Helai P Mohammad

Helai P Mohammad

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Helai P Mohammad

Helai P Mohammad

Publications by authors named "Helai P Mohammad"

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Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer.

Nat Med 2019 03 6;25(3):403-418. Epub 2019 Mar 6.

Epigenetics Department, Oncology, GlaxoSmithKline, Collegeville, PA, USA.

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http://dx.doi.org/10.1038/s41591-019-0376-8DOI Listing
March 2019

Targeting Histone Methylation in Cancer.

Cancer J 2017 Sep/Oct;23(5):292-301

From the Cancer Epigenetics Discovery Performance Unit, Oncology R&D, GlaxoSmithKline, Collegeville, PA.

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http://dx.doi.org/10.1097/PPO.0000000000000283DOI Listing
May 2018

Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.

Structure 2016 05 7;24(5):774-781. Epub 2016 Apr 7.

Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA 19426, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2016.03.010DOI Listing
May 2016

Antitumor activity of LSD1 inhibitors in lung cancer.

Mol Cell Oncol 2016 Mar 6;3(2):e1117700. Epub 2016 Jan 6.

Cancer Epigenetics, GlaxoSmithKline , Collegeville, PA, USA.

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http://dx.doi.org/10.1080/23723556.2015.1117700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905412PMC
March 2016

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.

Nucleic Acids Res 2012 May 25;40(10):4334-46. Epub 2012 Jan 25.

Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1093/nar/gks031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378872PMC
May 2012

Linking cell signaling and the epigenetic machinery.

Nat Biotechnol 2010 Oct;28(10):1033-8

Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nbt1010-1033DOI Listing
October 2010

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island.

PLoS Genet 2008 Aug 15;4(8):e1000155. Epub 2008 Aug 15.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America.

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https://dx.doi.org/10.1371/journal.pgen.1000155
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http://dx.doi.org/10.1371/journal.pgen.1000155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491723PMC
August 2008

Targeted overexpression of luteinizing hormone causes ovary-dependent functional adenomas restricted to cells of the Pit-1 lineage.

Endocrinology 2003 Oct 17;144(10):4626-36. Epub 2003 Jul 17.

Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

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http://dx.doi.org/10.1210/en.2003-0357DOI Listing
October 2003