Publications by authors named "Helen Chapel"

68Publications

Defining B-cell defects and correlation with complications in patients with common variable immune deficiency.

J Allergy Clin Immunol 2019 09 29;144(3):654-655. Epub 2019 Jun 29.

Primary Immunodeficiency Unit, Department of Experimental Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Clinical Immunology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.06.018DOI Listing
September 2019

Ralph Josiah Patrick Wedgwood (1924-2017).

J Clin Immunol 2018 02 27;38(2):153-154. Epub 2017 Dec 27.

Department of Pediatrics, British Columbia Children's Hospital, International Pediatric Association, Vancouver, BC, V6H 3V4, Canada.

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http://dx.doi.org/10.1007/s10875-017-0471-xDOI Listing
February 2018

Assessment of Local Adverse Reactions to Subcutaneous Immunoglobulin (SCIG) in Clinical Trials.

J Clin Immunol 2017 08 10;37(6):517-518. Epub 2017 Jul 10.

Oxford University Hospitals, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1007/s10875-017-0410-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940704PMC
August 2017

Common Variable Immunodeficiency Disorders (CVID) - Diagnoses of Exclusion, Especially Combined Immune Defects.

Authors:
Helen Chapel

J Allergy Clin Immunol Pract 2016 Nov - Dec;4(6):1158-1159

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132198163040
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http://dx.doi.org/10.1016/j.jaip.2016.09.006DOI Listing
August 2018

Challenges in the Role of Gammaglobulin Replacement Therapy and Vaccination Strategies for Hematological Malignancy.

Front Immunol 2016 22;7:317. Epub 2016 Aug 22.

Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of Clinical Immunology, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.3389/fimmu.2016.00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993076PMC
September 2016

Secondary immunodeficiency in lymphoproliferative malignancies.

Hematol Oncol 2016 Sep 12;34(3):121-32. Epub 2016 Jul 12.

Department of Clinical Immunology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/hon.2323DOI Listing
September 2016

Hypomorphic function and somatic reversion of DOCK8 cause combined immunodeficiency without hyper-IgE.

Clin Immunol 2016 Feb 8;163:17-21. Epub 2015 Dec 8.

Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, UK; Oxford NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.clim.2015.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758821PMC
February 2016

The ratio of mean daily IgG increment/mean daily dose in immunoglobulin replacement therapy in primary antibody deficiencies.

J Allergy Clin Immunol Pract 2015 Nov-Dec;3(6):998-1000.e2. Epub 2015 Aug 2.

Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2015.07.001DOI Listing
August 2016

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

Clin Immunol 2015 Oct 26;160(2):301-14. Epub 2015 Jun 26.

Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601528PMC
October 2015

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Authors:
Jenny C Taylor Hilary C Martin Stefano Lise John Broxholme Jean-Baptiste Cazier Andy Rimmer Alexander Kanapin Gerton Lunter Simon Fiddy Chris Allan A Radu Aricescu Moustafa Attar Christian Babbs Jennifer Becq David Beeson Celeste Bento Patricia Bignell Edward Blair Veronica J Buckle Katherine Bull Ondrej Cais Holger Cario Helen Chapel Richard R Copley Richard Cornall Jude Craft Karin Dahan Emma E Davenport Calliope Dendrou Olivier Devuyst Aimée L Fenwick Jonathan Flint Lars Fugger Rodney D Gilbert Anne Goriely Angie Green Ingo H Greger Russell Grocock Anja V Gruszczyk Robert Hastings Edouard Hatton Doug Higgs Adrian Hill Chris Holmes Malcolm Howard Linda Hughes Peter Humburg David Johnson Fredrik Karpe Zoya Kingsbury Usha Kini Julian C Knight Jonathan Krohn Sarah Lamble Craig Langman Lorne Lonie Joshua Luck Davis McCarthy Simon J McGowan Mary Frances McMullin Kerry A Miller Lisa Murray Andrea H Németh M Andrew Nesbit David Nutt Elizabeth Ormondroyd Annette Bang Oturai Alistair Pagnamenta Smita Y Patel Melanie Percy Nayia Petousi Paolo Piazza Sian E Piret Guadalupe Polanco-Echeverry Niko Popitsch Fiona Powrie Chris Pugh Lynn Quek Peter A Robbins Kathryn Robson Alexandra Russo Natasha Sahgal Pauline A van Schouwenburg Anna Schuh Earl Silverman Alison Simmons Per Soelberg Sørensen Elizabeth Sweeney John Taylor Rajesh V Thakker Ian Tomlinson Amy Trebes Stephen Rf Twigg Holm H Uhlig Paresh Vyas Tim Vyse Steven A Wall Hugh Watkins Michael P Whyte Lorna Witty Ben Wright Chris Yau David Buck Sean Humphray Peter J Ratcliffe John I Bell Andrew Om Wilkie David Bentley Peter Donnelly Gilean McVean

Nat Genet 2015 Jul 18;47(7):717-726. Epub 2015 May 18.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/ng.3304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601524PMC
July 2015

Key stages of bone marrow B-cell maturation are defective in patients with common variable immunodeficiency disorders.

J Allergy Clin Immunol 2015 Aug 26;136(2):487-90.e2. Epub 2015 Feb 26.

Nuffield Department of Medicine, University of Oxford, Oxford University Hospital, Headley Way, Oxford, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1943DOI Listing
August 2015

Rare variants at 16p11.2 are associated with common variable immunodeficiency.

J Allergy Clin Immunol 2015 Jun 10;135(6):1569-77. Epub 2015 Feb 10.

Center for Applied Genomics, Abramson Research Center, Children's Hospital of Philadelphia, Philadelphia, Pa; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine Philadelphia, University of Pennsylvania, Philadelphia, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.12.1939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461447PMC
June 2015

Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe.

Front Immunol 2014 12;5:629. Epub 2014 Dec 12.

Centrum für chronische Immunodeficienz (CCI), University Medical Centre, University of Freiburg , Freiburg im Breisgau , Germany.

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http://dx.doi.org/10.3389/fimmu.2014.00629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263903PMC
January 2015

Primary immune deficiencies - principles of care.

Front Immunol 2014 15;5:627. Epub 2014 Dec 15.

International Patient Organisation for Primary Immunodeficiencies (IPOPI) , Downderry , UK.

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http://dx.doi.org/10.3389/fimmu.2014.00627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266088PMC
January 2015

Immunoglobulin replacement therapy for primary immunodeficiencies.

Immunotherapy 2014 ;6(7):853-69

Primary Immunodeficiency Unit, Level 7, Nuffield Department of Medicine, Oxford University Hospital, John Radcliffe Site, Headley Way, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.2217/imt.14.54DOI Listing
July 2015

Antibody deficiency secondary to chronic lymphocytic leukemia: Should patients be treated with prophylactic replacement immunoglobulin?

J Clin Immunol 2014 Apr 21;34(3):277-82. Epub 2014 Feb 21.

Nuffield Department of Medicine, University of Oxford, Oxford, UK,

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http://dx.doi.org/10.1007/s10875-014-9995-5DOI Listing
April 2014

Subcutaneous immunoglobulin replacement therapy: the European experience.

Curr Opin Allergy Clin Immunol 2013 Dec;13(6):623-9

aPrimary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK bDivision of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

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http://dx.doi.org/10.1097/ACI.0000000000000013DOI Listing
December 2013

Cholangiocarcinoma complicating secondary sclerosing cholangitis from cryptosporidiosis in an adult patient with CD40 ligand deficiency: case report and review of the literature.

Int Arch Allergy Immunol 2012 1;159(2):204-8. Epub 2012 Jun 1.

Department of Hepatology, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1159/000337457DOI Listing
December 2012

Direct ex-vivo evaluation of pneumococcal specific T-cells in healthy adults.

PLoS One 2011 24;6(10):e25367. Epub 2011 Oct 24.

MRC Human Immunology Unit, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025367PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200321PMC
February 2012

Genome-wide association identifies diverse causes of common variable immunodeficiency.

J Allergy Clin Immunol 2011 Jun 17;127(6):1360-7.e6. Epub 2011 Apr 17.

Division of Allergy and Immunology, Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jaci.2011.02.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646656PMC
June 2011

Polycystic parotid disease in a male child: report of a case and review of the literature.

J Oral Maxillofac Surg 2011 May 21;69(5):1375-9. Epub 2011 Jan 21.

Department of Plastic Surgery, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK.

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http://dx.doi.org/10.1016/j.joms.2010.05.018DOI Listing
May 2011

Rapid effector function of circulating CD4+ T cells specific for immunodominant regions of the conserved serine/threonine kinase found in Streptococcus pneumoniae (StkP) in healthy adults.

FEMS Immunol Med Microbiol 2010 Nov 18;60(2):113-22. Epub 2010 Aug 18.

MRC Human Immunology Unit, Oxford NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1111/j.1574-695X.2010.00724.xDOI Listing
November 2010

Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years.

J Allergy Clin Immunol 2010 Jun 14;125(6):1354-1360.e4. Epub 2010 May 14.

Department of Clinical Immunology, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2010.02.040DOI Listing
June 2010

Immunomodulatory therapy to achieve maximum efficacy: doses, monitoring, compliance, and self-infusion at home.

J Clin Immunol 2010 May;30 Suppl 1:S84-9

Department of Clinical Immunology, John Radcliffe Hospital, Level 4A, Oxford, UK.

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http://dx.doi.org/10.1007/s10875-010-9400-yDOI Listing
May 2010

Toll-like receptor responses in IRAK-4-deficient neutrophils.

J Innate Immun 2010 16;2(3):280-7. Epub 2009 Dec 16.

Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. r.vanbruggen @ sanquin.nl

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http://dx.doi.org/10.1159/000268288DOI Listing
September 2010

Women advancing science.

Eur J Immunol 2010 Mar;40(3):589-92

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http://dx.doi.org/10.1002/eji.201090009DOI Listing
March 2010

Primary immunodeficiencies: 2009 update.

J Allergy Clin Immunol 2009 Dec;124(6):1161-78

Division of Immunology, Children's Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797319PMC
December 2009

Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles.

Mol Immunol 2009 Dec 7;47(2-3):575-81. Epub 2009 Oct 7.

Sanquin Research, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.molimm.2009.09.018DOI Listing
December 2009

Dissecting the group of common variable immunodeficiency disorders.

Clin Infect Dis 2009 Nov;49(9):1339-40

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http://dx.doi.org/10.1086/606057DOI Listing
November 2009

Update in understanding common variable immunodeficiency disorders (CVIDs) and the management of patients with these conditions.

Br J Haematol 2009 Jun 30;145(6):709-27. Epub 2009 Mar 30.

Department of Clinical Immunology, Oxford Radcliffe Hospitals, Oxford, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2009.07669.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718064PMC
June 2009

Self-infusion programmes for immunoglobulin replacement at home: feasibility, safety and efficacy.

Immunol Allergy Clin North Am 2008 Nov;28(4):821-32, ix

Department of Clinical Immunology, Nuffield Department of Medicine and Oxford Radcliffe Hospitals, Oxford, UK.

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http://dx.doi.org/10.1016/j.iac.2008.06.005DOI Listing
November 2008

Prescribing intravenous immunoglobulin: summary of Department of Health guidelines.

BMJ 2008 Oct 20;337:a1831. Epub 2008 Oct 20.

Department of Haematology, Barts and the London NHS Trust, The Royal London Hospital, London E1 2ES.

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http://dx.doi.org/10.1136/bmj.a1831DOI Listing
October 2008

A fast procedure for the detection of defects in Toll-like receptor signaling.

Pediatrics 2006 Dec;118(6):2498-503

Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes, Institut National de la Santé et de la Recherche Médicale U550, Necker Medical School, Paris, France.

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http://dx.doi.org/10.1542/peds.2006-1845DOI Listing
December 2006

Primary immunodeficiency diseases consortium conference.

Clin Immunol 2005 Sep;116(3):279-80

Children's Hospital of Philadelphia, Div Immunologic and Infectious Disease, 34th St. and Civic Center Blvd., Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.clim.2005.05.006DOI Listing
September 2005

Shigella sonnei meningitis due to interleukin-1 receptor-associated kinase-4 deficiency: first association with a primary immune deficiency.

Clin Infect Dis 2005 May 31;40(9):1227-31. Epub 2005 Mar 31.

Department of Clinical Immunology, Nuffield Department of Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

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http://dx.doi.org/10.1086/428733DOI Listing
May 2005

European surveillance of immunoglobulin safety--results of initial survey of 1243 patients with primary immunodeficiencies in 16 countries.

Clin Immunol 2002 Sep;104(3):231-6

Department of Clinical Immunology, University of Rome La Sapienza, Viale dell'Università 37, 00185, Rome, Italy.

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http://dx.doi.org/10.1006/clim.2002.5239DOI Listing
September 2002