Publications by authors named "Helen Colhoun"

100Publications

Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design.

Am Heart J 2020 Jul 17;229:61-69. Epub 2020 Jul 17.

Department of Cardiovascular Medicine, Cleveland Clinic Coordinating Center for Clinical Research (C5Research), Cleveland, OH. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ahj.2020.07.008DOI Listing
July 2020

John Fuller, 21 October 1937-2 July 2020.

Diabetologia 2020 Nov;63(11):2251-2252

Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-020-05267-5DOI Listing
November 2020

Erratum. Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control. Diabetes 2019;68:441-456.

Diabetes 2020 Jun 27;69(6):1306. Epub 2020 Apr 27.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db20-er06aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243291PMC
June 2020

Diabetes in Scotland: a rising tide.

Lancet Diabetes Endocrinol 2020 05;8(5):375-376

the Metabolic Unit, Western General Hospital, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-8587(20)30124-8DOI Listing
May 2020

Diabetic Neuropathy Is a Substantial Burden in People With Type 1 Diabetes and Is Strongly Associated With Socioeconomic Disadvantage: A Population-Representative Study From Scotland.

Diabetes Care 2020 04 23;43(4):734-742. Epub 2020 Jan 23.

Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, Edinburgh Medical School: Molecular, Genetic and Population Health Sciences, University of Edinburgh, Edinburgh, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/dc19-1582DOI Listing
April 2020

Predicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus.

Diabetologia 2020 03 5;63(3):636-647. Epub 2019 Dec 5.

MRC Institute of Genetic and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-019-05052-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997248PMC
March 2020

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

J Am Soc Nephrol 2019 10 19;30(10):2000-2016. Epub 2019 Sep 19.

Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2019030218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779358PMC
October 2019

Factors associated with stillbirth in women with diabetes.

Diabetologia 2019 10 29;62(10):1938-1947. Epub 2019 Jul 29.

Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-019-4943-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731193PMC
October 2019

Biomarker panels associated with progression of renal disease in type 1 diabetes.

Diabetologia 2019 09 20;62(9):1616-1627. Epub 2019 Jun 20.

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-019-4915-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677704PMC
September 2019

Pharmacoepidemiology: Using randomised control trials and observational studies in clinical decision-making.

Br J Clin Pharmacol 2019 09 24;85(9):1907-1924. Epub 2019 Jul 24.

Queen's Medical Research Institute, University of Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.14024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710512PMC
September 2019

Body Weight Variability and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus.

Circ Cardiovasc Qual Outcomes 2018 11;11(11):e004724

Department of Cardiology, Zuckerberg San Francisco General Hospital, CA (D.D.W.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004724DOI Listing
November 2018

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Diabetes 2019 02 28;68(2):441-456. Epub 2018 Nov 28.

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db18-0567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341299PMC
February 2019

Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.

Lancet 2018 10 4;392(10155):1311-1320. Epub 2018 Oct 4.

Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(18)31652-0DOI Listing
October 2018

Earthquake brain: Impairment of spatial memory following long-term earthquake-related stress.

Aust N Z J Psychiatry 2019 01 27;53(1):37-47. Epub 2018 Jul 27.

1 Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0004867418789498DOI Listing
January 2019

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

Diabetes 2018 07 27;67(7):1414-1427. Epub 2018 Apr 27.

Wellcome Centre Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-0914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014557PMC
July 2018

Development and Validation of a Path Length Calculation for Carotid-Femoral Pulse Wave Velocity Measurement: A TASCFORCE, SUMMIT, and Caerphilly Collaborative Venture.

Hypertension 2018 05 19;71(5):937-945. Epub 2018 Mar 19.

From the Division of Molecular and Clinical Medicine, College of Medicine, University of Dundee, United Kingdom (J.R.W.-M., L.B., J.S., F.K., A.D.S., J.G.H.); NHS Tayside Clinical Radiology, Ninewells Hospital, Dundee, United Kingdom (P.T., M.B.-M., S.C.C.); Department of Research and Innovation, North York General Hospital, University of Toronto, Canada (F.S.); Centre for Genomic and Experimental Medicine, The University of Edinburgh, Western General Hospital, United Kingdom (H.M.C.); NIHR Exeter Clinical Research Facility, Royal Devon and Exeter Hospital and University of Exeter Medical School, United Kingdom (A.C.S., K.A.); Lund University Diabetes Centre, Lund University, Malmö, Sweden (L.G.); Department of Clinical Sciences Malmö, Lund University, Sweden (J.N.); Department of Cardiology, Wales Heart Research Institute, Cardiff, United Kingdom (J.R.C.); Division of Experimental Medicine & Immunotherapeutics, University of Cambridge, United Kingdom (C.M.M., I.B.W.); and Population Health Sciences, University of Bristol, United Kingdom (Y.B.-S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902134PMC
May 2018

Efficacy and safety of lipid lowering by alirocumab in chronic kidney disease.

Kidney Int 2018 06 8;93(6):1397-1408. Epub 2018 Mar 8.

Department of Hypertension, Medical University of Lodz, Lodz, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2017.12.011DOI Listing
June 2018

Biomarkers of diabetic kidney disease.

Diabetologia 2018 05 8;61(5):996-1011. Epub 2018 Mar 8.

Department of Paediatrics, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-018-4567-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448994PMC
May 2018

Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes.

BMC Cardiovasc Disord 2018 02 13;18(1):31. Epub 2018 Feb 13.

Division of Molecular and Clinical Medicine, University of Dundee, Mailbox 2, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12872-018-0770-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809843PMC
February 2018

Diabetes and pregnancy: national trends over a 15 year period.

Diabetologia 2018 05 11;61(5):1081-1088. Epub 2018 Jan 11.

Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-017-4529-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448996PMC
May 2018

Type 2 diabetes, socioeconomic status and life expectancy in Scotland (2012-2014): a population-based observational study.

Diabetologia 2018 01 26;61(1):108-116. Epub 2017 Oct 26.

Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Medical School, Teviot Place, Edinburgh, EH8 9AG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-017-4478-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448945PMC
January 2018

Modelling cumulative exposure for inference about drug effects in observational studies.

Pharmacoepidemiol Drug Saf 2017 Dec 12;26(12):1527-1533. Epub 2017 Oct 12.

Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/pds.4327
Publisher Site
http://dx.doi.org/10.1002/pds.4327DOI Listing
December 2017

Efficacy and safety of alirocumab in insulin-treated individuals with type 1 or type 2 diabetes and high cardiovascular risk: The ODYSSEY DM-INSULIN randomized trial.

Diabetes Obes Metab 2017 12 10;19(12):1781-1792. Epub 2017 Oct 10.

University of California San Diego School of Medicine, and Center for Metabolic Research, Veterans Affairs, San Diego Healthcare System, San Diego, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698740PMC
December 2017

Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia.

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, United Kingdom (M.K.S., A.V., C.M., R.T., F.C., E.P., J.G., A.D., C.N.A.P.); Centre for Genomic and Experimental Medicine (H.C.) and Usher Institute of Population Health Sciences and Informatics (A.D.M.), University of Edinburgh, United Kingdom; Institute of Translational Medicine, University of Liverpool, United Kingdom (M.P., A.A.); Department of Medical Sciences, Clinical Pharmacology and Science of Life Laboratory, Uppsala University, Sweden (M.W.); Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, The Netherlands (A.H.M.v.d.Z.); Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, The Netherlands (A.H.M.v.d.Z.); Brigham and Women's Hospital and Harvard Medical School, Boston, MA (P.M.R., D.I.C.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.117.001737DOI Listing
August 2017

Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Dec 4;1071:58-67. Epub 2017 Apr 4.

Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2017.04.002DOI Listing
December 2017

Antidrug Antibodies in Patients Treated with Alirocumab.

N Engl J Med 2017 04 17;376(16):1589-90. Epub 2017 Mar 17.

University of Edinburgh, Edinburgh, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1616623DOI Listing
April 2017

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.

J Med Genet 2016 12 1;53(12):835-845. Epub 2016 Sep 1.

Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jmedgenet-2016-103966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309131PMC
December 2016

Trends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013.

Diabetologia 2016 10 28;59(10):2106-13. Epub 2016 Jul 28.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-016-4054-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016553PMC
October 2016

Development and Validation of a Model to Predict Absolute Vascular Risk Reduction by Moderate-Intensity Statin Therapy in Individual Patients With Type 2 Diabetes Mellitus: The Anglo Scandinavian Cardiac Outcomes Trial, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, and Collaborative Atorvastatin Diabetes Study.

Circ Cardiovasc Qual Outcomes 2016 05 11;9(3):213-21. Epub 2016 May 11.

From the Department of Vascular Medicine (L.K., F.L.J.V.) and Julius Centre for Health Sciences and Primary Care (Y.v.d.G.), University Medical Centre Utrecht, Utrecht, The Netherlands; ICCH, Imperial College London, London, United Kingdom (N.R.P., P.S.S.); Biomedical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom (H.M.C., S.J.L.); Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands (S.M.B.); and University of Texas Health Science Center, Houston (S.L.P., B.R.D.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCOUTCOMES.115.001980DOI Listing
May 2016

A Genome-Wide Association Study Provides New Evidence That CACNA1C Gene is Associated With Diabetic Cataract.

Invest Ophthalmol Vis Sci 2016 Apr;57(4):2246-50

Division of Population Health Sciences Ninewells Hospital and School of Medicine, University of Dundee, Dundee, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.16-19332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855826PMC
April 2016

A Genome-wide Association Study Provides Evidence of Sex-specific Involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) With Diabetic Neuropathic Pain.

EBioMedicine 2015 Oct 4;2(10):1386-93. Epub 2015 Aug 4.

Division of Population Health Sciences, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee DD2 4BF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634194PMC
October 2015

Effect of atorvastatin on glycaemia progression in patients with diabetes: an analysis from the Collaborative Atorvastatin in Diabetes Trial (CARDS).

Diabetologia 2016 Feb 17;59(2):299-306. Epub 2015 Nov 17.

Diabetes Epidemiology Unit, Division of Population Health Sciences, University of Dundee, The Mackenzie Building, Kirsty Semple Way, Dundee, DD2 4BF, Scotland, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-015-3802-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705133PMC
February 2016

Cohort comparison study of cardiac disease and atherosclerotic burden in type 2 diabetic adults using whole body cardiovascular magnetic resonance imaging.

Cardiovasc Diabetol 2015 Sep 18;14:122. Epub 2015 Sep 18.

Division of Cardiovascular and Diabetes Medicine, Medical Research Institute, University of Dundee, Level 7, Ninewells Hospital, Dundee, DD1 9SY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12933-015-0284-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574534PMC
September 2015

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes.

Arterioscler Thromb Vasc Biol 2015 Jul 7;35(7):1723-31. Epub 2015 May 7.

From the Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden (I.G., E.B., A.E., P.D., G.N.F., H.B., G.Ö., M.P., J.N.); Medical Research Institute, University of Dundee, Dundee, UK (H.M.C., F.K., H.C.L., F.A., J.B.); Institute of Biomedical and Clinical Science, Diabetes and Vascular Medicine, NIHR Exeter Clinical Research Facility and University of Exeter Medical School, Exeter, UK (A.C.S., K.A., F.C., K.G., D.S.); Department of Clinical and Experimental Medicine (A.N., S.P., E.V.) and Department of Surgical, Medical, Molecular and Critical Area Pathology (C.P., M.K.), University of Pisa, Pisa, Italy; and AstraZeneca, Cardiovascular and Metabolic Diseases, Mölndal, Sweden (L.-M.G., V.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.115.305631DOI Listing
July 2015

Ethnicity and risk of cardiovascular disease (CVD): 4.8 year follow-up of patients with type 2 diabetes living in Scotland.

Diabetologia 2015 Apr 12;58(4):716-25. Epub 2015 Feb 12.

Institute of Cardiovascular and Medical Sciences, BHF Glasgow, Cardiovascular Research Centre, University of Glasgow, 126 University Place, G12 8TA, Glasgow, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00125-015-3492-0
Publisher Site
http://dx.doi.org/10.1007/s00125-015-3492-0DOI Listing
April 2015

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Authors:
Iris Postmus Stella Trompet Harshal A Deshmukh Michael R Barnes Xiaohui Li Helen R Warren Daniel I Chasman Kaixin Zhou Benoit J Arsenault Louise A Donnelly Kerri L Wiggins Christy L Avery Paula Griffin QiPing Feng Kent D Taylor Guo Li Daniel S Evans Albert V Smith Catherine E de Keyser Andrew D Johnson Anton J M de Craen David J Stott Brendan M Buckley Ian Ford Rudi G J Westendorp P Eline Slagboom Naveed Sattar Patricia B Munroe Peter Sever Neil Poulter Alice Stanton Denis C Shields Eoin O'Brien Sue Shaw-Hawkins Y-D Ida Chen Deborah A Nickerson Joshua D Smith Marie Pierre Dubé S Matthijs Boekholdt G Kees Hovingh John J P Kastelein Paul M McKeigue John Betteridge Andrew Neil Paul N Durrington Alex Doney Fiona Carr Andrew Morris Mark I McCarthy Leif Groop Emma Ahlqvist Joshua C Bis Kenneth Rice Nicholas L Smith Thomas Lumley Eric A Whitsel Til Stürmer Eric Boerwinkle Julius S Ngwa Christopher J O'Donnell Ramachandran S Vasan Wei-Qi Wei Russell A Wilke Ching-Ti Liu Fangui Sun Xiuqing Guo Susan R Heckbert Wendy Post Nona Sotoodehnia Alice M Arnold Jeanette M Stafford Jingzhong Ding David M Herrington Stephen B Kritchevsky Gudny Eiriksdottir Leonore J Launer Tamara B Harris Audrey Y Chu Franco Giulianini Jean G MacFadyen Bryan J Barratt Fredrik Nyberg Bruno H Stricker André G Uitterlinden Albert Hofman Fernando Rivadeneira Valur Emilsson Oscar H Franco Paul M Ridker Vilmundur Gudnason Yongmei Liu Joshua C Denny Christie M Ballantyne Jerome I Rotter L Adrienne Cupples Bruce M Psaty Colin N A Palmer Jean-Claude Tardif Helen M Colhoun Graham Hitman Ronald M Krauss J Wouter Jukema Mark J Caulfield

Nat Commun 2014 Oct 28;5:5068. Epub 2014 Oct 28.

1] NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK [2] Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M6BQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220464PMC
October 2014