharmacogenetic factors in cancer: a systematic review and meta-analysis.

Clin Cancer Res 2012 Sep 25;18(17):4526-37. Epub 2012 Jun 25.

Ontario Cancer Institute; Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital/University Health Network and University of Toronto, Toronto, CA.

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http://clincancerres.aacrjournals.org/content/18/17/4526.ful
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http://clincancerres.aacrjournals.org/content/early/2012/06/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-12-1315DOI Listing
September 2012

Hedgehog pathway signaling in cervical carcinoma and outcome after chemoradiation.

Cancer 2012 Jun 25;118(12):3105-15. Epub 2011 Oct 25.

Ontario Cancer Institute/Princess Margaret Hospital and The Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.26635DOI Listing
June 2012

Genetic polymorphisms as predictive and prognostic biomarkers in gynecological cancers: a systematic review.

Gynecol Oncol 2012 Feb 6;124(2):354-65. Epub 2011 Nov 6.

Division of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2011.10.034DOI Listing
February 2012

Ovarian immature teratoma: treatment and outcome in a single institutional cohort.

Gynecol Oncol 2011 Oct 20;123(1):50-3. Epub 2011 Jul 20.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S009082581100506
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http://dx.doi.org/10.1016/j.ygyno.2011.06.037DOI Listing
October 2011

The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer.

J Oncol 2010 16;2010:151750. Epub 2009 Dec 16.

Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1155/2010/151750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798102PMC
July 2011

Clear cell carcinoma of the ovary: a report from the first Ovarian Clear Cell Symposium, June 24th, 2010.

Gynecol Oncol 2011 May 26;121(2):407-15. Epub 2011 Jan 26.

Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2011.01.005DOI Listing
May 2011

Complementary and alternative medicine use among women receiving chemotherapy for ovarian cancer in 2 patient populations.

Int J Gynecol Cancer 2011 Apr;21(3):587-93

Princess Margaret Hospital, University Health Network, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/IGC.0b013e31820fa24aDOI Listing
April 2011

Pure dysgerminoma of the ovary 35 years on: a single institutional experience.

Gynecol Oncol 2010 Apr 25;117(1):23-6. Epub 2010 Jan 25.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2009.12.024DOI Listing
April 2010

A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184.

Gynecol Oncol 2010 Feb 8;116(2):163-7. Epub 2009 Sep 8.

Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2009.08.012DOI Listing
February 2010

Other new targets.

Int J Gynecol Cancer 2009 Dec;19 Suppl 2:S49-54

Princess Margaret Hospital, University of Toronto, 610 University Ave., Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/IGC.0b013e3181bf830dDOI Listing
December 2009

Evaluation of an intraperitoneal chemotherapy program implemented at the Princess Margaret Hospital for patients with epithelial ovarian carcinoma.

Gynecol Oncol 2009 Mar 10;112(3):450-4. Epub 2009 Jan 10.

Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, 610 University Ave, Totonto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1016/j.ygyno.2008.11.021DOI Listing
March 2009

Treatment of rectal cancer metastases to the thyroid gland: report of two cases.

Clin Colorectal Cancer 2008 Jul;7(4):280-2

Department of Medical Oncology and Hematology, University of Toronto, Princess Margaret Hospital, Ontario, Canada.

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http://dx.doi.org/10.3816/CCC.2008.n.036DOI Listing
July 2008

Targeting the protein kinase C family: are we there yet?

Nat Rev Cancer 2007 07;7(7):554-62

University of Toronto, Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nrc2168DOI Listing
July 2007

Locally advanced breast cancer in octogenarian women.

Breast Cancer Res Treat 2005 Jan;89(1):81-90

Beatson Oncology Centre, Glasgow, UK.

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http://dx.doi.org/10.1007/s10549-004-1003-yDOI Listing
January 2005