Publications by authors named "Helen J Mackay"

48Publications

Intraperitoneal chemotherapy: Hot, timely, and relevant?

Cancer 2020 Dec 15;126(24):5206-5209. Epub 2020 Sep 15.

National Cancer Institute, Bethesda, Maryland.

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http://dx.doi.org/10.1002/cncr.33163DOI Listing
December 2020

Quality of adverse event reporting in phase III randomized controlled trials of breast and colorectal cancer: A systematic review.

Cancer Med 2020 Jul 26;9(14):5035-5050. Epub 2020 May 26.

Division of Medical Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/cam4.3095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367648PMC
July 2020

Therapeutic Targets and Opportunities in Endometrial Cancer: Update on Endocrine Therapy and Nonimmunotherapy Targeted Options.

Am Soc Clin Oncol Educ Book 2020 Mar;40:1-11

Section of Hematology-Oncology, Department of Medicine, The University of Chicago, Chicago, IL.

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http://dx.doi.org/10.1200/EDBK_280495DOI Listing
March 2020

Incidence of Brain Metastases in Nonmetastatic and Metastatic Breast Cancer: Is There a Role for Screening?

Clin Breast Cancer 2020 02 11;20(1):e54-e64. Epub 2019 Jul 11.

Division of Medical Oncology and Hematology, Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2019.06.007DOI Listing
February 2020

Endocrine therapy in endometrial cancer: An old dog with new tricks.

Gynecol Oncol 2019 04 5;153(1):175-183. Epub 2019 Jan 5.

Division of Medical Oncology and Hematology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2018.12.018DOI Listing
April 2019

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.

Cell Death Differ 2018 12 23;25(12):2195-2208. Epub 2018 May 23.

Sunnybrook Research Institute, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1038/s41418-018-0115-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261950PMC
December 2018

HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology.

J Clin Oncol 2017 Feb 14;35(4):446-464. Epub 2016 Nov 14.

Angela N. Bartley, St Joseph Mercy Hospital, Ann Arbor, MI; Mary Kay Washington, Vanderbilt University Medical Center, Nashville, TN; Carol Colasacco and Christina B. Ventura, College of American Pathologists, Northfield; Al B. Benson III, Northwestern University, Chicago, IL; Nofisat Ismaila, American Society of Clinical Oncology, Alexandria, VA; Alfredo Carrato, Ramón y Cajal University Hospital, Madrid, Spain; Margaret L. Gulley, University of North Carolina, Chapel Hill, NC; Dhanpat Jain, Yale University School of Medicine, New Haven, CT; Sanjay Kakar, University of California, San Francisco, CA; Helen J. Mackay, Princess Margaret Cancer Centre; Catherine Streutker, St Michael's Hospital, University of Toronto, Toronto, Canada; Laura Tang, Memorial Sloan Kettering Cancer Center, New York, NY; Megan Troxell, Stanford University Medical Center, Stanford, CA; and Jaffer A. Ajani, The University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.69.4836DOI Listing
February 2017

Validation of microRNA pathway polymorphisms in esophageal adenocarcinoma survival.

Cancer Med 2017 02 11;6(2):361-373. Epub 2017 Jan 11.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cam4.989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313634PMC
February 2017

Ovarian Sex Cord-Stromal Tumors: The Challenge of Rare Gynecologic Malignancies.

J Oncol Pract 2016 10;12(10):947-948

Odette Cancer Centre, Sunnybrook Health Sciences, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JOP.2016.016998DOI Listing
October 2016

Prevention of carboplatin-induced hypersensitivity reactions in women with ovarian cancer.

J Oncol Pharm Pract 2018 Mar 17;24(2):83-90. Epub 2016 Nov 17.

1 Division of Medical Oncology and Hematology, Faculty of Medicine, University of Toronto, Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1078155216679028DOI Listing
March 2018

HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and American Society of Clinical Oncology.

Arch Pathol Lab Med 2016 Dec 14;140(12):1345-1363. Epub 2016 Nov 14.

From the Department of Pathology, St. Joseph Mercy Hospital, Ann Arbor, Michigan (Dr Bartley); the Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee (Dr Washington); Surveys (Ms Ventura) and Governance (Ms Colasacco), College of American Pathologists, Northfield, Illinois; Quality and Guidelines Department, American Society of Clinical Oncology, Alexandria, Virginia (Dr Ismaila); the Division of Hematology/Oncology, Northwestern University, Chicago, Illinois (Dr Benson); Medical Oncology Department, Ramon y Cajal University Hospital, Madrid, Spain (Dr Carrato); the Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill (Dr Gulley); the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Dr Jain); the Department of Pathology and Laboratory Medicine, UCSF, San Francisco, California (Dr Kakar); the Division of Medical Oncology and Hematology, University of Toronto/Sunnybrook Odette Cancer Centre, Toronto, Ontario, Canada (Dr Mackay); the Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada (Dr Streutker); the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Tang); the Department of Pathology, Stanford University Medical Center, Stanford, California (Dr Troxell); and the Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston (Dr Ajani).

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http://dx.doi.org/10.5858/arpa.2016-0331-CPDOI Listing
December 2016

Endometrial cancer: Not your grandmother's cancer.

Cancer 2016 09 16;122(18):2787-98. Epub 2016 Jun 16.

Division of Medical Oncology and Hematology, Faculty of Medicine, University of Toronto, Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.30094DOI Listing
September 2016

Update on Intraperitoneal Chemotherapy for the Treatment of Epithelial Ovarian Cancer.

Am Soc Clin Oncol Educ Book 2016 ;35:143-51

From the Edinburgh Cancer Research Centre, Medical Research Council, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; Stephenson Cancer Center, University of Oklahoma, Health Sciences Center, Oklahoma City, OK; Faculty of Medicine, University of Toronto, Sunnybrook Odette Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1200/EDBK_158927DOI Listing
January 2017

Current and emerging treatment options in the management of advanced ovarian cancer.

Expert Opin Pharmacother 2016 Jun 16;17(8):1063-76. Epub 2016 Mar 16.

a Division of Medical Oncology and Hematology, Princess Margaret Hospital , University of Toronto , Toronto , Ontario , Canada.

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http://dx.doi.org/10.1517/14656566.2016.1159295DOI Listing
June 2016

Discovery and validation of vascular endothelial growth factor (VEGF) pathway polymorphisms in esophageal adenocarcinoma outcome.

Carcinogenesis 2015 Sep 25;36(9):956-62. Epub 2015 May 25.

Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Cancer Centre and University of Toronto, 610 University Ave, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1093/carcin/bgv073DOI Listing
September 2015

Nonsurgical management of cervical cancer: locally advanced, recurrent, and metastatic disease, survivorship, and beyond.

Am Soc Clin Oncol Educ Book 2015 :e299-309

From the Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre/Deptartment of Medicine, University of Toronto, Ontario, Canada; Department of Medicine and Public Health, University of California, Irvine, Irvine, CA; Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia.

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http://dx.doi.org/10.14694/EdBook_AM.2015.35.e299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920478PMC
February 2016

Breaking down the evidence for bevacizumab in advanced cervical cancer: past, present and future.

Gynecol Oncol Res Pract 2015 21;2. Epub 2015 Sep 21.

Division of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2 M9 Canada.

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http://dx.doi.org/10.1186/s40661-015-0015-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881045PMC
May 2016

Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer.

Gynecol Oncol 2014 Nov 28;135(2):184-9. Epub 2014 Aug 28.

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto ON Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00908258140107
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http://dx.doi.org/10.1016/j.ygyno.2014.06.033DOI Listing
November 2014

Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.

Cancer 2014 Dec 31;120(24):3932-9. Epub 2014 Jul 31.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28933DOI Listing
December 2014

Patient-derived xenograft models in gynecologic malignancies.

Am Soc Clin Oncol Educ Book 2014 :e258-66

From The Walter and Eliza Hall Institute of Medical Research and Royal Women's Hospital, Parkville, Victoria, Australia; Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Canada; Department of Oncology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156101PMC
November 2015

State of the science in cervical cancer: where we are today and where we need to go.

Cancer 2014 Aug 15;120(15):2282-8. Epub 2014 Apr 15.

Gillette Center for Gynecologic Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28722DOI Listing
August 2014

Recent and current Phase II clinical trials in endometrial cancer: review of the state of art.

Expert Opin Investig Drugs 2014 Jun 9;23(6):773-92. Epub 2014 Apr 9.

Princess Margaret Hospital, Division of Medical Oncology and Hematology , 610 University Avenue, Toronto, Ontario, M5G 2M9 , Canada

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http://dx.doi.org/10.1517/13543784.2014.907272DOI Listing
June 2014

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.

Nat Genet 2014 May 23;46(5):438-43. Epub 2014 Mar 23.

1] Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada. [2] Department of Medical Genetics, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. [3] Department of Human Genetics, McGill University, Montreal, Quebec, Canada. [4] Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.

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http://www.nature.com/articles/ng.2931
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http://dx.doi.org/10.1038/ng.2931DOI Listing
May 2014

Current phase II clinical data for ridaforolimus in cancer.

Expert Opin Investig Drugs 2013 Nov 21;22(11):1485-93. Epub 2013 Aug 21.

Princess Margaret Hospital, Division of Medical Oncology and Hematology , 610 University Avenue, Toronto, Ontario, M5G 2M9 , Canada +1 416 846 2253 ; +1 416 946 6546 ;

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http://dx.doi.org/10.1517/13543784.2013.831404DOI Listing
November 2013

Treatment of metastatic cervical cancer: future directions involving targeted agents.

Crit Rev Oncol Hematol 2013 Mar 9;85(3):303-14. Epub 2012 Aug 9.

Division of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.critrevonc.2012.07.006DOI Listing
March 2013

Vascular endothelial growth factor pathway polymorphisms as prognostic and pharmacogenetic factors in cancer: a systematic review and meta-analysis.

Clin Cancer Res 2012 Sep 25;18(17):4526-37. Epub 2012 Jun 25.

Ontario Cancer Institute; Division of Medical Oncology and Hematology, Department of Medicine, Princess Margaret Hospital/University Health Network and University of Toronto, Toronto, CA.

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http://clincancerres.aacrjournals.org/content/18/17/4526.ful
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http://clincancerres.aacrjournals.org/content/early/2012/06/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-1315DOI Listing
September 2012

Other new targets.

Int J Gynecol Cancer 2009 Dec;19 Suppl 2:S49-54

Princess Margaret Hospital, University of Toronto, 610 University Ave., Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/IGC.0b013e3181bf830dDOI Listing
December 2009

The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer.

J Oncol 2010 16;2010:151750. Epub 2009 Dec 16.

Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada M5G 2M9.

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http://dx.doi.org/10.1155/2010/151750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798102PMC
July 2011

A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184.

Gynecol Oncol 2010 Feb 8;116(2):163-7. Epub 2009 Sep 8.

Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2009.08.012DOI Listing
February 2010

Treatment of rectal cancer metastases to the thyroid gland: report of two cases.

Clin Colorectal Cancer 2008 Jul;7(4):280-2

Department of Medical Oncology and Hematology, University of Toronto, Princess Margaret Hospital, Ontario, Canada.

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http://dx.doi.org/10.3816/CCC.2008.n.036DOI Listing
July 2008

Targeting the protein kinase C family: are we there yet?

Nat Rev Cancer 2007 07;7(7):554-62

University of Toronto, Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nrc2168DOI Listing
July 2007