Publications by authors named "Helen E Stevens"

17Publications

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

Authors:

Antony J Cutler Joao Oliveira Ricardo C Ferreira Ben Challis Neil M Walker Sarah Caddy Jia Lu Helen E Stevens Deborah J Smyth Marcin L Pekalski Jane Kennet Kara M D Hunter Ian Goodfellow Linda S Wicker John A Todd Frank Waldron-Lynch

Wellcome Open Res 2017 5;2:28. Epub 2017 Oct 5.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus,Cambridge, CB2 0XY, UK.

View Article and Find Full Text PDF

October 2017

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

View Article and Find Full Text PDF

August 2017

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

PLoS Med 2016 Oct 11;13(10):e1002139. Epub 2016 Oct 11.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, United Kingdom.

View Article and Find Full Text PDF

October 2016

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Authors:

Kate Downes M Loredana Marcovecchio Pamela Clarke Jason D Cooper Ricardo C Ferreira Joanna M M Howson Jennifer Jolley Sarah Nutland Helen E Stevens Neil M Walker Chris Wallace David B Dunger John A Todd

Diabetologia 2014 Feb 22;57(2):366-72. Epub 2013 Nov 22.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 0XY, UK.

View Article and Find Full Text PDF

February 2014

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

J Immunol 2013 Mar 15;190(6):2554-66. Epub 2013 Feb 15.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

View Article and Find Full Text PDF

March 2013

Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status.

Authors:

Bernice Lo Austin D E Swafford Kimberly A Shafer-Weaver Lawrence F Jerome Luba Rakhlin Douglas R Mathern Conor A Callahan Ping Jiang Lucy J Davison Helen E Stevens Carrie L Lucas Jill White Reid von Borstel John A Todd Michael J Lenardo

J Transl Med 2011 Nov 28;9:203. Epub 2011 Nov 28.

Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

View Article and Find Full Text PDF

November 2011

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.

Authors:

Nada M Saleh Srilakshmi M Raj Deborah J Smyth Chris Wallace Joanna M M Howson Louise Bell Neil M Walker Helen E Stevens John A Todd

Diabetes Metab Res Rev 2011 Nov;27(8):838-43

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.

View Article and Find Full Text PDF

November 2011

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.

Authors:

Lucy J Davison Chris Wallace Jason D Cooper Nathan F Cope Nicola K Wilson Deborah J Smyth Joanna M M Howson Nada Saleh Abdullah Al-Jeffery Karen L Angus Helen E Stevens Sarah Nutland Simon Duley Richard M R Coulson Neil M Walker Oliver S Burren Catherine M Rice Francois Cambien Tanja Zeller Thomas Munzel Karl Lackner Stefan Blakenberg Peter Fraser Berthold Gottgens John A Todd Tony Attwood Stephanie Belz Peter Braund François Cambien Jason Cooper Abi Crisp-Hihn Patrick Diemert Panos Deloukas Nicola Foad Jeanette Erdmann Alison H Goodall Jay Gracey Emma Gray Rhian G Williams Susanne Heimerl Christian Hengstenberg Jennifer Jolley Unni Krishnan Heather Lloyd-Jones Ingrid Lugauer Per Lundmark Seraya Maouche Jasbir S Moore David Muir Elizabeth Murray Chris P Nelson Jessica Neudert David Niblett Karen O'Leary Willem H Ouwehand Helen Pollard Angela Rankin Catherine M Rice Hendrik Sager Nilesh J Samani Jennifer Sambrook Gerd Schmitz Michael Scholz Laura Schroeder Heribert Schunkert Ann-Christine Syvannen Stefanie Tennstedt Chris Wallace

Hum Mol Genet 2012 Jan 11;21(2):322-33. Epub 2011 Oct 11.

View Article and Find Full Text PDF

January 2012

Evidence of association with type 1 diabetes in the SLC11A1 gene region.

Authors:

Jennie H M Yang Kate Downes Joanna M M Howson Sarah Nutland Helen E Stevens Neil M Walker John A Todd

BMC Med Genet 2011 Apr 27;12:59. Epub 2011 Apr 27.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

View Article and Find Full Text PDF

April 2011

Common genetic determinants of vitamin D insufficiency: a genome-wide association study.

Authors:

Thomas J Wang Feng Zhang J Brent Richards Bryan Kestenbaum Joyce B van Meurs Diane Berry Douglas P Kiel Elizabeth A Streeten Claes Ohlsson Daniel L Koller Leena Peltonen Jason D Cooper Paul F O'Reilly Denise K Houston Nicole L Glazer Liesbeth Vandenput Munro Peacock Julia Shi Fernando Rivadeneira Mark I McCarthy Pouta Anneli Ian H de Boer Massimo Mangino Bernet Kato Deborah J Smyth Sarah L Booth Paul F Jacques Greg L Burke Mark Goodarzi Ching-Lung Cheung Myles Wolf Kenneth Rice David Goltzman Nick Hidiroglou Martin Ladouceur Nicholas J Wareham Lynne J Hocking Deborah Hart Nigel K Arden Cyrus Cooper Suneil Malik William D Fraser Anna-Liisa Hartikainen Guangju Zhai Helen M Macdonald Nita G Forouhi Ruth J F Loos David M Reid Alan Hakim Elaine Dennison Yongmei Liu Chris Power Helen E Stevens Laitinen Jaana Ramachandran S Vasan Nicole Soranzo Jörg Bojunga Bruce M Psaty Mattias Lorentzon Tatiana Foroud Tamara B Harris Albert Hofman John-Olov Jansson Jane A Cauley Andre G Uitterlinden Quince Gibson Marjo-Riitta Järvelin David Karasik David S Siscovick Michael J Econs Stephen B Kritchevsky Jose C Florez John A Todd Josee Dupuis Elina Hyppönen Timothy D Spector

Lancet 2010 Jul 10;376(9736):180-8. Epub 2010 Jun 10.

Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.

View Article and Find Full Text PDF

July 2010

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

Authors:

Nick Craddock Matthew E Hurles Niall Cardin Richard D Pearson Vincent Plagnol Samuel Robson Damjan Vukcevic Chris Barnes Donald F Conrad Eleni Giannoulatou Chris Holmes Jonathan L Marchini Kathy Stirrups Martin D Tobin Louise V Wain Chris Yau Jan Aerts Tariq Ahmad T Daniel Andrews Hazel Arbury Anthony Attwood Adam Auton Stephen G Ball Anthony J Balmforth Jeffrey C Barrett Inês Barroso Anne Barton Amanda J Bennett Sanjeev Bhaskar Katarzyna Blaszczyk John Bowes Oliver J Brand Peter S Braund Francesca Bredin Gerome Breen Morris J Brown Ian N Bruce Jaswinder Bull Oliver S Burren John Burton Jake Byrnes Sian Caesar Chris M Clee Alison J Coffey John M C Connell Jason D Cooper Anna F Dominiczak Kate Downes Hazel E Drummond Darshna Dudakia Andrew Dunham Bernadette Ebbs Diana Eccles Sarah Edkins Cathryn Edwards Anna Elliot Paul Emery David M Evans Gareth Evans Steve Eyre Anne Farmer I Nicol Ferrier Lars Feuk Tomas Fitzgerald Edward Flynn Alistair Forbes Liz Forty Jayne A Franklyn Rachel M Freathy Polly Gibbs Paul Gilbert Omer Gokumen Katherine Gordon-Smith Emma Gray Elaine Green Chris J Groves Detelina Grozeva Rhian Gwilliam Anita Hall Naomi Hammond Matt Hardy Pile Harrison Neelam Hassanali Husam Hebaishi Sarah Hines Anne Hinks Graham A Hitman Lynne Hocking Eleanor Howard Philip Howard Joanna M M Howson Debbie Hughes Sarah Hunt John D Isaacs Mahim Jain Derek P Jewell Toby Johnson Jennifer D Jolley Ian R Jones Lisa A Jones George Kirov Cordelia F Langford Hana Lango-Allen G Mark Lathrop James Lee Kate L Lee Charlie Lees Kevin Lewis Cecilia M Lindgren Meeta Maisuria-Armer Julian Maller John Mansfield Paul Martin Dunecan C O Massey Wendy L McArdle Peter McGuffin Kirsten E McLay Alex Mentzer Michael L Mimmack Ann E Morgan Andrew P Morris Craig Mowat Simon Myers William Newman Elaine R Nimmo Michael C O'Donovan Abiodun Onipinla Ifejinelo Onyiah Nigel R Ovington Michael J Owen Kimmo Palin Kirstie Parnell David Pernet John R B Perry Anne Phillips Dalila Pinto Natalie J Prescott Inga Prokopenko Michael A Quail Suzanne Rafelt Nigel W Rayner Richard Redon David M Reid Renwick Susan M Ring Neil Robertson Ellie Russell David St Clair Jennifer G Sambrook Jeremy D Sanderson Helen Schuilenburg Carol E Scott Richard Scott Sheila Seal Sue Shaw-Hawkins Beverley M Shields Matthew J Simmonds Debbie J Smyth Elilan Somaskantharajah Katarina Spanova Sophia Steer Jonathan Stephens Helen E Stevens Millicent A Stone Zhan Su Deborah P M Symmons John R Thompson Wendy Thomson Mary E Travers Clare Turnbull Armand Valsesia Mark Walker Neil M Walker Chris Wallace Margaret Warren-Perry Nicholas A Watkins John Webster Michael N Weedon Anthony G Wilson Matthew Woodburn B Paul Wordsworth Allan H Young Eleftheria Zeggini Nigel P Carter Timothy M Frayling Charles Lee Gil McVean Patricia B Munroe Aarno Palotie Stephen J Sawcer Stephen W Scherer David P Strachan Chris Tyler-Smith Matthew A Brown Paul R Burton Mark J Caulfield Alastair Compston Martin Farrall Stephen C L Gough Alistair S Hall Andrew T Hattersley Adrian V S Hill Christopher G Mathew Marcus Pembrey Jack Satsangi Michael R Stratton Jane Worthington Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem Ouwehand Miles Parkes Nazneen Rahman John A Todd Nilesh J Samani Peter Donnelly

Nature 2010 Apr;464(7289):713-20

View Article and Find Full Text PDF

April 2010

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.

Nature 2007 Dec 14;450(7171):887-92. Epub 2007 Nov 14.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK.

View Article and Find Full Text PDF

December 2007

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.

Authors:

Paul R Burton David G Clayton Lon R Cardon Nick Craddock Panos Deloukas Audrey Duncanson Dominic P Kwiatkowski Mark I McCarthy Willem H Ouwehand Nilesh J Samani John A Todd Peter Donnelly Jeffrey C Barrett Dan Davison Doug Easton David M Evans Hin-Tak Leung Jonathan L Marchini Andrew P Morris Chris C A Spencer Martin D Tobin Antony P Attwood James P Boorman Barbara Cant Ursula Everson Judith M Hussey Jennifer D Jolley Alexandra S Knight Kerstin Koch Elizabeth Meech Sarah Nutland Christopher V Prowse Helen E Stevens Niall C Taylor Graham R Walters Neil M Walker Nicholas A Watkins Thilo Winzer Richard W Jones Wendy L McArdle Susan M Ring David P Strachan Marcus Pembrey Gerome Breen David St Clair Sian Caesar Katharine Gordon-Smith Lisa Jones Christine Fraser Elaine K Green Detelina Grozeva Marian L Hamshere Peter A Holmans Ian R Jones George Kirov Valentina Moskivina Ivan Nikolov Michael C O'Donovan Michael J Owen David A Collier Amanda Elkin Anne Farmer Richard Williamson Peter McGuffin Allan H Young I Nicol Ferrier Stephen G Ball Anthony J Balmforth Jennifer H Barrett Timothy D Bishop Mark M Iles Azhar Maqbool Nadira Yuldasheva Alistair S Hall Peter S Braund Richard J Dixon Massimo Mangino Suzanne Stevens John R Thompson Francesca Bredin Mark Tremelling Miles Parkes Hazel Drummond Charles W Lees Elaine R Nimmo Jack Satsangi Sheila A Fisher Alastair Forbes Cathryn M Lewis Clive M Onnie Natalie J Prescott Jeremy Sanderson Christopher G Matthew Jamie Barbour M Khalid Mohiuddin Catherine E Todhunter John C Mansfield Tariq Ahmad Fraser R Cummings Derek P Jewell John Webster Morris J Brown Mark G Lathrop John Connell Anna Dominiczak Carolina A Braga Marcano Beverley Burke Richard Dobson Johannie Gungadoo Kate L Lee Patricia B Munroe Stephen J Newhouse Abiodun Onipinla Chris Wallace Mingzhan Xue Mark Caulfield Martin Farrall Anne Barton Ian N Bruce Hannah Donovan Steve Eyre Paul D Gilbert Samantha L Hilder Anne M Hinks Sally L John Catherine Potter Alan J Silman Deborah P M Symmons Wendy Thomson Jane Worthington David B Dunger Barry Widmer Timothy M Frayling Rachel M Freathy Hana Lango John R B Perry Beverley M Shields Michael N Weedon Andrew T Hattersley Graham A Hitman Mark Walker Kate S Elliott Christopher J Groves Cecilia M Lindgren Nigel W Rayner Nicolas J Timpson Eleftheria Zeggini Melanie Newport Giorgio Sirugo Emily Lyons Fredrik Vannberg Adrian V S Hill Linda A Bradbury Claire Farrar Jennifer J Pointon Paul Wordsworth Matthew A Brown Jayne A Franklyn Joanne M Heward Matthew J Simmonds Stephen C L Gough Sheila Seal Michael R Stratton Nazneen Rahman Maria Ban An Goris Stephen J Sawcer Alastair Compston David Conway Muminatou Jallow Melanie Newport Giorgio Sirugo Kirk A Rockett Suzannah J Bumpstead Amy Chaney Kate Downes Mohammed J R Ghori Rhian Gwilliam Sarah E Hunt Michael Inouye Andrew Keniry Emma King Ralph McGinnis Simon Potter Rathi Ravindrarajah Pamela Whittaker Claire Widden David Withers Niall J Cardin Dan Davison Teresa Ferreira Joanne Pereira-Gale Ingeleif B Hallgrimsdo'ttir Bryan N Howie Zhan Su Yik Ying Teo Damjan Vukcevic David Bentley Matthew A Brown Alastair Compston Martin Farrall Alistair S Hall Andrew T Hattersley Adrian V S Hill Miles Parkes Marcus Pembrey Michael R Stratton Sarah L Mitchell Paul R Newby Oliver J Brand Jackie Carr-Smith Simon H S Pearce R McGinnis A Keniry P Deloukas John D Reveille Xiaodong Zhou Anne-Marie Sims Alison Dowling Jacqueline Taylor Tracy Doan John C Davis Laurie Savage Michael M Ward Thomas L Learch Michael H Weisman Mathew Brown

Nat Genet 2007 Nov 21;39(11):1329-37. Epub 2007 Oct 21.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK.

View Article and Find Full Text PDF

November 2007

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

Nat Genet 2007 Jul 6;39(7):857-64. Epub 2007 Jun 6.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0XY, UK.

View Article and Find Full Text PDF

July 2007

Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.

Authors:

Felicity Payne Jason D Cooper Neil M Walker Alex C Lam Luc J Smink Sarah Nutland Helen E Stevens Jayne Hutchings John A Todd

J Leukoc Biol 2007 Mar 5;81(3):581-3. Epub 2007 Jan 5.

Juvenile Diabetes Research Foundation/Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge, UK.

View Article and Find Full Text PDF

March 2007

Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing.

Authors:

Jeffrey S Szeszko Joanna M M Howson Jason D Cooper Neil M Walker Rebecca C J Twells Helen E Stevens Sarah L Nutland John A Todd

Diabetes 2006 Feb;55(2):559-62

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK.

View Article and Find Full Text PDF

February 2006

Population structure, differential bias and genomic control in a large-scale, case-control association study.

Authors:

David G Clayton Neil M Walker Deborah J Smyth Rebecca Pask Jason D Cooper Lisa M Maier Luc J Smink Alex C Lam Nigel R Ovington Helen E Stevens Sarah Nutland Joanna M M Howson Malek Faham Martin Moorhead Hywel B Jones Matthew Falkowski Paul Hardenbol Thomas D Willis John A Todd

Nat Genet 2005 Nov 9;37(11):1243-6. Epub 2005 Oct 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, CB2 2XY, UK.

View Article and Find Full Text PDF

November 2005