Helen Chen

Helen Chen

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Helen Chen

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Caring for the mother-child dyad as a family physician.

Singapore Med J 2019 Oct;60(10):497-501

Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.11622/smedj.2019128DOI Listing
October 2019

Maternal Anxiety, Parenting Stress, and Preschoolers' Behavior Problems: The Role of Child Self-Regulation.

J Dev Behav Pediatr 2019 Sep 24. Epub 2019 Sep 24.

Centre for Research in Child Development, National Institute of Education, Nanyang Technological University, Singapore, Singapore.

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http://dx.doi.org/10.1097/DBP.0000000000000737DOI Listing
September 2019

Identifying trajectories of antenatal depression in women and their associations with gestational age and neonatal anthropometry: A prospective cohort study.

Gen Hosp Psychiatry 2019 Sep 12;61:26-33. Epub 2019 Sep 12.

Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.genhosppsych.2019.09.001DOI Listing
September 2019

Television viewing and child cognition in a longitudinal birth cohort in Singapore: the role of maternal factors.

BMC Pediatr 2019 Aug 16;19(1):286. Epub 2019 Aug 16.

Department of Paediatrics, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, 1E Kent Ridge Road, Singapore, 119228, Singapore.

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http://dx.doi.org/10.1186/s12887-019-1651-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696668PMC
August 2019

Intrauterine Microbiota: Missing, or the Missing Link?

Trends Neurosci 2019 Jun 30;42(6):402-413. Epub 2019 Apr 30.

Department of Psychiatry and Behavioral Health, Wexner Medical Center at The Ohio State University, Columbus, OH, USA; Department of Neuroscience, Wexner Medical Center at The Ohio State University, Columbus, OH, USA; Department of Obstetrics and Gynecology, Wexner Medical Center at The Ohio State University, Columbus, OH, USA; Institute of Behavioral Medicine Research, Wexner Medical Center at The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2019.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604064PMC
June 2019

A cross-sectional survey of what patients find most therapeutic in perinatal mental healthcare in Singapore.

Asian J Psychiatr 2019 Jun 3;43:57-59. Epub 2019 May 3.

Department of Psychological Medicine, Women's Mental Wellness Service, KK Women's and Children's Hospital, Singapore.

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http://dx.doi.org/10.1016/j.ajp.2019.05.007DOI Listing
June 2019

Prognostic value of volumetric metabolic parameter changes determined by during and after radiotherapy-based F-FDG PET/CT in stage III non-small cell lung cancer.

Kaohsiung J Med Sci 2019 Mar;35(3):151-159

Nuclear Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.1002/kjm2.12027DOI Listing
March 2019

Maternal Parenting Stress, Child Exuberance, and Preschoolers' Behavior Problems.

Child Dev 2019 01 2;90(1):136-146. Epub 2018 Nov 2.

Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR).

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http://dx.doi.org/10.1111/cdev.13180DOI Listing
January 2019

Maternal sensitivity during infancy and the regulation of startle in preschoolers.

Attach Hum Dev 2018 Nov 8:1-18. Epub 2018 Nov 8.

a Singapore Institute for Clinical Sciences (SICS) , Agency for Science and Technology (A*STAR) , Singapore.

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https://www.tandfonline.com/doi/full/10.1080/14616734.2018.1
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http://dx.doi.org/10.1080/14616734.2018.1542737DOI Listing
November 2018

Antenatal Anxiety: Prevalence and Patterns in a Routine Obstetric Population.

Ann Acad Med Singapore 2018 Oct;47(10):405-412

Department of  Psychological Medicine, KK Women's and Children's Hospital, Singapore.

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October 2018

Threatened miscarriage and depressive and anxiety symptoms among women and partners in early pregnancy.

J Affect Disord 2018 09 12;237:1-9. Epub 2018 Apr 12.

Duke-NUS Medical School, 8 College Road, 169857, Singapore.

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http://dx.doi.org/10.1016/j.jad.2018.04.012DOI Listing
September 2018

Greater caregiving risk, better infant memory performance?

Hippocampus 2018 07;28(7):497-511

Singapore Institute for Clinical Sciences, A*STAR, Singapore 117609, Singapore.

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http://dx.doi.org/10.1002/hipo.22949DOI Listing
July 2018

An Adventure in Open Payments.

Authors:
Helen Chen

Ann Intern Med 2018 07;169(2):135

Hebrew SeniorLife, Boston, Massachusetts (H.C.).

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http://dx.doi.org/10.7326/L18-0204DOI Listing
July 2018

Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis.

Int J Mol Sci 2018 May 16;19(5). Epub 2018 May 16.

Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan.

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http://dx.doi.org/10.3390/ijms19051486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983780PMC
May 2018

Factors influencing dialysis withdrawal: a scoping review.

BMC Nephrol 2018 04 24;19(1):96. Epub 2018 Apr 24.

School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, ON, Canada.

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-0894-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921369PMC
April 2018

Investigation of variants in estrogen receptor genes and perinatal depression.

Neuropsychiatr Dis Treat 2018 29;14:919-925. Epub 2018 Mar 29.

Paediatrics Academic Clinical Programme, SingHealth Duke-NUS Medical School, Singapore, Singapore.

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http://dx.doi.org/10.2147/NDT.S160424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880413PMC
March 2018

FKBP5 Moderates the Association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphology.

Neuropsychopharmacology 2018 02 3;43(3):564-570. Epub 2017 Oct 3.

Department of Biomedical Engineering and Clinical Imaging Research Center, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/npp.2017.232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770768PMC
February 2018

Perinatal maternal depressive symptoms alter amygdala functional connectivity in girls.

Hum Brain Mapp 2018 02 2;39(2):680-690. Epub 2017 Nov 2.

Department of Biomedical Engineering and Clinical Imaging Research Center, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/hbm.23873DOI Listing
February 2018

Relation of plasma tryptophan concentrations during pregnancy to maternal sleep and mental well-being: The GUSTO cohort.

J Affect Disord 2018 01 23;225:523-529. Epub 2017 Aug 23.

Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Clinical Nutrition Research Center, Agency for Science, Technology and Research, Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2017.08.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667743PMC
January 2018

The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation.

Mol Biol Cell 2018 Jan 31. Epub 2018 Jan 31.

Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4

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http://dx.doi.org/10.1091/mbc.E17-08-0531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905292PMC
January 2018

Patterns and predictors of treatment outcome for antenatal major depression.

Singapore Med J 2017 Nov 1;58(11):642-648. Epub 2016 Jun 1.

Department of Psychological Medicine, KK Women's and Children's Hospital, Singapore.

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http://dx.doi.org/10.11622/smedj.2016100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691227PMC
November 2017

Polyunsaturated Fatty Acids in Perinatal Depression: A Systematic Review and Meta-analysis.

Biol Psychiatry 2017 Oct 9;82(8):560-569. Epub 2017 Mar 9.

Department of Psychiatry, Brain Disease Research Center, and Mind-Body Interface Laboratory , China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.02.1182DOI Listing
October 2017

Wheat germ agglutinin-induced paraptosis-like cell death and protective autophagy is mediated by autophagy-linked FYVE inhibition.

Oncotarget 2017 Oct 24;8(53):91209-91222. Epub 2017 Aug 24.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://www.oncotarget.com/fulltext/20436
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http://dx.doi.org/10.18632/oncotarget.20436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710917PMC
October 2017

Neurobiological correlates of state-dependent context fear.

Learn Mem 2017 09 16;24(9):385-391. Epub 2017 Aug 16.

Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1101/lm.045542.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580530PMC
September 2017

Improving radiotherapy in cancer treatment: Promises and challenges.

Oncotarget 2017 Sep 8;8(37):62742-62758. Epub 2017 Jun 8.

Division of Clinical Radiation Oncology, Department of Radiation Oncology, National Cheng Kung University Hospital, Department of Radiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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http://dx.doi.org/10.18632/oncotarget.18409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617545PMC
September 2017

Phase III Prospective Randomized Comparison Trial of Depot Octreotide Plus Interferon Alfa-2b Versus Depot Octreotide Plus Bevacizumab in Patients With Advanced Carcinoid Tumors: SWOG S0518.

J Clin Oncol 2017 May 6;35(15):1695-1703. Epub 2017 Apr 6.

James C. Yao and Cesar Moran, MD Anderson Cancer Center, Houston, TX; Katherine A. Guthrie and Shannon McDonough, Fred Hutchinson Cancer Research Center, Seattle, WA; Jonathan R. Strosberg, H. Lee Moffitt Cancer Center, Tampa, FL; Matthew H. Kulke and Jennifer A. Chan, Dana Farber Cancer Institute, Boston, MA; Noelle LoConte, University of Wisconsin, Carbone Cancer Center, Madison, WI; Robert R. McWilliams, Mayo Clinic College of Medicine, Rochester, MN; Edward M. Wolin, University of Kentucky, Lexington, KY; Edward M. Wolin, Montifiore Einstein Cancer Center, New York, NY; Bassam Mattar, Wichita NCORP/Cancer Center of Kansas, Wichita, KS; Helen Chen, NCI Cancer Therapy Evaluation Program, Bethesda, MD; Charles D. Blanke, Oregon Health & Science University, Portland, OR; and Howard S. Hochster, Yale Cancer Center, New Haven, CT.

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http://dx.doi.org/10.1200/JCO.2016.70.4072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455764PMC
May 2017

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.

Cancer Lett 2017 03 30;388:54-63. Epub 2016 Nov 30.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.11.028DOI Listing
March 2017

Heterologous protein-DNA interactions lead to biased allelic expression of circadian clock genes in interspecific hybrids.

Sci Rep 2017 03 27;7:45087. Epub 2017 Mar 27.

Department of Molecular Biosciences and Center for Computational Biology and Bioinformatics, The University of Texas at Austin, Austin, Texas 78712, USA.

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http://dx.doi.org/10.1038/srep45087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366859PMC
March 2017

Kruppel-like factor4 regulates expression through binding to an autoimmune risk allele.

JCI Insight 2017 01 12;2(1):e89569. Epub 2017 Jan 12.

Center for Autoimmune and Musculoskeletal Diseases and.

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http://dx.doi.org/10.1172/jci.insight.89569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214232PMC
January 2017

Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory.

Learn Mem 2016 11 17;23(11):631-638. Epub 2016 Oct 17.

Department of Psychiatry and Behavioral Sciences, The Asher Center for the Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

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http://dx.doi.org/10.1101/lm.043133.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066603PMC
November 2016

Understanding How Postnatal Depression Screening and Early Intervention Work in the Real World - A Singaporean Perspective.

Ann Acad Med Singapore 2016 Oct;45(10):466-470

Department of Psychological Medicine, KK Women's and Children's Hospital, Singapore.

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October 2016

Effects of Cu(II) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding: Insights into the regulation of copper homeostasis and platinum drug transport.

J Inorg Biochem 2016 08 27;161:37-9. Epub 2016 Apr 27.

Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jinorgbio.2016.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912872PMC
August 2016

Cost effectiveness of cancer treatment in Taiwan.

J Formos Med Assoc 2016 Aug 11;115(8):609-18. Epub 2016 Jun 11.

Department of Public Health, National Cheng Kung University College of Medicine, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department Occupational and Environmental Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2016.04.002DOI Listing
August 2016

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.

Cell Metab 2016 Jun 26;23(6):1154-1166. Epub 2016 May 26.

Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909537PMC
June 2016

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case-control study.

Neuropsychiatr Dis Treat 2016 9;12:1333-9. Epub 2016 Jun 9.

Department of Women's Anaesthesia, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, KK Women's and Children's Hospital, Singapore.

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https://www.dovepress.com/investigating-analgesic-and-psycho
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http://dx.doi.org/10.2147/NDT.S105918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908936PMC
June 2016

Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.

Expert Opin Ther Targets 2015 25;19(10):1307-17. Epub 2015 May 25.

i 9 The University of Texas MD Anderson Cancer Center, Department of Translational Molecular Pathology , Unit 2951, LSP 9.4206, 2130 W. Holcombe Blvd, Houston, TX 77030, USA +1 713 834 6038 ; +1 713 834 6085 ;

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http://dx.doi.org/10.1517/14728222.2015.1043269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846984PMC
May 2016

Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2.

Cell Cycle 2014 29;13(14):2248-61. Epub 2014 May 29.

Department of Pediatrics; Child and Family Research Institute; University of British Columbia; Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4161/cc.29270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111680PMC
December 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Retrospective observation of mental disorders during postpartum period: Results from the Singapore mental health study.

BMC Womens Health 2015 Dec 16;15:119. Epub 2015 Dec 16.

Research Division, Institute of Mental Health, 10 Buangkok View, Singapore, 539747, Singapore.

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http://dx.doi.org/10.1186/s12905-015-0279-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682228PMC
December 2015

Case-control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depression.

BMC Pregnancy Childbirth 2015 Oct 30;15:283. Epub 2015 Oct 30.

Paediatrics Academic Clinical Programme, SingHealth Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://bmcpregnancychildbirth.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s12884-015-0720-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628323PMC
October 2015

GABAergic mechanisms regulated by miR-33 encode state-dependent fear.

Nat Neurosci 2015 Sep 17;18(9):1265-71. Epub 2015 Aug 17.

Department of Psychiatry and Behavioral Sciences, The Asher Center of Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nn.4084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880671PMC
September 2015

Phase I/II Trial of Imatinib and Bevacizumab in Patients With Advanced Melanoma and Other Advanced Cancers.

Oncologist 2015 Aug 17;20(8):952-9. Epub 2015 Jun 17.

Developmental Therapeutics Program, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, USA; Cancer Therapeutics Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1634/theoncologist.2015-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524755PMC
August 2015

The Prevalence and Impact of Hyperglycemia and Hyperlipidemia in Patients With Advanced Cancer Receiving Combination Treatment With the Mammalian Target of Rapamycin Inhibitor Temsirolimus and Insulin Growth Factor-Receptor Antibody Cixutumumab.

Oncologist 2015 Jul 8;20(7):737-41. Epub 2015 Jun 8.

Departments of Endocrine Neoplasia and Hormonal Disorders, Head and Neck Surgery, Biostatistics, and Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA; Cancer Therapy Evaluation Program, National Institutes of Health/National Cancer Institute, Rockville, Maryland, USA; Center for Personalized Cancer Therapy, University of California, San Diego, Moores Cancer Center, La Jolla, California, USA

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http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theon
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http://dx.doi.org/10.1634/theoncologist.2015-0065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492245PMC
July 2015

Genomic Profiling: Building a Continuum From Knowledge to Care.

JAMA Oncol 2015 Jul;1(4):474-5

Cancer Therapy Evaluation Program, Division of Cancer Therapy and Diagnosis, National Cancer Institute, Rockville, Maryland.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2015.1333DOI Listing
July 2015

Phase I study of the anti-IGF1R antibody cixutumumab with everolimus and octreotide in advanced well-differentiated neuroendocrine tumors.

Endocr Relat Cancer 2015 Jun 21;22(3):431-41. Epub 2015 Apr 21.

Department of Gastrointestinal Medical OncologyThe University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Street, Unit 426, Houston, Texas 77030, USANational Cancer InstituteRockville, Maryland, USA

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http://dx.doi.org/10.1530/ERC-15-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566955PMC
June 2015

Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors.

J Clin Oncol 2015 May 8;33(14):1551-6. Epub 2014 Dec 8.

Timothy J. Hobday, Rui Qin, and Charles Erlichman, Mayo Clinic, Rochester, MN; Diane Reidy-Lagunes, Memorial Sloan Kettering Cancer Center, New York; Andreas Kaubisch, Montefiore Medical Center, Bronx, NY; Malcolm J. Moore, Princess Margaret Hospital, Toronto, Ontario, Canada; Jonathan Strosberg, H. Lee Moffitt Cancer Center, Tampa, FL; Manisha Shah, Ohio State University, Columbus, OH; Hedy Lee Kindler, University of Chicago, Chicago, IL; Heinz-Josef Lenz, University of Southern California, Los Angeles, CA; and Helen Chen, National Cancer Institute, Rockville, MD.

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http://dx.doi.org/10.1200/JCO.2014.56.2082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417726PMC
May 2015

Antenatal maternal anxiety predicts variations in neural structures implicated in anxiety disorders in newborns.

J Am Acad Child Adolesc Psychiatry 2015 Apr 30;54(4):313-21.e2. Epub 2015 Jan 30.

Singapore Institute for Clinical Sciences; National University of Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jaac.2015.01.013DOI Listing
April 2015

A phase II trial of bevacizumab plus temsirolimus in patients with advanced hepatocellular carcinoma.

Invest New Drugs 2015 Feb 16;33(1):241-6. Epub 2014 Oct 16.

Staff Medical Oncologist, Gastrointestinal Oncology Lead, Princess Margaret Cancer Centre, University of Toronto, 5-210, 610 University Ave, Toronto, ON, M5G 2 M9, USA,

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http://link.springer.com/content/pdf/10.1007/s10637-014-0169
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February 2015

COMT haplotypes modulate associations of antenatal maternal anxiety and neonatal cortical morphology.

Am J Psychiatry 2015 Feb 31;172(2):163-72. Epub 2014 Oct 31.

From the Department of Biomedical Engineering and Clinical Imaging Research Center, National University of Singapore, Singapore; the Singapore Institute for Clinical Sciences, Singapore; the Department of Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, Singapore; the Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; the Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal; the Sackler Program for Epigenetics and Psychobiology at McGill University, Montreal; the Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; the KK Women's and Children's Hospital, Singapore; and the Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

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http://www.bioeng.nus.edu.sg/cfa/publications/appi_ajp_2014.
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http://psychiatryonline.org/doi/abs/10.1176/appi.ajp.2014.14
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http://dx.doi.org/10.1176/appi.ajp.2014.14030313DOI Listing
February 2015

Comparison of expected health impacts for major cancers: integration of incidence rate and loss of quality-adjusted life expectancy.

Cancer Epidemiol 2015 Feb 30;39(1):126-32. Epub 2014 Dec 30.

Department of Public Health, National Cheng Kung University College of Medicine, Tainan 704, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan; Department of Occupational and Environmental Medicine, National Cheng Kung University Hospital, Tainan 704, Taiwan. Electronic address:

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February 2015

Necroptotic signaling in adaptive and innate immunity.

Semin Cell Dev Biol 2014 Nov 18;35:33-9. Epub 2014 Jul 18.

Institute for Immunology, Department of Molecular Biology and Biochemistry, 3215 McGaugh Hall, University of California, Irvine, Irvine, CA 92697-3900, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197103PMC
November 2014

Estimation of loss of quality-adjusted life expectancy (QALE) for patients with operable versus inoperable lung cancer: adjusting quality-of-life and lead-time bias for utility of surgery.

Lung Cancer 2014 Oct 18;86(1):96-101. Epub 2014 Aug 18.

Department of Internal Medicine, National Cheng Kung University College of Medicine and Hospital, No. 138, Sheng Li Road, Tainan 704, Taiwan; Department of Public Health, National Cheng Kung University College of Medicine and Hospital, No. 138, Sheng Li Road, Tainan 704, Taiwan. Electronic address:

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October 2014

Immune checkpoint inhibitors in clinical trials.

Chin J Cancer 2014 Sep;33(9):434-44

Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.5732/cjc.014.10122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190433PMC
September 2014

Cancer immunotherapy.

Authors:
Li Yan Helen X Chen

Chin J Cancer 2014 Sep;33(9):413-5

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http://dx.doi.org/10.5732/cjc.014.10153DOI Listing
September 2014

Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling.

J Pathol 2014 Jul 29;233(3):247-57. Epub 2014 Apr 29.

Institute of Neuropathology, University Hospital Bellvitge, University of Barcelona, Bellvitge Institute for Biomedical Research (IDIBELL), CIBERNED, L'Hospitalet del Llobregat, Barcelona, Catalonia, Spain.

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July 2014

Inhibiting glucosylceramide synthase facilitates the radiosensitizing effects of vinorelbine in lung adenocarcinoma cells.

Cancer Lett 2014 Jul 13;349(2):144-51. Epub 2014 Apr 13.

Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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July 2014

Association of premenstrual/menstrual symptoms with perinatal depression and a polymorphic repeat in the polyglutamine tract of the retinoic acid induced 1 gene.

J Affect Disord 2014 Jun 15;161:43-6. Epub 2014 Mar 15.

Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore; Department of Psychological Medicine, KK Women׳s and Children׳s Hospital, Singapore.

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June 2014

Are we ready for the 10% solution?

Oncologist 2014 May 22;19(5):439-40. Epub 2014 Apr 22.

Cancer Therapy Evaluation Program, Biometric Research Branch, and Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012974PMC
May 2014

The influence of anxiety and depressive symptoms during pregnancy on birth size.

Paediatr Perinat Epidemiol 2014 Mar 24;28(2):116-26. Epub 2013 Nov 24.

Department of Psychological Medicine, National University Hospital, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Singapore Institute for Clinical Sciences, Singapore.

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March 2014

Discovery of MK-7655, a β-lactamase inhibitor for combination with Primaxin®.

Bioorg Med Chem Lett 2014 Feb 3;24(3):780-5. Epub 2014 Jan 3.

Department of Medicinal Chemistry, Merck Research Labs, Rahway, NJ 07065, USA; Department of Infectious Diseases, Merck Research Labs, Rahway, NJ 07065, USA.

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February 2014

Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals.

J Biol Inorg Chem 2014 Jan 17;19(1):17-27. Epub 2013 Oct 17.

Department of Translational Molecular Pathology (Route 2951), The University of Texas MD Anderson Cancer Center, 2130 W. Holcombe Blvd., Houston, TX, 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889686PMC
January 2014

Estimating the lifelong health impact and financial burdens of different types of lung cancer.

BMC Cancer 2013 Dec 5;13:579. Epub 2013 Dec 5.

Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, 138 Sheng Li Road, Tainan 70403, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234193PMC
December 2013

Overcoming platinum drug resistance with copper-lowering agents.

Anticancer Res 2013 Oct;33(10):4157-61

Department of Translational Molecular Pathology (Unit 951), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.

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October 2013

Postnatal depression: a family medicine perspective.

Singapore Med J 2013 Sep;54(9):477-9; quiz 480-1

Department of Psychological Medicine, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229899.

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September 2013