Publications by authors named "Helen Byers"

40Publications

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.

Authors:
Haoyu Zhang Thomas U Ahearn Julie Lecarpentier Daniel Barnes Jonathan Beesley Guanghao Qi Xia Jiang Tracy A O'Mara Ni Zhao Manjeet K Bolla Alison M Dunning Joe Dennis Qin Wang Zumuruda Abu Ful Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Volker Arndt Kristan J Aronson Banu K Arun Paul L Auer Jacopo Azzollini Daniel Barrowdale Heiko Becher Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Katarzyna Bialkowska Ana Blanco Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Bernardo Bonanni Davide Bondavalli Ake Borg Hiltrud Brauch Hermann Brenner Ignacio Briceno Annegien Broeks Sara Y Brucker Thomas Brüning Barbara Burwinkel Saundra S Buys Helen Byers Trinidad Caldés Maria A Caligo Mariarosaria Calvello Daniele Campa Jose E Castelao Jenny Chang-Claude Stephen J Chanock Melissa Christiaens Hans Christiansen Wendy K Chung Kathleen B M Claes Christine L Clarke Sten Cornelissen Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Peter Devilee Orland Diez Susan M Domchek Thilo Dörk Miriam Dwek Diana M Eccles Arif B Ekici D Gareth Evans Peter A Fasching Jonine Figueroa Lenka Foretova Florentia Fostira Eitan Friedman Debra Frost Manuela Gago-Dominguez Susan M Gapstur Judy Garber José A García-Sáenz Mia M Gaudet Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Jacek Gronwald Pascal Guénel Lothar Häberle Eric Hahnen Christopher A Haiman Christopher R Hake Per Hall Ute Hamann Elaine F Harkness Bernadette A M Heemskerk-Gerritsen Peter Hillemanns Frans B L Hogervorst Bernd Holleczek Antoinette Hollestelle Maartje J Hooning Robert N Hoover John L Hopper Anthony Howell Hanna Huebner Peter J Hulick Evgeny N Imyanitov Claudine Isaacs Louise Izatt Agnes Jager Milena Jakimovska Anna Jakubowska Paul James Ramunas Janavicius Wolfgang Janni Esther M John Michael E Jones Audrey Jung Rudolf Kaaks Pooja Middha Kapoor Beth Y Karlan Renske Keeman Sofia Khan Elza Khusnutdinova Cari M Kitahara Yon-Dschun Ko Irene Konstantopoulou Linetta B Koppert Stella Koutros Vessela N Kristensen Anne-Vibeke Laenkholm Diether Lambrechts Susanna C Larsson Pierre Laurent-Puig Conxi Lazaro Emilija Lazarova Flavio Lejbkowicz Goska Leslie Fabienne Lesueur Annika Lindblom Jolanta Lissowska Wing-Yee Lo Jennifer T Loud Jan Lubinski Alicja Lukomska Robert J MacInnis Arto Mannermaa Mehdi Manoochehri Siranoush Manoukian Sara Margolin Maria Elena Martinez Laura Matricardi Lesley McGuffog Catriona McLean Noura Mebirouk Alfons Meindl Usha Menon Austin Miller Elvira Mingazheva Marco Montagna Anna Marie Mulligan Claire Mulot Taru A Muranen Katherine L Nathanson Susan L Neuhausen Heli Nevanlinna Patrick Neven William G Newman Finn C Nielsen Liene Nikitina-Zake Jesse Nodora Kenneth Offit Edith Olah Olufunmilayo I Olopade Håkan Olsson Nick Orr Laura Papi Janos Papp Tjoung-Won Park-Simon Michael T Parsons Bernard Peissel Ana Peixoto Beth Peshkin Paolo Peterlongo Julian Peto Kelly-Anne Phillips Marion Piedmonte Dijana Plaseska-Karanfilska Karolina Prajzendanc Ross Prentice Darya Prokofyeva Brigitte Rack Paolo Radice Susan J Ramus Johanna Rantala Muhammad U Rashid Gad Rennert Hedy S Rennert Harvey A Risch Atocha Romero Matti A Rookus Matthias Rübner Thomas Rüdiger Emmanouil Saloustros Sarah Sampson Dale P Sandler Elinor J Sawyer Maren T Scheuner Rita K Schmutzler Andreas Schneeweiss Minouk J Schoemaker Ben Schöttker Peter Schürmann Leigha Senter Priyanka Sharma Mark E Sherman Xiao-Ou Shu Christian F Singer Snezhana Smichkoska Penny Soucy Melissa C Southey John J Spinelli Jennifer Stone Dominique Stoppa-Lyonnet Anthony J Swerdlow Csilla I Szabo Rulla M Tamimi William J Tapper Jack A Taylor Manuel R Teixeira MaryBeth Terry Mads Thomassen Darcy L Thull Marc Tischkowitz Amanda E Toland Rob A E M Tollenaar Ian Tomlinson Diana Torres Melissa A Troester Thérèse Truong Nadine Tung Michael Untch Celine M Vachon Ans M W van den Ouweland Lizet E van der Kolk Elke M van Veen Elizabeth J vanRensburg Ana Vega Barbara Wappenschmidt Clarice R Weinberg Jeffrey N Weitzel Hans Wildiers Robert Winqvist Alicja Wolk Xiaohong R Yang Drakoulis Yannoukakos Wei Zheng Kristin K Zorn Roger L Milne Peter Kraft Jacques Simard Paul D P Pharoah Kyriaki Michailidou Antonis C Antoniou Marjanka K Schmidt Georgia Chenevix-Trench Douglas F Easton Nilanjan Chatterjee Montserrat García-Closas

Nat Genet 2020 06 18;52(6):572-581. Epub 2020 May 18.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41588-020-0609-2DOI Listing
June 2020

A case-control evaluation of 143 single nucleotide polymorphisms for breast cancer risk stratification with classical factors and mammographic density.

Int J Cancer 2020 04 13;146(8):2122-2129. Epub 2019 Jul 13.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/ijc.32541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065068PMC
April 2020

Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants.

Breast Cancer Res Treat 2019 Jul 2;176(1):141-148. Epub 2019 Apr 2.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Charterhouse Square, Barts and The London, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1007/s10549-019-05210-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548748PMC
July 2019

A Dominantly Inherited 5' UTR Variant Causing Methylation-Associated Silencing of BRCA1 as a Cause of Breast and Ovarian Cancer.

Am J Hum Genet 2018 08;103(2):213-220

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK; Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Manchester M20 4BX, UK; Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080768PMC
August 2018

Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction.

JAMA Oncol 2018 Apr;4(4):476-482

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England.

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http://dx.doi.org/10.1001/jamaoncol.2017.4881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885189PMC
April 2018

Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials.

J Clin Oncol 2017 Mar 28;35(7):743-750. Epub 2016 Dec 28.

Jack Cuzick, Adam R. Brentnall, Caroline Reuter, and Ivana Sestak, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London; Corrinne Segal, The Institute of Cancer Research; Corrinne Segal, Simone Detre, Elena Lopez-Knowles, and Mitchell Dowsett, Royal Marsden Hospital; Trevor J. Powles, Cancer Centre London, London; Helen Byers and William G. Newman, University of Manchester and Central Manchester Foundation Trust; and Anthony Howell, The Christie NHS Foundation Trust, Manchester, United Kingdom.

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http://ascopubs.org/doi/10.1200/JCO.2016.69.8944
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http://dx.doi.org/10.1200/JCO.2016.69.8944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455424PMC
March 2017

The impact of a panel of 18 SNPs on breast cancer risk in women attending a UK familial screening clinic: a case-control study.

J Med Genet 2017 02 28;54(2):111-113. Epub 2016 Oct 28.

Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2016-104125DOI Listing
February 2017

Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment.

Reprod Biomed Online 2016 Sep 17;33(3):391-7. Epub 2016 Jun 17.

Department of Reproductive Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.rbmo.2016.06.001DOI Listing
September 2016

Sensitivity of BRCA1/2 testing in high-risk breast/ovarian/male breast cancer families: little contribution of comprehensive RNA/NGS panel testing.

Eur J Hum Genet 2016 11 8;24(11):1591-1597. Epub 2016 Jun 8.

Genomic Medicine, Institute of Human Development, St. Mary's Hospital, Manchester Academic Health Science Centre, Central Manchester Foundation Trust, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/ejhg.2016.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110056PMC
November 2016

AMH type II receptor and AMH gene polymorphisms are not associated with ovarian reserve, response, or outcomes in ovarian stimulation.

J Assist Reprod Genet 2016 Aug 3;33(8):1085-91. Epub 2016 May 3.

Department of Reproductive Medicine, St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.1007/s10815-016-0711-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974219PMC
August 2016

The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes.

Hum Mutat 2016 Mar 11;37(3):250-6. Epub 2016 Jan 11.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.1002/humu.22938DOI Listing
March 2016

Detection of a mosaic PIK3CA mutation in dental DNA from a child with megalencephaly capillary malformation syndrome.

Clin Dysmorphol 2016 Jan;25(1):16-8

Manchester Centre for Genomic Medicine, Manchester, UK.

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http://dx.doi.org/10.1097/MCD.0000000000000099DOI Listing
January 2016

Common variants modify the age of onset for basal cell carcinomas in Gorlin syndrome.

Eur J Hum Genet 2015 May 27;23(5):708-10. Epub 2014 Aug 27.

1] Manchester Centre for Genomic Medicine, University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), Manchester, UK [2] Department of Genetic Medicine, Manchester Centre for Genomic Medicine, MAHSC, St Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust (CMFT), Manchester, UK.

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http://dx.doi.org/10.1038/ejhg.2014.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402640PMC
May 2015

Identification of a novel familial FGF16 mutation in metacarpal 4-5 fusion.

Clin Dysmorphol 2014 Jul;23(3):95-7

aManchester Centre for Genomic Medicine, University of Manchester bManchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust cDepartment of Surgery, University Hospital South Manchester, Wythenshawe, Manchester, UK.

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http://dx.doi.org/10.1097/MCD.0000000000000043DOI Listing
July 2014

Intronic splicing mutations in PTCH1 cause Gorlin syndrome.

Fam Cancer 2014 Sep;13(3):477-80

Manchester Centre for Genomic Medicine, University of Manchester, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.1007/s10689-014-9712-9DOI Listing
September 2014

Increased rate of phenocopies in all age groups in BRCA1/BRCA2 mutation kindred, but increased prospective breast cancer risk is confined to BRCA2 mutation carriers.

Cancer Epidemiol Biomarkers Prev 2013 Dec 27;22(12):2269-76. Epub 2013 Nov 27.

Authors' Affiliations: Department of Genetic Medicine, The University of Manchester, Manchester Academic Health Science Centre, St. Mary's Hospital; Genesis Prevention Centre, University Hospital of South Manchester Southmoor Road; Centre for Health Informatics, Institute of Population Health, The University of Manchester, Manchester; and Centre for Rare Diseases and Personalised Medicine, School of Clinical and Experimental Medicine, University of Birmingham College of Medical and Dental Sciences, and West Midlands Regional Genetics Service, Birmingham, United Kingdom.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0316-TDOI Listing
December 2013

FSH receptor genotype does not predict metaphase-II oocyte output or fertilization rates in ICSI patients.

Reprod Biomed Online 2013 Sep 20;27(3):305-9. Epub 2013 Jun 20.

Department of Reproductive Medicine, St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

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http://dx.doi.org/10.1016/j.rbmo.2013.06.005DOI Listing
September 2013

Spontaneous ovarian hyperstimulation syndrome: case report, pathophysiological classification and diagnostic algorithm.

Eur J Obstet Gynecol Reprod Biol 2013 Jul 3;169(2):143-8. Epub 2013 Apr 3.

O&G Department, Burnley General Hospital, East Lancashire Hospitals NHS Trust, Casterton Avenue, Burnley, UK.

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http://dx.doi.org/10.1016/j.ejogrb.2013.03.004DOI Listing
July 2013

G6PC3 mutations cause non-syndromic severe congenital neutropenia.

Mol Genet Metab 2013 Feb 21;108(2):138-41. Epub 2012 Dec 21.

Genetic Medicine, St Mary's Hospital, Manchester Academic Health Sciences Centre, University of Manchester, and St Mary's Hospital, Manchester, M13 9WL, UK.

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http://dx.doi.org/10.1016/j.ymgme.2012.12.001DOI Listing
February 2013

Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn.

Mol Neurodegener 2011 Jan 26;6:12. Epub 2011 Jan 26.

MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.

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http://dx.doi.org/10.1186/1750-1326-6-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037338PMC
January 2011

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin.

FASEB J 2008 Sep 29;22(9):3186-95. Epub 2008 May 29.

MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry (P037), De Crespigny Park, SE5 8AF London, UK.

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http://dx.doi.org/10.1096/fj.08-109181DOI Listing
September 2008

Comparison of cellular ribonucleoprotein complexes associated with the APOBEC3F and APOBEC3G antiviral proteins.

J Virol 2008 Jun 26;82(11):5636-42. Epub 2008 Mar 26.

Department of Infectious Diseases, King's College London School of Medicine, London SE1 9RT, United Kingdom.

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http://dx.doi.org/10.1128/JVI.00287-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2395208PMC
June 2008

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

J Biol Chem 2007 Aug 11;282(32):23645-54. Epub 2007 Jun 11.

MRC Centre for Neurodegeneration Research, Department of Neuroscience, King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M703269200DOI Listing
August 2007

Purification and identification of the STAT5 protease in myeloid cells.

Biochem J 2007 May;404(1):81-7

Division of Infection, Immunity and Inflammatory Diseases, Guy's Campus, King's College London, London SE1 9RT, UK.

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http://dx.doi.org/10.1042/BJ20061877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868840PMC
May 2007

Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granules.

J Virol 2007 Mar 13;81(5):2165-78. Epub 2006 Dec 13.

Department of Infectious Diseases, King's College London School of Medicine, 2nd floor, New Guy's House, Guy's Hospital, London Bridge, London SE1 9RT, United Kingdom.

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http://jvi.asm.org/cgi/doi/10.1128/JVI.02287-06
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http://dx.doi.org/10.1128/JVI.02287-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865933PMC
March 2007

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.

J Biol Chem 2005 Oct 26;280(41):34735-40. Epub 2005 Jul 26.

Departments of Neuroscience and Neurology, Institute of Psychiatry, Kings College, London SE5 8AF, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M506216200
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http://dx.doi.org/10.1074/jbc.M506216200DOI Listing
October 2005

Effect of high-fat diet on the expression of proteins in muscle, adipose tissues, and liver of C57BL/6 mice.

Proteomics 2004 Aug;4(8):2270-82

Biomedical Proteomics Research Group, BPRG, Central Clinical Chemistry Laboratory University Hospital, Geneva, Switzerland.

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http://dx.doi.org/10.1002/pmic.200300810DOI Listing
August 2004

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.

J Biol Chem 2004 May 18;279(21):22084-91. Epub 2004 Mar 18.

Department of Neuroscience, The Institute of Psychiatry, King's College London, London, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M311479200
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http://dx.doi.org/10.1074/jbc.M311479200DOI Listing
May 2004

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

Mol Cell Neurosci 2003 Dec;24(4):851-7

Department of Neuroscience, The Institute of Psychiatry, Kings College, London, UK.

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http://dx.doi.org/10.1016/j.mcn.2003.07.002DOI Listing
December 2003

Reversible cysteine-targeted oxidation of proteins during renal oxidative stress.

J Am Soc Nephrol 2003 Aug;14(8 Suppl 3):S290-6

The Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas' Hospital, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1097/01.asn.0000078024.50060.c6DOI Listing
August 2003

PCR-based assays for the fish pathogen Aeromonas salmonicida. II. Further evaluation and validation of three PCR primer sets with infected fish.

Dis Aquat Organ 2002 May;49(2):139-44

Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, VIC.

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http://dx.doi.org/10.3354/dao049139DOI Listing
May 2002

PCR-based assays for the fish pathogen Aeromonas salmonicida. I. Evaluation of three PCR primer sets for detection and identification.

Dis Aquat Organ 2002 May;49(2):129-38

Australian Animal Health Laboratory, CSIRO Livestock Industries, Geelong, Victoria.

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http://dx.doi.org/10.3354/dao049129DOI Listing
May 2002

Detection, quantitation, purification, and identification of cardiac proteins S-thiolated during ischemia and reperfusion.

J Biol Chem 2002 Mar 2;277(12):9806-11. Epub 2002 Jan 2.

Centre for Cardiovascular Biology and Medicine, The Rayne Institute, St Thomas' Hospital, King's College London, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111454200
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http://dx.doi.org/10.1074/jbc.M111454200DOI Listing
March 2002